Clinical trials: COMBO Condition
Carcinoma, Non-Small Cell Lung
ZD6474(Vandetanib) + Alimta Combo Study
The main purpose of this trial is to look to see if adding ZD6474 (100 mg or 300mg tablets) to Alimta chemotherapy in patients with non-small cell lung cancer is safe and will help control their symptoms and disease better than…
- Conditions
- Carcinoma, Non-Small Cell Lung, Lung Cancer
- Trial name
- NCT00506051
- Testing
- ZD6474 (vandetanib) 100mg, pemetrexed, ZD6474 (vandetanib) 300mg
- Volunteers
- 21 people
- Sponsor
- Genzyme, a Sanofi Company
Metastatic Breast Cancer
Intensive Combo Chemo With Autologous BM Rescue for Metastatic Breast Cancer
To determine the therapeutic efficacy of high-dose cyclophosphamide and BCNU with autologous bone marrow transplantation after initial tumor cytoreduction for patients with receptor-negative metastatic breast carcinoma and to…
- Trial name
- NCT00584766
- Testing
- High-dose chemotherapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Oklahoma
Type 2 Diabetes Mellitus
A Trial to Investigate the Dose-linearity of BioChaperone® Combo 75/25 and the Safety at Three Different Doses in Subjects With Type 2 Diabetes
This is a bicentric, double-blinded, randomised, four-period crossover phase 1 trial, using automated 30-hour euglycemic clamp in subjects with type 2 diabetes mellitus.
- Trial name
- NCT03180710
- Testing
- BioChaperone® Combo 75/25 at 0.6 U/kg, BioChaperone® Combo 75/25 at 0.8 U/kg, BioChaperone® Combo 75/25 at 1.0 U/kg
- Where
- 2 sites in Germany
- Volunteers
- 32 people
- Sponsor
- Adocia
Coronary Artery Disease
Sort Out XI - Combo Stent Versus BioMatrix Alpha Stent
SORT OUT XI Comparison of Combo™ stent and BioMatrix Alpha™ stent in the treatment of unselected patients with ischemic heart disease.
- Trial name
- SORTOUTXI (NCT03952273)
- Testing
- PCI with BioMatrix Alpha™ stent, PCI with Combo™ stent
- Where
- 2 sites in Denmark
- Volunteers
- 3,141 people
- Sponsor
- Phillip Freeman
Melanoma
Ipilimumab and Nivolumab Followed by Adjuvant Nivolumab in Locally Advanced or Limited Metastatic Melanoma
This is open label, single arm study for pts with stage IIIB-IV melanoma, accordingly with AJCC staging criteria (8th ed.), with potentially resectable disease.
- Trial name
- NCT06566391
- Testing
- Ipilimumab
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- European Institute of Oncology
Melanoma
Ph I Ipilimumab Vemurafenib Combo in Patients With v-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF)
Treatment of subjects who have metastatic melanoma that expresses an activated mutant form of the BRAF oncogene (V600E) with a combination of the specific BRAF inhibitor, Vemurafenib, and the Cytotoxic T Lymphocyte Antigen 4…
- Trial name
- NCT01400451
- Testing
- Ipilimumab (BMS-734016), Vemurafenib
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Bristol-Myers Squibb
Leukemia
Phase 2 Dasatinib Combo With Smoothened (SMO) Antagonist (BMS-833923)
The purpose of the study is to compare response rates in newly diagnosed Chronic Phase (CP) CML subjects treated with dasatinib plus BMS-833923 versus dasatinib alone.
- Trial name
- NCT01357655
- Testing
- Dasatinib, BMS-833923
- Where
- 24 sites in United States, Argentina and 6 more
- Volunteers
- 70 people
- Sponsor
- Bristol-Myers Squibb
Type 2 Diabetes Mellitus
A Trial to Compare Post Prandial Blood Glucose Control of BioChaperone® Combo With Humalog® Mix25 and With Simultaneous Injections of Humalog® and Lantus® in Subjects With Type 2 Diabetes
This is a two-centre, randomised, double-blind, double-dummy, 3-treatment, 3-period cross-over study using a standardised solid meal test in subjects with type 2 diabetes to investigate postprandial glucose control of…
- Trial name
- NCT02915250
- Testing
- BioChaperone® Combo, Humalog® Mix25, Humalog®
- Where
- 2 sites in Germany
- Volunteers
- 36 people
- Sponsor
- Adocia
Type 2 Diabetes
An 18 Week Efficacy and Safety Study of Saxagliptin and Metformin XR Combination in Subjects With Type 2 Diabetes
The purpose of this study is to compare reduction in A1C for subjects taking Saxagliptin and Metformin XR vs. uptitrated Metformin XR.
- Trial name
- SCORE (NCT00960076)
- Testing
- Saxagliptin, Metformin XR
- Where
- 35 sites in United States, Colombia and 3 more
- Volunteers
- 282 people
- Sponsor
- AstraZeneca
Coronary Artery Disease
PREPARE-CALC-COMBO: Severely Calcified Coronary Lesions Prepared With Rotational Atherectomy and Modified Balloons
A prospective single-arm trial of rotational atherectomy in combination with cutting balloon in severely calcified coronary lesions.
