Clinical trials: CHF
Heart Failure With Preserved Ejection Fraction
Optimising Management of Patients With Heart Failure With Preserved Ejection Fraction in Primary Care
Heart failure (HF) accounts for 2% of National Health Service (NHS) expenditure, and 5% of emergency hospitalisations. Patients with HF with preserved ejection fraction (HFpEF) are older, have more comorbidities, have similarly…
- Trial name
- OPTIMISEHFpEF (NCT03617848)
- Where
- United Kingdom
- Volunteers
- 153 people
- Sponsor
- Professor Christi Deaton
Heart Disease, Coronary Arterial Disease (CAD)
Feasibility Study of the Supira System in Patients Undergoing HRPCI With Support Beyond the PCI Procedure
The objective of this study is to assess the safety and feasibility of the Supira System in heart failure patients with low LVEF, undergoing HRPCI with use of mechanical circulatory support who may benefit from cardiovascular…
- Conditions
- Heart Disease, Coronary Arterial Disease (CAD), Heart Failure
- Trial name
- NCT07407816
- Testing
- Supira System
- Where
- 2 sites in Georgia
- Volunteers
- 45 people
- Sponsor
- Supira Medical
Diabetes (DM), Hypertension
Multimodal Cardiovascular Magnetic Resonance Imaging for Cardiometabolic Pre-HF and HFpEF
This is an observational study aiming to characterize the pathophysiological features and clinical significance of cardiometabolic early-stage heart failure using advanced multimodal cardiovascular magnetic resonance (CMR)…
- Conditions
- Diabetes (DM), Hypertension, Heart Failure, Obesity & Overweight
- Trial name
- NCT07336316
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Heart Failure, Congestive
Torsion Optimization to Reduce Symptoms and Improve Outcomes in Non-responders
Approximately 40% of resynchronization therapy recipients do not appear to clearly benefit. These patients are termed 'non-responders'.
- Trial name
- TORSION (NCT00867984)
- Testing
- Torsion optimized, Usual Care
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Advanced Heart Failure
Hong Kong and Taiwan HM3 PMS
Hong Kong and Taiwan HM3 PMS is a prospective, single arm, post market surveillance is designed to evaluate clinical and functional outcomes with the HM3 LVAS as a treatment for advanced heart failure.
- Trial name
- NCT04703855
- Testing
- HeartMate 3™ left ventricular assist system (HM3 LVAS)
- Where
- 3 sites in Hong Kong, Taiwan
- Volunteers
- 3 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Aneurysm
Coronary Artery Aneurysm Registry
International registry gathering patients with angiographically confirmed coronary aneurysm.
- Trial name
- CAAR (NCT02563626)
- Where
- Spain
- Volunteers
- 1,565 people
- Sponsor
- St Carlos Hospital, Madrid, Spain
Heart Failure
Attain Success Clinical Trial
The purpose of the study is to assess lead implant success and complication rate using the Medtronic Attain Family of left-heart leads and delivery catheters.
- Trial name
- NCT00990964
- Testing
- Attain Success Lead
- Where
- 108 sites in United States, Canada and 14 more
- Volunteers
- 2,014 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Bronchial Asthma
Efficacy and Tolerability of Beclomethasone Dipropionate 100 µg + Formoterol 6 µg pMDI Via HFA-134a Vs. Budesonide 160 µg + Formoterol 4,5 µg Dry Powder Via Turbuhaler®. (Symbicort®)
The aim of this study was to compare the efficacy and tolerability of the fixed combination beclomethasone/formoterol pMDI with that of budesonide/formoterol dry powder via Turbuhaler.
- Trial name
- NCT00413387
- Testing
- beclomethasone dipropionate plus formoterol fumarate combination, budesonide plus formoterol combination
- Where
- 13 sites in Austria, Poland and 1 more
- Volunteers
- 219 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Heart Failure
Drug Management in Heart Failure
Aim of the proposal is to create an interactive AI-based multicentre prospective database to provide information on how to improve the QoC for pts with HF.This will provide detailed information on pts characteristics,treatment…
- Trial name
- DRUM-HF (NCT06915584)
- Where
- Italy
- Volunteers
- 450 people
- Sponsor
- IRCCS San Raffaele Roma
Heart Failure
Multicenter Study of Family Nursing to Treat Heart Failure
The purpose of this study is to determine whether Family Focused Nursing are effective in the treatment of heart failure outpatients with respect to health-related quality of life.
