Clinical trials: CIN
Uterine Cervical Dysplasia
Trial on Safety and Pharmacokinetics of Intravaginal Curcumin
The main objective of this study is to determine the maximum tolerable dose and safety of intravaginal curcumin in a normal population of women (women with no evidence of cervical cytological abnormalities by pap testing).
- Trial name
- NCT01035580
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Emory University
Herpes Genitalis, Genital Wart
Safety and Efficacy of Laser Therapy in Gynaecology
The aim of this study is to retrospectively evaluate the effectiveness and safety of Er:YAG laser for treatment of different gynecological indication, e.g.
- Conditions
- Herpes Genitalis, Genital Wart, Lichen Sclerosus, Cervical Intraepithelial Neoplasia
- Trial name
- NCT04073082
- Where
- Slovenia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Juna d.o.o.
Uterine Fibroid, Ovary Cyst
TWO DİFFERENT ELECTROSURGERY DEVICES AS MONOPOLAR HOOC AND PLASMAKINETIC BIPOLAR SPATULA EFFECTIVENESS DURING COLPOTOMY
WE DECIDED TO COMPARE TWO DIFFERENT ELECTROSURGERY DEVİCES TO PROVIDE COLPOTOMY. ONE OF THEM İS MONOPOLAR HOOC, THE OTHER DEVİCE İS PLASMAKİNETİC BİPOLAR SPATULA.
- Conditions
- Uterine Fibroid, Ovary Cyst, Endometrial Hyperplasia, Cervical Dysplasia
- Trial name
- NCT04191603
- Testing
- MONOPOLAR HOOC, PLASMAKINETIC BIPOLAR SPATULA
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Alkü Alanya Education and Research Hospital
Cervical Dysplasia, Pain
Virtual Reality: Influence on Satisfaction, Pain, and Anxiety in Patients Undergoing Colposcopy
Cervical cancer is one of the most common cancers in women and one of the leading causes of death in women worldwide. Pre-cancerous lesions (dysplasias) are detected by the screening smear test at the gynecologist's office and…
- Conditions
- Cervical Dysplasia, Pain, Anxiety
- Trial name
- NCT04751799
- Testing
- Virtual reality headset before colposcopy, Virtual reality headset during colposcopy
- Where
- Germany
- Volunteers
- 247 people
- Sponsor
- Ruhr University of Bochum
Cervical Dysplasia
Coherence Imaging of the Cervical Epithelium With Scanning a/LCI
The purpose of this study is to develop a low coherence interferometry (LCI) endoscopic probe that can examine the cervix for evidence of cervical dysplasia.
- Trial name
- NCT03502798
- Testing
- scanning a/LCI
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Duke University
Cervical Intraepithelial Neoplasia, Cervix Neoplasms
Cold Knife Conization With and Without Lateral Hemostatic Sutures
The treatment of high grade Cervical Intraepithelial Neoplasia (CIN) 2, 3 is defined according to the colposcopic evaluation of the patient.
- Trial name
- NCT02184975
- Testing
- Cold Knife Conization with stitches, Cold knife Conization without stitches
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Barretos Cancer Hospital
Cervical Cancer, Precancerous Condition
SGN-00101 Immunotherapy in Treating Patients With Grade III Cervical Intraepithelial Neoplasia
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer or to treat early cancer.
- Trial name
- NCT00075569
- Testing
- HspE7
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- Albert Einstein College of Medicine
Uterine Cervical Dysplasia, Uterine Cervix Cancer
The SAFE Study: Satisfaction and Adherence to Follow-Up With Colposcopy Exams
This study is intended to improve the patient experience of communication of colposcopy results and follow-up recommendations to patients.
- Trial name
- NCT03296566
- Testing
- Patient Liaison
- Where
- Canada
- Volunteers
- 297 people
- Sponsor
- University of British Columbia
Cervical Intraepithelial Neoplasia, HPV-Related Cervical Carcinoma
FASTER-Tlalpan Study in Mexico: HPV Vaccination Impact on Cervical Cancer Screening Program
Objective. To evaluate the impact of HPV vaccination as part of a hrHPV-based primary screening program to extend screening intervals. Materials and methods.
- Trial name
- FASTER (NCT03105856)
- Testing
- CERVARIX, GARDASIL
- Where
- Mexico
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
Cervical Cancer, Cervical Intraepithelial Neoplasia
Randomized Controlled Trial of Human Papillomavirus Testing in Primary Cervical Cancer Screening
Human papillomavirus (HPV)-based cervical screening is known to increase sensitivity for detection of high-grade cervical intraepithelial neoplasia (CIN).
- Trial name
- SWEDESCREEN (NCT00479375)
- Testing
- Adding Human Papillomavirus testing to organised cervical screening
- Where
- Sweden
- Volunteers
- 12,527 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Cervical Intraepithelial Neoplasia, Cervical Cancer
The Development of a "Mother/Child, Screen, Treat and Vaccinate Program" in Manchay and Iquitos, Peru
This project will use a community based participatory research orientation to develop a model for large scale "campaign" preventive healthcare interventions.
