Clinical trials: CNS Infection
Meningococcal Meningitis
Comparison of Two Meningococcal ACWY Conjugate Vaccines
There is evidence of waning immunity in individuals vaccinated against meningitis C as part of the UK infant immunisation schedule.
- Trial name
- PRIME (NCT01192997)
- Testing
- Menveo, MenACWY-TT
- Where
- 3 sites in United Kingdom
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Public Health England
Multiple Sclerosis, COVID-19 (Severe Coronavirus Disease 2019)
A Study to Assess the Potential Impact of Disease Modifying Therapies on COVID-19 Outcomes and the Antibody Response Following an Infection With SARS-CoV-2 in Patients With Multiple Sclerosis Within the Swiss Multiple Sclerosis Cohort.
This nested project of the Swiss Multiple Sclerosis Cohort (SMSC) is to assess the severity of COVID-19 and the magnitude of antibody response after infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in…
- Trial name
- MS COVID-19 (NCT04760990)
- Testing
- data collection, analysis of blood samples
- Where
- 7 sites in Switzerland
- Volunteers
- 1,181 people
- Sponsor
- University Hospital, Basel, Switzerland
Creutzfeldt-Jakob Disease (CJD) | Prion Disease
CLIME-CJD: A Multimodal Study
Creutzfeldt-Jakob disease (CJD) is a rare and rapidly progressive neurological disorder. This study aims to describe and summarize the key features of CJD by looking back at medical records of patients who were diagnosed with CJD…
- Trial name
- NCT07589283
- Testing
- No Interventions
- Where
- China
- Volunteers
- 150 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Poliovirus Vaccine, Inactivated, Poliomyelitis
Comparison of Immunity Following IPV Versus fIPV: a Community Based Randomized Controlled Trial in Pakistan
This study will be conducted in four low-income areas of Bin Qasim Town Karachi. This will be a community based randomized control trial of 21 months duration.
- Conditions
- Poliovirus Vaccine, Inactivated, Poliomyelitis, Immunization; Infection
- Trial name
- CODI (NCT03286803)
- Testing
- Inactivated Poliovirus vaccine
- Where
- Pakistan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Dementia
A Pilot Study of an RCT to Improve Infection Management in Advanced Dementia
To conduct a pilot study of cluster randomized clinical trial of an practice intervention to improve the quality of care for suspected lower respiratory and and urinary tract infections among 60 nursing home residents with…
- Trial name
- NCT01966523
- Testing
- Intervention, Control
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Hebrew SeniorLife
HIV Disease
Advanced Neuroimaging Evaluation of the Central Nervous System Biological Changes Associated With Efavirenz Therapy and Switch to an Elvitegravir-based Regimen
In this study we will use a multi-modal imaging approach of MRS and fMRI to comprehensively assess the biological changes in the brain associated with EFV-based regimen (EFV/FTC/TDF), specifically alterations in the brain…
- Trial name
- NCT01929759
- Testing
- Stribild (elvitegravir, cobicistat, emtricitabine and tenofovir)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Varicella, Measles
Immunogenicity and Safety Study of Proquad® and Infanrix® Hexa When Administered Concomitantly (V221-035)
Primary Objective: To demonstrate that ProQuad® can be administered concomitantly with a booster dose of Infanrix® hexa to healthy children 12 to 23 months of age without impairing either the antibody response rates to measles…
- Conditions
- Varicella, Measles, Mumps, Rubella
- Trial name
- NCT00432042
- Testing
- ProQuad®, Infanrix® hexa
- Where
- 50 sites in Germany, Italy
- Volunteers
- 955 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Diphtheria, Tetanus
Study of an Investigational Vaccine in Healthy Infants in Taiwan (V441-001)(COMPLETED)
The purpose of this study is to evaluate the safety, tolerability, and immune response of an investigational vaccine being evaluated to reduce the incidence of diphtheria, pertussis, tetanus, hepatitis B, poliomyelitis, and…
- Conditions
- Diphtheria, Tetanus, Pertussis, Hepatitis B
- Trial name
- NCT00092469
- Testing
- V441, diptheria, tetanus, acellular pertussis, inactivated poliomyelitis, hepatitis B (recombinant), & Haemophilus influenza type b conjugate vaccine
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
IPV
ID Administration of fIPV Using Intradermal Adapters vs. BCG Syringe
The investigators will assess the usability and immune response following fractional dose inactivated polio virus vaccine (fIPV) administration with two novel intradermal adapters (ID adapter by West Pharmaceutical services Inc.
- Trial name
- ID-ADAP (NCT02769923)
- Testing
- Westpharma ID adapter, Star ID syringe, BCG NS
- Volunteers
- 450 people
- Sponsor
- Aga Khan University
Poliomyelitis
Immunogenicity of Monovalent Type 2 Oral Poliovirus Vaccine
This is an open-label phase IV, randomized controlled trial of mOPV2 alone and mOPV2 along with IPV. This trial will assess the impact on type 2 immunogenicity by reducing the interval between mOPV2 doses.
