Clinical trials: CLBP - Chronic Low Back Pain
Back Pain, Low Back Pain
Tapentadol Prolonged Release (PR) Versus Oxycodone/Naloxone Prolonged Release in Severe Chronic Low Back Pain With a Neuropathic Component.
This was a clinical effectiveness trial designed to compare the effectiveness, safety, and tolerability of treatment with tapentadol prolonged release with that of oxycodone/naloxone prolonged release in non-opioid pre-treated…
- Conditions
- Back Pain, Low Back Pain, Neuropathic Pain
- Trial name
- NCT01838616
- Testing
- Tapentadol Prolonged Release, Oxycodone/Naloxone Prolonged Release
- Where
- 50 sites in Austria, Germany and 2 more
- Volunteers
- 367 people
- Sponsor
- Grünenthal GmbH
Low Back Pain
Buprenorphine Transdermal System (BTDS) in Subjects With Moderate to Severe Chronic Low Back Pain
The objective of this study is to determine the analgesic efficacy and safety of Buprenorphine Transdermal System (BTDS) 10 and 20 compared to placebo in opioid-naïve subjects with moderate to severe chronic low back pain.
- Trial name
- NCT00490919
- Testing
- Buprenorphine transdermal system
- Where
- 86 sites in United States
- Volunteers
- 539 people
- Sponsor
- Purdue Pharma LP
Chronic Low Back Pain, Sacroiliitis
Effectiveness of Ultrasound Guided Platelet Rich Plasma Injections in the Sacroiliac Joint
This prospective study will be quantitatively analyzing the effectiveness of platelet-rich-plasma (PRP) injections into the sacroiliac (SI) joint in relieving sacroiliitis and low back pain originating from the SI joint.
- Conditions
- Chronic Low Back Pain, Sacroiliitis, Sacroiliac; Backache, Platelet Rich Plasma
- Trial name
- NCT03122119
- Testing
- Platelet Rich Plasma Joint Injection
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Star Spine and Sport
Chronic Pain, Low Back Pain
High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System
Study designed to compare the conventional stimulation programming versus the high frequency stimulation programming of the spinal cord stimulator for subjects who already have a spinal cord stimulator.
- Conditions
- Chronic Pain, Low Back Pain, Radiculopathy, Complex Regional Pain Syndrome (CRPS)
- Trial name
- HFSCS (NCT02265848)
- Testing
- High frequency stimulation, Low frequency stimulation
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The Center for Clinical Research, Winston-Salem, NC
Major Depressive Disorder, Back Pain
Duloxetine Treatment of Major Depression and Chronic Low Back Pain For Older Adults
The following primary hypotheses will be tested: 1. During Step 1: Major Depressive Disorder (MDD) or Chronic Low Back Pain (CLBP) in < 40% of the initial 60 subjects treated with duloxetine (DUL) + Clinical Management(CM) during…
- Conditions
- Major Depressive Disorder, Back Pain, Aged
- Trial name
- ACHIEVE2 (NCT00696293)
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Peptic Ulcer
Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-associated Ulcers
The purpose of this study is to evaluate whether HZT-501 is effective in reducing the rate of development of ibuprofen-associated ulcers in patients who require long-term daily use of ibuprofen.
- Trial name
- NCT00450658
- Testing
- HZT-501, Ibuprofen
- Volunteers
- 627 people
- Sponsor
- Amgen
Chronic Low Back Pain
Bright Light Treatment At Home To Manage Chronic Pain In U.S. Veterans
Nearly 50% of U.S. veterans report they experience pain on a regular basis. This chronic pain often co-occurs with other disorders including post-traumatic stress disorder (PTSD), depression, anxiety and insomnia.
- Trial name
- NCT02373189
- Testing
- Bright light
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Rush University Medical Center
Low Back Pain
Targeted Interventions to Prevent Chronic Low Back Pain in High Risk Patients
Low back pain (LBP) is a common problem among US adults. Initial episodes tend to be self-limited ("acute"), but some people can progress to a state of persistent pain.
- Trial name
- TARGET (NCT02647658)
- Testing
- Guideline Based Care plus Psychologically Informed Physical Therapy, Guideline Based Care (GBC)
- Where
- 5 sites in United States
- Volunteers
- 2,300 people
- Sponsor
- University of Pittsburgh
Primary Insomnia
Study of the Insomnia in Patients With Low Back Pain
The purpose of this study is to examine whether insomnia due to chronic low back pain can improve with use of eszopiclone.
- Trial name
- NCT00365976
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Duke University
Chronic Low Back Pain
Gait in Low Back Pain Patients After Spinal Mobilization
Introduction: patients with chronic back pain as a result of degenerated disc disease, besides pain also present with impaired gait.
