Clinical trials: CIPN - Chemotherapy-Induced Peripheral Neuropathy
CIPN - Chemotherapy-Induced Peripheral Neuropathy
Effect of Immersive Virtual Reality on Postural Control and Risk of Fall in Patients With Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a major cause of functional disability in cancer survivors. Patients with CIPN typically present with numbness, tingling, burning pain, and loss of proprioception, particularly…
- Trial name
- NCT07854574
- Testing
- The intervention will consist of conventional physical therapy exercise, Immersive Virtual Reality
- Volunteers
- 40 people
- Sponsor
- Cairo University
Chemotherapy-induced Peripheral Neuropathy, Breast Cancer Metastatic
NR in Chemo-induced Peripheral Neuropathy
The purpose of this single-arm phase II trial is to determine whether nicotinamide riboside (NIAGEN®) prevents the progression of peripheral sensory neuropathy in patients receiving infusions of paclitaxel or nab-paclitaxel for…
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Breast Cancer Metastatic, Platinum-resistant Recurrent Ovarian Cancer, Head and Neck Cancer Stage IV
- Trial name
- NCT03642990
- Testing
- Nicotinamide Riboside
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Donna Hammond, PhD
Cancer, Childhood Cancer
Light Therapy for Chemotherapy Induced Peripheral Neuropathy in Childhood Cancer Survivors
The purpose of this study is to determine feasibility and acceptability of a six-week at-home light therapy protocol in childhood cancer survivors, to identify facilitators and barriers to implementing this intervention, and to…
- Conditions
- Cancer, Childhood Cancer, Chemotherapy-induced Peripheral Neuropathy
- Trial name
- NCT07019259
- Testing
- Anodyne Therapy System
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Peripheral Neuropathy
SINF: Peripheral Neuropathy in Cancer Survivors
The goal of this clinical research study is to learn if one acupuncture treatment approach is more effective than another in helping to relieve neuropathy in cancer patients.
- Trial name
- NCT02168894
- Testing
- Acupuncture, Nerve Function Tests, Questionnaires
- Sponsor
- M.D. Anderson Cancer Center
Chemotherapy-Induced Peripheral Neuropathy, Hematopoietic and Lymphoid Cell Neoplasm
Duloxetine and Neurofeedback Training for the Treatment of Chemotherapy Induced Peripheral Neuropathy
This phase II trial investigates how well duloxetine and neurofeedback training work in treating patients with chemotherapy induced peripheral neuropathy.
- Conditions
- Chemotherapy-Induced Peripheral Neuropathy, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT04560673
- Testing
- Duloxetine, Neurofeedback, Quality-of-Life Assessment
- Where
- 2 sites in United States
- Volunteers
- 336 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Carcinoma, Chemotherapy-Induced Peripheral Neuropathy
Phytocannabinoids for the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors
This clinical trial tests how well phytocannabinoids (cannabidiol [CBD] and tetrahydrocannbinol [THC]) work in reducing chronic chemotherapy-induced peripheral neuropathy (CIPN) in breast and colon cancer survivors.
- Conditions
- Breast Carcinoma, Chemotherapy-Induced Peripheral Neuropathy, Colon Carcinoma
- Trial name
- NCT05672342
- Testing
- Cannabidiol, Delta-8-Tetrahydrocannabinol, Questionnaire Administration
- Where
- United States
- Sponsor
- City of Hope Medical Center
Peripheral Neuropathy
L-glutamine Supplementation to Alleviate Symptoms of Taxane-Induced Neuropathy in Patients With Breast Cancer
The purpose of the study is to determine whether daily, high-dose administration of l-glutamine can reduce numbness and tingling caused by a taxane chemotherapy in patients with breast cancer.
- Trial name
- NCT02215083
- Testing
- L-glutamine
- Where
- United States
- Sponsor
- Eastern Regional Medical Center
Chemotherapy-induced Peripheral Neuropathy
A New Method for Identifying Sensory Changes in Painful Chemotherapy-induced Peripheral Neuropathy (CIPN)
The investigators propose that using the Diode Laser fiber type Selective Stimulator (DLss) in patients with chemotherapy-induced peripheral neuropathy (CIPN) will allow for the assessment of changes in small-fiber pain…
- Trial name
- NCT03687970
- Testing
- Brief Pain Inventory, Hospital Anxiety and Depression Scale, Neuropathic Pain Symptom Inventory
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Chemotherapy-induced Peripheral Neuropathy
Clinical Biomarker of Paclitaxel-induced Peripheral Neuropathy
Investigation of which patients treated with paclitaxel have an increased risk of developing peripheral neuropathy.
- Trial name
- NCT06430814
- Testing
- No intervention
- Where
- 3 sites in Denmark
- Volunteers
- 188 people
- Sponsor
- University of Southern Denmark
Neuropathy
Pilates Versus Gyrotonic Expansion System on Chemotherapy Induced Peripheral Neuropathy and Fall Risk
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting side effect of neurotoxic chemotherapy (ie, taxanes, vinca alkaloids, platinum, and bortezomib) that interferes with patients' daily function and…
- Trial name
- NCT07137078
- Testing
- pilates, gyrotonic expansion exercise
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- MTI University
Patients With Taxane-induced Chronic Neuropathic Pain
Chemotherapy Induced Peripheral Neuropathy by Taxanes and Capsaicin 8%.
