Clinical trials: CNS
Parkinson Disease
Effects of Different Percentages Body Weight Supported Treadmill Training on Gait, Balance, Quality of Life and Fatigue in Parkinson's Disease
Body weight supported treadmill training (BWSTT) is an important rehabilitative choice for neurologically impaired subjects such as Parkinson's disease (PD).
- Trial name
- NCT03799887
- Testing
- 0% unweighed BWSTT, 10% unweighed BWSTT, 20% unweighed BWSTT
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Hitit University
Stroke
Transcranial Stimulation in Motor Stroke Rehabilitation
Patients were randomized in 3 groups: two intervent groups and a control group. The first group received two weeks of daily session of repetitive Transcranial Magnetic Stimulation (rTMS, 10 sessions) and, at least 6 months after…
- Trial name
- NCT02525393
- Testing
- tDCS, rTMS
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- University of Turin, Italy
Balance, Gait Analysis
Effectiveness of Dance Therapy in Stroke Patients.
Hemiparesis following a stroke is associated with persistent deficits in postural control, balance, and social participation, especially in the chronic phase.
- Conditions
- Balance, Gait Analysis, Thermography, Range of Motion, Articular
- Trial name
- NCT07578493
- Testing
- Dance therapy, Regular physiotherapy
- Where
- Spain
- Volunteers
- 16 people
- Sponsor
- University of Salamanca
Spasticity/Paresis, Cerebral Palsy
Efficacy of Extracorporeal Shock Wave Therapy in Children With Cerebral Palsy
Spastic plantar and palmar flexion deformities are very common in children with cerebral palsy (CP). These deformities usually involve spasticity of the plantar or palmar muscle complexes, weakness of the antagonist dorsiflexor…
- Trial name
- NCT06128616
- Testing
- ESWT, Botulinum Toxin Type A, Serial Casting
- Volunteers
- 40 people
- Sponsor
- Kocaeli University
Multiple Sclerosis
NARCOMS Registry: A Multiple Sclerosis Registry
This project is based on the idea that we can learn about the complexities of MS by following disease and treatment patterns in a large group of people over several years. The information gathered is used for research only.
- Trial name
- NARCOMS (NCT01018537)
- Where
- United States
- Volunteers
- 50,000 people
- Sponsor
- University of Texas Southwestern Medical Center
Parkinson's Disease
Carbidopa-Levodopa (CD-LD) ER Alone or in Combination With CD-LD IR to IPX066 Followed by IPX066 Extension Safety Study
The study had three distinct parts and is described as follows: Part 1: To evaluate the dose conversion from CD-LD ER taken alone or in combination with CD-LD IR to IPX066 in subjects with advanced PD To evaluate the utility of…
- Trial name
- NCT01411137
- Testing
- IPX066
- Where
- 8 sites in United States
- Volunteers
- 43 people
- Sponsor
- Impax Laboratories, LLC
Parkinson's Disease
Exercise for People With Parkinson's Disease
This randomized, controlled exercise intervention with three groups compares two exercise approaches to standard of care. Supervised interventions are administered for four months, with emphasis on patients adopting exercise…
- Trial name
- NCT01257945
- Testing
- Aerobic Exercise, Flexibility and Function exercise program, Home exercise program
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- University of Colorado, Denver
Caregiver Burden, Stroke
Evaluation of Musculoskeletal System in Caregivers of Rehabilitation Patients
In this study, musculoskeletal-related pain, posture, spine function, the condition of the low back and neck regions, musculoskeletal system disorders, fatigue, and quality of life will be examined in caregivers of rehabilitation…
- Conditions
- Caregiver Burden, Stroke, Cerebral Palsy, Neurologic Disorder
- Trial name
- NCT05839795
- Testing
- Assessment study
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Essential Tremor
A Pilot Efficacy and Safety Study of ST101 in Essential Tremor
This study will look at the ability of ST101 to treat symptoms in subjects with Essential Tremor. This study will also examine the safety and tolerability of the drug.
- Trial name
- NCT01332695
- Testing
- ST101
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Sonexa Therapeutics, Inc.
Dementias With Lewy Bodies
A Study to Determine the Metabolism and Elimination of [14C]E2027 in Healthy Male Participants
The primary objective of the study is to achieve mass balance recovery of [14C]-radiolabel in urine and feces and to identify and quantify the main elimination pathways of E2027.
