Clinical trials: CD - Crohn's Disease
Crohn Disease
BI 695501 Versus Humira in Patients With Active Crohn's Disease: a Trial Comparing Efficacy, Endoscopic Improvement, Safety, and Immunogenicity
Primary Objective: The primary objective of this trial is to compare the clinical efficacy of BI 695501 with EU-approved Humira® in patients with active Crohn's disease (CD).
- Trial name
- NCT02871635
- Testing
- BI 695501, HUMIRA
- Where
- 92 sites in United States, Belarus and 12 more
- Volunteers
- 147 people
- Sponsor
- Boehringer Ingelheim
Anemia, Bowel Diseases, Inflammatory
Anemia in Inflammatory Bowel Disease
Anemia is a clinical manifestation, which is commonly observed in patients with inflammatory bowel disease, and it accounts for significant loss in the quality of life of these patients.
- Trial name
- IBD (NCT02760940)
- Testing
- oral liposomal iron
- Volunteers
- 200 people
- Sponsor
- Federal University of Juiz de Fora
Inflammatory Bowel Diseases, Ulcerative Colitis
Post-Marketing Use Of CT-P13 (Infliximab) For Standard Of Care Treatment Of Inflammatory Bowel Disease
This is a post-marketing observational study of patients with Inflammatory Bowel Disease (specifically, Crohn's disease or Ulcerative Colitis) who have been prescribed CT-P13 (infliximab) or Remicade (infliximab) for treatment.
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn's Disease
- Trial name
- CONNECT-IBD (NCT02539368)
- Testing
- CT-P13, Remicade
- Where
- 140 sites in Belgium, Czechia and 11 more
- Volunteers
- 2,565 people
- Sponsor
- Pfizer
Crohn Disease
Evaluation of Immunological Markers, Inflammatory and Clinical Relapse Psychological Predictive During Crohn's Disease
Crohn disease (CD) usually evolves by surges interspersed by periods of unpredictable remission. the probability of recurrence of CD in a patient in remission is even stronger if it pre-exists endoscopic lesions of the intestinal…
- Trial name
- NCT02504255
- Testing
- Biological samplings, Questionnaires
- Where
- 3 sites in France
- Volunteers
- 144 people
- Sponsor
- Hospices Civils de Lyon
Crohn's Disease, Vitamin D Deficiency
Trial of High Dose Vitamin D in Patient's With Crohn's Disease
Crohn's disease is more common in areas of the world with less sunlight exposure. Sunlight is a major source of vitamin D. There is some research to suggest that patient's with higher vitamin D levels are less likely to undergo…
- Trial name
- RODIN-CD (NCT02208310)
- Testing
- Cholecalciferol 10,000 IU, Cholecalciferol 400 IU
- Where
- 4 sites in United States
- Volunteers
- 11 people
- Sponsor
- University of Michigan
Crohn's Disease
A Phase II Study in Patients With Moderate to Severe Active Crohn's Disease
The proposed study is a randomized, double-blind, placebo-controlled, multi-center Phase II study to investigate the safety and efficacy of SHR0302 in patients with moderate to severe active Crohn's Disease.
- Trial name
- NCT03677648
- Testing
- SHR0302
- Where
- 82 sites in United States, China and 2 more
- Volunteers
- 112 people
- Sponsor
- Reistone Biopharma Company Limited
Crohn's Disease
Impact of the Fecal Flora Transplantation on Crohn's Disease
Crohn's disease is a chronic and relapsing inflammatory bowel disease. Many data show that the intestinal flora is involved in the disease and it has been show that patients with Crohn's disease exhibit an abnormal fecal flora…
- Trial name
- IMPACT-Crohn (NCT02097797)
- Testing
- Fecal Transplantation
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn's Disease
Positron Emission Tomography (PET) Study of Changes in [11C]AZ14132516 Uptake Following Administration of AZD7798 to Healthy Participants and Patients With Crohn's Disease
The purpose of this study is to measure the changes in small bowel uptake of radioligand [11^C]AZ14132516 after intravenous (IV) administration of single and repeat doses of AZD7798 in healthy participants and participants with…
- Trial name
- NCT06053424
- Testing
- AZD7798, [11C]AZ14132516
- Where
- Sweden
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Inflammatory Bowel Diseases
Study of an Environmental Risk Factor in Crohn's Disease
Inflammatory bowel disease (IBD) are lifelong chronic diseases affecting the gastrointestinal tract. The precise etiology and the different actors participating to the pathophysiological process leading to the disease development…
- Trial name
- EVICTION (NCT04960826)
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Crohn's Disease
The Crohn's Disease Exclusion Diet With Partial Enteral Nutrition or Alone in Adult Patients With Crohn's Disease
This study will evaluate a novel diet for adult crohn's disease patients (The Crohn's Disease Exclusion Diet - CDED). Half of the patients in this study will receive the CDED alone while the other half will receive the CDED and a…
- Trial name
- CDED-AD (NCT02231814)
- Testing
- Crohns Disease Exclusion Diet + PEN, Crohns Disease Exclusion Diet
- Where
- 4 sites in Israel
- Volunteers
- 40 people
- Sponsor
- Prof. Arie Levine
Crohn's Disease
Helmsley 3.0: Abbreviated MRE
The purpose of our study is to compare an abbreviated magnetic resonance imaging (MRI) of the bowel or magnetic resonance enterography (MRE) protocol to a conventional, standard of care MRE in children and adults with Crohn's…
- Trial name
- NCT06533228
- Testing
- Magnetic Resonance Imaging (MRI) or Magnetic Resonance Enterography (MRE)
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Crohn's Disease
Long-term Safety and Efficacy of FURESTEM-CD Inj. in Patients With Moderately Active Crohn's Disease(CD)
The purpose of this clinical trial is to evaluate long-term safety and efficacy in patients who has history of FURESTEM-CD injection at least once.
