Clinical trials: CD - Crohn's Disease
Inflammatory Bowel Disease, Crohn's Disease
Assessment of the Social Cost of Crohn's Disease: Economic and Quality of Life Aspects (Study P04560)
This observational study will evaluate the social cost and quality of life of participants who have had Crohn's Disease for at least 6 months and have active disease despite drug therapy.
- Trial name
- COSMO (NCT00723840)
- Testing
- Observational Studies: participants treated according to the real clinical practice.
- Volunteers
- 245 people
- Sponsor
- Merck Sharp & Dohme LLC
Crohn's Disease
A Comparative Study of Capsule Endoscopy, Magnetic Resonance Imaging and Computer Tomography Scanning of the Small Bowel in Crohn's Disease
The aim of this study is to evaluate three diagnostic methods for assessing small bowel disease in patients with suspected or known Crohn's disease.
- Trial name
- NCT01019460
- Testing
- Magnetic resonance imaging, computed tomography scanning and capsule endoscopy
- Volunteers
- 150 people
- Sponsor
- University of Southern Denmark
Crohn Disease
Surgically Resected Crohn's Disease Patients: Prognostic Factors for Re-operation and New Score Building
The project will consist of a multicentre, prospective, observational study with a total duration of 24 months. Clinical, endoscopic and ultrasound data will be collected in a dedicated database (on IG-IBD Register), which will…
- Trial name
- POCD2017 (NCT03150238)
- Testing
- observation of prognostic factors for relapse
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- Istituto Clinico Humanitas
Crohn's Disease
VOICE-Early Response to Vedolizumab and IL-23 Antagonists in Participants With Crohn's Disease: A Prospective Observational Study
The primary aim of this study is to explore the time course of response to Vedolizumab in participants with CD as measured by the Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference-short form…
- Trial name
- VOICE (NCT06249555)
- Testing
- Vedolizumab (VDZ), Ustekinumab (UST), Risankizumab (RISA)
- Where
- 24 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- Alimentiv Inc.
Crohn´s Disease
Osteopathy Non-manipulative in Patients With Crohn's Disease.
Crohn's disease (CD) is an inflammatory bowel disease with a high prevalence. Its etiology is unknown and is considered a multifactorial disease.
- Trial name
- ONManCD (NCT02763293)
- Testing
- Manual Therapy
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- University of Valencia
Crohn's Disease
TOward a Better Understanding of the autoPhagy Machinery for the Identification of Potential Novel Biomarkers and Therapeutic Targets in Crohn's Disease - TOPIC Study
Crohn's disease (CD) belongs to chronic inflammatory bowel diseases (IBD) affecting over 2 million individuals in the North America and 3.2 million in Europe with an increasing incidence rate in newly industrialized countries…
- Trial name
- TOPIC (NCT06244849)
- Testing
- Blood samples, Stool simple, Ileocolonic biopsies
- Where
- 2 sites in France
- Volunteers
- 170 people
- Sponsor
- Hospices Civils de Lyon
Crohn Disease, Pediatric Inflammatory Bowel Diseases
Microplastic Analysis in Pediatric Inflammatory Bowel Disease
The goal of this observational study is to measure and compare the presence of microplastics in children with inflammatory bowel disease (IBD) and children without IBD.
- Conditions
- Crohn Disease, Pediatric Inflammatory Bowel Diseases, Ulcerative Colitis (UC), Inflammatory Bowel Disease (IBD)
- Trial name
- MAP-IBD (NCT07141238)
- Testing
- Environmental microplastic exposure
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Gdansk
Crohn Disease (CD)
Concordance Between Inflammatory Activity Assessed by Enteric MRI With and Without Intestinal Distension Product in Patients With Ileal Crohn's Disease.
Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) that can significantly impair patients' quality of life. Due to its transmural nature (affecting the entire thickness of the intestinal wall), it naturally…
- Trial name
- CONFORT (NCT07471438)
- Testing
- MRI
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
CD - Crohn's Disease
The CURE - CD Trial
A prospective randomized three-arms controlled trial of Crohn's Disease (CD) patients in remission of <24 months duration. Patients will undergo screening by Magnetic Resonance Enterography (MRE) and patency capsule, and (if…
- Trial name
- NCT03555058
- Testing
- Treatment escalation
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
IBD
Intestinal Epithelial Fucosylation Affects the Efficacy of Ustekinumab in Crohn's Disease
The loss of response rate of ustekinumab(UST) is high, and the specific mechanism has not yet been elucidated. Molecular markers that can accurately predict the efficacy of UST are urgently needed to provide theoretical basis for…
- Trial name
- NCT06203158
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Crohn Disease
The Effects of Bifidobacterium Breve Bif195 for Small Intestinal Crohn's Disease
The purpose of this study is to investigate if the probiotic Bifidobacterium breve Bif195 (Bif195) will result in improvement in clinical outcome in patients with small intestinal Crohn's disease.