- Trial name
- NCT02643368
- Testing
- mOPV2 at 6 and 7 weeks of age, mOPV2 at 6 and 8 weeks of age, mOPV2 at 6 and 10 weeks of age
- Where
- Bangladesh
- Volunteers
- 760 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
HTLV-I Infection
Raltegravir for HAM/TSP
Background: Human T-cell lymphotropic virus type 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an infection of the spinal cord.
- Trial name
- NCT01867320
- Testing
- Raltegravir
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epidemic Meningitis, Meningococcal Vaccines
Phase Ⅲ Trial of Group ACYW135 Meningococcal Conjugate Vaccine in Children Aged 2-6 Years
The goal of this clinical trial is to evaluate the immunogenicity and safety of an investigational group ACYW135 meningococcal conjugate vaccine in healthy children aged 2 to 6 years.
- Trial name
- NCT07505888
- Testing
- experimental vaccine, active comparator vaccine
- Where
- China
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Urinary Tract Infection, Spinal Cord Injury
Vitamin C for Prevention of Urinary Tract Infections in the Spinal Cord Injured
After spinal cord injury, patients have frequent urinary tract infections (UVI). Vitamin C is usually prescribed to prevent such infection, but the efficacy of the treatment is poorly documented.
- Trial name
- NCT00869427
- Testing
- vitamin C
- Volunteers
- 40 people
- Sponsor
- Sunnaas Rehabilitation Hospital
Urinary Retention, Neurogenic Bladder
Connected Catheter- Safety and Effectiveness Study
The Connected Catheter is a fully internal, urethral indwelling urinary prosthesis designed for improved bladder management in males with urinary retention disorders requiring catheterization.
- Conditions
- Urinary Retention, Neurogenic Bladder, Urologic Diseases
- Trial name
- NCT03843073
- Testing
- Connected Urinary Catheter
- Where
- 9 sites in United States
- Volunteers
- 9 people
- Sponsor
- Spinal Singularity
Poliomyelitis
Safety and Immunogenicity of 1 or 2 Doses of IPV in Latin American Infants Primed With Bivalent OPV Vaccine
This study is a Phase IV, open, randomized, multi-center, controlled vaccine trial conducted in healthy Latin American infants, utilizing one or two supplemental doses of IPV in children previously vaccinated with 3 doses of…
- Trial name
- NCT01831050
- Testing
- Bivalent Oral Polio Vaccine (bOPV), Trivalent Oral Polio Vaccine (tOPV), Monovalent Oral Polio Vaccine Type 2 (mOPV2)
- Where
- 4 sites in Colombia, Dominican Republic and 2 more
- Volunteers
- 1,420 people, healthy volunteers welcome
- Sponsor
- Fidec Corporation
Poliomyelitis
Immunogenicity of Inactivated and Live Polio Vaccines
This study is an open-label phase III randomized clinical trial that would compare immunogenicity after receiving one of five different combinations of polio vaccines.
- Trial name
- NCT01813604
- Testing
- Group A: Trivalent Oral Polio Vaccine, Group B: Bivalent Oral Polio Vaccine, Group C: Inactivated Polio Vaccine
- Where
- Bangladesh
- Volunteers
- 1,206 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Hemorrhage, Pneumonia
Oral Hygiene and Prophylactic Antibiotics to Prevent Intracerebral Hemorrhage Associated Pneumonia
Project Name: Randomized Controlled Clinical Study on oral hygiene and prophylactic antibiotics to prevent Intracerebral Hemorrhage associated pneumonia Research Objectives: To evaluate the effectiveness, safety and health…
- Trial name
- OCEAN (NCT07311343)
- Testing
- wether apply enhanced oral care combined with prophylactic antibiotics
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Myeloproliferative Disorders, Leukemia
12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone Marrow Disorder
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: This phase I trial is studying the side effects and best dose of…
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00004058
- Testing
- tetradecanoylphorbol acetate
- Where
- United States
- Sponsor
- University of Medicine and Dentistry of New Jersey
Brain Abscess
Circulating Cell-Free DNA for Brain Abscess Diagnosis: A Pilot Study
Brain abscess is a severe intracranial infection associated with significant morbidity and mortality. Standard management combines neurosurgical intervention, when feasible, with prolonged intravenous antibiotic therapy.
- Trial name
- METABCES-PoC (NCT07479225)
- Testing
- Plasma Microbial Cell-Free DNA Metagenomic Sequencing
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Grenoble
Gaucher Disease, Hepatitis C
Examining the Immune Response in Patients With Gaucher Disease and Hepatitis C
Study objectives: Investigate the anti-HCV response in patients with Gaucher disease(GD) Define the potential role of high levels of Glucocerebroside in the immune system Study hypothesis: High levels of Glucocerebroside can be…
- Trial name
- NCT01274208
- Where
- 2 sites in Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center