- Trial name
- NCT02926300
- Testing
- stem cells
- Where
- 7 sites in South Korea
- Volunteers
- 24 people
- Sponsor
- Kang Stem Biotech Co., Ltd.
Crohn's Disease, Perianal Fistula
MIRICURE: Mirikizumab With Curettage and Repair (Closure) for Perianal Fistulizing Crohn's Disease
This Phase 4, single-arm, open-label study will evaluate the effectiveness and safety of mirikizumab combined with surgical curettage and closure in adults with active perianal fistulizing Crohn's disease.
- Trial name
- MIRICURE (NCT07782021)
- Testing
- Mirikizumab, Fistula Tract Curettage and Closure
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Crohn's Disease
Multicenter Trial For Patients With Acute Crohn's Disease
The purpose of this study is to see if etiprednol dicloacetate is safe and effective for the treatment of acute Crohn's disease.
- Trial name
- NCT00035503
- Testing
- etiprednol dicloacetate
- Where
- 11 sites in United States, Canada
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Crohn Disease
Small Bowel Deep Learning Algorithm Project
Crohn's disease affects 200,000 people in the UK (~1 in 500), most are young (diagnosed < 35 years) with costs of direct medical care exceeding £500 million.
- Trial name
- NCT03706664
- Testing
- Machine learning algorithm
- Where
- United Kingdom
- Volunteers
- 226 people
- Sponsor
- London North West Healthcare NHS Trust
Pediatric Inflammatory Bowel Disease
Impact of Therapeutic Strategies in the Pediatric Inflammatory Bowel Disease: a Population Based Study (1988-2011).
Crohn's disease (CD) and ulcerative colitis (UC) are chronic Inflammatory Bowel Disease (IBD) and may affect all segments of the digestive tract.
- Trial name
- Inspired (NCT02392221)
- Where
- 2 sites in France
- Volunteers
- 966 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Crohn's Disease
Impact of Fecal Biotherapy (FBT) on Microbial Diversity in Patients With Moderate to Severe Inflammatory Bowel Disease
The human immune system is usually tolerant of the millions of beneficial commensal bacteria (the microbiome), which colonize the healthy intestinal tract.
- Trial name
- NCT01847170
- Testing
- Fecal Microbial Transplantation
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Beth Israel Deaconess Medical Center
Upper Gastrointestinal Lesions, Crohn's Disease
Upper Gastrointestinal Lesions in Crohn's Disease
A cross-sectional study was performed from 2017 to 2018. Consecutive Crohn's disease patients diagnosed in the Inflammatory bowel disease center of the Sixth Affiliated Hospital of Sun Yat-sen University were recruited.
- Trial name
- NCT03524144
- Testing
- gastroscopy
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Ileocolic Crohn Disease, Kono S Anastomosis
The Remeasure Trial
Aim of the present study is to compare a stapled, functional end-to-end, ileo-colic anastomosis with removal of the mesentery vs the manual, functional end-to-end, ileo-colic Kono-S anastomosis with mesentery preservation, in…
- Conditions
- Ileocolic Crohn Disease, Kono S Anastomosis, Resection of the Mesentery
- Trial name
- NCT07164209
- Testing
- Excision of the mesentery: the mesentery is fully dissected and excised to the limit of macroscopic "fat wrapping", where mesenteric fat is inflamed and extends beyond its normal anatomical distribut, Kono S Anastomosis
- Where
- Italy
- Volunteers
- 73 people
- Sponsor
- Azienda Ospedaliera Ordine Mauriziano di Torino
Crohn's Disease
Study to Assess Efficacy and Safety of Cx601, Adult Allogeneic Expanded Adipose-derived Stem Cells (eASC) for the Treatment of Complex Perianal Fistula(s) in Participants With Crohn's Disease (CD)
The purpose of this study is to evaluate the combined remission of complex perianal fistulas, defined as the clinical assessment at Week 24 of closure of all treated external openings that were draining at baseline despite gentle…
- Trial name
- ADMIRE-CD-II (NCT03279081)
- Testing
- Cx601
- Where
- 159 sites in United States, Belgium and 13 more
- Volunteers
- 568 people
- Sponsor
- Tigenix S.A.U.
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