The goal of this study is to compare the evolution of the density of small nerve fibers assessed with skin biopsies at the foot between two groups of patients with taxane-induced chronic neuropathic pain matched for sex and age…
- Trial name
- capsaNeP (NCT07602387)
- Testing
- Capsaicin 8% Patch, antidepressants (tricyclics and serotonin reuptake inhibitor SRIs), antiepiletics, lidocaine patches, and neurostimulation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospital Ambroise Paré Paris
Breast Cancer, Peripheral Neuropathy, Secondary to Drugs or Chemicals
Chemotherapy Induced Peripheral Neuropathy. Could Physical Therapy Help Treat Symptoms?
The cause of Chemotherapy-Induced Peripheral Neuropathy (CIPN) is still unknown. An estimated 55-60% of patients will experience lasting symptoms affecting function for years post-treatment.
- Trial name
- NCT02239601
- Testing
- Physical Therapy
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- CancerCare Manitoba
Chronic Myeloproliferative Disorders, Leukemia
Baclofen-Amitriptyline Hydrochloride-Ketamine Gel in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
RATIONALE: Baclofen-amitriptyline-ketamine (BAK) gel may lessen peripheral neuropathy caused by chemotherapy. It is not yet known whether BAK gel is more effective than a placebo in treating peripheral neuropathy caused by…
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Lymphoproliferative Disorder
- Trial name
- NCT00516503
- Testing
- baclofen/amitriptyline/ketamine gel
- Where
- 165 sites in United States
- Volunteers
- 208 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Cancer Female, Gynecologic Cancer
Transcranial Magnetic Stimulation for Chemotherapy-Induced Peripheral Neuropathy in Breast and Gynecologic Cancer Survivors
The goal of this study is to evaluate the change in pain scores among patients with chemotherapy-induced peripheral neuropathy after receiving treatment with repetitive transcranial magnetic stimulation (rTMS).
- Trial name
- rTMS for CIPN (NCT07120100)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Utah
Breast Cancer Patients, Chemotherapy Induced Peripheral Neuropathy (CIPN)
The Effect of Cold Salt Water Foot Bath on the Development Of Chemotherapy-Induced Peripheral Neuropathy
This prospective, randomised, controlled study was designed to evaluate the effectiveness of salt and unsalted cold water foot baths in preventing chemotherapy-induced peripheral neuropathy (CIPN) in patients receiving…
- Conditions
- Breast Cancer Patients, Chemotherapy Induced Peripheral Neuropathy (CIPN), Paclitaxel-induced Peripheral Neuropathy
- Trial name
- NCT06964802
- Testing
- Cold salt water foot bath, Cold water foot bath
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Tuba Eryiğit
Colorectal Cancer, Chemotherapy-induced Peripheral Neuropathy
Preventive Treatment of Oxaliplatin Induced Peripheral Neuropathy in Metastatic Colorectal Cancer (POLAR-M)
This study evaluates the investigational drug PledOx in the prevention of chronic chemotherapy induced peripheral neuropathy (CIPN) induced by the drug oxaliplatin.
- Trial name
- POLAR-M (NCT03654729)
- Testing
- Calmangafodipir (2 µmol/kg), Calmangafodipir (5 µmol/kg)
- Where
- 98 sites in United States, Belgium and 11 more
- Volunteers
- 291 people
- Sponsor
- Egetis Therapeutics AB (publ)
Chemotherapy-induced Peripheral Neuropathy (CIPN)
Auricular Point Acupressure: Examining the Scientific Underpinnings of Pain Relief
Chemotherapy-induced peripheral neuropathy (CIPN)-numbness, burning and stunning pain distributed in hands and feet-is a major challenge among cancer patients.
- Trial name
- NCT03634527
- Testing
- Auricular Point Acupressure, Control Auricular Point Acupressure-
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Chemotherapy-induced Peripheral Neuropathy (CIPN)
Topical Herbal Medicine for Chemotherapy-Induced Peripheral Neuropathy
The goal of this clinical trial is to learn if menthol works to relieve chronic neuropathic pain and chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- NCT07693387
- Testing
- menthol-based hand and foot gloves
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taiwan Municipal An-Nan Hospital-China Medical University
Nasopharyngeal Carcinoma, CIPN - Chemotherapy-Induced Peripheral Neuropathy
Compression Therapy as a Prophylactic Method Against CIPN: a Prospective Self-controlled Trial
This is a single-center, self-controlled, evaluator-blinded prospective study, which applies pressurized gloves and foot caps to prevent paclitaxel-induced peripheral neuropathy in patients with nasopharyngeal carcinoma.
- Trial name
- CIPN (NCT05531916)
- Testing
- Pressurized gloves and foot caps
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Sun Yat-sen University
Neuropathy, Peripheral Neuropathy
Study of Nicotine for Pain Associated With Chemotherapy-Induced Peripheral Neuropathy
Assess the efficacy of short-term nicotine transdermal patch administration for the treatment of chemotherapy-induced peripheral neuropathy (CIPN) in cancer stable patients or patients in remission.
- Conditions
- Neuropathy, Peripheral Neuropathy, Neuropathic Pain, Chemotherapy-induced Peripheral Neuropathy
- Trial name
- NCT04468230
- Testing
- Nicotine Transdermal Patch
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Virginia Commonwealth University