Clinical trials: CKD - Chronic Kidney Disease
Chronic Renal Failure, Hemodialysis
Comparing the Hemodiafiltration On-line and Conventional Hemodialysis in Terms of Cost-benefit
The site where the clinical trial will be conducted is at the St-Luc hospital from the CHUM. This is a prospective randomized study that will compare the two treatment modalities, HD and HDF, through economics and…
- Trial name
- PHARMACO-$ (NCT02374372)
- Testing
- conventional hemodialysis, hemodiafiltration On-line
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Anemia
OPTIMA: An Observational Study of Mircera (Methoxy Polyethylene Glycol-Epoetin Beta) in Participants With Chronic Kidney Disease Stages 3 and 4 Not on Dialysis
This prospective observational study evaluated the efficacy and safety of Mircera (methoxy polyethylene glycol-epoetin beta) in chronic kidney disease participants on dialysis with renal anemia.
- Trial name
- OPTIMA (NCT01902628)
- Where
- 24 sites in Greece
- Volunteers
- 437 people
- Sponsor
- Hoffmann-La Roche
Chronic Kidney Diseases
RENACTIF: Reduction of the Thrombotic Phenotype in Renal Insufficiency With N-AcetylCysteine
Chronic Kidney Disease (CKD) is a known risk factor of cardiovascular morbidity and mortality. In CKD, decline of renal function results in the accumulation of uremic toxins in blood and tissue, such as Indoxyl Sulfate (IS).
- Trial name
- RENACTIF (NCT03636932)
- Testing
- N-acetylcysteine (NAC), Blood sample
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Chronic Renal Disease
Biomarkers of Cardiovascular Complications in Chronic Kidney Disease
Identification of new retention solutes associated with cardiovascular (CV) toxicity in Chronic Kidney Disease (CKD) patients will help to better understand the pathophysiological mechanisms at stake and to prevent CKD-associated…
- Trial name
- BioClaCK (NCT03274921)
- Testing
- Biological determination
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Toulouse
Hypertension, Chronic Kidney Disease
Renal Sympathetic Denervation in Moderate to Severe Chronic Kidney Disease
A pilot, single-center, prospective, interventional study. The objective is to demonstrate that catheter-based renal denervation using carbon dioxide renal angiography in patients with moderate to severe chronic kidney disease…
- Trial name
- NCT02863510
- Testing
- Renal Sympathetic Denervation
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Heart of England NHS Trust
Kidney Diseases, Kidney Failure
Enhance Access to Kidney Transplantation and Living Kidney Donation
Compared to dialysis, kidney transplantation is associated with improved survival, better quality of life and substantial cost savings to healthcare systems.
- Conditions
- Kidney Diseases, Kidney Failure, End Stage Renal Disease
- Trial name
- EnAKT LKD (NCT03329521)
- Testing
- Multicomponent intervention
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Kidney Disease, Periodontal Disease
Kidney and Periodontal Disease Study
The purpose of this study is (1) to determine whether a 12-month trial of patients from underserved communities with clinically significant gum disease and kidney disease randomly assigned to intensive gum disease treatment or…
- Trial name
- KAPD (NCT01802216)
- Testing
- Scaling and root planing, Minocycline
- Volunteers
- 51 people
- Sponsor
- University of California, San Francisco
Heart Failure, Congestive Heart Failure
Care Transitions App for Patients With Multiple Chronic Conditions
The objective of this study is to widely implement and evaluate the Care Transitions App in a randomized controlled trial. The app the investigators designed for patients with multiple chronic conditions has four envisioned…
- Conditions
- Heart Failure, Congestive Heart Failure, Diabetes, Diabetes Mellitus
- Trial name
- NCT06051058
- Testing
- Care Transitions App
- Where
- United States
- Volunteers
- 798 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Chronic Kidney Disease Stage 4
Effect of Henagliflozin on Renal Outcomes in Non-dialysis Patients With Advanced Chronic Kidney Disease : A Multicenter Prospective, Randomized Controlled Trial（HERO -aCKD）
This is a multicenter, prospective, randomized, controlled study that will enroll approximately 429 subjects. The screening period will last 4-8 weeks.
- Trial name
- NCT07027774
- Testing
- Henagliflozin 5 mg Group, Henagliflozin 10 mg Group, Conventional therapy group
- Volunteers
- 429 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Iron Deficiency, Heart Failure
Hospitalization & Mortality in Patients With Iron Deficiency CKD and HF Treated With i.v. Iron.