- Trial name
- NCT01378247
- Testing
- Family Focused Nursing
- Where
- 3 sites in Denmark
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Heart Failure, Dilated Cardiomyopathy
Myocardial Telomere Recapping Study for Dilated Cardiomyopathy
The aim of this study is to determine the safety and feasibility of giving an adeno-associated viral vector expressing a modified telomerase protein (TERT), driven by cardiac troponin T promoter (AAV9-cTnT-modTERT), to 12 dilated…
- Trial name
- MERCURY-DCM (NCT05837143)
- Testing
- JV001
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Shanghai East Hospital
Idiopathic Cardiomyopathy, Left Ventricular (LV) Systolic Dysfunction
Performance of the Cardiac Microcurrent (C-MIC) System With a Less Invasively Placed Left Ventricular Lead
Patients with idiopathic dilated cardiomyopathy in heart failure (NYHA class III - IV) with a baseline left ventricular ejection fraction between ≥25% and ≤35%, and patients with non-ischemic cardiomyopathy in heart failure (NYHA…
- Conditions
- Idiopathic Cardiomyopathy, Left Ventricular (LV) Systolic Dysfunction, Non-ischemic Cardiomyopathy
- Trial name
- NCT06920030
- Testing
- Subcutaneous cardiac microcurrent treatment
- Where
- 4 sites in Bosnia and Herzegovina, Serbia
- Volunteers
- 22 people
- Sponsor
- Berlin Heals GmbH
Stage D Heart Failure
Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study
The purpose of the study is to evaluate how well tolerated and effective an angiotensin receptor-neprilysin inhibitor (sacubitril-valsartan) is in patients with contemporary durable continuous flow left ventricular assist device…
- Trial name
- SEAL-IT (NCT04191681)
- Testing
- Sacubitril-Valsartan, Usual care (standard-of-care) arm
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Cleveland Clinic
Cystic Fibrosis, Non-Cystic Fibrosis Bronchiectasis
A Clinical Study to Investigate Safety, Tolerability and Distribution of CHF 6333 After One or After Repeated Inhalation in Patients With Cystic Fibrosis (CF) and in Patients With Non Cystic Fibrosis (NCFB) Bronchiectasis
CHF 6333 is a medicinal product on development for the treatment of cystic fibrosis and non-CF bronchiectasis and undergoing clinical testing. It has not yet been approved by the authorities for the treatment of these diseases.
- Trial name
- NCT04010799
- Testing
- CHF 6333
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Refractory Heart Failure
Levacor™ Ventricular Assist Device (VAD) Bridge to Transplant Study
The Levacor™ Ventricular Assist Device (VAD) has been designed for mechanical circulatory support in heart failure patients. The purpose of this clinical study is to determine its safety and efficacy as a bridge to transplant…
- Trial name
- NCT01001793
- Testing
- Levacor Ventricular Assist Device
- Where
- 6 sites in United States
- Volunteers
- 15 people
- Sponsor
- World Heart Corporation
Cardiorenal Syndrome
The Effect in Renal Function on Patients With Type 1 Cardiorenal Syndrome Treated With Two Strategies of Furosemide.
In double-blind clinical trial, determine renal recovery with two different furosemide strategies in patients with type 1 cardiorenal syndrome.
- Trial name
- NCT04393493
- Testing
- Furosemide intravenous solution, Chlortalidone, Spironolactone
- Where
- 2 sites in Mexico
- Volunteers
- 80 people
- Sponsor
- Hospital Civil de Guadalajara
Acute Coronary Syndrome, Congestive Cardiac Failure
Palliative Care for Patients With Advanced Heart Disease
Patients admitted as an unscheduled hospital admission with either a acute heart failure syndrome (ACF) or acute coronary syndrome (ACS) will be eligible if their 6-12 month mortality risk is estimated to be 20% or greater at the…
- Conditions
- Acute Coronary Syndrome, Congestive Cardiac Failure, Palliative Care
- Trial name
- FLAME (NCT02302014)
- Testing
- Palliative Care Intervention
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Edinburgh
Chronic Heart Failure (CHF)
Effect of a Cardiac Rehabilitation Program on Chronic Heart Failure Patients in Yaoundé, Cameroon
CARECA-CHF study is a non-randomized, prospective, single-arm study, enrolled ambulatory patients with stable chronic heart failure [New York Heart Association (NYHA) class II/III].
- Trial name
- CARECA-CHF (NCT04790214)
- Testing
- CHF Patients
- Where
- Cameroon
- Volunteers
- 30 people
- Sponsor
- Yaounde Central Hospital
Advanced Heart Failure, Heart Failure With Reduced Ejection Fraction
Screening for Advanced Heart Failure IN Stable outPatientS - The SAINTS Study (SAINTS B)
SAINTS B is a randomized, controlled, clinical trial. Patients identified with advanced heart failure in SAINTS A who are unwilling or unable to undergo heart transplantation or left ventricular assist device implantation will be…
- Trial name
- SAINTS B (NCT05284955)
- Testing
- CardioMEMS HF System, Standard heart failure medical therapy
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Finn Gustafsson
Heart Failure
Metabolic Effects of Chronic Ketosis (KETO-CHF Metabolic)
Heart Failure (HF) is a major public health issue because the disease affects 1-2% of the Western population and the lifetime risk of HF is 20%.
- Trial name
- NCT05161676
- Testing
- Ketone monoester
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus