Clinical trials: CHD, open to volunteers
Coronary Heart Disease (CHD)
REsiduAL rISk Under Intensive Lipid-lowering Therapy In Coronary Heart Disease
Intensive lipid-lowering therapy is a cornerstone treatment for coronary heart disease (CHD). However, coronary plaque progression persists in a subset of patients even under intensive lipid-lowering therapy, which may be…
- Trial name
- REALISTIC (NCT06936111)
- Testing
- Assessment of residual cholesterol and inflammatory risk factors
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Shanghai Zhongshan Hospital
Cardiac Arrest, Congenital Heart Disease
Resuscitation Registry in CHD
Children with congenital heart defects are far more likely to suffer a cardiovascular arrest and be in the need of cardiopulmonary resuscitation than healthy children or those with diseases of other organ systems, especially…
- Trial name
- PRO-CHD (NCT05373498)
- Where
- 3 sites in Germany
- Volunteers
- 400 people
- Sponsor
- Leipzig Heart Science gGmbH
Congenital Heart Disease (CHD), Congenital Heart Disease in Children
Adaptive Digital Exercise Rehabilitation for Children After CHD Surgery
The goal of this clinical trial is to evaluate whether a Just-in-Time Adaptive Intervention (JITAI)-based digital exercise rehabilitation program can improve postoperative recovery in children after congenital heart disease (CHD)…
- Trial name
- NCT07574463
- Testing
- JITAI-Based Digital Exercise Rehabilitation Program, Standard Exercise Rehabilitation Program
- Where
- China
- Volunteers
- 130 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Coronary Heart Disease (CHD)
Single vs. Dual Antiplatelet Therapy in Patients Undergoing Percutaneous Intervention With DCB-only Strategy (KONG-FREEDOM-I)
This investigator-initiated, multicenter, open-label, randomized clinical trial evaluates the safety and efficacy of single antiplatelet therapy (SAPT) utilizing a P2Y12 inhibitor compared to dual antiplatelet therapy (DAPT) in…
- Trial name
- KONG-FREEDOM-I (NCT07587099)
- Testing
- Drug-coated balloon, Single antiplatelet therapy (SAPT), Dual antiplatelet therapy (DAPT)
- Where
- 14 sites in China
- Volunteers
- 2,170 people
- Sponsor
- Gan Lijun
Congenital Heart Disease (CHD)
Impact of Vitamin C Supplementation on Hospital Outcomes in Children Undergoing Corrective Heart Surgery for Congenital Heart Diseases
Vitamin C will be given before admission in the immediate preoperative preceding 7 days (the dose 30 -45 mg per day ) in oral drops preparations Inflammatory markers including CRP , TLC ,PNI , GPS NLR will be checked on admission…
- Trial name
- RCT (NCT06789640)
- Testing
- Vitamin C
- Volunteers
- 20 people
- Sponsor
- Cairo University
Congenital Heart Disease, Cyanotic Congenital Heart Disease
Prenatal Maternal Mental Health and Neurodevelopment in Congenital Heart Disease
Congenital heart disease (CHD) is the leading cause of congenital malformations, representing 1% of live births. Progress in surgical care have led to the dramatic increase in the population of children and adults living with…
- Conditions
- Congenital Heart Disease, Cyanotic Congenital Heart Disease, d-Transposition of the Great Arteries, Hypoplastic Left Heart Syndrome
- Trial name
- Neuro-Moms (NCT06711666)
- Where
- 5 sites in France
- Volunteers
- 174 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Coronary Heart Disease (CHD)
Assessment of the Diagnostic Performance of the Detection System and Establishment of an Intelligent and Rapid Triage Model
The rapid triage of patients with acute chest pain remains an important issue in clinical practice. This study will establish a cohort of patients suspected of acute coronary syndrome (ACS) to construct a multi-marker dynamic…
- Trial name
- NCT06864676
- Volunteers
- 2,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
Congenital Heart Disease
The Co-Op @ HeartWorks
This protocol is a research study involving human subjects diagnosed with Congenital Heart Defects/Disease (CHD). The Co-Op @ HeartWorks is a cooperative between the research platform at HeartWorks and members of the CHD…
- Trial name
- NCT06469918
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- HeartWorks, Inc.
Coronary Heart Disease (CHD)
Effect of eHealth Cardiac Rehabilitation Incorporating Mindfulness for Patients With Coronary Heart Disease
People with coronary heart disease (CHD) often feel more stressed, which can increase the risk of having another heart problem. Cardiac rehabilitation (CR) is a common treatment for those with CHD, focusing on changing lifestyles…
- Trial name
- eCR (NCT07109752)
- Testing
- eHealth cardiac rehabilitation
- Where
- Hong Kong
- Volunteers
- 146 people
- Sponsor
- Tung Wah College
Coronary Heart Disease (CHD)
The Effectiveness of a Theory-driven Behavioral Change Intervention on Sedentary Behavior in Individuals With Coronary Heart Disease: A Randomised Controlled Trial
The objective of this randomised controlled trial is to examine the effectiveness of a theory-driven behavioural change intervention on total sedentary time (primary outcomes), moderate-to-vigorous physical activity time…
- Trial name
- NCT07357961
- Testing
- A theory-driven behavioural change intervention, Attentive control group
- Volunteers
- 232 people
- Sponsor
- Chinese University of Hong Kong
Congenital Heart Disease
Assessment of Psychiatric Problems in Pre- and Post-Intervention in Patients With CHD
The goal of this observational study is to learn about the relationship between cardiac intervention and subsequent psychiatric symptoms in patients with CHD.