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Cervical Neoplasm, Cervical Dysplasia
- Trial name
- PERCAPS (NCT01338051)
- Testing
- Gardasil
- Where
- 2 sites in Peru
- Volunteers
- 642 people, healthy volunteers welcome
- Sponsor
- Preventive Oncology International, Inc.
Human Papilloma Virus, Cervical Cancer
Prevaccination Study of Cervical Human Papillomavirus Types in Yangtze River Delta Area, China
Human papilloma virus (HPV) infection contributes as a main causative factor to the development of invasive cervical cancer (ICC) and its precursors (cervical intraepithelial neoplasia, CIN).
- Conditions
- Human Papilloma Virus, Cervical Cancer, Cervical Intraepithelial Neoplasia
- Trial name
- NCT01487681
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Xing Xie, MD
CIN
To Compare Intravenous and Oral Hydration of the Prevention for CIN in Elderly Patients Undergoing Intravenous CECT
To Compare Intravenous and Oral Hydration of the Prevention for Contrast-induced Nephropathy in Elderly Patients Undergoing Intravenous Contrast-enhanced Computed Tomography.
- Trial name
- CINOECT (NCT03872739)
- Testing
- enhanced computed tomography
- Where
- China
- Volunteers
- 1,368 people
- Sponsor
- Yu Danqing
Cervical Intraepithelial Neoplasia Grade 2/3
Effectiveness of Cervical Screening in HPV Vaccinated Women
The main objective of the study is to identify whether or not being informed infrequently results about screening is: 1) At least as safe and accurate as frequently obtaining all information from the present combination of…
- Trial name
- HPV-004 (NCT02149030)
- Testing
- Cytological screening in A1 and A3
- Where
- 31 sites in Finland
- Volunteers
- 6,958 people, healthy volunteers welcome
- Sponsor
- Tampere University
Cervical Cancer Screening, p16 Protein
Immunohistochemical Staining of p16 for the Screening of Cervical Cancer
Cyclin kinase inhibitor P16INK4A has overexpression in cervical cancer, and hence becoming an alternative method for cervical cancer screening.
- Conditions
- Cervical Cancer Screening, p16 Protein, Cytology, High-risk Human Papillomavirus
- Trial name
- NCT04650711
- Testing
- p16 protein expression
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Lei Li
Cervical Intraepithelial Neoplasia
TMTP1-ICG Mapping in Colposcopy-directed Biopsy
Investigators aimed to determine the validity of the novel tumor targeted fluorescent TMTP1-ICG to increased accuracy of colposcopy-directed biopsy.
- Trial name
- NCT03321461
- Testing
- TMTP1, ICG
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Huazhong University of Science and Technology
CIN3, Cervical Intraepithelial Neoplasia
Vvax001 Cancer Vaccine in Premalignant Cervical Lesions - Phase II
This is an open label phase II study in patients with newly diagnosed human papilloma virus type 16 (HPV16) induced cervical intraepithelial neoplasia grade 3 (CIN3).
- Conditions
- CIN3, Cervical Intraepithelial Neoplasia, Cervical Intraepithelial Neoplasia Grade 3, HPV 16 Infection
- Trial name
- Vvax (NCT06015854)
- Testing
- Vvax001 therapeutic cancer vaccine
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- University Medical Center Groningen
Human Papillomavirus (HPV)
Fourth Dose of Human Papillomavirus (HPV) DNA Plasmid (VGX-3100) + EP in Adult Females Previously Vaccinated With Three Doses of VGX-3100
DNA vaccines, which are small pieces of DNA also known as plasmids, have several advantages over traditional vaccines such as live attenuated virus and recombinant protein-based vaccines.
- Trial name
- NCT01188850
- Testing
- VGX-3100
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 14 people
- Sponsor
- Inovio Pharmaceuticals
Lymphedema, Stage 0 Cervical Cancer
Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer
This randomized phase III trial is studying Flexitouch® home maintenance therapy to see how well it works compared with standard home maintenance therapy in treating patients with lower-extremity lymphedema caused by treatment…
- Conditions
- Lymphedema, Stage 0 Cervical Cancer, Stage 0 Uterine Corpus Cancer, Stage 0 Vulvar Cancer
- Trial name
- NCT00577317
- Testing
- Management of Therapy Complications, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Gynecologic Oncology Group
Papillomavirus Infections
Gardasil Vaccination as Therapy in Low Grade Cervical Abnormalities
This project will compare the rate of regression of minimally abnormal Pap smears to normal in women who receive Gardasil to a historical control group.
- Trial name
- NCT00501189
- Testing
- human papillomavirus vaccine L1, type 6,11,16,18
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Eisenhower Army Medical Center