Clinical trials: CNS
Alzheimer's Disease
Long Term Extension Study Evaluating Safety, Tolerability And Immunogenicity Of ACC-001 In Japanese Subjects With Mild To Moderate Alzheimer's Disease
The purpose of this long term extension study is to assess safety, tolerability and immunogenicity of ACC-001 with QS-21 adjuvant in Japanese subjects with mild to moderate AD who were randomized in the preceding P2 double blind…
- Trial name
- NCT01238991
- Testing
- ACC-001
- Where
- 11 sites in Japan
- Volunteers
- 53 people
- Sponsor
- Pfizer
Multiple Sclerosis
Effectiveness of Ankle Foot Orthoses on Gait in Multiple Sclerosis
The purpose of this study is to investigate the impact of a specifically designed ankle foot orthosis (AFO, hinged, with tamarack joint and adjustable check strap) on the spatial and temporal gait parameters, electromyography…
- Trial name
- NCT01796860
- Testing
- AFO
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Texas Southwestern Medical Center
Stroke
Long-term Cardiac Monitoring After Cryptogenic Stroke (CMACS)
Atrial fibrillation (AF) is a common and treatable cause of ischemic stroke, but it can be paroxysmal and asymptomatic, and therefore difficult to detect.
- Trial name
- CMACS (NCT00932425)
- Testing
- Cardionet Mobile Cardiac Outpatient Telemetry (MCOT)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Depression, Parkinson's Disease
The Effects of Sertraline on Depression in Parkinson's Disease
The aim of this open-label, self-control study is to evaluate the efficacy of sertraline in treating depression in Patients with Parkinson's disease.
- Trial name
- PD (NCT01437189)
- Testing
- Sertraline
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Zhejiang University
Multiple Sclerosis
Prospective Observational Long-term Safety Registry of Multiple Sclerosis Participants Who Have Participated in Cladribine Clinical Trials
Prospective Observational Long-term Safety Registry of Multiple Sclerosis Participants who Have Participated in Cladribine Clinical Trials
- Trial name
- PREMIERE (NCT01013350)
- Where
- United States
- Volunteers
- 1,161 people
- Sponsor
- EMD Serono
Multiple Sclerosis
Retrospective Cohort Study of Rebif® Use in Pediatric Multiple Sclerosis (MS) Subjects (REPLAY)
The aim of this retrospective study is to review and describe safety, tolerability and efficacy of Rebif® (subcutaneous interferon [IFN]-beta-1a) in children and adolescents, using information already recorded in medical records.
- Trial name
- REPLAY (NCT01207648)
- Testing
- Rebif®
- Where
- 18 sites in United States, Argentina and 6 more
- Volunteers
- 307 people
- Sponsor
- EMD Serono
Stroke
Robot-Assisted Hand Motor Therapy for Subjects With Hemiparetic Stroke
The purpose of this study is to develop and assess the effectiveness of robot-assisted movement therapy in enhancing hand motor function in subjects with chronic hemiparetic stroke, and to identify predictors of treatment…
- Trial name
- Robot3 (NCT01244243)
- Testing
- Hand & Wrist Assisting Robotic Device
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of California, Irvine
Hypoxic Ischemic Encephalopathy
Darbe Administration in Newborns Undergoing Cooling for Encephalopathy
Selective head cooling or whole body hypothermia has become the standard of care for neonatal hypoxia-ischemia encephalopathy (HIE).
- Trial name
- DANCE (NCT01471015)
- Testing
- Darbepoetin alfa
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Utah
Obstructive Sleep Apnea, Stroke
Diagnosis and Treatment of Sleep Apnea in Cerebrovascular Disease
Sleep apnea is common among Veterans with cerebrovascular disease (stroke or transient ischemic attack [TIA]), leads to hypertension, and is associated with recurrent stroke and death.
- Conditions
- Obstructive Sleep Apnea, Stroke, Transient Ischemic Attack, Hypertension
- Trial name
- Go To Sleep (NCT00984308)
- Testing
- CPAP Therapy for Newly Diagnosed Obstructive Sleep Apnea (OSA)
- Where
- 2 sites in United States
- Volunteers
- 225 people
- Sponsor
- VA Office of Research and Development
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors
RATIONALE: Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs in chemotherapy, such as ifosfamide, carboplatin, and etoposide, work in different ways to stop the growth of…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Kidney Cancer
- Trial name
- NCT00788125
- Testing
- carboplatin, dasatinib, etoposide phosphate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- City of Hope Medical Center
Ischemic Stroke
Efficacy and Safety of Mexidol® in Stroke Therapy
The main purpose of the clinical trial is to evaluate the efficacy and safety of Mexidol® in sequential treatment for patients in the acute and early recovery periods of ischemic stroke compared to placebo.
