Clinical trials: CERVICAL NEOPLASMS
Metastatic Head and Neck Cancer, Recurrent Head and Neck Cancer
Study of PDS0101 and Pembrolizumab Combination I/O in Subjects With HPV16 + Recurrent and/or Metastatic HNSCC
VERSATILE-002 is a Phase 2, open-label, multicenter study of the efficacy and safety of PDS0101 administered in combination with pembrolizumab in adults with HPV16 and PD-L1 positive recurrent or metastatic head and neck squamous…
- Conditions
- Metastatic Head and Neck Cancer, Recurrent Head and Neck Cancer, HPV Positive Oropharyngeal Squamous Cell Carcinoma, Neoplasms, Head and Neck
- Trial name
- VERSATILE002 (NCT04260126)
- Testing
- Pembrolizumab (KEYTRUDA®) and PDS0101
- Where
- 23 sites in United States, Ireland and 2 more
- Volunteers
- 95 people
- Sponsor
- PDS Biotechnology Corp.
Esophageal Cancer
CCRT With Twice Weekly Paclitaxel and Cisplatin Followed by Surgery for Locally Advanced Esophageal Cancer
CCRT with twice weekly paclitaxel and cisplatin in patient with locally advanced esophageal cancer.
- Trial name
- NCT00154804
- Testing
- Paclitaxel, Cisplatin,Surgery, CCRT
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Esophageal Cancer
Dose Escalation by Boosting Radiation Dose Within the Primary Tumor Using 18FDG-PET/CT for Unresectable Thoracic Esophageal Cancer
Most local failures after definitive chemoradiation for unresectable esophageal cancer occur in the gross tumor volume (GTV). And the metabolic active areas post-treatment were located in the high FDG uptake areas prior to the…
- Trial name
- NCT01843049
- Testing
- Radiotherapy, Chemotherapy (5-FU+DDP)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fudan University
Uterine Cervical Cancer
Clinical Triage and Treatment of Atypical Glandular Cells (AGC) Detected in Screening
The risk of cervical cancer after diagnosis with atypical glandular cells (AGC) detected by screening is elevated for 15 years after discovery.
- Trial name
- NCT05231993
- Testing
- Conization, Colposcopy
- Where
- Sweden
- Volunteers
- 280 people
- Sponsor
- Karolinska Institutet
Esophageal Cancer
dCRT vs. Surgery in Resectable ESCC Patients Achieving cCR/PR After Induction Chemoimmunotherapy
This study is evaluating two treatment approaches for patients with locally advanced, resectable esophageal squamous cell carcinoma (ESCC) who have a good response to 2-3 cycles of induction chemoimmunotherapy.
- Trial name
- SORT (NCT07162506)
- Testing
- Surgery, Radiotherapy, Chemotherapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Head and Neck Carcinoma, Radiotherapy Side Effects
The SHINE-MDT Randomized Controlled Trial
Radiotherapy is one of the main treatments for head and neck Carcinoma. The incidence of radiotherapy-related adverse events is greater than 90%, and severe adverse events may lead to the interruption of radiotherapy.
- Trial name
- NCT05828004
- Testing
- Whole-Course Multidisciplinary Care Intervention
- Where
- China
- Volunteers
- 233 people
- Sponsor
- West China Hospital
Esophageal Cancer, Dysplasia
VEGF-targeted Fluorescence Near-Infrared (NIR) Endoscopy in (Pre)Malignant Esophageal Lesions
To improve detection of esophageal (pre)malignant lesions during surveillance endoscopy of patients at risk of developing malignancies, for example in Barrett's Esophagus (BE), there is a need for better endoscopic visualization…
- Trial name
- VICE (NCT02129933)
- Testing
- Bevacizumab-IRDye800CW, Near infrared fluorescence endoscopy platform
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- University Medical Center Groningen
Thyroid Neoplasms
The Effects of Deep Neuromuscular Blockade During Robot-assisted Transaxillary Thyroidectomy on Postoperative Pain and Sensory Change
As robotic surgery has been applied to various surgeries, the minimally invasive surgery is rapidly evolving. In particular, robot-assisted thyroidectomy is one of the leading techniques in minimally invasive surgery fields.
- Trial name
- NCT03871387
- Testing
- Deep Group, Control Group
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Yonsei University
Squamous Cell Carcinoma
Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Design
The goal of this clinical research study is to learn which chemotherapy combination may be more effective in treating locally advanced head and neck squamous cell carcinoma (HNSCC).
- Trial name
- NCT02128906
- Testing
- Cisplatin, IMRT, Docetaxel
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Christopher Wilke
Oropharyngeal Cancer
CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC)
CompARE is a multicentre, phase III open-label randomised controlled trial using an adaptive, Multi-Arm, Multi-Stage (MAMS) design.
- Trial name
- CompARE (NCT04116047)
- Testing
- Cisplatin, Durvalumab, Radiotherapy
- Where
- 38 sites in Ireland, United Kingdom
- Volunteers
- 785 people
- Sponsor
- University of Birmingham
Stroke, Mouth Neoplasms
The Feasibility Study of Dual-Section Nasogastric Tube
The purpose of this studyis to assess the feasibility and safety of novel designed two-piece nasogastric tube.
