Clinical trials: CONTROL Condition
Hyperlipidemia
LAPLACE-TIMI 57: Low-density Lipoprotein Cholesterol (LDL-C) Assessment With PCSK9 monoclonaL Antibody Inhibition Combined With Statin thErapy
To evaluate the effect of 12 weeks of subcutaneous (SC) evolocumab (AMG 145) administered every 2 weeks (Q2W) or every 4 weeks (Q4W), compared with placebo, on percent change from baseline in LDL-C when used in addition to a…
- Trial name
- LAPLACE (NCT01380730)
- Testing
- Evolocumab
- Where
- 100 sites in United States, Canada and 3 more
- Volunteers
- 631 people
- Sponsor
- Amgen
Rheumatoid Arthritis
Study to Evaluate Safety and Efficacy of CCX 354-C in Subjects With Rheumatoid Arthritis
The purpose of this study is to evaluate the safety and tolerability of multiple oral doses of CCX354-C at a number of dose levels in subjects with stable rheumatoid arthritis (RA).
- Trial name
- CARAT-1 (NCT01027728)
- Testing
- CCX 354-C
- Where
- 5 sites in Belgium, Romania
- Volunteers
- 24 people
- Sponsor
- Amgen
Gestational Diabetes
The Effects of Resistance Exercises in Glycemic Control of Women With Gestational Diabetes
The object of this study is to evaluate patients with a diagnosis of GD who are included in a program of RE carried out with rubber tubes, comparing the frequency of women who will use insulin in the group who will participate in…
- Trial name
- NCT00815828
- Testing
- Resistance exercises
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- University of Sao Paulo
Hepatocellular Carcinoma
Toripalimab or Placebo as Adjuvant Therapy in Hepatocellular Carcinoma After Radical Resection
This study will investigate if Toripalimab (A PD-1 Inhibitor) will improve recurrence-free survival (RFS) compared to placebo in participants with HCC and are at high risk of recurrence after complete resection with no residual…
- Trial name
- JUPITER 04 (NCT03859128)
- Testing
- TORIPALIMAB INJECTION(JS001 )
- Where
- China
- Volunteers
- 427 people
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Cardiovascular Disease
The Fibrin Pad CV Phase III Study
The objective of this study is to evaluate the safety and effectiveness of the EVARREST™ Fibrin Sealant Patch as an adjunct to hemostasis during cardiovascular surgery.
- Trial name
- NCT02040428
- Testing
- EVARREST™ Fibrin Sealant Patch, Topical hemostat
- Where
- 24 sites in United States, Australia and 3 more
- Volunteers
- 156 people
- Sponsor
- Ethicon, Inc.
Pemphigus
A Study of PRN1008 in Patients With Pemphigus
This was a Phase 3 randomized, parallel-group, double-blind, placebo-controlled trial (blinded treatment [BT] period) followed by an open-label extension [OLE] period intended to evaluate the efficacy and safety of oral PRN1008…
- Trial name
- NCT03762265
- Testing
- Rilzabrutinib
- Where
- 88 sites in United States, Argentina and 17 more
- Volunteers
- 131 people
- Sponsor
- Principia Biopharma, a Sanofi Company
Postoperative Pain
Thoracic Paravertebral Block Versus Rhomboid Block for Postoperative Pain Control in Thoracic Surgeries
The main aim of this study is to compare thoracic paravertebral block and rhomboid block for postoperative analgesia and analgesic usage in thoracic surgeries.
- Trial name
- NCT05061667
- Testing
- Thoracic Paravertebral Block, Rhomboid Block
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Koç University
Nicotine Dependence, Substance Use Disorders
Healthy People Initiative (HPI)
Addictions do not occur in isolation. Tackling addictions requires addressing social determinants such as isolation, homelessness, marginalization, and unemployment.
- Trial name
- HPI (NCT03506867)
- Testing
- Life skills, training, education and work/volunteer opportunities, Usual Care
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Cholesterol, Hypercholesterolaemia
Efficacy of Lactobacillus Mucosae DPC6426 on Blood-lipids
Cardiovascular disease (CVD) is the leading cause of death and morbidity in the EU. Among the recommendations to avoid heart disease is the maintenance of normal blood cholesterol levels, by ingesting a cardioprotective diet and…
- Trial name
- NCT07519967
- Testing
- Lactobacillus mucosae DPC6426
- Where
- Ireland
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University College Cork
Schizophrenia
Study Evaluating the Efficacy and Safety of WID-RGC20(Cariprazine) in Patients With Schizophrenia
This Study is a Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center, Fixed-Dose, Phase 3 Clinical Trial Evaluating the Efficacy and Safety of WID-RGC20 3 mg/day and 6 mg/day in Patients with Acute Psychotic…
- Trial name
- NCT05168007
- Testing
- WID-RGC20(Cariprazine) 3mg/day, WID-RGC20(Cariprazine) 6mg/day
- Where
- South Korea
- Volunteers
- 342 people
- Sponsor
- Whanin Pharmaceutical Company
Overweight and Obesity
PRALIMAP-CINeCO: Comparison of Health E-coaching Versus Referral to the Usual Care System
This study involves young adults from the PRALIMAP-INES trial and student volunteers from the University of Lorraine, who are overweight or obese.