- Trial name
- SpinMob (NCT02645123)
- Testing
- TENS, spinal mobilization, swedish type massage
- Volunteers
- 75 people
- Sponsor
- University of Ioannina
Post-Traumatic Stress Disorder, Chronic Low Back Pain
Yoga and Mantram for Chronic Pain and PTSD
PTSD is prevalent among Veterans and is associated with physical and functional impairments in addition to PTSD symptoms. Veterans with PTSD experience more chronic pain and pain-related functional limitations than Veterans…
- Conditions
- Post-Traumatic Stress Disorder, Chronic Low Back Pain, Chronic Neck Pain
- Trial name
- NCT03816007
- Testing
- Yoga and Mantram Repetition, Veteran Calm
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- VA Office of Research and Development
Lumbar Post-Laminectomy Syndrome, Chronic Low Back Pain
Determining the Prognostic Value of Continuous Intrathecal Infusion
The purpose of this study will be to determine the efficacy and the prognostic value of a continuous intrathecal prognostic infusion test in an in-hospital setting for selecting patients who would have better long term outcomes…
- Conditions
- Lumbar Post-Laminectomy Syndrome, Chronic Low Back Pain, Vertebral Compression Fracture, Failed Back Surgery Syndrome
- Trial name
- NCT03523000
- Testing
- Continuous intrathecal prognostic infusion test, Bupivacaine, Fentanyl
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University Hospitals Cleveland Medical Center
Low Back Pain
The Glucosamine-study: The Effect of Glucosamine in Treatment of Chronic Low Back Pain
Low back pain (LBP) is the most frequent cause of sick leave and disability pension, and degenerative and osteoarthritic (OA) changes is a significant cause of pain and disability.
- Trial name
- NCT00404079
- Testing
- Glucosamine sulphate
- Where
- Norway
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Ullevaal University Hospital
Chronic Low-back Pain, Chronic Pain
Digital Clinical Hypnosis for Chronic Pain Management
This ClinicalTrials.gov posting contains two randomized controlled trials. The study procedures were identical, except Study 1 was funded by NIH and enrolled adults with chronic low back pain, whereas Study 2 was funded by the UW…
- Trial name
- NCT06050083
- Testing
- Hypnosis audio recordings
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Washington
Low Back Pain
RN624 In Adult Patients With Chronic Low Back Pain
The primary objective of this study is to evaluate the analgesic efficacy of RN624 compared with placebo and compared with naproxen in the treatment of adult patients with chronic low back pain.
- Trial name
- NCT00584870
- Testing
- Naproxen, PF-04383119 (RN624)
- Where
- 38 sites in United States
- Volunteers
- 220 people
- Sponsor
- Pfizer
Chronic Low Back Pain
Implementation of Pedometer for Monitoring Step Count Pre and Post Lumbar ESI for Radicular Pain
Our aim is to assess usability and compliance of a wireless pedometer for monitoring step count after a lumbar epidural steroid injection for the treatment of radicular pain in low back pain patients.
- Trial name
- NCT02356783
- Testing
- Pedometer
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Hospital for Special Surgery, New York
Chronic Low Back Pain
Virtual Reality Therapy for Chronic Low Back Pain
This study will test the efficacy of an evidence-based virtual reality (VR) therapy program as a non-pharmacological supplement for the management of chronic lower back pain.
- Trial name
- NCT04409353
- Testing
- Distraction-Based VR, Skills-Based VR, Activity Tracker
- Where
- United States
- Volunteers
- 413 people
- Sponsor
- Cedars-Sinai Medical Center
Chronic Low Back Pain, Chronic Leg Pain
Comparison of the Effects of Two Spinal Cord Stimulation (SCS) Therapies on Subject Reported Pain (BENEFIT-02)
A BIOTRONIK wearable stimulator will be utilized in order to investigate the effects of two study spinal cord stimulation (SCS) therapies on subject reported pain and paresthesia perception observed over 12 days of study…
- Trial name
- NCT03594266
- Testing
- Therapy A spinal cord stimulation parameter set using BIO-RNA system and associated components, Therapy B spinal cord stimulation parameter set using BIO-RNA system and associated components
- Where
- 18 sites in United States
- Volunteers
- 136 people
- Sponsor
- Biotronik, Inc.
Back Pain Lower Back Chronic
A Study of Duloxetine (LY248686) in Participants With Chronic Low Back Pain
The purpose of the study is to assess the efficacy and safety of duloxetine in participants with Chronic Low Back Pain (CLBP).
- Trial name
- NCT01855919
- Testing
- Duloxetine
- Where
- Japan
- Volunteers
- 458 people
- Sponsor
- Eli Lilly and Company
Chronic Low Back Pain
Strategies to Assist With Management of Pain
Chronic low back pain (CLBP) has no known effective treatment. While often treated with long-term opioid therapy, opioids do not work well for many patients and can cause serious side effects, including addiction, poorer mental…
- Trial name
- STAMP (NCT03115359)
- Testing
- Mindfulness Based Therapy, Cognitive Behavioral Therapy
- Where
- 4 sites in United States
- Volunteers
- 770 people
- Sponsor
- University of Wisconsin, Madison