Clinical trials: CIN
Cervical Intraepithelial Neoplasia Grade 2/3
Validation of Human Papillomavirus Assays and Collection Devices for Self-samples and Urine Samples
The VALHUDES study is a Diagnostic Test Accuracy study that aims to document the clinical accuracy of hrHPV testing on urine samples, collected under standardised and optimised conditions, and on two types of vaginal self-samples…
- Trial name
- VALHUDES (NCT03064087)
- Testing
- Colli-Pee, Multi-Collect Swab, Evalyn Brush
- Where
- 5 sites in Belgium
- Volunteers
- 500 people
- Sponsor
- Marc Arbyn
Cervical Intraepithelial Neoplasia Grade 2/3, Cervical Lesion
Accurate Screening and Prevention of Cervical Lesions-- Development of Accurate Screening Methods for Cervical Lesions
The goal of this observational study is to compare the accuracy and sensitivity of High-throughput human papilloma virus(HPV) typing and integrated assays with routine screening protocols (Cobas HPV test combined with thinprep…
- Trial name
- NCT05851079
- Testing
- TCT test, Vaginoscopy, High throughput HPV typing and integration detection methods
- Where
- China
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Cervical Intraepithelial Neoplasia
Adjuvant VaccInation After Conization for the Treatment for CervicAL Dysplasia
HPV vaccination has emerged as a strategy to reduce the risk of recurrence oafter excisional treatment. However, only few data are aviable.
- Trial name
- VITAL (NCT06611020)
- Where
- 2 sites in Italy
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Cervix Cancer, Cervix Intraepithelial Neoplasia Grade 3
Pharmacokinetics of Intravaginal, Self-administered Artesunate Vaginal Pessaries Among Women in Kenya
This study investigates the pharmacokinetics of Artesunate (AS) and dihydroartemisinin (DHA), the active metabolite of Artesunate, following intravaginal use at the dosing and frequency being studied for cervical precancer…
- Conditions
- Cervix Cancer, Cervix Intraepithelial Neoplasia Grade 3, Cervix; Intraepithelial Neoplasia, Grade I, Cervix; Intraepithelial Neoplasia, Grade II
- Trial name
- NCT06263582
- Testing
- Artesunate pessary, blood draws for pharmacokinetics of the study drug
- Where
- Kenya
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Human Papilloma Virus, Cervical Intraepithelial Neoplasia
HPV-based Screening Among Women 23-29 Years of Age
The aim of the trial is to determine whether organized screening with primary HPV analysis provide higher cancer protection in the age group 23-29 years compared to primary cytology.
- Conditions
- Human Papilloma Virus, Cervical Intraepithelial Neoplasia, Cervical Cancer
- Trial name
- NCT05229679
- Testing
- HPV testing
- Where
- 2 sites in Sweden
- Volunteers
- 180,000 people
- Sponsor
- Karolinska Institutet
Educational Problems, Cervix, Dysplasia
Colposcopy Education Using Operant Learning
Images will be collected during routine colposcopy and paired with their pathology results to be used for resident education
- Trial name
- Colpo (NCT04340011)
- Testing
- Colposcopy
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Virginia
HPV Infection, Cervical Cancer
What is the Optimal Training Model for Cervical Awareness?
Cervical cancer represents the fourth most prevalent malignant disease and the fourth leading cause of mortality among women on a global scale.
- Conditions
- HPV Infection, Cervical Cancer, Cervical Dysplasia
- Trial name
- NCT06562595
- Testing
- Education Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Izmir City Hospital
Cervical Intraepithelial Neoplasia, Cervix Neoplasm
Comparing Two Techniques of Haemostasis After Cervical Conization
The LEEP conization is commonly used for cervical pathologies treatment. The techniques for hemostasis usually used are: cautery, Monsel's solution and vaginal pack.
- Trial name
- NCT03293628
- Testing
- Vaginal Packing
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Barretos Cancer Hospital
Cervical Cancer
Spectroscopy Versus Standard Care in Cervical Cancer Patients
Primary objectives 1. To conduct a randomized clinical trial of the emerging technology fluorescence and reflectance spectroscopy, comparing colposcopy to colposcopy + spectroscopy in the diagnostic setting, stratifying patients…
- Trial name
- NCT00529464
- Testing
- Fluorescence Spectroscopy, Colposcopy, LEEP Procedure
- Where
- 3 sites in United States, Canada
- Volunteers
- 2 people
- Sponsor
- M.D. Anderson Cancer Center
ASC-US, Human Papilloma Virus
Can B12 and Folate Levels Predict HPV Penetration in Patients With ASCUS?
Non-classified atypical squamous cells (ASCUS) is the most common abnormal cervical cytology (%39). The risk of cervical intraepithelial neoplasia 2-3 is 5% and the risk of carcinoma is around 0.1% after diagnosis.
