Clinical trials: CHILD Syndrome
Alport Syndrome, Metformin
Treatment With Metformin in Chinese Children With Alport Syndrome
This single-center, prospective, double-blind randomized placebo-controlled trial will evaluate the efficacy and safety of metformin in Chinese children with Alport syndrome who have received (and continue to receive)) ACEi/ARB.
- Trial name
- NCT05655728
- Testing
- Metformin
- Volunteers
- 78 people
- Sponsor
- Peking University First Hospital
Autism Spectrum Disorder, Fra(X) Syndrome
Establishing a Diagnostic and Therapeutic Index in Autism Spectrum Disorder (ASD) and Fragile X Syndrome
The purpose of this study is to accumulate and quantitatively analyze data on the microbiome, serotonin signaling and genetics, and inflammatory cytokines from patients with Autism Spectrum Disorder and Fragile X Syndrome.
- Trial name
- NCT04869930
- Testing
- specimen collection
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nova Mentis Life Science Corp
Nephrotic Syndrome in Children
Predictors of Steroid Response in Childhood Nephrotic Syndrome
Retrospective study of predictors of steroid response in childhood nephrotic syndrom
- Trial name
- NCT06130631
- Volunteers
- 79 people
- Sponsor
- Maha Radwan
Kawasaki Disease, Inflammation
Characterization of Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Relationship to Kawasaki Disease
Beginning in mid-March 2020, pediatricians in communities in Western Europe, the UK, and the Eastern U.S. that had been severely affected by the Covid-19 pandemic noted an increased number of children presenting with fever and…
- Trial name
- NCT04538495
- Where
- United States
- Volunteers
- 268 people
- Sponsor
- University of California, San Diego
Autism Spectrum Disorder, Autism
Genetic Contributions to Autism Spectrum Disorders
This study is working towards gaining a better understanding of the genetic and environmental factors involved in autism spectrum disorders (ASD), which includes autism, pervasive developmental disorder (PDD), and Asperger's…
- Conditions
- Autism Spectrum Disorder, Autism, Asperger's Syndrome, Pervasive Developmental Disorder
- Trial name
- NCT01160783
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Boston Children's Hospital
Nephrotic Syndrome
Therapeutic Effect of Tacrolimus on Primary Nephrotic Syndrome in Children
To determine the efficacy of tacrolimus in the management of NS(nephrotic syndrome) , the investigators designed this prospective study.
- Trial name
- NCT01162005
- Testing
- Tacrolimus
- Where
- South Korea
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
IBD (Inflammatory Bowel Disease)
Neurological Manifestations in Children Diagnosed With Inflammatory Bowel Disease
screen for neurologic and psychiatric disorders in children and adolescents with IBD.
- Trial name
- NCT07247994
- Volunteers
- 44 people
- Sponsor
- Bishoy Shehata Fahim
HIV Infection
Phase I Study to Evaluate the Safety and Immunogenicity of HIV-1 Immunogen in Children With HIV-1 Infection
This is a single dose, phase I study to evaluate the safety/tolerance and the immunogenicity of HIV-1 Immunogen, gp120-depleted inactivated HIV-1 preparation in Incomplete Freund's Adjuvant (IFA), in children with HIV-1…
- Trial name
- NCT00001445
- Testing
- HIV-1 Immunogen
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- National Cancer Institute (NCI)
Acute Respiratory Distress Syndrome (ARDS)
Trial of an Alternate Mode of Providing Artificial Breaths to Children With Very Severe Pneumonia
This study attempts to study a new ventilation mode in children with Acute respiratory distress syndrome (ARDS). Despite decades of research, no intervention has brought about a significant decrease in ARDS mortality.
- Trial name
- APRiCE (NCT02167698)
- Testing
- Airway Pressure Release Ventilation (APRV), Low-tidal volume ventilation, Methylprednisolone
- Where
- India
- Volunteers
- 52 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hereditary Angioedema (HAE)
Donidalorsen Treatment in Children With Hereditary Angioedema
The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of donidalorsen in pediatric participants with hereditary angioedema (HAE) Type I (HAE-1) or Type II (HAE-2).
- Trial name
- NCT07298447
- Testing
- Donidalorsen
- Where
- 18 sites in United States, Australia and 3 more
- Volunteers
- 20 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Symptom Cluster, Anxiety
Effect Of Virtual Reality Distraction on Symptom Control and Anxiety in Children With Leukemia
This study aim to evaluate the effect of virtual reality distraction on symptom management and anxiety in children aged 7-18 years with leukemia.
- Trial name
- VR-Ege (NCT05818748)
- Testing
- virtual reality
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Dokuz Eylul University
Pediatric Obesity, Type 2 Diabetes
A Family Based Intervention to Reduce the Risk of Type 2 Diabetes in Children
The purpose of this study was to determine if a family-focused lifestyle intervention helps to improve the health status, behaviors, and adjustment of overweight children.
- Conditions
- Pediatric Obesity, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- FBI (NCT01146314)
- Testing
- Family Focused Lifestyle Intervention
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Nemours Children's Clinic
Growth Hormon Deficiency, Turner Syndrome in Pre-pubertal Children
Long Term Follow up Study of Predictive Markers in GHD and TS Children
Primary objective is to assess the relationship between changes from serum biomarkers observed after 1 month of Saizen® therapy and change in height, weight after up to 5 years of treatment with Growth Hormone in children with…
- Trial name
- PREDICT LT FUP (NCT00699855)
- Volunteers
- 182 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Kabuki Syndrome
Assessment of Memory in Children With Kabuki Syndrom
Mnesic function has not, at present, been evaluated in patients with Kabuki Syndrome. Some data from the neuroimagery suggest an impairment of memory function.
- Trial name
- MEM-K (NCT03547609)
- Testing
- No arm intervention
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Montpellier
Psychiatric or Mood Diseases or Conditions, Neuropsychiatric Syndrome
Effect and Cost-effectiveness of the Everyday Life Rehabilitation Intervention
The person-centered, motivational, recovery-, and activity-based intervention model 'Everyday Life Rehabilitation´ (ELR), integrated in sheltered and supported housing facilities for people with severe psychiatric disabilities…
- Conditions
- Psychiatric or Mood Diseases or Conditions, Neuropsychiatric Syndrome, Psychosis, Autism
- Trial name
- ELR (NCT05056415)
- Testing
- Everyday Life Rehabilitation (ELR), Treatment as usual (TAU)
- Where
- Sweden
- Volunteers
- 161 people
- Sponsor
- Umeå University
Nephrotic Syndrome in Children
Steroid Sensitive Nephrotic Syndrome in Children
Idiopathic nephrotic syndrome (INS) is one of the most common glomerular pathologies in children and corticosteroid therapy is its most effective treatment.
- Trial name
- NCT03878914
- Testing
- Corticosteroids
- Where
- 2 sites in United States, China
- Volunteers
- 34 people
- Sponsor
- Wayne State University
Concussion Post Syndrome
Auditory Slow Wave Enhancement After Concussion
The prevalence of a traumatic brain injury (TBI) in children and adolescents is around 30% with 70-90% being classified as mild (concussion).
- Trial name
- NCT04770116
- Testing
- Auditory Stimulation
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Non-alcoholic Fatty Liver Disease, Obesity
Effect of Exercise on Hepatic Fat in Overweight Children
The objective of the present study is to evaluate the effect of 6 months exercise intervention program on hepatic fat fraction in overweight children.
- Conditions
- Non-alcoholic Fatty Liver Disease, Obesity, Metabolic Syndrome
- Trial name
- EFIGRO (NCT02258126)
- Testing
- Multidisciplinary intervention program
- Where
- Spain
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of the Basque Country (UPV/EHU)
Concussion, Mild, Post Concussion Symptoms
RTL Concussion Communication
This study is aimed at improving health outcomes for adolescents who sustain sport and recreation related concussions (SRRC) by enhancing Return to Learn (RTL).
- Conditions
- Concussion, Mild, Post Concussion Symptoms, Cognitive Impairments, Cognitive Impairments, Mild
- Trial name
- NCT06212726
- Testing
- InjureFree
- Sponsor
- University of Florida
Mental Disorders
Effects of Emotion on Episodic Memory in Typically Developing Children and Children With Williams-Beuren Syndrome
It's well established in the literature that emotional events are more likely to be remembered than neutral events. Although this Emotional Enhancement of Memory (EEM) has been well demonstrated in the adult literature, little is…
- Trial name
- EEM-TAdev (NCT03688516)
- Testing
- Manipulation of valence and modality, Spatial and recognition memory, Source and content memory
- Where
- France
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier