Clinical trials: CKD - Chronic Kidney Disease
Hypertension, Chronic Kidney Diseases
Primary Care CKD Registry
This study examines whether a safety-net primary care CKD registry directed at the entire primary care team can enhance the delivery of guideline concordant CKD care, including BP control, ACEi/ARB use and albuminuria…
- Trial name
- NCT03473509
- Testing
- CKD Registry
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Anemia Due to Chronic Kidney Disease
A Study of AND017 to Evaluate Efficacy and Safety in Patients With Anemia Due to Non-Dialysis-Dependent Chronic Kidney Disease (NDD-CKD)
This is a Phase III, randomized, open-label, active-controlled study to evaluate the safety and efficacy of AND017 in non-dialysis-dependent (NDD)-CKD patients compared with the active control, ESA treatment
- Trial name
- NCT07487727
- Testing
- AND017, ESA
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Kind Pharmaceuticals LLC
Kidney Failure, Chronic, Cardiovascular Diseases
Effects of Phosphate Binding With Sevelamer in Stage 3 Chronic Kidney Disease
The purpose of this study is to determine whether lowering phosphate in patients with early chronic kidney disease with the phosphate binder sevelamer has beneficial effects on cardiovascular structure and function.
- Trial name
- NCT00806481
- Testing
- Sevelamer carbonate
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Infection-Associated Acute Kidney Injury
Folate Treatment to Reduce Death Risk in the Year After Infection-Related Acute Kidney Injury
The goal of this clinical trial is to evaluate if taking folic acid (a form of vitamin B9) can help reduce the risk of death and improve kidney recovery in adults with acute kidney injury (AKI) caused by infections or sepsis.
- Trial name
- FOL-AKI (NCT07377071)
- Testing
- Folic Acid 5 MG
- Where
- Hong Kong
- Volunteers
- 382 people
- Sponsor
- The University of Hong Kong
Periodontitis, Chronic Kidney Disease
Periodontal Infection and Systemic Inflammation in Renal Patients
The purpose of this study is to examine the role of gum disease in affecting the long term prognosis of renal patients. This disease if untreated causes inflammatory response throughout the body.
- Trial name
- PeriRen (NCT01094639)
- Testing
- Scaling root planing, Supragingival Prophylaxis
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- UConn Health
Chronic Kidney Diseases, Deficiency, Vitamin D
Drug Metabolizing Enzyme and Transporter Function in Chronic Kidney Disease
This study investigates the effect of vitamin D deficiency on drug metabolism and transport in patients with chronic kidney disease (CKD) and in healthy controls.
- Trial name
- NCT02360644
- Testing
- Cholecalciferol
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Chronic Kidney Diseases
Dapagliflozin on Renal Morphology and Renal Perfusion in Patients One Year After Kidney Transplantation
The aim of this study is to observe the mechanisms of dapagliflozin on the renal interstitial tissue and renal perfusion. For this purpose, renal transplanted patients as an excellent model of CKD and high cardiovascular risk…
- Trial name
- NCT06560801
- Testing
- Dapagliflozin 10mg Tab
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Chronic Kidney Disease
Clinical Pharmacist Intervention on Medication Adherence and Clinical Outcomes in Chronic Kidney Disease Patients
The purpose of this research study is to evaluate the impact of clinical pharmacist interventions on treatment outcomes, health-related quality of life (HRQoL),and medication adherence among chronic kidney disease patients.
- Trial name
- NCT06071065
- Testing
- Pharmacist counselling
- Where
- Pakistan
- Volunteers
- 130 people
- Sponsor
- Hamdard University
Chronic Kidney Disease(CKD)
Medication Adherence Given Individual SystemCHANGE(TM) in Advancing Nephropathy (MAGICIAN) Pilot Study
The purpose of this 2-group, randomized, controlled trial is to evaluate the refined SystemCHANGE™ against attention control patient education in CKD patients taking RAAS medications.
- Trial name
- MAGICIAN (NCT04616612)
- Testing
- SystemCHANGE (TM), Attention Control
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Chronic Kidney Diseases, High Cholesterol
Evolocumab In Advanced Chronic Kidney Disease Trial
110 individuals with stage 4-5 Chronic Kidney Disease (CKD) will be randomized to 1-year of blinded Evolocumab or placebo. Subjects will undergo evaluation of circulating lipids at baseline and end of study.
- Trial name
- EVO-CKD (NCT04510844)
- Testing
- Evolocumab
- Where
- 2 sites in United States
- Sponsor
- NYU Langone Health
Chronic Kidney Disease
Evaluate the Efficacy and Safety of ABP-671 in Subjects With Chronic Kidney Disease and Hyperuricaemia
This is a phase 2, international, multicenter, randomized, double blind, placebo-controlled trial to evaluate the efficacy and safety of ABP-671 in subjects with CKD and hyperuricaemia, to preliminarily evaluate the efficacy of…
- Trial name
- NCT07323095
- Testing
- ABP-671 plus febuxostat Group 1, ABP-671 plus febuxostat Group 2, ABP-671 Group
- Where
- 10 sites in Australia, China
- Volunteers
- 80 people
- Sponsor
- Atom Therapeutics Co., Ltd
Non-valvular Atrial Fibrillation (NVAF): Paroxysmal, Persistent, Permanent
Left Atrial Appendage Closure in Patients With Non-valvular Atrial Fibrillation and End-stage Chronic KIDNEY Disease
In the proposed event driven trial, LAA closure devices will be compared in a 1:1 randomization to best medical care in AF patients at high risk of stroke and bleeding with ESKD.