Iron deficiency, independent of anemia, appears to increase morbidity and mortality as well as impairing health-related quality of life in chronic heart failure (CHF), and these effects are compounded when patients also…
- Conditions
- Iron Deficiency, Heart Failure, Chronic Kidney Disease
- Trial name
- NCT02392910
- Testing
- Iron Sucrose
- Where
- Argentina
- Volunteers
- 40 people
- Sponsor
- Hospital Aleman
Chronic Kidney Diseases
Effects of Curcumin in Patients in Chronic Kidney Disease
Many studies have been conducted to identify therapeutic strategies to modulate inflammation and oxidative stress, complications that contribute to the increased morbidity and cardiovascular mortality in patients with chronic…
- Trial name
- NCT03475017
- Testing
- Active Comparator: Supplement A
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Denise Mafra
Chronic Kidney Disease
Determinants of Muscle Strength in Chronic Kidney Disease
Aim of this study is to determine in chronic kidney disease patients: the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle…
- Trial name
- NCT02806089
- Testing
- Handheld dynamometer, Creatinine index, Electrical bioimpedance analysis
- Where
- 3 sites in France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Montpellier
Mild Nephropathy, Moderate Nephropathy
Single Dose, Single Administration Study of Technosphere Inhalation Powder in Diabetic Subjects With Mild or Moderate Kidney Disease Compared to Diabetic Subjects With Normal Kidney Function
24 diabetics with mild \& moderate renal disease and 12 diabetics without renal disease. One screening, one dosing \& one follow-up visit with Technosphere® Inhalation Powder given at Visit 2 via MedTone® Inhaler and PK testing…
- Conditions
- Mild Nephropathy, Moderate Nephropathy, Diabetes Mellitus
- Trial name
- NCT00626249
- Testing
- Technosphere Inhalation Powder
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Mannkind Corporation
Chronic Kidney Diseases, General Anesthesia
Effect of N-acetylcysteine on Renal Functioning of Chronic Kidney Diseases(CKD) Patients After General Anesthesia
Acute kidney injury (AKI) is one of the most serious and frequent complication of general anesthesia. Patients suffer from chronic kidney diseases (CKD) predispose to develop AKI.
- Trial name
- NCT01251029
- Testing
- N-acetylcysteine, Siran (N-acetylcysteine)
- Where
- Israel
- Sponsor
- Assaf-Harofeh Medical Center
Vitamin D Deficiency, Malnutrition
Optimizing Treatment Programs for Chronic Kidney Disease-mineral and Bone Disorder and Malnutrition
Multi-center, prospective, randomized, controlled study to verify the clinical effectiveness of K / DOQI guidelines. The efficiency and safety of Vitamin D2 and low protein diet treatment for prevention and treatment of CKD-MBD…
- Trial name
- NCT02005302
- Testing
- 1,25(OH)2 Vitamin D3, Vitamin D2, low protein diet
- Where
- 5 sites in China
- Volunteers
- 600 people
- Sponsor
- Wenhu Liu
Covid19, AKI
Global Assessment of Acute and Chronic Kidney Disease Incidence and Outcomes in Patients With COVID-19 Infection
The coronavirus (COVID-19) pandemic has created a significant strain on health care resources across the world for managing critically ill patients.
- Conditions
- Covid19, AKI, CKD, ESRD
- Trial name
- NCT04491227
- Where
- 12 sites in United States, Bolivia and 4 more
- Volunteers
- 2,000 people
- Sponsor
- University of California, San Diego
Chronic Kidney Disease, Hypertension (HTN)
Investigating Vascular Properties of HEMI and SPG Signals in Individuals With or at Risk for Chronic Kidney Disease
This prospective, single-center clinical investigation conducted in France will evaluate two non-invasive investigational devices (HEMI and SPG-NINOX) designed to assess microcirculation in adults.
- Conditions
- Chronic Kidney Disease, Hypertension (HTN), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- STIMULUS-CKD (NCT07604922)
- Testing
- HEMI device, SPG-NINOX device
- Where
- France
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Type 2 Diabetes, Chronic Kidney Disease
Metformin Use in Chronic Kidney Disease: The CKD-Met Study
Metformin is the most widely prescribed oral treatment for diabetes, and the only one that showed a survival benefit. Yet, there is no consensus on the optimal dose and withdrawal of metformin in chronic kidney disease (CKD)…
- Trial name
- CKD-Met (NCT02844153)
- Testing
- modalities of metformin prescription
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Hospices Civils de Lyon
Kidney Failure
Clotting With Different Dialyzer Membranes
Primary Objective: The purpose of this study is to measure the amount of convection achieved with two different haemodiafilters designed for haemodiafiltration and clotting during haemodiafiltration treatment.
- Trial name
- TAGPSOLACEA (NCT02546037)
- Testing
- FX100 dialyzer, SOLACEA 21H
- Volunteers
- 10 people
- Sponsor
- University College, London
Chronic Kidney Diseases, Pregnancy Related
PREDICT: Thinking About Pregnancy Risk in Women With Kidney Disease
Currently, there is no robust evidence about how women with Chronic Kidney Disease (CKD) perceive pregnancy risk. The aims of this research are to understand women with CKD's perception of risk in pregnancy.
- Trial name
- PREDICT_RP (NCT04370769)
- Where
- United Kingdom
- Volunteers
- 115 people
- Sponsor
- King's College London