Clinical trials: CKD - Chronic Kidney Disease
Exercise, Diet Interventions
Multimodal Intervention for Early Chronic Kidney Disease in Young People: Dysbiosis and Inflammation (CKD)
Chronic kidney disease (CKD) is a progressive condition associated with substantial morbidity, mortality, and healthcare costs. Early detection and timely intervention are critical to modify disease trajectory, particularly in…
- Conditions
- Exercise, Diet Interventions, Symbiotic, CKD Stage 1
- Trial name
- CKD (NCT07483697)
- Testing
- symbiotic
- Where
- Mexico
- Volunteers
- 200 people
- Sponsor
- Centenario Hospital Miguel Hidalgo
Muscular Atrophy
LPD+α-ketoacids on Autophagy and Improving Muscle Wasting in CKD
To investigate the effects of different dietary regimens on muscle wasting, insulin/IGF-1 resistance. Further, to explore whether LPD+KA decrease the activation of autophagy associate with insulin/IGF-1 pathway.
- Trial name
- NCT02568020
- Testing
- keto-amino acids
- Volunteers
- 60 people
- Sponsor
- YUAN Wei-jie
Child, Only, Chronic Renal Failure in Children
The Effect of a Mobile Game Application on Children With CRF
The aim of this study was to investigate the effect of a mobile game application developed for children with Chronic Renal Failure (CRF) on disease management. The study was a randomized controlled trial.
- Conditions
- Child, Only, Chronic Renal Failure in Children, Gambling, Disease
- Trial name
- NCT07162220
- Testing
- The clinic's routine education program, Mobile game app
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Akdeniz University
Chronic Renal Failure
Dermodialysis as Adjuvant Therapy in Renal Failure
Using sweat as the vehicle for removing molecules normally excreted in the urine(dermodialysis) was identified some decades ago.The study will include 66 ESRD patients and 20 CKD stage 5 patients not on dialysis who met inclusion…
- Trial name
- NCT03810989
- Testing
- infra-red sauna, argometer and treadmill, combination of sauna and hot bath
- Volunteers
- 86 people
- Sponsor
- Assiut University
Time Restricted Feeding, Renal Insufficiency, Chronic
Effects of TRF on Obese Patients With CKD Stage 3-4
Obesity is associated with glomerular hyperfiltration leading to renal impairment and is a risk factor for the progression of kidney disease.Weight loss can reduce proteinuria and improve eGFR.Intermittent fasting is safe and…
- Conditions
- Time Restricted Feeding, Renal Insufficiency, Chronic, Obesity
- Trial name
- NCT05037747
- Testing
- Time-restricted feeding(TRF)
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Chronic Kidney Disease
Effect of Valsartan vs Perindopril on HOMA-IR Index in Patients With Chronic Kidney Disease
The purpose of this study is to compare the effect of valsartan and perindopril on HOMA-IR Index in patients with chronic kidney disease.
- Trial name
- NCT02299310
- Testing
- Valsartan, Perindopril
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese PLA General Hospital
Osteoporosis, Chronic Kidney Disease 5D
Study Evaluating Denosumab on Vascular and Bone Metabolism in Osteoporotic Chronic Kidney Disease (HDENOBS)
Aim of this study is to evaluate in a population of osteoporotic chronic kidney disease patients the effect of denosumab: on coronary artery calcification scores evolution after 24 months of followup on abdominal aorta…
- Trial name
- HDENOBS (NCT05234047)
- Testing
- MDCT (multidetector computed tomography), Dual-energy X-ray absorptiometry
- Volunteers
- 21 people
- Sponsor
- University Hospital, Montpellier
Diabetic Chronic Kidney Disease Patients
Impact of Diabetes-Related Metabolic Derangements on Clinical Outcomes in Hospitalized Patients With Chronic Kidney Disease
This observational study will collect clinical and laboratory information from hospitalized patients with chronic kidney disease to identify diabetes mellitus and selected metabolic findings during hospitalization
- Trial name
- NCT07354958
- Testing
- Primary aim 1. To assess the frequency of diabetes mellitus among hospitalized CKD patients. 2. To evaluate the frequency and types of metabolic abnormalities (e.g., hypoglycemia, diabetic ketoacidosi
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Sohag University
Chronic Kidney Disease
The COMBINE Study: The CKD Optimal Management With BInders and NicotinamidE
The COMBINE clinical trial is a pilot study evaluating the effects of nicotinamide and lanthanum carbonate on serum phosphate and fibroblast growth factor 23 (FGF23) in patients with Chronic Kidney Disease (CKD) stages 3-4.
- Trial name
- COMBINE (NCT02258074)
- Testing
- Nicotinamide, Lanthanum Carbonate
- Where
- 7 sites in United States
- Volunteers
- 205 people
- Sponsor
- The Cleveland Clinic
Chronic-kidney Disease Stage 5D on Stable Hemodialysis
Study of Safety and Tolerability of BPS804 in Patients With Late-stage Chronic Kidney Disease
The purpose of the study is to evaluate the safety, tolerability, and PK following a single administration of BPS804 in patients with chronic kidney disease stage 5D (CKD-5D) on hemodialysis.
