Clinical trials: CHILD Syndrome
HIV Infection
A Pilot Study of the Immunologic Reconstitution in HIV-1 Infected Children Receiving Highly Active Antiretroviral Therapy With Combination Ritonavir, Nevirapine and Stavudine
This is a pilot study to evaluate the ability of highly active antiretroviral therapy administered to children with HIV-1 infection to effect immunoreconstitution in children with HIV-1 infection.
- Trial name
- NCT00001688
- Testing
- Ritonavir, Nevirapine, Stavudine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Cancer Institute (NCI)
Tourette Syndrome, Tourette Syndrome in Children
Tourette Discrimination (TD) Stigma Scale
The goal of this qualitative study is to understand the challenges of stigmatization and discrimination in children and young adults with Chronic Tic Disorders (CTD), including Tourette Syndrome.
- Conditions
- Tourette Syndrome, Tourette Syndrome in Children, Tourette Syndrome in Adolescence, Tic Disorder, Childhood
- Trial name
- TD (NCT05696769)
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Wake Forest University Health Sciences
Brain and Central Nervous System Tumors, Kidney Cancer
Early Enteral Tube Feedings in Children Receiving Chemo for AML/MDS & High Risk Solid Tumors
RATIONALE: Tubefeeding may help maintain good nutrition and lessen weight loss in younger patients receiving chemotherapy for cancer.
- Conditions
- Brain and Central Nervous System Tumors, Kidney Cancer, Leukemia, Liver Cancer
- Trial name
- NCT00624962
- Testing
- nutritional intervention, therapeutic nutritional supplementation
- Sponsor
- Vanderbilt University
Kbg Syndrome, ADHD - Combined Type
Methylphenidate in KBG Syndrome: N-of-1 Series
The goal of this clinical trial] is to learn about the effect of methylphenidate in children and adolescents with KBG syndrome. The main question it aims to answer is: What is the effectiveness of methylphenidate on attention…
- Trial name
- KBGS_N_of_1 (NCT06465641)
- Testing
- Methylphenidate Hydrochloride
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Shaken Baby Syndrome
Evaluation of Young Parents' Knowledge of Shaken Baby Syndrome in Maternity Wards
As part of everyday clinical practice, messages about preventing Shaken Baby Syndrome are delivered to young parents in maternity wards. The modality of these messages changes regularly.
- Trial name
- NCT06222060
- Testing
- Questionnaire about Shaken Baby Syndrome
- Where
- France
- Volunteers
- 686 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
HIV Infections
Vitamin D Supplementation in HIV Youth
The purpose of this study is to determine the correct dose of Vitamin D to give to prevent HIV related complications.
- Trial name
- NCT01523496
- Testing
- Vitamin D control dose, Vitamin D supplementation-
- Where
- 2 sites in United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Idiopathic Nephrotic Syndrome
Cyclophosphamide Versus Mycophenolate Mofetil for the Treatment of Steroid-dependent Nephrotic Syndrome in Children
Idiopathic nephrotic syndrome is steroid-sensitive in more than 90% of cases in children. However 60% of cases are steroid dependent and required treatment with immunosuppressive agent.
- Trial name
- NEPHROMYCY (NCT01092962)
- Testing
- Cyclophosphamide, Mycophenolate mofetil
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hereditary Angioedema Types I and II
Study to Assess the Tolerability and Safety of Ecallantide in Children and Adolescents With Hereditary Angioedema
The objective of this study is to evaluate the safety and tolerability of a single Subcutaneous (SC) dose of Ecallantide in children and adolescents with Hereditary Angioedema (HAE).
- Trial name
- NCT01832896
- Testing
- Ecallantide subcutaneous dosing
- Where
- United States
- Sponsor
- NYU Langone Health
Childhood Obesity
Effect of Polysaccharide-based Complex Administration on the Gut Microbiome and Cardio-Metabolic Profile in Children With Obesity and Metabolic Syndrome.
Childhood obesity is a growing public health concern and is associated with long-term health issues. Changing lifestyle habits, especially improving diet and maintaining these changes over time, can be challenging for children…
- Trial name
- Polymets (NCT07321184)
- Testing
- Polysaccharide-based complex
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- University of Milan
Prader-Willi Syndrome
Register of Patients With Prader-Willi Syndrome
Prader-Willi Syndrome (PWS) is a rare syndrome with a prevalence of 15 to 20 000 at birth. PWS represents a large fraction of mental retardation syndromes due to a genetic cause and the most frequent cause of genetic obesity.
- Trial name
- NCT02829684
- Testing
- Data collection
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Toulouse
Coeliac Disease, Celiac Disease in Children
Validation of the CDAT in the Polish Paediatric Population
The English version of the Celiac Dietary Adherence Test (CDAT) will be translated into Polish using the "forward-backwards-forward" translation model, with the author's consent (already obtained by the applicants).