- Trial name
- NCT04014595
- Testing
- Rotational atherectomy in combination with cutting balloon
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Segeberger Kliniken GmbH
Ovarian Cancer, Peritoneal Cancer
PH I SRC Kinase, Dasatinib Combo Paclitaxel & Carboplatin in Pts w Ovarian, Peritoneal, & Tubal Cancer
Primary objective to determine the maximal tolerated (MTD) of dasatinib in combination with paclitaxel and carboplatin during the first cycle of treatment.
- Conditions
- Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
- Trial name
- NCT00672295
- Testing
- Dasatinib, Paclitaxel, and Carboplatin
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- AA Secord
Visceral Leishmaniasis
Phase III, Study of Three Short Course Combo (Ambisome®, Miltefosine, Paromomycin) Compared With AmBisome for the Treatment of VL in Bangladesh
This protocol will evaluate the efficacy and safety of various combinations of the three drugs; AmBisome, Paromomycin and Miltefosine at reduced total dosage against the standard treatment with a total dose of 15mg/kg of AmBisome.
- Trial name
- NCT01122771
- Testing
- Liposomal amphotericin B, liposomal amphotericin B + miltefosine, liposomal amphotericin B + paromomycin
- Where
- 4 sites in Bangladesh
- Volunteers
- 602 people
- Sponsor
- Drugs for Neglected Diseases
Open-Angle Glaucoma
A Study of the iStent in Combo With Cataract Surgery in Newly Diagnosed Open Angle Glaucoma or OH Patients.
The purpose of this study is to evaluate the safety and efficacy of the iStent trabecular micro-bypass stent in reducing intraocular pressure (IOP) in subjects with newly diagnosed open-angle glaucoma and subjects diagnosed with…
- Trial name
- NCT00326066
- Testing
- Glaucoma Surgery, cataract surgery only
- Where
- 9 sites in Austria, Germany and 3 more
- Volunteers
- 47 people
- Sponsor
- Glaukos Corporation
Non Small Cell Lung Cancer
Study of Autologous Tumor Infiltrating Lymphocytes (LN-145) In Combo With Durvalumab in Non-Small Cell Lung Cancer
This study is a Phase 2, open-label, multicenter study evaluating adoptive cell therapy (ACT) with autologous TIL therapy (LN-145) in combination with Anti-PD-L1 inhibitor durvalumab.
- Trial name
- NCT03419559
- Testing
- LN-145, Durvalumab
- Where
- 8 sites in United States
- Sponsor
- Iovance Biotherapeutics, Inc.
Human Immunodeficiency Viruses
Evaluation of Diagnostic HIV Ag/Ab Combo Assay
To test blood specimens using a new investigational test that detects antigen and antibody to human immunodeficiency virus (HIV).
- Trial name
- NCT00933933
- Testing
- ARCHITECT HIV Ag/Ab Combo
- Where
- 13 sites in United States
- Volunteers
- 635 people, healthy volunteers welcome
- Sponsor
- Abbott Diagnostics Division
Multiple Myeloma
SWOG-9321 Melphalan, TBI, and Transplant vs Combo Chemo in Untreated Myeloma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells.
- Trial name
- NCT00002548
- Testing
- recombinant interferon alfa, carmustine, cyclophosphamide
- Where
- 34 sites in United States
- Volunteers
- 899 people
- Sponsor
- SWOG Cancer Research Network
Coronary Arteriosclerosis
Safety and Efficacy of the Combo Bio-engineered Sirolimus-eluting Stent Versus the Nano Polymer-free Sirolimus-eluting Stent in the Treatment of Patients With de Novo Stenotic Lesions
To evaluate the safety, efficacy and deliverability of the Combo bio-engineered sirolimus-eluting stent versus the Nano polymer-free sirolimus- eluting stents in the treatment of patients with de novo stenotic lesions of native…
- Trial name
- RECOVERY (NCT02542007)
- Testing
- OrbusNeich Combo stent™, sirolimus-eluting stent system
- Where
- 15 sites in China
- Volunteers
- 440 people
- Sponsor
- OrbusNeich
Chlamydia Trachomatis, Gonorrhea
Clinical Evaluation of the Aptima® Combo 2® Assay Using the Panther® System in Female Urine Samples
The objective of this study is to evaluate the performance characteristics of the AC2 assay on the Panther system using female urine specimens.
- Trial name
- NCT02795975
- Where
- 18 sites in United States
- Volunteers
- 1,766 people, healthy volunteers welcome
- Sponsor
- Hologic, Inc.
Type 1 Diabetes
Accu-Chek Combo in Young Patients
This is an open, prospective, descriptive study aiming to evaluate the change in treatment satisfaction of primary care givers of young children who use the Accu-Chek Combo System.
- Trial name
- NCT01657630
- Testing
- Accu-Chek Combo System
- Where
- Israel
- Volunteers
- 13 people
- Sponsor
- Rabin Medical Center
Asthma
Efficacy Study of the Product "CHF 1535" Versus Beclomethasone (BDP) and Free Combo in Asthmatic Children
The purpose of this study is to demonstrate that CHF 1535 in pressurized metered dose inhaler (pMDI) is non-inferior to the corresponding dose of free combination of Beclomethasone (BDP) and Formoterol Fumarate (FF) and superior…
- Trial name
- PAED2/FRESH (NCT01475032)
- Testing
- CHF 1535, Beclomethasone (BDP), Beclomethasone (BDP) + Formoterol Fumarate (FF)
- Where
- 11 sites in Bulgaria, France and 9 more
- Volunteers
- 638 people
- Sponsor
- Chiesi Farmaceutici S.p.A.