- Trial name
- NCT04023877
- Testing
- E2027
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Stroke
A Study of tDCS for Unilateral Neglect in Stroke Patients
The primary objective of this study is to confirm and compare the effect of methods of transcranial direct current stimulation(tDCS) in the unilateral neglect of stroke patients
- Trial name
- NCT02506075
- Testing
- Transcranical direct current stimulator, Visual inattention training
- Where
- South Korea
- Volunteers
- 105 people
- Sponsor
- Pusan National University
Tension-Type Headache
Manual Therapy in Tension-type Headache
Tension-type headache (TTH) causes a significant negative impact on working and daily life due to the reduction in work productivity and family and social activities causes.
- Trial name
- NCT04546165
- Testing
- manipulation plus exercise, suboccipital inhibition plus exercise, exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Brain Disorder, Smart Device Rehabilitation
Development of Quantitative Parameter of Upper Extremity Function in Patients With Brain Disorder Using Smart-Board and Smart-Glove.
The aim of this study is to develop a novel quantitative metric for assessing upper-limb function in patients with neurological disorders.
- Trial name
- NCT07397767
- Testing
- smart device
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Samsung Medical Center
Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Hodgkin Lymphoma
Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial)
This phase II Pediatric MATCH trial studies how well tazemetostat works in treating patients with brain tumors, solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that have come back (relapsed) or do not respond to…
- Conditions
- Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Hodgkin Lymphoma, Ann Arbor Stage III Non-Hodgkin Lymphoma, Ann Arbor Stage IV Hodgkin Lymphoma
- Trial name
- NCT03213665
- Testing
- Tazemetostat
- Where
- 117 sites in United States, Puerto Rico
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Family Caregivers, Dementia
Primary Care-based Study of an Online Workshop for Family Caregivers of PLWD
Many family and friend caregivers of persons living with dementia experience depression, stress, and other adverse health consequences due to the responsibilities of their caregiving role.
- Conditions
- Family Caregivers, Dementia, Self-management, Depression
- Trial name
- NCT06928467
- Testing
- Building Better Caregivers workshop
- Where
- 2 sites in United States
- Volunteers
- 109 people
- Sponsor
- University of California, San Francisco
Hereditary Hemorrhagic Telangiectasia
Cerebral Hemorrhage Risk in Hereditary Hemorrhagic Telangiectasia
This study is one of the three projects of an NIH Rare Disease Clinical Research Consortium. A "consortium" is a group of centres sharing information and resources to perform research.
- Trial name
- BVMC6203 (NCT01158807)
- Where
- 19 sites in United States, Canada and 1 more
- Volunteers
- 2,272 people
- Sponsor
- Unity Health Toronto
Urea Cycle Disorders
Study to Evaluate the Efficacy of HepaStem in Urea Cycle Disorders Paediatric Patients (HEP002)
The aim of the study is to assess the efficacy of HepaStem treatment in paediatric patients suffering from urea cycle disorders.
- Trial name
- NCT02489292
- Testing
- HepaStem
- Where
- 6 sites in Belgium, France and 2 more
- Volunteers
- 5 people
- Sponsor
- Cellaion SA
Parkinson Disease
Convection Enhanced Delivery of CSF in DBS for Parkinson's
This study will evaluate safety foremost but also the distribution and initial effectiveness of infusion-enhanced, MRI-guided DBS for patients with medication-refractory, Parkinson's disease
- Trial name
- NCT03540134
- Testing
- Intracerebral Infusion of Autologous Cerebral Spinal Fluid
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Jeff Elias, MD
Stroke
Cutaneous Silent Period and Spasticity
The cutaneous silent period (CSP) is a brief transient suppression of the voluntary muscle contraction that follows a noxious cutaneous nerve stimulation.
- Trial name
- NCT03421509
- Testing
- cutaneous silent period
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Marmara University
Spinal Cord Injuries
Resistance Training to Improve Strength and Functional Trunk Stability in Adults With Paraplegia
The purpose of this study is to examine the effectiveness of an 8- week resistance training routine to improve functional trunk strength, muscle activation, and physical functioning in exercise in 30 adults with paraplegic SCI.
- Trial name
- NCT03949699
- Testing
- Resistance training
- Volunteers
- 11 people
- Sponsor
- Spaulding Rehabilitation Hospital