Clinical trials: CERVICAL NEOPLASMS
Head and Neck Cancer
Airway Ultrasound in Oncologic Maxillofacial Patients
This prospective observational cohort study will evaluate ultrasound-based airway measurements in adult patients with oncologic maxillofacial disease undergoing surgery under general anesthesia.
- Trial name
- NCT07910149
- Where
- 2 sites in Croatia
- Volunteers
- 30 people
- Sponsor
- University Hospital Dubrava
Squamous Cell Carcinoma of Oropharynx, HPV Positive Cancer
ctHPVDNA in HPV Positive Squamous Cell Carcinoma of the Oropharynx
This study is a prospective phase II trial, designed to assess the efficacy and feasibility of adjuvant treatment deintensification guided by ctHPVDNA levels for patients with HPV+OPSCC who undergo transoral surgery and neck…
- Conditions
- Squamous Cell Carcinoma of Oropharynx, HPV Positive Cancer, Throat Cancer, Tonsil Cancer
- Trial name
- NCT06915038
- Testing
- NavDx, Adjuvant Radiation 30 Gray, Adjuvant Radiation 40 Gray
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Indiana University
Cervical Carcinoma
Cervical Cancer Screening Intervention Among Korean American Women
This is a randomized trial to evaluate the effects of a community-based intervention on increasing cervical cancer screening rates in underserved Korean American women.
- Trial name
- NCT02594826
- Testing
- Culturally appropriate intervention, General health education control
- Where
- United States
- Volunteers
- 744 people, healthy volunteers welcome
- Sponsor
- Fox Chase Cancer Center
Mucositis
Local Anesthetic Treatment of Oral Pain in Patients With Mucositis
Oral mucositis is a damage to the mucosa of the oral cavity and pharynx. It is a serious and painful adverse effect caused by the radio therapy and/or chemo therapy patients with head and neck cancer receive.
- Trial name
- NCT02252926
- Testing
- Bupivacaine, Standard treatment (lidocaine viscous solution, morphine, paracetamol, NSAID, gabapentin)
- Where
- 2 sites in Denmark
- Volunteers
- 70 people
- Sponsor
- Hvidovre University Hospital
Esophageal Cancer, Nutrition Aspect of Cancer
Assessing Timing of Enteral Feeding Support in Esophageal Cancer Patients on Muscle functTion and Survival
The surgical stress of an esophagectomy causes a detrimental impact on the physiological response of the body. In this perspective, one could question whether the current feeding regimens of starting early nutritional support at…
- Conditions
- Esophageal Cancer, Nutrition Aspect of Cancer, Postoperative Complications, Muscle Weakness
- Trial name
- EFECTS (NCT03676478)
- Testing
- delayed start enteral support @ POD5
- Where
- Belgium
- Volunteers
- 239 people
- Sponsor
- University Hospital, Gasthuisberg
Head and Neck Cancer
Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Head and Neck Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00002476
- Testing
- bleomycin sulfate, fluorouracil, leucovorin calcium
- Where
- 7 sites in India, United Kingdom
- Sponsor
- Cancer Research UK
Cervix Cancer
Hyaluronic Acid-based Gel Spacers in Gynecologic Malignancies
This pilot feasibility study evaluates the use of a hyaluronic acid-based spacing gel (Barrigel) in participants with cervical cancer undergoing chemoradiotherapy (chemoRT), including brachytherapy, as part of standard care.
- Trial name
- NCT07292818
- Testing
- Barrigel gel spacer
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Stage III Esophageal Squamous Cell Carcinoma, Stage II Esophageal Squamous Cell Carcinoma
Megestrol Acetate for the Improvement of Quality of Life in Esophageal Cancer With Chemoradiotherapy
Megestrol is a semisynthetic progesterone derivatives, have promote anabolic effects. Can improve appetite, weight gain, and improve bone marrow suppression, increase the tolerance put, chemotherapy, improve the quality of life…
- Trial name
- NCT02644408
- Testing
- Megestrol（Yining）, radiotherapy, chemotherapy
- Where
- China
- Volunteers
- 184 people
- Sponsor
- The First Affiliated Hospital of Henan University of Science and Technology
Head and Neck Squamous Cell Carcinoma, Metastases
Sintilimab Combined With Chemotherapy and SBRT in Limited Metastatic Head and Neck Squamous Cell Carcinoma (LM-HNSCC)
To evaluate the safety and efficacy of combination of Sintilimab and SBRT on the basis of platinum-containing chemotherapy as the first-line treatment of limited metastatic head and neck squamous cell carcinoma (LM-HNSCC).
