Clinical trials: CHD, open to volunteers
Surgical Site Infection
Novosyn® CHD vs Polyglactin 910 Suture to Close Wounds After Emergency or Elective Laparotomy or Laparoscopic Surgery
The aim of the study is to elucidate, if the colonization of bacteria is lower on the Novosyn® CHD suture compared to uncoated Polyglactin 910 suture, which will be assessed by the incidence of surgical site infections (SSI: A1…
- Trial name
- POLYNOVO-CHD (NCT05966961)
- Testing
- Novosyn® in emergency or elective laparotomy or laparoscopic surgery, Polyglactin 910 in emergency or elective laparotomy or laparoscopic surgery
- Where
- 4 sites in Italy, Spain
- Volunteers
- 2,998 people
- Sponsor
- Aesculap AG
Coronary Heart Disease
Vitamin K and Cognition in Coronary Heart Disease (NutriCog)
The purpose of this pilot study is to obtain a preliminary assessment of the effect of VK supplementation on cognitive performance and vascular function in adults with stable Coronary Heart Disease (CHD)
- Trial name
- Nutricog (NCT06855953)
- Testing
- Vitamin K
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Montreal Heart Institute
Congenital Heart Disease, Health Behavior
Heart2Heart for Teens With CHD
The goal of this clinical trial is to learn if teens living with congenital heart disease like and will use Heart2Heart and if it affects how they think and feel about e-cigarettes.
- Trial name
- NCT07764510
- Testing
- Heart2Heart
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Kristen Fox
Coronary Heart Disease (CHD)
AI-Driven Dynamic Prediction of Non-Target Lesion Progression After PCI: A Chinese Multicenter Cohort Study
Coronary artery disease remains a leading cause of global mortality. Although percutaneous coronary intervention (PCI) improves patient outcomes, the long-term risk of major adverse cardiovascular events (MACE) driven by the…
- Trial name
- VISION-PCI (NCT07312318)
- Testing
- percutaneous coronary intervention
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- China-Japan Friendship Hospital
Colon Disease
Safety, Efficacy and Tolerability of Bowel Preparation and Colonoscopy in Patient With CHD, CKD and CLD
Consecutive eligible patients will be enrolled and written informed consent will be obtained from all participants. Routine blood investigations will be sent.
- Trial name
- NCT06874036
- Testing
- Colonoscopy
- Where
- India
- Volunteers
- 74 people
- Sponsor
- Asian Institute of Gastroenterology, India
CHD - Congenital Heart Disease
Home-based Cardiovascular Rehabilitation in Young Patients With Congenital Heart Disease: the "Muscle Your Heart" Program
Standard cardiovascular rehabilitation is performed in a medical care and rehabilitation centre. However, it may not be adapted to the patient's profile and there are few medical care and rehabilitation centres specialized in…
- Trial name
- Muscletoncoeur (NCT07115589)
- Testing
- Muscle Your Heart home-based program
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Bordeaux
Coronary Artery Disease
Influencing Factors and Outcomes of DCB Angioplasty
This ambiprospective observational study evaluates the long-term safety and efficacy of Paclitaxel Drug-Coated Balloon (DCB) angioplasty in approximately 20,000 patients withcoronary artery lesions in large vessels.
- Trial name
- FWHZ-DCB (NCT06620458)
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Congenital Heart Disease, Liver Dysfunction
Prevalence of Liver Dysfunction in Pediatric Patients With Congenital Heart Disease at Assiut.
Liver dysfunction is a well-documented complication in patients with congenital heart disease (CHD). The mechanisms leading to hepatic dysfunction may be multifactorial.
- Trial name
- CHD (NCT07144501)
- Testing
- Ultrasonography, Blood Sampling
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Congenital Heart Disease (CHD), Postoperative Sleep
Starry-Sky Projection and Maternal Voice for Sleep After Pediatric Cardiac Surgery
The goal of this clinical trial is to determine whether a starry-sky projection affects sleep during the early period after cardiac surgery in young children.
- Trial name
- NCT07854145
- Testing
- Starry-Sky Projection, Conventional Lighting, Maternal Voice
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
CHD - Congenital Heart Disease
Bilateral Ultrasound Guided Superficial Parasternal Intercostal Plane Block Versus Erector Spinae Plane Block
Group (A): This group will receive fentanyl infusion at a dose of (0.5μg/kg/h) all through the whole operation plus ultrasound guided bilateral superficial parasternal intercostal Plane block which will be done by injecting…
- Trial name
- NCT06958120
- Testing
- superficial parasternal intercostal Plane block, Erecto spinea plane block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Congenital Heart Disease (CHD), Hypoxic Encephalopathy
Early Detection of Brain Injury After Congenital Heart Surgery in Infants
Infants with congenital heart disease undergoing cardiac surgery with extracorporeal circulation are at risk for perioperative hypoxic-ischaemic brain injury.