- Trial name
- MIR (NCT06437626)
- Testing
- Mexidol (Ethylmethylhydroxypyridine Succinate)
- Where
- 17 sites in Kazakhstan, Russia and 1 more
- Volunteers
- 304 people
- Sponsor
- Pharmasoft
Multiple Sclerosis, Optic Neuritis
Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis
The current study is a continuation of the 5 year extension study of the phase III CHAMPS study (see reference). This study was designed to determine if immediate initiation of therapy with Interferon Beta-1a (AVONEX) after a…
- Conditions
- Multiple Sclerosis, Optic Neuritis, Transverse Myelitis, Acute Brainstem/Cerebellar Syndrome
- Trial name
- CHAMPIONS10 (NCT00179478)
- Testing
- interferon beta 1a 30 ug IM once weekly
- Where
- 26 sites in United States, Canada
- Volunteers
- 155 people
- Sponsor
- Beth Israel Deaconess Medical Center
Parkinson's Disease
Cognitive Decline in Non-demented PD
The purpose of this study is to determine the relationship between attention and quality of life and how rivastigmine and atomoxetine alter attention in non-demented persons with Parkinson's disease (PD).
- Trial name
- NCT01340885
- Testing
- Strattera, Exelon
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Oregon Health and Science University
Multiple Sclerosis, Fatigue
A Study of Suvorexant in Patients With Multiple Sclerosis Fatigue and Insomnia
This study assesses the safety, tolerability, and efficacy of suvorexant in multiple sclerosis patients. Enrolled subjects will receive 2 weeks of treatment during treatment period 1 with either suvorexant or matching placebo…
- Conditions
- Multiple Sclerosis, Fatigue, Insomnia
- Trial name
- DREAM (NCT03110315)
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Theodore R. Brown, MD MPH
Parkinson's Disease
Cholinergic Augmentation in Frequently Falling Subjects With Parkinson's Disease
The purpose of this study is to find out if a medication that increases levels of a brain chemical called acetylcholine will improve balance and reduce falls in patients with parkinson's disease who have the problem of very poor…
- Trial name
- NCT00912808
- Testing
- Donepezil
- Volunteers
- 23 people
- Sponsor
- Oregon Health and Science University
Epilepsy
Brivaracetam Efficacy and Safety Study in Subjects With Partial Onset Seizures
This study will evaluate the efficacy and safety of brivaracetam at doses of 100 and 200mg/day compared to placebo as adjunctive treatment in adult focal epilepsy subjects with partial onset seizures not fully controlled despite…
- Trial name
- BRITE (NCT01261325)
- Testing
- Brivaracetam, Antiepileptic drugs with market authorization available per country
- Where
- 207 sites in United States, Austria and 26 more
- Volunteers
- 768 people
- Sponsor
- UCB Pharma
Parkinson's Disease, Gaucher's Disease
Intravenous N-acetylcysteine for the Treatment of Gaucher's Disease and Parkinson's Disease
The investigators are interested in determining if the investigators are able to detect changes in brain chemistry using Magnetic Resonance Spectroscopy (MRS) in individuals with Parkinson's disease (PD), those with Gaucher's…
- Trial name
- NCT01427517
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Metastatic Cancer, Unspecified Adult Solid Tumor, Protocol Specific
Stereotactic Radiosurgery in Treating Patients With Brain Metastases
RATIONALE: Stereotactic radiosurgery may be able to send x-rays directly to the tumor and cause less damage to normal tissue. Giving stereotactic radiosurgery before surgery may make the tumor smaller and reduce the amount of…
- Trial name
- NCT00811655
- Testing
- therapeutic conventional surgery, stereotactic radiosurgery
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Duke University
Parkinson Disease, Cognitive Impairment
Low Frequency Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease
Prospective trial of low frequency deep brain stimulation of the ventral subthalamic nucleus to improve cognitive performance in patients with advanced Parkinson's disease.
- Trial name
- NCT03204526
- Testing
- deep brain stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, Davis
Parkinson's Disease
CUSTOM-DBS: Current Steering to Optimize Deep Brain Stimulation
The objective of the study is to compare different deep brain stimulation (DBS) settings using the commercially approved Boston Scientific Neuromodulation Vercise system.
- Trial name
- CUSTOM-DBS (NCT01896115)
- Testing
- Vercise DBS settings
- Where
- 10 sites in United States, Austria and 3 more
- Volunteers
- 40 people
- Sponsor
- Boston Scientific Corporation
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