- Trial name
- NCT01649349
- Testing
- two-piece nasogastric tube
- Volunteers
- 10 people
- Sponsor
- Changhua Christian Hospital
Oral Cancer
The Role of SDF-1/CXCR4 in Metastasis of Oral Squamous Cell Carcinoma
Investigate the role of SDF-1/CXCR4 in the metastasis of oral squamous cell carcinoma
- Trial name
- NCT00173849
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Head and Neck Squamous Cell Carcinoma
Becotatug Vedotin Combined With Pucotenlimab as Neoadjuvant Therapy for Resectable Recurrent Head and Neck Squamous Cell Carcinoma After Progression on Immunotherapy: A Prospective Phase II Study
This is a prospective, single-arm, multi-center, Phase II clinical trial evaluating the efficacy and safety of neoadjuvant becotatug vedotin (an anti-EGFR antibody-drug conjugate) combined with pucotenlimab (HX008, an anti-PD-1…
- Trial name
- GATEWAY (NCT07589049)
- Testing
- Becotatug Vedotin, Pucotenlimab
- Where
- 12 sites in China
- Volunteers
- 42 people
- Sponsor
- Sun Yat-sen University
Oral Cancer, Oral Leukoplakia
Oral Cancer Screening and Education in Hong Kong
This study will be conducted to obtain data on oral cancer risk factors to generate machine learning models with good predictive accuracy for stratifying individuals with high-oral cancer risk and delineating high-risk and…
- Conditions
- Oral Cancer, Oral Leukoplakia, Oral Submucous Fibrosis, Proliferative Verrucous Leukoplakia
- Trial name
- NCT04487938
- Testing
- No intervention utilised
- Volunteers
- 3,190 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Thyroid Cancer, Non-Cancer Thyroid Disease
Scientific Protocol for the Study of Thyroid Cancer and Other Thyroid Disease in Belarus Following the Chernobyl Accident
Iodine-131(131I) and other radioisotopes of Iodine are contained in fallout from atmospheric nuclear weapons tests and are among the radionuclides most likely to be released in a nuclear reactor accident.
- Conditions
- Thyroid Cancer, Non-Cancer Thyroid Disease, Non Thyroid Cancer
- Trial name
- NCT00339716
- Where
- 2 sites in Belarus
- Volunteers
- 19,456 people
- Sponsor
- National Cancer Institute (NCI)
Papillary Thyroid Cancer
Percutaneous Ethanol Injection for Primary Papillary Thyroid Microcarcinoma
We assess the effectiveness of percutaneous ethanol ablation for the treatment of thyroid cancer.
- Trial name
- NCT01974284
- Testing
- percutaneous ethanol ablation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Yale University
Cervical Cancer
A Safety and Efficacy of CCRT With Paclitaxel/Carboplatin as Adjuvant Therapy to Post-operative Cervical Cancer Patients
The purpose of this study is to determine whether post-operative concurrent chemoradiation with paclitaxel/carboplatin is effective and safe in the treatment of high risk cervical cancer patients.
- Trial name
- NCT00340184
- Testing
- paclitaxel, carboplatin
- Where
- South Korea
- Volunteers
- 55 people
- Sponsor
- Korean Gynecologic Oncology Group
Laryngeal Carcinoma, Hypopharyngeal Carcinoma
Comparing Neoadjuvant Chemotherapy Combined With PD-1 Inhibitor Versus Neoadjuvant Chemotherapy in Locally Advanced Laryngeal and Hypopharyngeal Carcinoma
Neoadjuvant chemotherapy combined with immunotherapy has achieved promising pathological remission rates in locally advanced head and neck squamous cell carcinoma and has offered new hope for patients with locally advanced…
- Trial name
- NCT06957938
- Testing
- Neoadjuvant Chemotherapy (NACT), Neoadjuvant and maintenance Tislelizumab, Concurrent chemo-radiotherapy (CCRT)
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Fudan University
Advanced Solid Tumors, Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Study of INCA 0186 in Subjects With Advanced Solid Tumors
This is an open-label, nonrandomized, multicenter, dose escalation, and dose expansion first-in human (FIH) Phase 1 study to determine the safety, tolerability, PK, pharmacodynamics, and preliminary efficacy of INCA00186 when…
- Conditions
- Advanced Solid Tumors, Squamous Cell Carcinoma of the Head and Neck (SCCHN), Gastrointestinal (GI) Malignancies
- Trial name
- NCT04989387
- Testing
- INCA00186, Retifanlimab, INCB106385
- Where
- 32 sites in United States, Austria and 4 more
- Volunteers
- 57 people
- Sponsor
- Incyte Corporation
Cervical Cancer, Radical Hysterectomy
Removal of Urinary Catheter After Radical Surgery
Currently, the treatment of cervical cancer in early stages is performed with a radical surgery called Radical Hysterectomy with Pelvic Lymphadenectomy.
- Conditions
- Cervical Cancer, Radical Hysterectomy, Bladder Dysfunction
- Trial name
- NCT03570593
- Testing
- REMOVAL OF URINARY CATHETER AFTER RADICAL SURGERY
- Volunteers
- 95 people
- Sponsor
- Barretos Cancer Hospital
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