- Trial name
- NCT03903952
- Testing
- Vitamin B12 and folate
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Cervical Intraepithelial Neoplasia
Comparison of Human Papillomavirus Integrated DNA and Messenger RNA in Cervical Neoplasia
The investigators hypothesis is HPV integration could result in expression of oncogene transcripts, and not only constitutive expression but also the level of expression will be decisive for transformation and the maintenance of…
- Trial name
- NCT02198365
- Where
- Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Cathay General Hospital
Precancerous Condition, Stage 0 Cervical Cancer
Protein Expression as a Potential Diagnostic Biomarker of Cervical Dysplasia and/or Cancer
This diagnostic trial is studying the presence of a specific protein as a potential biomarker of cervical dysplasia and/or cancer.
- Trial name
- NCT00003384
- Testing
- Cervical Papanicolaou Test, Conization, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 684 people
- Sponsor
- Gynecologic Oncology Group
Inflammatory Bowel Disease, Uterine Cervical Dysplasia
Immune Response to the Human Papillomavirus Vaccine in Young Women With Inflammatory Bowel Disease
The Gardasil vaccine, a vaccine targeted towards the human papillomavirus (HPV), has been shown to prevent the transmission of several strains of HPV in young women.
- Trial name
- NCT01034358
- Testing
- Human Papillomavirus Vaccine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Precancerous Conditions, Neoplasms
Cervical Cancer Prevention: From DNA to mRNA? - New Technologies for Cervical Cancer Screening 2
In industrialized countries, cervical cancer is a well controlled disease thanks to the diffusion of Pap test and, in particular, to organized screening programs, which are able to detect and treat pre-invasive lesions (cervical…
- Trial name
- NTCC2 (NCT01837693)
- Testing
- Experimental: immediate colposcopy
- Where
- 5 sites in Italy
- Volunteers
- 41,127 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Cervical Cancer
Mobile High-Resolution Microendoscopy (mHRME) for the Detection of Cervical Dysplasia in El Salvador
Evaluate the performance of the mHRME in a study of 3,000 women in San Salvador to assess whether mHRME imaging improves specificity of screening by VIA or HPV DNA without reducing sensitivity for cervical precancer and cancer.
- Trial name
- NCT04472455
- Testing
- HRME
- Volunteers
- 1,827 people, healthy volunteers welcome
- Sponsor
- William Marsh Rice University
Human Papillomavirus Infection, Cervical Cancer
Clinical Evaluation of Detection of High Risk HPV in Urine
Cervical cancer is one of the most common tumors in women, which seriously threatens women's life quality and safety. Human papilloma virus (HPV) infection is the most common cause of cervical cancer.
- Conditions
- Human Papillomavirus Infection, Cervical Cancer, Human Papilloma Virus, Negative for Intraepithelial Lesion or Malignancy
- Trial name
- Urine-hrHPV (NCT05210348)
- Where
- 3 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Stage 0 Cervical Cancer, High-grade Squamous Intraepithelial Lesion
S0212 Celecoxib in Treating Patients With High-Grade Squamous Intraepithelial Lesions of the Cervix
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. Celecoxib may be effective in preventing cervical cancer.
- Trial name
- NCT00072540
- Testing
- celecoxib, anti-cytokine therapy, antiangiogenesis therapy
- Sponsor
- SWOG Cancer Research Network
Cervical Dysplasia
Digital Imaging Aid for Assessment of Cervical Dysplasia
The overall objective of this study is to evaluate whether polarized or green filtered digital imaging can assist clinicians to screen for premalignant lesions in the cervix.
- Trial name
- NCT00511758
- Testing
- Digital Imaging
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
CIN2
Empowering Women - Shared Decision Making in Managing Cervical Precancer
The aim of this stepped-wedge randomized clinical trial is to assess the impact of implementing a patient decision aid during consultations with patients diagnosed with cervical precancer.
- Trial name
- NCT07146152
- Testing
- Patient Decision Aid
- Where
- Denmark
- Volunteers
- 138 people
- Sponsor
- University of Aarhus
Uterine Cervical Neoplasms, Uterine Cervical Dysplasia
Self-sampling and Human Papillomavirus (HPV)-Testing for Unscreened Women in Cervical Cancer Prevention
Scientific Context High-risk types of human papillomavirus (HPV) are the causative agents for cervical cancer. Cervical cancer screening strategies rely on periodic Papanicolaou (Pap) testing.
- Trial name
- APACHE-1 (NCT01014026)
- Testing
- Screening test
- Where
- 5 sites in France
- Volunteers
- 734 people
- Sponsor
- University Hospital, Tours