- Conditions
- Head and Neck Squamous Cell Carcinoma, Metastases, Immunotherapy, Stereotactic Body Radiotherapy
- Trial name
- LM-HNSCC (NCT05136768)
- Testing
- Sintilimab, SBRT, Platinum based chemotherapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Jun-Lin Yi, MD
Hypopharyngeal Cancer
Neoadjuvant Chemotherapy for Locally Advanced Squamous Cell Cancer of the Head and Neck (SCCHN)
The investigators will examine whether 2-cycles of DFP chemotherapy before definitive concurrent chemoradiation therapy (CCRT) can improve progression-free survival in locally advanced (Stage III \& IVM0) hypopharyngeal and base…
- Trial name
- NCT01312350
- Testing
- neoadjuvant docetaxel/cisplatin/fluorouracil, No treatment before definitive CCRT
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Adrenal Cortical Cancer, Brain Cancer
Spectroscopy With Surface Coils and Decoupling
The purpose of this study is to obtain chemical information from part of your body without a biopsy. This is done using a technique called magnetic resonance spectroscopy (MRS) which is similar to magnetic resonance imaging (MRI)…
- Conditions
- Adrenal Cortical Cancer, Brain Cancer, Breast Cancer, CNS Cancer
- Trial name
- NCT00581815
- Testing
- Proton-decoupled 31P MRS at 1.5T, 1H Spectroscopy at 1.5T and 3T
- Where
- United States
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Nasopharyngeal Cancer
Nab-paclitaxel Based TPX Neoadjuvant Chemotherapy for NPC Patients: a Dose-escalation Study
Neoadjuvant chemotherapy followed by concurrent chemoradiation (CCRT) has been recommended in the treatment of locoregionally-advanced nasopharyngeal carcinoma (NPC), with docetaxel, cisplatin (DDP) and 5-fluorouracil (5-Fu)…
- Trial name
- NCT04850235
- Testing
- Nab paclitaxel
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Sun Yat-sen University
Cervical Cancer
CervIcal Cancer Screening Trial by Randomization of HPV Testing Intervention for Upcoming Screening （CITRUS Study）
The aim of this study is to assess efficacy of the screening with concurrent liquid-based cytology and HPV DNA testing for the primary cervical cancer screening over 7 years.
- Trial name
- NCT01895517
- Testing
- LBC, LBC plus HPV DNA testing
- Where
- Japan
- Volunteers
- 18,471 people, healthy volunteers welcome
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Rehabilitation, Neck Cancer
Rehabilitation Nursing Program in Otolaryngology
The European Commission's current political guidelines demonstrate into a joint plan aimed at improving and controlling cancer disease. Head and neck cancer (HNC) are the sixth most common cancer worldwide.
- Conditions
- Rehabilitation, Neck Cancer, Otorhinolaryngologic Neoplasms
- Trial name
- NCT05246891
- Testing
- rehabilitation nursing
- Where
- Portugal
- Volunteers
- 151 people
- Sponsor
- University of Évora
Esophageal Cancer
Phase I/II Study of TPF as First-line Chemotherapy in Patients With Metastatic Esophageal Cancer.
A phase I/II study is conducted to determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), and efficacy of a combination chemotherapy using docetaxel, cisplatin and 5-fluorouracil (TPF) in untreated patients…
- Trial name
- NCT00209690
- Testing
- Taxotere, 5-FU, Briplatin
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Hokkaido Gastrointestinal Cancer Study Group
Head and Neck Cancer, Cytokine
Study of the Role of Oncostatin M in Head and Neck Squamous Cell Carcinoma
The ROMCOR study will be interested in the impact and the role of oncostatin M (OSM), a cytokine belonging to IL-6 superfamily, in the physiopathology of head and neck squamous cell carcinoma.
- Trial name
- NCT06199947
- Testing
- Biopsies and Blood collection
- Volunteers
- 119 people
- Sponsor
- Poitiers University Hospital
Cervical Cancer Screening, HPV Infections
Cervical Cancer Screening of Postmenopausal Women in Low- and Middle-income Countries Using HPV Self-sampling and Triage by Genotyping and Cytology
Cervical cancer remains a major cause of mortality in low- and middle-income countries, especially among women aged 50 years and older who are often under-screened.
- Conditions
- Cervical Cancer Screening, HPV Infections, Cervical Intraepithelial Neoplasia
- Trial name
- NCT07244315
- Testing
- Vaginal specimens for HPV test will be collected by participants themselves using flocked swabs after explanations by co-investigators.
- Where
- Cameroon
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Nasopharyngeal Neoplasms
A New EBV Related Technologies of T Cells in Treating Malignant Tumors and Clinical Application
The purpose of this study is to evaluate the safety of the designed LMP1-CAR -T cells and determine whether the CAR-T cells are effective in the treatment of EBV associated malignant tumors.
- Trial name
- NCT02980315
- Testing
- CAR-T cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Locally Advanced Cervical Cancer, Prognostic Biomarker
Evaluation of Persistent Infection by Oncogenic Human Papillomavirus (HPV) in Patients Treated for Cervical Carcinoma and Its Relation to Prognostic Factors
Cervical cancer is strongly associated with HPV infection, yet current post-treatment follow-up relies on cytology and imaging, which have limited accuracy, particularly after radiotherapy.
- Trial name
- ANIHTA (NCT07600515)
- Volunteers
- 100 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Thyroid Nodules, Hypocalcemia
Phase II Pre-operative Vitamin D Supplementation to Prevent Post-thyroidectomy Hypocalcemia
One of the major side effects of surgery to remove the thyroid gland is transient (lasting for a short time) low calcium levels in the blood, or "hypocalcemia." Low calcium levels can cause symptoms such as numbness around the…
- Trial name
- NCT01868750
- Testing
- Calcitriol, Control Pill
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- David Shonka, MD
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