- Trial name
- NCT01806610
- Testing
- BPS804
- Sponsor
- Ultragenyx Pharmaceutical Inc
Nephrology
Efficacy of Epoetin Alfa Deep Tank in Treatment of Anemia in Patients With Chronic Kidney Disease Receiving Hemodialysis
The purpose of this study is to evaluate whether the efficacy of Epoetin alfa DT is equivalent to that of Epoetin alfa RB for the treatment of anemia in patients with CKD receiving hemodialysis
- Trial name
- NCT00146224
- Testing
- Epoetin alfa RB, Epoetin alfa DT
- Volunteers
- 420 people
- Sponsor
- Amgen
Contrast Induced Nephropathy
Statins for Prevention of Contrast Induced Nephropathy
In this randomized study the investigators wish to explore the role of pre-procedural statin therapy for the prevention of contrast induced nephropathy in patients with moderate-to-severe renal dysfunction, submitted to elective…
- Trial name
- NCT00770796
- Testing
- Atorvastatin
- Volunteers
- 304 people
- Sponsor
- Ospedale Misericordia e Dolce
Chronic Kidney Disease, Anemia
A Study to Determine the Pharmacokinetic and Pharmacodynamic Profiles of PROCRIT (Epoetin Alfa) in Anemic Patients With Chronic Kidney Disease
The primary objective of this study is to describe how four different dosing regimens of PROCRIT (epoetin alfa) are utilized in patients with anemia due to non-dialysis chronic kidney disease (CKD).
- Trial name
- NCT00641589
- Testing
- epoetin alfa
- Volunteers
- 40 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Fabry Disease, Proteinuria
The Fabrazyme® and Arbs and ACE Inhibitor Treatment (FAACET) Study
The primary hypothesis is that titration of ACE inhibitor and Angiotensin Receptor Blockers (ARBs)to reduce urine protein excretion to < 500 mg per day in Fabry Patients receiving agalsidase beta therapy at 1 mg/kg every two…
- Trial name
- FAACET (NCT00446862)
- Testing
- enalapril and other angiotensin converting enzyme inhibitors; losartan and other angiotensin receptor blockers
- Where
- 6 sites in United States, Slovenia
- Volunteers
- 36 people
- Sponsor
- University of Alabama at Birmingham
Hyperparathyroidism, Secondary
Subtotal Parathyroidectomy or Total Parathyroidectomy With Autograft in Chronic Kidney Disease Patients Under Dialysis
This study evaluates the metabolic and clinical results of two well recognized and accepted surgical techniques in the management of severe hyperparathyroidism in patients under regular dialysis treatment.
- Trial name
- NCT02464072
- Testing
- Subtotal Parathyroidectomy, Total Parathyroidectomy + 45 autografts, Total Parathyroidectomy + 90 autografts
- Where
- Brazil
- Volunteers
- 133 people
- Sponsor
- University of Sao Paulo General Hospital
Anemia
A Study of Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) for the Treatment of Chronic Renal Anemia in Participants With Diabetic Nephropathy
This single arm, open label study will assess the efficacy, safety and tolerability of methoxy polyethylene glycol-epoetin beta for the treatment of chronic renal anemia in participants with chronic kidney disease (CKD) secondary…
- Trial name
- NCT01191983
- Testing
- Methoxy polyethylene glycol-epoetin beta [Mircera]
- Where
- 14 sites in India
- Volunteers
- 102 people
- Sponsor
- Hoffmann-La Roche
Chronic Renal Failure
Efficacy and Safety of Everolimus+EC-MPS After Early CNI Elimination vs EC-MPS +Tacrolimus in Renal Transplant Recipients
The primary objective of this trial is to show non-inferiority of a CNI-free regimen with respect to the renal function at Month 9 post Tx assessed by glomerular filtration rate - Nankivell method - as compared to the standard…
- Trial name
- NCT00965094
- Testing
- Everolimus, Tacrolimus (FK506), Basiliximab
- Where
- 3 sites in Israel
- Volunteers
- 36 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Kidney Disease (DKD), Type 2 Diabetes Mellitus (T2DM)
Goal-Directed Therapy to Reduce Kidney and Cardiovascular Risk in Diabetic Kidney Disease (GOLD-STANDARD)
GOLD-STANDARD is a pragmatic, open-label pilot randomized controlled trial evaluating the feasibility, safety, and implementation of an early goal-directed Cardio-Kidney-Metabolic (CKM) care strategy compared with usual care in…
- Conditions
- Diabetic Kidney Disease (DKD), Type 2 Diabetes Mellitus (T2DM), Chronic Kidney Disease
- Trial name
- GOLD-STANDARD (NCT07434791)
- Testing
- Early goal-directed Cardio-Kidney-Metabolic (CKM) care, Standard care (Comparison arm)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cardiovascular Disease, Sarcopenia
Trial of Oral Glutamine on Mitochondrial Function in CKD
The primary goal of proposed investigation is to study the impact of oral glutamine supplementation on muscle mitochondrial and endothelial cell function measured mitochondrial energetics and vascular function using 31P magnetic…
- Conditions
- Cardiovascular Disease, Sarcopenia, Endothelial Dysfunction, Muscle Mitochondrial Function
- Trial name
- NCT02838979
- Testing
- First Intervention (14 days), Washout (3 weeks), Second Intervention (14 days)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Washington
Kidney Diseases
Conversion From Standard Phosphate Binder Therapy to Fosrenol® (Lanthanum Carbonate) in Chronic Kidney Disease Stage 5
The main aim of this research study is to see if giving Fosrenol®, a chewable tablet, to patients on haemodialysis works as well as other treatments currently used to lower blood phosphorus levels.
- Trial name
- NCT00452478
- Testing
- Lanthanum carbonate
- Where
- 14 sites in Austria, Belgium and 4 more
- Volunteers
- 68 people
- Sponsor
- Shire
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