- Trial name
- NCT07424976
- Testing
- Observational study: blood analisys, EEG, MRI
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Congenital Heart Disease (CHD), Artifical Intelligence
AI-Assisted Versus Independent Heart Sound Screening for Congenital Heart Disease in Children
This is a prospective, school-based, cluster-randomized controlled trial conducted in Qinghai Province, China. The study will evaluate whether artificial intelligence (AI) can help primary care physicians identify congenital…
- Conditions
- Congenital Heart Disease (CHD), Artifical Intelligence, Screening, Cardiac Auscultation
- Trial name
- NCT07830251
- Testing
- AI-Assisted Cardiac Auscultation
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Kun Sun
AKI, CHD - Congenital Heart Disease
NO During CPB in Neonates to Reduce Risk of AKI
Acute kidney injury (AKI) following cardiac surgery for congenital heart defects (CHD) in children affects up to 60% of high risk-patients and is a major cause of both short- and long-term morbidity and mortality.
- Conditions
- AKI, CHD - Congenital Heart Disease, Surgery
- Trial name
- NCT04216927
- Testing
- Nitric Oxide, Oxygen
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pediatric Heart Failure, Congenital Heart Disease (CHD)
MedlyPeds Feasibility Study
SickKids and UHN have developed MedlyPeds which is a smart phone application designed to remotely monitor patients with heart disease.
- Conditions
- Pediatric Heart Failure, Congenital Heart Disease (CHD), Acquired Heart Disease, Pulmonary Hypertension
- Trial name
- NCT07556185
- Testing
- MedlyPeds App
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- The Hospital for Sick Children
Coronary Heart Disease (CHD), Heart Failure
Community Exercise Treating Effect on Cardiopulmonary Disease Patients
The goal of this clinical trial is to learn if community-based exercise training can benefit patients aged 18 to 85 with diminished cardiovascular and pulmonary function.
- Conditions
- Coronary Heart Disease (CHD), Heart Failure, Cardiomyopathy, COPD
- Trial name
- NCT07154355
- Testing
- community-based exercise training
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Guangdong Provincial People's Hospital
Coronary Artery Disease, Atherosclerotic Cardiovascular Disease (ASCVD)
Hs-CRP-Guided Colchicine Treatment Targets in Very-High-Risk Patients With Coronary Artery Disease After PCI (TARGET-CHD)
This multicenter, randomized, open-label, noninferiority trial will compare two high-sensitivity C-reactive protein (hs-CRP) target-guided colchicine strategies in 1,768 adults with very-high-risk coronary artery disease after…
- Conditions
- Coronary Artery Disease, Atherosclerotic Cardiovascular Disease (ASCVD), Residual Inflammatory Risk
- Trial name
- NCT07920133
- Testing
- Colchicine (Colcrys®)
- Where
- China
- Volunteers
- 1,768 people
- Sponsor
- Sir Run Run Shaw Hospital
Delirium - Postoperative, Sleep Problems
Preoperative Sleep Disorders and Postoperative Delirium in Children Undergoing Congenital Heart Surgery
The investigators are going to conduct a prospective observational cohort study in pediatric patients aged 28 days to 14 years old scheduled for elective cardiac surgery with cardiopulmonary bypass.
- Conditions
- Delirium - Postoperative, Sleep Problems, Congenital Heart Disease (CHD)
- Trial name
- NCT06686550
- Testing
- This is a observational study and there is no intervention.
- Volunteers
- 435 people
- Sponsor
- Yan Fuxia
Congenital Heart Disease, Congenital Heart Disease (CHD)
Starlight Cardiovascular Lifeline Ductus Arteriosus Stent IDE Study
Starlight Cardiovascular, Inc. is sponsoring a prospective, multi-center, study to evaluate safety and effectiveness of the Lifeline Ductus Arteriosus Stent System.
- Trial name
- NCT07114718
- Testing
- Ductus Arteriosus Stent
- Where
- 11 sites in United States
- Volunteers
- 45 people
- Sponsor
- Starlight Cardiovascular Inc
Chronic Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF)
Yiqi Fumai Lyophilized Injection for Chronic Heart Failure Caused by Coronary Heart Disease
This study will evaluate whether adding Yiqi Fumai lyophilized injection to stable guideline-directed treatment improves symptoms, physical limitations, and NT-proBNP in adults with stable chronic heart failure caused by coronary…
- Conditions
- Chronic Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Coronary Heart Disease (CHD)
- Trial name
- NCT07803471
- Testing
- Yiqi Fumai Lyophilized Injection(YQFM), Stable Guideline-Directed Medical Therapy
- Where
- 4 sites in China
- Volunteers
- 100 people
- Sponsor
- China Academy of Chinese Medical Sciences
Congenital Heart Disease (CHD)
Transition and Transfer of Congenital Heart Disease Care From Pediatrics to Adulthood
Adults with congenital heart disease (CHD) are a growing patient population in need of ongoing specialized care. Lapses in appropriate transition and transfer processes from childhood to adulthood in CHD care can lead to loss in…
- Trial name
- NCT07585175
- Testing
- Multi-pronged transfer program
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Ottawa Heart Institute Research Corporation