Clinical trials: CKD - Chronic Kidney Disease
CKD Stage 5
Potential Therapeutic Role of Effervescent Calcium-Magnesium Citrate in Chronic Kidney Disease Stage V
The Investigators plan to conduct a long-term trial to explore therapeutic implications of effervescent calcium magnesium citrate (EffCaMgCit) in CKD Stage V (end stage renal disease on hemodialysis).
- Trial name
- NCT03565913
- Testing
- EffCaMgCit, CaAcS
- Where
- United States
- Volunteers
- 269 people
- Sponsor
- University of Texas Southwestern Medical Center
Kidney Failure, Acute, Kidney Failure, Chronic
An Investigation of N-acetylcysteine and Fenoldopam as Renal Protection Agents for Cardiac Surgery
Patients with abnormal kidney function are at increased risk for complications following heart surgery, including worsening kidney function possibly requiring dialysis, a prolonged stay in the critical care unit and hospital, and…
- Conditions
- Kidney Failure, Acute, Kidney Failure, Chronic, Cardiac Surgical Procedures
- Trial name
- NCT00122018
- Testing
- N-acetylcysteine, fenoldopam
- Volunteers
- 80 people
- Sponsor
- Linda F. Barr, M.D.
Chronic Kidney Disease (CKD), Elderly
Sertraline and the Risk of Serious Adverse Events
The goal of this population-based cohort study is to assess the safety of initiating a new outpatient prescription of 50 mg/day of Sertraline, a higher dose, compared to 25 mg/day, a lower dose, in adults aged 65+ with low kidney…
- Conditions
- Chronic Kidney Disease (CKD), Elderly, Outpatient
- Trial name
- NCT07387120
- Testing
- Sertraline 50 mg, Sertraline 25 mg
- Where
- Canada
- Volunteers
- 6,893 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Kidney Failure, Chronic Kidney Disease stage3
Pathophysiological Characterization of the Neuromuscular Function of a Population With Multiple Comorbidities Suffering From Chronic Renal Failure in Pre-dialysis.
The evolution of chronic kidney disease (CKD) causes a systemic upheaval on the body and a deep fatigue is very often described by patients (50-70% of the patients) even before the start of dialysis (pre-dialysis).
- Conditions
- Chronic Kidney Failure, Chronic Kidney Disease stage3, Chronic Kidney Disease, Stage 4 (Severe), Chronic Kidney Disease Stage 5
- Trial name
- PIONNIER (NCT03998917)
- Testing
- Discrimination of neuromuscular alterations protocol
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre Hospitalier le Mans
Chronic Kidney Disease
The Effects of Dietary Fiber in CKD: A Systematic Review and Meta-analysis
Chronic kidney disease (CKD) is a debilitating condition in which there is a gradual decline of renal function associated with increased overall mortality.
- Trial name
- NCT01844882
- Volunteers
- 1 people
- Sponsor
- Unity Health Toronto
Obstructive Sleep Apnea, Chronic Kidney Diseases
The Effect of OSA on Severity and Prognosis of Patients With CKD
This study aims to investigate the influence of obstructive sleep apnea hypopnea syndrome (OSA) on the severity and prognosis of patients with chronic kidney disease (CKD), and to evaluate the therapeutic effect of continuous…
- Trial name
- NCT06393023
- Testing
- Continuous Positive Airway Pressure
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Refractory Heart Failure, Chronic Kidney Disease
The Role of Peritoneal Dialysis in Patients With Refractory Heart Failure and Chronic Kidney Disease
In patients with advanced heart failure (HF), systemic congestion is the main indication for hospitalization. Recent evidence has highlighted the role of fluid retention in the pathogenesis of renal dysfunction and subsequent…
- Trial name
- NCT01758627
- Testing
- Peritoneal dialysis (PD)
- Where
- South Korea
- Volunteers
- 7 people
- Sponsor
- Yonsei University
Chronic Kidney Disease
Effect of Valsartan vs Perindopril on HOMA-IR Index in Patients With Chronic Kidney Disease
The purpose of this study is to compare the effect of valsartan and perindopril on HOMA-IR Index in patients with chronic kidney disease.
- Trial name
- NCT02299310
- Testing
- Valsartan, Perindopril
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese PLA General Hospital
Chronic Renal Failure, Hemodialysis
Effects of Shenkang Decoction on Creatinine and Blood Urea Nitrogen in Chronic Renal Failure Hemodialysis Patients
To explore the clinical effect of Shenkang Decoction in chronic renal failure (CRF) patients with hemodialysis (HD).
- Trial name
- NCT05631782
- Testing
- Shenkang decoction
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The First People's Hospital of Zunyi
Atrial Fibrillation, Chronic Kidney Diseases
Check@Home: General Population Screening for Early Detection of Atrial Fibrillation and Chronic Kidney Disease
The aim of the Check@Home consortium is to set up a roadmap and infrastructure for a program to early detect atrial fibrillation and chronic kidney disease in the general population.
