Clinical trials: CHD - Coronary Heart Disease
Coronary Heart Disease
Trial of Lycopene/Ateronon for Secondary Prevention of Coronary Heart Disease
The purpose of this study is to determine whether Ateronon, a nutritional supplement that contains lycopene from tomatoes has a favorable effect on carotid atherosclerosis, lipid levels, and other biomarkers of coronary heart…
- Trial name
- NCT00939237
- Testing
- Ateronon
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Brigham and Women's Hospital
Hypercholesterolemia, Metabolic Syndrome
Ezetimibe/Simvastatin in Patients With Metabolic Syndrome (0653A-107)(COMPLETED)
A 6-week clinical trial in patients with metabolic syndrome and hypercholesterolemia at high risk for coronary heart disease to study the effects of ezetimibe/simvastatin and atorvastatin on lipids.
- Trial name
- NCT00409773
- Testing
- ezetimibe (+) simvastatin, Comparator: atorvastatin calcium
- Volunteers
- 1,143 people
- Sponsor
- Organon and Co
Coronary Heart Disease
Effect of CYP3A Genetic Polymorphisms on the Pharmacokinetics of Atorvastatin
The aim of the study is to investigate the effects of CYP3A polymorphisms on the pharmacokinetics of Atorvastatin in Chinese subjects with coronary heart disease.
- Trial name
- ECGPPA (NCT00973986)
- Testing
- Atorvastatin
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Liuhuaqiao Hospital
Myocardial Ischaemic Syndrome, Coronary Heart Disease
Protective Effect of PCSK9 Inhibitor Against Negative Inflammatory Response and Organ Dysfunction After Coronary Artery Bypass Grafting (PANDA VIII)
This is a multi-center, randomized controlled study to investigate whether early offering PCSK9 inhibitor can protect against negative inflammatory response and organ dysfunction after coronary artery bypass grafting (CABG).
- Trial name
- PANDA (NCT06730802)
- Testing
- PCSK9 inhibitor, Statin
- Where
- 2 sites in China
- Volunteers
- 400 people
- Sponsor
- Nanjing Medical University
Coronary Heart Disease
A Study of Dalcetrapib in Patients Hospitalized For An Acute Coronary Syndrome (Dal-ACUTE)
This double-blind, randomized, placebo-controlled, multi-center study will evaluate the safety and efficacy of dalcetrapib in patients hospitalized for an acute coronary syndrome (ACS).
- Trial name
- NCT01323153
- Testing
- dalcetrapib
- Where
- 33 sites in United States, Czechia and 2 more
- Volunteers
- 300 people
- Sponsor
- Hoffmann-La Roche
Coronary Heart Disease
A Long Term Extension of Study NC19453 Evaluating Safety and Efficacy of RO4607381
This 2 arm study will assess the long term safety and efficacy of RO4607381 in patients with coronary heart disease or a coronary heart disease (CHD) risk equivalent who have completed study NC19453.
- Trial name
- NCT00400439
- Testing
- dalcetrapib (RO4607381)
- Where
- 9 sites in United States
- Volunteers
- 77 people
- Sponsor
- Hoffmann-La Roche
Dilated Cardiomyopathy
Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy
The purpose of this study is to determine the safety and clinical effectiveness of umbilical cord mesenchymal cells transplanted by intravenous infusion in patients with heart failure.
- Trial name
- RIMECARD (NCT01739777)
- Testing
- ucMSC, Controls
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Universidad de los Andes, Chile
CHD, AMI
Lifestyle Intervention in a General Population for Prevention of Ischaemic Heart Disease
In spite of declining trend coronary heart disease (CHD) is still a leading cause of morbidity and mortality. Many years of epidemiological research have identified several risk factors for CHD.
- Conditions
- CHD, AMI, CVD, Type 2 Diabetes
- Trial name
- NCT00289237
- Testing
- Lifestyle intervention
- Where
- Denmark
- Volunteers
- 61,301 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Biomarkers
Metabolomics Profiling of Coronary Heart Disease
This study sought to assess the diagnostic and prognostic values of metabolomics in coronary artery disease(CAD).
- Trial name
- NCT05138731
- Testing
- treatments according guidelines
- Where
- 5 sites in China
- Volunteers
- 821 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Coronary Heart Disease
Vein External Support Trial
Prospective, multi-center, randomized, controlled pilot study to demonstrate the safety and effectiveness of the VGS Fluent external support device, supporting saphenous vein grafts in patients with coronary heart disease.
- Trial name
- VEST (NCT01415245)
- Testing
- Fluent (VGS Fluent external support device)
- Where
- 3 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Vascular Graft Solutions Ltd.