- Trial name
- NCT07326384
- Testing
- Cardiac interventions
- Volunteers
- 60 people
- Sponsor
- Assiut University
Coronary Heart Disease (CHD), Anxiety Disorders
Closed-Loop Neurofeedback Targeting the Right Dorsolateral Prefrontal Cortex for Cardiac Autonomic Modulation in Coronary Artery Disease With Anxiety
The goal of this clinical trial is to test whether real-time fNIRS-BCI neurofeedback targeting the right dorsolateral prefrontal cortex (right DLPFC), using active volitional control during a slow-wave auditory acoustic paradigm…
- Trial name
- HEART-SET-1 (NCT07238920)
- Testing
- Real-time fNIRS-ECG neurofeedback
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Shenyang Medical College
Congenital Heart Disease (CHD)
The Effect of Therapeutic Play on Preoperative Anxiety in Hospitalized Children With Congenital Heart Disease
Congenital Heart Disease (CHD) is the most common congenital malformation in children and the leading cause of death from birth defects in infancy.
- Trial name
- TP-CHD (NCT07643168)
- Testing
- Therapeutic Play Intervention, Routine Preoperative Nursing
- Volunteers
- 204 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Congenital Heart Disease
Implementing Models for Mechanical Circulatory Support Presurgical Assessment in Congenital Heart Disease Treatment
The purpose of this research study is to look at the advantages of using a 3D printed heart model for surgical planning in children who have been diagnosed with Congenital Heart Disease (CHD) and clinical heart failure and will…
- Trial name
- IMMPACT (NCT03891160)
- Testing
- 3D model of heart
- Where
- 6 sites in United States
- Volunteers
- 36 people
- Sponsor
- Columbia University
Coronary Heart Disease (CHD), Coronary Arterial Disease (CAD)
Effectiveness of a Tele-cardiac Rehabilitation (Tele-CR) Program
This study represents the second phase of a three-year research project aimed at evaluating both the short- and long-term effects of a six-month tele-cardiac rehabilitation (tele-CR) program in patients with coronary heart…
- Trial name
- NCT07110389
- Testing
- A tele-CR program, Attention-controlled
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- Chang Gung University of Science and Technology
Heart Failure, Coronary Heart Disease (CHD)
Reliability of Multiple-Repetition-Maximum Tests in Patients With Cardiovascular Disease or Risk Factors
Exercise training is a cornerstone in the prevention and rehabilitation of cardiovascular disease. While research has primarily focused on endurance training, resistance training becomes more and more important.
- Conditions
- Heart Failure, Coronary Heart Disease (CHD), Atrial Fibrillation (AF), Diabetes Mellitus
- Trial name
- NCT06796582
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technical University of Munich
Heart Disease Congenital, Neurodevelopmental Disorder
Characterization and Support of Neurodevelopmental Disorders Associated With Congenital Cardiac malfoRmations - Neonatal
Congenital heart defects (CHD), as the leading cause of birth defects, affect 12 million people globally and approximately 41,000 newborns each year in Europe.
- Trial name
- CATAMARAN - NN (NCT06690151)
- Testing
- Neurodevelopmental assessment (Bayley-IV), Biological sampling, ELFE dietary questionnaire
- Where
- 8 sites in France
- Volunteers
- 450 people
- Sponsor
- Nantes University Hospital
Lymphatic Disorders, Plastic Bronchitis
European Registry Study on Lymphatic Interventions
This European multicenter observational study aims to evaluate the real-world use, timing, and outcomes of lymphatic interventions in patients with congenital heart disease and/or primary lymphatic disorders.
- Conditions
- Lymphatic Disorders, Plastic Bronchitis, Protein Losing Enteropathy, Chylothorax
- Trial name
- EURO-LYMPH (NCT07131293)
- Testing
- Lymphatic intervention
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Congenital Heart Disease (CHD)
Construction of a Multi-center Clinical Research Collaboration Network for Children with Congenital Heart Disease in China
This project intends to unite the representatives of typical congenital heart disease hospitals in various provinces and cities across the country to jointly establish a multi-center clinical research collaboration network for…
- Trial name
- NCT06885307
- Where
- 6 sites in China
- Volunteers
- 35,000 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
CHD - Congenital Heart Disease
Ultrafast Ultrasound Imaging in Pediatric Cardiology
About 13 in 1000 children are born with heart disease. Current tools poorly assess heart filling in children, limiting treatment.
- Trial name
- NCT07255144
- Testing
- Cardiac Ultrafast Ultrasound
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Bordeaux