- Trial name
- LAA-KIDNEY (NCT05204212)
- Testing
- Left Atrial Appendage closure
- Where
- Germany
- Volunteers
- 430 people
- Sponsor
- Prof. Dr. med. Ingo Eitel
Myocardial Fibrosis, End Stage Renal Failure on Dialysis
MRI Assessment of Myocardial Fibrosis Associated With Monocyte Phenotype in End Stage Renal Failure
Firstly, this study aims to understand how cardiac fibrosis mediated by inflammatory microvascular disease evolves during advanced chronic kidney disease and end stage renal failure and importantly how this changes with…
- Conditions
- Myocardial Fibrosis, End Stage Renal Failure on Dialysis, Chronic Kidney Disease, Stage IV (Severe), Chronic Kidney Disease Stage V
- Trial name
- CM3 (NCT03857633)
- Testing
- Cardiac MRI 1 - With Gadolinium Contrast, Cardiac MRI 2 - With Gadolinium Contrast, Cardiac MRI 3 - Without Gadolinium Contrast
- Where
- United Kingdom
- Sponsor
- Imperial College London
Kidney Disease, Chronic Kidney Disease
Cinacalcet HCl in Chronic Kidney Disease Subjects With Secondary Hyperparathyroidism Not Receiving Dialysis
The purpose of this study is to evaluate the efficacy and safety of cinacalcet compared with placebo in patients with stage 3 and 4 Chronic Kidney Disease (CKD).
- Trial name
- NCT00094484
- Testing
- Cinacalcet HCl
- Volunteers
- 400 people
- Sponsor
- Amgen
Chronic Kidney Diseases, Health Behaviors
Exploring Life Experience and Lifestyle Intervention Program Among Patients With CKD
to compare the effectiveness of tailored TTM-based interventions (intervention group) compared to usual care (control group) on biomarkers of kidney function, physical indicators, adoption of health-promoting lifestyle behaviors…
- Conditions
- Chronic Kidney Diseases, Health Behaviors, Patient Education
- Trial name
- NCT01194518
- Testing
- Lifestyle counseling Program
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Cheng Kung University
End Stage Renal Disease and Cognitive Impairment
Blood-Brain Barrier Evaluation In Nephrology (BREIN)
Patients with Chronic Kidney Disease (CKD) have impaired psycho-cognitive functions in parallel with deteriorating kidney function.
- Trial name
- BREIN (NCT04328415)
- Testing
- Cerebral scintigraphy
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Chronic Kidney Disease
Expanding and Promoting Alternative Care and kNowledge in Decision-making Trial
The goal of this clinical trial is to compare two health system-based approaches for offering kidney failure treatment options to older patients with kidney failure, specifically, to ensure patients are actively involved in a…
- Trial name
- ExPAND (NCT06243068)
- Testing
- Educate and Engage, Educate and Engage Plus Kidney Supportive Care Program
- Where
- 25 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- George Washington University
Type 2 Diabetes, Chronic Kidney Disease
A Study Comparing Dulaglutide With Insulin Glargine on Glycemic Control in Participants With Type 2 Diabetes (T2D) and Moderate or Severe Chronic Kidney Disease (CKD)
The purpose of this study is to determine the glycemic efficacy and safety of dulaglutide compared to insulin glargine in the treatment of participants with type 2 diabetes and moderate or severe chronic kidney disease.
- Trial name
- AWARD-7 (NCT01621178)
- Testing
- Dulaglutide, Insulin glargine, Insulin lispro
- Where
- 89 sites in United States, Brazil and 7 more
- Volunteers
- 577 people
- Sponsor
- Eli Lilly and Company
Chronic Kidney Disease, Metabolic Acidosis
Comparison of Standard Versus Low Bicarbonate Hemodialysis
This study will compare acid-base changes during hemodialysis treatments with a standard dialysis bath versus a lower bicarbonate dialysis bath, and aims to define the factors that limit equilibration of the bicarbonate…
- Trial name
- NCT01777178
- Testing
- Low bicarbonate dialysis
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Albert Einstein College of Medicine
Chronic Kidney Diseases
DYNAMic Renal Assessment: NOvel Methods to Assess KIDNEY Functional Reserve
This is a feasibility study to assess new, more practical ways of measuring renal reserve.
- Trial name
- DYNAMO (NCT06572215)
- Testing
- Dapagliflozin
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
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