- Conditions
- Atrial Fibrillation, Chronic Kidney Diseases, Diabetes Mellitus, Type 2
- Trial name
- NCT06330480
- Testing
- Intervention group
- Where
- Netherlands
- Volunteers
- 320,000 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Folkert W. Asselbergs
Hemodialysis, Healthy
Study to Evaluate the Pharmacokinetics and Metabolism of [14C] CR845 (Difelikefalin) in Patients With End Stage Renal Disease on Hemodialysis and in Healthy Subjects
The objectives of this study are to evaluate the in vivo metabolite profiling and characterization of CR845 administered intravenously (IV) in patients on hemodialysis (HD) and in healthy subjects; and to determine the…
- Trial name
- NCT03947970
- Testing
- [14C] CR845
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cara Therapeutics, Inc.
Lung Transplantation, Cystic Fibrosis
Predictive Value of PIIINP Urinary for the Development of Chronic Renal Failure in Patients With Cystic Fibrosis After Lung Transplantation (MUCO-IRC)
Chronic renal failure is a serious complication of lung transplantation especially in patients with cystic fibrosis. Their medical history prior to the Lung Transplantation has already exposed to kidney damage.
- Conditions
- Lung Transplantation, Cystic Fibrosis, Renal Failure
- Trial name
- MUCO-IRC (NCT01572194)
- Testing
- Urinary levels of PIIINP as a marker of changes in renal function
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Nantes University Hospital
Chronic Kidney Diseases
Effect of Folic Acid and/or Pentoxifylline on Patients With Chronic Kidney Disease
The aim of this study is to evaluate the effect of administration of folic acid and /or pentoxifylline on patients with chronic kidney disease (CKD).
- Trial name
- NCT05284656
- Testing
- combination of Pentoxifylline 400 MG and Folic Acid, folic acid, Pentoxifylline 400 MG
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Al-Azhar University
End Stage Renal Disease, Chronic Kidney Diseases
Berinert (C1INH) vs Placebo for DGF/IRI
This is a Phase I/II double-blind, randomized, placebo-controlled study assessing safety and limited efficacy of intraoperative C1INH (500U/kidney) vs.
- Trial name
- NCT04696146
- Testing
- Berinert
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Cedars-Sinai Medical Center
Chronic Kidney Disease (CKD)
Sleep Disorders in Pediatric Dialysis
Sleep disorders (SD) are common in adults with Chronic Kidney Disease (CKD) on dialysis with a reported prevalence of 60-80%. To date three studies have reported on SDs in children with CKD but these have all been based on…
- Trial name
- NCT01667588
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- The Hospital for Sick Children
Adverse Event, Peritoneal Dialysis
Efficacy and Safety of Nalfurafine Hydrochloride ODT for Moderate-to-Severe Pruritus in Patients on Peritoneal Dialysis
Moderate to severe pruritus significantly impairs the quality of life in peritoneal dialysis patients, and effective treatment options remain limited.
- Conditions
- Adverse Event, Peritoneal Dialysis, Moderate-to-severe Pruritus, Chronic Kidney Disease-associated Itch
- Trial name
- KARE-PD (NCT07098351)
- Testing
- Remitch
- Where
- China
- Volunteers
- 93 people
- Sponsor
- Guangdong Provincial People's Hospital
Chronic Kidney Failure, Secondary Hyperparathyroidism
Paricalcitol Oral Therapy in Predialysis CKD Patients. The Greek Experience
The purpose of this study is to obtain data on the use of Zemplar (paricalcitol) capsules in real-life clinical practice in predialysis patients with chronic kidney disease (CKD) and secondary hyperparathyroidism.
- Trial name
- PROTECT (NCT01083186)
- Where
- 24 sites in Greece
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- AbbVie (prior sponsor, Abbott)
CKD
Chronic Kidney Disease in Pregnant Females
Screening of Chronic Kidney Disease among pregnant women for early detection
- Trial name
- NCT06738069
- Testing
- Participants are not assigned an intervention as a part of the study
- Volunteers
- 497 people
- Sponsor
- Assiut University
Diabetic Nephropathy, Chronic Kidney Disease
Mycophenolate Mofetil, Carnitine and PDE5 Inhibitor, Three Potential Treatments for Resistant Proteinuria Slowing Diabetic Nephropathy Deterioration
Diabetes mellitus (DM) is a growing disease and it is a public health concern, and projections of its future effect are alarming. About one third of those affected will develop diabetic nephropathy at 20 years after diagnosis.
- Trial name
- Myridian (NCT01566006)
- Testing
- Mycophenolate Mofetil (MMF) ,phosphodiesterase 5 inhibitors , CARNITINE
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- The Nazareth Hospital, Israel
Anorexia, Thalassemia
Clinical Diagnosis of Teenagers Admitted to Pediatric Departments
This study intends to analyze the clinical characteristics of teenagers admitted to pediatric wards due to organic illness and non organic diagnosis, including patients suffering from chronic diseases and comorbidity.
- Conditions
- Anorexia, Thalassemia, Sickle Cell Anemia, Chronic Renal Failure
- Trial name
- NCT00735540
- Testing
- Observational
- Where
- Israel
- Volunteers
- 1,389 people
- Sponsor
- HaEmek Medical Center, Israel
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