- Trial name
- NCT04842149
- Testing
- Bif195 capsules
- Where
- Denmark
- Volunteers
- 33 people
- Sponsor
- Hvidovre University Hospital
Crohn's Disease, Ankylosing Spondylitis
Post Marketing Surveillance of Remicade
The purpose of this study is to understand the safety and effectiveness of infliximab when used in clinical practice. This is a post-marketing surveillance study.
- Trial name
- NCT00724529
- Testing
- Infliximab
- Volunteers
- 938 people
- Sponsor
- Janssen Korea, Ltd., Korea
Crohn's Disease
The Efficacy of Open Label Infliximab for the Induction and Maintenance of Mucosal Healing in Small Bowel Crohn's Disease Assessed Through Wireless Camera Endoscopy
This is a pilot study to estimate the efficacy of infliximab in inducing and maintaining healing of lesions in the mucosa of subjects with Crohn's disease involving their small bowel.
- Trial name
- ICE (NCT01181765)
- Testing
- Infliximab 5 mg/kg body weight infused over 2 hours
- Where
- 2 sites in Canada
- Volunteers
- 1 people
- Sponsor
- Janssen Inc.
Crohn Disease
Study on the Long-Term Risk of Recurrence of Anoperineal Fistula in Crohn's Disease
This research aims to evaluate the long-term recurrence risk of perianal fistulas in Crohn's disease patients who have undergone treatment with anti-TNF therapy and seton drainage.The research seeks to identify factors…
- Trial name
- LT-SAFCD (NCT06514092)
- Testing
- anti-TNF therapy and seton drainage
- Where
- France
- Volunteers
- 63 people
- Sponsor
- University Hospital, Toulouse
Hypertension, Depression
Patient-Centred Innovations for Persons With Multimorbidity - Quebec
The aim of Patient-Centred Innovations for Persons With Multimorbidity (PACE in MM) study is to reorient the health care system from a single disease focus to a multimorbidity focus; centre on not only disease but also the…
- Conditions
- Hypertension, Depression, Anxiety, Musculoskeletal Pain
- Trial name
- PACEinMM-QC (NCT02789800)
- Testing
- DIMAC02
- Where
- 2 sites in Canada
- Volunteers
- 284 people
- Sponsor
- Université de Sherbrooke
Crohn's Disease
The Effect on Mucosal Healing With Pentasa Sachet in Mild to Moderate Active "Drug: Crohn's Disease"
The purpose of this study is to visualize the healing effect on mucosal lesions with Pentasa Sachet 4g in patients with mild to moderate active small bowel CD by video capsule endoscopy.
- Trial name
- NCT00245505
- Testing
- Mesalazine (Mesalamine)
- Where
- Sweden
- Volunteers
- 3 people
- Sponsor
- Ferring Pharmaceuticals
Crohn Disease
Contrast Enhanced Ultrasound in Human Crohn's Disease-Lumason
The investigators plan to compare contrast-enhanced ultrasound to CT and MRI for the detection and quantification of intestinal inflammation in the the setting of pediatric small bowel Crohns disease
- Trial name
- NCT03492944
- Testing
- Ultrasound Microbubble Contrast Agent, Ultrasound Imaging
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Crohn's Disease
Capsule Endoscopy Crohn's Disease Activity Index - Validation Multi Center Study
The Study 1. Prospective trial of the Niv score validating score against known activity indices - see addendum A for Niv score 2.
- Trial name
- NCT00596700
- Testing
- Given® Diagnostic System including PillCamTM SB Capsules
- Where
- 4 sites in Ireland, Israel
- Volunteers
- 100 people
- Sponsor
- Rabin Medical Center
Crohn's Disease, Colitis
A Study to Evaluate the Safety and Efficacy of Ustekinumab Maintenance Therapy in Patients With Moderately to Severely Active Crohn's Disease (IM-UNITI)
The primary purpose of this study is to evaluate the efficacy and safety of 2 maintenance regimens of ustekinumab administered subcutaneously to patients with moderately to severely active Crohn's disease who responded to…
- Conditions
- Crohn's Disease, Colitis, IBD, Inflammatory Bowel Disease
- Trial name
- NCT01369355
- Testing
- Ustekinumab 90 mg SC q8w, Ustekinumab 130 mg IV, Ustekinumab 90 mg SC q12w
- Where
- 220 sites in United States, Australia and 24 more
- Volunteers
- 1,282 people
- Sponsor
- Janssen Research & Development, LLC
Colitis, Ulcerative, Inflammatory Bowel Diseases
Patient Attitudes and Preferences for Outcomes of Inflammatory Bowel Disease Therapeutics
The investigators will test the hypothesis that that greater efficacy of anti-tumor necrosis factor (antiTNF) therapy results in reduced need for bowel resection surgery, fewer serious infections, and reduced short term mortality…
- Conditions
- Colitis, Ulcerative, Inflammatory Bowel Diseases, Crohn's Disease
- Trial name
- PPOD (NCT02316678)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 9,573 people
- Sponsor
- University of Pennsylvania
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