- Trial name
- CD-PL-CDAT (NCT07142148)
- Testing
- CDAT - phase 1, CDAT - phase 2
- Volunteers
- 20 people
- Sponsor
- Medical University of Warsaw
X-Linked Combined Immunodeficiency Diseases
Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age With X-Linked Severe Combined Immunodeficiency
The purpose of this study is to evaluate the safety and effectiveness of lentiviral gene transfer treatment at restoring immune function to participants with X-linked severe combined immunodeficiency (XSCID) who are 2 to 40 years…
- Trial name
- LVXSCID-OC (NCT03315078)
- Testing
- CD34+ HSCs transduced with the lentivirus vector, VSV-G pseudotyped CL20-4i-EF1α-hγc-OPT, Palifermin, Busulfan
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hemoglobinuria, Paroxysmal
Eculizumab Pharmacokinetics/Pharmacodynamics Study in Pediatric/Adolescent Paroxysmal Nocturnal Hemoglobinuria (PNH)
The primary objective of this study was to evaluate the pharmacokinetic (PK) and pharmacodynamic (PD) parameter estimates of eculizumab to confirm the dose regimens for pediatric and adolescent participants with PNH.
- Trial name
- NCT00867932
- Testing
- Eculizumab
- Where
- 3 sites in United States
- Volunteers
- 7 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Tourette Disorder, Tic Disorders
Evaluating the Efficacy and Safety of Yi-Gan San in Children and Adolescents With Tourette's Disorder
Yigansan was used in Ming dynasty by Xue Kai as a remedy for restlessness and agitation in children. We expect that the total YGTSS scores of Yigansan-treated subjects will be significantly reduced compared to that of…
- Trial name
- NCT03564132
- Testing
- Yigansan
- Where
- Taiwan
- Volunteers
- 38 people
- Sponsor
- China Medical University Hospital
Renal Insufficiency, Chronic
Efficacy and Safety Study to Delay Renal Failure in Children With Alport Syndrome
This is a phase III, multi-centre, randomised, placebo-controlled, patient and investigator-blind study in paediatric patients with early stages of Alport syndrome to assess the safety and efficacy of the ACEi ramipril in slowing…
- Trial name
- NCT01485978
- Testing
- Ramipril
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH
FPIES, IgE Mediated Food Allergy
Quality of Life and Eating Disorders in Children With FPIES, Food Allergy or Celiac Disease
Food allergies are associated with a decrease in quality of life. Patients with FPIES often have more food avoidance than necessary. The greater the number of avoided foods, the greater the risk of eating disorders.
- Conditions
- FPIES, IgE Mediated Food Allergy, Celiac Disease
- Trial name
- QUALIM (NCT04643704)
- Where
- France
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV Infections
Dolutegravir Study in HIV-1 Participants Completing IMPAACT Studies P1093 and P2019
Dolutegravir is a potent integrase strand transfer inhibitor. Abacavir/dolutegravir/lamivudine (ABC/DTG/3TC) is a fixed dose combination regimen containing two nucleoside reverse transcriptase inhibitors and dolutegravir.
- Trial name
- NCT03016533
- Testing
- Dolutegravir film-coated tablets, Dolutegravir film-coated dispersible tablets, ABC/DTG/3TC immediate release tablets
- Where
- 17 sites in United States, Botswana and 5 more
- Volunteers
- 100 people
- Sponsor
- ViiV Healthcare
Obstructive Sleep Apnea, Difficult Airway
Airway Ultrasound Prediction and Correlation
This is a novel approach to assess the use of ultrasound to support the identification of obstructive sleep apnea syndrome (OSAS) on a screening questionnaire, and potentially to predict a difficult pediatric airway.
- Trial name
- NCT03313947
- Testing
- Ultrasound, Questionnaire
- Where
- United States
- Sponsor
- Vidya Raman
Multisystem Inflammatory Syndrome in Children
Infusions of Mesenchymal Stromal Cells in Children With Multisystem Inflammatory Syndrome
The purpose of this multi-site, pilot study is to test whether infusions of human cord tissue mesenchymal stromal cells (hCT-MSC) are safe in children with multi system inflammatory syndrome (MIS-C).
- Trial name
- MISTIC (NCT04549285)
- Testing
- Human Cord Tissue Mesenchymal Stromal Cells (hCT-MSCs)
- Where
- 3 sites in United States
- Sponsor
- Joanne Kurtzberg, MD
Small for Gestational Age
Study of Growth-promoting and Metabolic Effects of Growth Hormone (rhGH)
Recombinant growth hormone (rhGH) treatment is widely used in France to normalize height during childhood and final height in children born small for gestational age (SGA).
- Trial name
- SGA (NCT00597480)
- Testing
- rhGH (Norditropine SimpleXx®), rhGH norditropine simple Xx
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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