Clinical trials: CKD Stage 5
End Stage Renal Disease on Dialysis
Comparative Study Evaluating the Effect of Vitamin K1 Versus Vitamin K2 on Vascular Calcification in Dialysis Patients
To evaluate the effect of supplementation of vitamin K2 (menaquinone, MK-7)vs vitamin k1 on circulating levels of calcification regulators and to assess their safety in patients on regular dialysis patients.
- Trial name
- NCT04477811
- Testing
- Vitamin K1, Vitamin k2
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Hemodialysis, Ventriculo-arterial Coupling
Ventriculo-Arterial Coupling and Intra-Dialytic Changes in Hemodialysis Patients: Prognostic Insights
The acute effect of hemodialysis (HD) on left ventricular mechanics has been evaluated in several studies, however their results are not uniform.
- Trial name
- NCT06622928
- Testing
- Echocardiogram
- Where
- Kazakhstan
- Volunteers
- 384 people
- Sponsor
- Nazarbayev University
Blood Coagulation Disorders, Atrial Fibrillation
Left Atrial Appendage Occlusion vs. Usual Care in Patients With Atrial Fibrillation and Severe Chronic Kidney Disease
The purpose of this study is to evaluate the superiority of left atrial appendage occlusion in comparison to oral anticoagulation with a vitamin K antagonist (INR 2-3) related to the frequency of occurrence of at least one…
- Conditions
- Blood Coagulation Disorders, Atrial Fibrillation, Thrombosis of Left Atrial Appendage, Chronic Kidney Disease Stage 4
- Trial name
- WatchAFIB (NCT02039167)
- Testing
- Left atrial appendage occlusion
- Where
- 4 sites in Germany
- Volunteers
- 14 people
- Sponsor
- University of Magdeburg
End Stage Renal Disease, Myocardial Microvascular Disease
Myocardial Microvascular Disease in ESRD
Cardiovascular diseases are the leading cause of mortality in patients with end stage renal disease (ESRD). They often have myocardial ischemia (a major predictor of mortality) on non invasive testing (Stress echocardiography…
- Trial name
- MICROCARD (NCT01291771)
- Testing
- Invasive FFR + CFR measurements are performed during coronary angiography using a pressure guide wire
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
End Stage Renal Disease
Triferic AVNU Infusion Via Freedom Pump During Hemodialysis
The main purpose of this study is to evaluate the delivery of Triferic AVNU intravenously using the Freedom Pump-20 during hemodialysis into the pre-dialyzer and post-dialyzer blood lines.
- Trial name
- NCT04689932
- Testing
- Triferic AVNU
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Rockwell Medical Technologies, Inc.
End Stage Renal Disease
Efficacy Study of Zinc Supplementation on Anemia, Oxidative Stress and Inflammation in Hemodialysis Patients
The purpose of the study is to evaluate the effect of Zinc supplementation on health status of hemodialysis patients through measurement of the following before and after Zinc administration: Inflammatory markers, Oxidative…
- Trial name
- NCT02335593
- Testing
- Zinc Sulphate, Corn Starch filled Hard Gel Capsules, Epoetin alfa 2000-4000 IU solution for injection
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
End-stage Renal Disease (ESRD), Hemodialysis
Oral L-carnitine and Inflammatory and Nutritional Biomarkers in Maintenance Hemodialysis
The goal of this clinical trial is to evaluate whether oral L-carnitine supplementation helps reduce inflammation and improve nutritional status in patients with end-stage kidney disease who are undergoing long-term hemodialysis.
- Trial name
- NCT07249229
- Testing
- L-carnitine 1000 Mg
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Darya Chamani
Latent Tuberculosis, End Stage Renal Disease
One-month Latent Tuberculosis Treatment for Renal Transplant Candidates
This is a prospective, single-center, single-arm, open-label study investigating the safety, compliance and pharmacokinetics of 1-month treatment of Isoniazid, Rifapentine and Vitamin B6 in renal transplant candidates.
- Conditions
- Latent Tuberculosis, End Stage Renal Disease, Renal Transplant Candidate for Right Kidney, Renal Transplant Candidate for Left Kidney
- Trial name
- NCT05411744
- Testing
- 1 month Rifapentine, Isoniazid and Vitamin B6
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Rutgers, The State University of New Jersey
Renal Insufficiency
Factors Related to Geographical Variation in the Incidence of End-stage Renal Failure: An Analysis in 5 French Regions
The REIN registry highlights significant disparities in the incidence of end-stage renal disease (ESRD) between regions, especially in the North East of France.
- Trial name
- VIgIE (NCT02849964)
- Where
- 4 sites in France
- Volunteers
- 6,835 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
End Stage Renal Disease, End-Stage Kidney Disease
Shared Decision Making for Kidney Transplant Candidates to Plan for an Organ Offer Decision
The goal of this pilot randomized trial is to learn about shared decision making in kidney transplant candidates. The aim of this proposal is to evaluate the Donor Plan Donor Choice tool to promote high-quality Shared Decision…
- Conditions
- End Stage Renal Disease, End-Stage Kidney Disease, Kidney Transplantation, Esrd
- Trial name
- NCT05879302
- Testing
- Kidney Offer Shared Decision Making
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Hennepin Healthcare Research Institute
Major Depression, End Stage Renal Disease
Bupropion for Depression in ESRD Patients on Hemodialysis
The proposed study will evaluate the response and remission rates for major depressive disorder (MDD) in end-stage renal disease (ESRD) patients undergoing maintenance hemodialysis (HD) treated with bupropion or fluoxetine for 12…
- Trial name
- NCT02238977
- Testing
- Fluoxetine, Bupropion
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Arkansas
Kidney Disease, Chronic Kidney Disease (Stages 4 and 5)
The Adaptive Platform Trial for Kidney Disease
Background: Randomized clinical trials (RCTs) are essential for evaluating intervention effects but are often challenged by regulatory and logistical burdens, high costs, and extended timelines.
- Conditions
- Kidney Disease, Chronic Kidney Disease (Stages 4 and 5), End-Stage Kidney Disease (ESKD), Dialysis
- Trial name
- APT-KIDNEY (NCT07595952)
- Testing
- APT-KIDNEY platform participation
- Volunteers
- 5,000 people
- Sponsor
- Nicholas Carlson
End Stage Renal Disease, Inflammation
A Study Evaluating the Association of Inflammation With Hemodialysis Access Type
To determine if the type of hemodialysis vascular access correlates with markers of inflammation, namely C-reactive protein and interleukin-6, and with both access and patient survival in the end stage renal disease population.
- Trial name
- NCT01011985
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Montefiore Medical Center
End-Stage Renal Disease
Study on the Safety and Efficacy of a Time-of-Day-Based Individualized Tacrolimus Dosing Regimen in Kidney Transplant Recipients
The goal of this clinical trial is to evaluate whether chronopharmacokinetic model-guided individualized unequal twice-daily tacrolimus dosing improves renal allograft function and reduces acute rejection in stable kidney…
- Trial name
- NCT07877103
- Testing
- Chronotherapy-based individualized low-morning high-evening tacrolimus dosing, conventional dosing regimen
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
End-Stage Kidney Disease (ESKD)
Pharmacokinetics of Oral Letermovir in Adults With End-Stage Kidney Disease With or Without Haemodialysis
This study aims to understand how the antiviral medication letermovir (PREVYMIS) is processed by the body in adults with end-stage kidney disease (ESKD), including those who are receiving intermittent haemodialysis and those who…
- Trial name
- NCT07101055
- Testing
- Letermovir 480 mg [PREVYMIS]
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jason A Roberts
Chronic Kidney Disease on Hemodialysis, Meals
Restorative and Supportive Meals at HomeCare
The pilot intervention study is designed to evaluate the feasibility of implementing a tailored medical nutrition therapy (MNT) meal-delivery for 25 elderly, low-income food insecure patients with end-stage kidney disease…
- Conditions
- Chronic Kidney Disease on Hemodialysis, Meals, Medical Nutrition Therapy
- Trial name
- RASA (NCT07283926)
- Testing
- Medical Nutrition Therapy + Meal Delivery
- Where
- 4 sites in Malaysia
- Volunteers
- 25 people
- Sponsor
- Universiti Putra Malaysia
End Stage Renal Disease
Comparison of Daily Home Hemodialysis (HD) With Conventional in Center HD in Terms of Patients Quality of Life and Clinical Outcomes
The objective of this study is to describe the characteristics of patients on daily home hemodialysis and to confirm in real practice in France the effectiveness shown in studies, mainly American, both in terms of clinical…
- Trial name
- SeCoIA (NCT03737578)
- Testing
- Delivery of a connected pedometer / accelerometer
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Physidia
End-stage Renal Disease
The Protective Effect of Remote Ischemic Conditioning on Residual Renal Function in Hemodialysis Patients (RIC-HD)
Hemodialysis (HD) is the main renal replacement therapy for patients with end-stage renal disease. However, factors such as hemodynamic instability can lead to gradual loss of residual renal function (RRF) in HD patients.
- Trial name
- RIC-HD (NCT06275152)
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yuanjun Yang
Kidney Failure, Chronic, End-Stage Renal Disease
Effect of Sevelamer on Glucose Tolerance and Insulin Sensitivity in Patients With Chronic Renal Failure (CKD)
The purpose of this study is to perform a randomized, controlled clinical trial to investigate if the phosphate binder sevelamer can improve insulin resistance and glucose handling in patients receiving maintenance hemodialysis.
- Conditions
- Kidney Failure, Chronic, End-Stage Renal Disease, Insulin Resistance, Hyperphosphatemia
- Trial name
- SIR (NCT00837655)
- Testing
- Sevelamer, Calcium carbonate
- Where
- 2 sites in Sweden
- Sponsor
- Karolinska Institutet
Chronic Kidney Disease (Stages 4 and 5), Hemodialysis
Inspiratory Muscle Training During Hemodialysis
This study will evaluate whether inspiratory muscle training performed during hemodialysis improves inspiratory muscle strength in adults receiving regular hemodialysis.
- Conditions
- Chronic Kidney Disease (Stages 4 and 5), Hemodialysis, Inspiratory Muscle Training
- Trial name
- RespDialysis (NCT07811947)
- Testing
- Inspiratory Muscle Training, Usual Care
- Where
- Portugal
- Volunteers
- 53 people
- Sponsor
- Tecsam - Tecnologia e Servicos Medicos