Coronary Heart Disease, Stroke
Hamburg City Health Study - a German Cohort Study
The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several risk and prognostic factors in major…
- Conditions
- Coronary Heart Disease, Stroke, Dementia, Cancer
- Trial name
- HCHS (NCT03934957)
- Where
- Germany
- Volunteers
- 45,000 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Idiopathic Inflammatory Myopathy
A Case-control Study to Assess Risk of Coronary Heart Disease in Idiopathic Inflammatory Myopathy
This study will be co-ordinated by Dr Hector Chinoy, Dr Robert G Cooper (Salford Royal NHS Foundation Trust / The University of Manchester) and Dr Ian N Bruce (Central Manchester University Hospitals NHS Foundation Trust/ The…
- Trial name
- NCT00971828
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northern Care Alliance NHS Foundation Trust
Dyslipidemia, Coronary Heart Disease
Observational Study to Estimate the Rates of Outcomes in Patients Undergoing Percutaneous Coronary Intervention (PCI) With Drug Eluting Stent (DES) Implantation Who Take Statins
To estimate the rates of percutaneous coronary intervention (PCI) outcomes in patients after drug-eluting stents implantation who take statins.
- Trial name
- OPTIMA (NCT01047176)
- Where
- Russia
- Volunteers
- 602 people
- Sponsor
- AstraZeneca
Cardiovascular Diseases, Percutaneous Coronary Intervention
PCI in Beijing Friendship Hospital
The goal of this study is to discover the potential risk factors related percutaneous coronary intervention. It aims to stratify the risk of PCI patients and discover the prognostic value of these risk fators.
- Trial name
- BF-PCI (NCT05728580)
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Friendship Hospital
Coronary Heart Disease
Different Dosage of Domestic and Imported Clopidogrel on the Platelet Inhibition Ratio in Patients Undergoing PCI
This is a single-center, randomized, single-blind, investigator-initiated, pharmacological study with a parallel design. Patients with non-ACS undergoing primary percutaneous coronary intervention will be randomized after…
- Trial name
- NCT03006835
- Testing
- Clopidogrel
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Coronary Arterial Disease (CAD), Myocardial Ischaemia
Clinical Application Study of Wearable Multi-channel Electrocardiogram Acquisition Equipment in the Diagnosis of Myocardial Ischemia in Patients with Suspected CHD
Backgroud: With the widespread application of artificial intelligence, sensor technology, and wearable technology in clinical and daily life, wearable devices have shown a promising application prospect and tremendous potential.
- Conditions
- Coronary Arterial Disease (CAD), Myocardial Ischaemia, Wearable Electronic Devices
- Trial name
- NCT06868940
- Testing
- wearable multi-channel ECG acquisition devices
- Volunteers
- 107 people
- Sponsor
- West China Hospital
Congenital Heart Disease (CHD), Chest Tube Removal
The Effect of Music and Musical Mobile Interventions on Pain and Physiological Parameters
Chest tube removal in infants undergoing surgery for congenital heart disease is an invasive procedure associated with significant pain and physiological stress responses.
- Trial name
- Music Pain Inf (NCT07564882)
- Testing
- Music Group, Musical Mobile Group
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Baskent University
Coronary Heart Disease, Multimorbidity
Randomized Control Trial to Evaluate Effectiveness of a Case Managment Program Regarding Psychosocial Well-being and Disease Symptoms Health for Patients With Multimorbid Coronary Heart Disease (CHD) Patients (KHK ProMA)
This randomized controlled trial (RCT) will examine a case management program for patients suffering from coronary heart disease with multimorbidity in Mannheim, Germany.
- Trial name
- KHK ProMA (NCT01725074)
- Testing
- Case Management "CM CHD", Social Interaction
- Where
- Germany
- Volunteers
- 320 people
- Sponsor
- Genossenschaft Gesundheitsprojekt Mannheim e.G
Atherosclerosis, Hypercholesterolemia
Comparison of Co-administration of Ezetimibe Plus Simvastatin Versus Simvastatin Alone in Primary Hypercholesterolemia (P03476)
This study will assess whether the daily co-administration of ezetimibe 10 mg with ongoing treatment of simvastatin 20 mg will be more effective than treatment with simvastatin 20 mg alone in further reducing LDL-C concentrations.
- Conditions
- Atherosclerosis, Hypercholesterolemia, Coronary Heart Disease
- Trial name
- NCT00651274
- Testing
- Ezetimibe
- Volunteers
- 144 people
- Sponsor
- Organon and Co
Congenital Heart Disease
Acute Maternal Hyperoxygenation in CHD
Congenital heart disease (CHD) is predominantly detected before birth. Using echocardiography and MRI, this study will determine whether acute exposure to maternal hyperoxygenation (MH) leads to measurable increases in fetal…
- Trial name
- NCT03944837
- Testing
- Oxygen gas
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- The Hospital for Sick Children
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