- Trial name
- PRALIMAPCINeCO (NCT05399407)
- Testing
- Health e-coaching
- Where
- France
- Volunteers
- 384 people
- Sponsor
- Central Hospital, Nancy, France
Interstitial Cystitis, Bladder Pain Syndrome
A Phase 2 Study of IW-3300 for the Treatment of Bladder Pain in Subjects With Interstitial Cystitis/Bladder Pain Syndrome
The aim of this study is to assess whether IW-3300 is safe and works for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS).
- Trial name
- NCT05740007
- Testing
- IW-3300 rectal foam
- Where
- 53 sites in United States
- Volunteers
- 98 people
- Sponsor
- Ironwood Pharmaceuticals, Inc.
Cholecystitis/Cholelithiasis
Effects of Intravenous Ibuprofen on Acute Pain After Laparoscopic Cholecystectomy
This clinical trial is a medical intervention study to evaluate the necessity and effectiveness of intravenous ibupropan for postoperative acute pain relief after laparoscopic cholecystectomy in benign gallbladder disease.
- Trial name
- NCT05676892
- Testing
- Laparoscopic cholecystectomy
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- Seoul St. Mary's Hospital
Periodontal Diseases
Effect of Intracanal Medicaments on Post-Operative Pain in Symptomatic Apical Periodontitis: An RCT
Comparison of different intracanal medicaments during root canal treatment to assess their effect on post-operative pain in teeth with Symptomatic Apical Periodontitis
- Trial name
- NCT07123792
- Testing
- Calcium Hydroxide (20%), Chlorhexidine Gel (2%), Modified Triple Antibiotic Paste
- Where
- Pakistan
- Volunteers
- 480 people
- Sponsor
- HITEC-Institute of Medical Sciences
Severe Aortic Stenosis, TAVI\(Transcatheter Aortic Valve Implantation\)
VARC-TAVI VALVE IMPLANTATION)
SUMMARY: The investigators are planning a clinical study to compare two methods of performing a procedure called TAVI, used in patients with severe aortic stenosis.
- Conditions
- Severe Aortic Stenosis, TAVI\(Transcatheter Aortic Valve Implantation\), Vascular Complications
- Trial name
- VARC-TAVI (NCT06177392)
- Testing
- Secondary TAVI access
- Volunteers
- 600 people
- Sponsor
- Hospital Universitario La Paz
Systemic Scleroderma
Sildenafil Effect on Digital Ulcer Healing in sClerodErma SEDUCE STUDY
Digital ulcers (DUs) are an expression of the microangiopathy in patients with scleroderma (SSc). DUs lead to pain and impaired hand use. DUs remain a severe complication for many patients and effective therapy remains elusive.
- Trial name
- SEDUCE (NCT01295736)
- Testing
- Sildenafil
- Where
- 24 sites in France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Lille
Hypertension
Effectiveness of SMS Text Reminders to Improve Blood Pressure Among Patients With Hypertension
Objective: To test the primary hypothesis that SMS text messages delivered to patients via mobile phone can improve blood pressure within 12 weeks compared to usual care Design: Parallel group, randomized, controlled trial; the…
- Trial name
- NCT01255436
- Testing
- SMS text reminders, Usual Care
- Where
- Philippines
- Volunteers
- 700 people
- Sponsor
- University of the Philippines
Worsening Chronic Heart Failure, Chronic Kidney Disease
A Study to Learn How BAY94-8862 Moves Into, Through and Out of the Body, How Safe it is and How it Affects the Body in Adult Participants With Reduced Kidney Function and in Healthy Participants With Similar Age, Weight and Gender Distribution
Researchers are looking for a better way to treat people who have worsening of chronic heart failure, a long-term condition where the heart does not pump blood as well as it should.
- Trial name
- NCT04908436
- Testing
- Finerenone (BAY94-8862)
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bayer
Aneurysmal Subarachnoid Hemorrhage
Early Hydrogen-Oxygen Gas Mixture Inhalation in Patients With Aneurysmal Subarachnoid Hemorrhage (HOMA)
This was a randomized, single-center trial. On the basis of standard-of-care, patients in the treatment group inhaled H2-O2 (66% hydrogen; 33% oxygen) at 3 L/min via nasal cannula by using the Hydrogen/Oxygen Generator (model…
- Trial name
- HOMA (NCT05282836)
- Testing
- Hydrogen Oxygen Generator with Nebulizer
- Volunteers
- 206 people
- Sponsor
- Beijing Tiantan Hospital
Drug-Induced Liver Injury, Cholestatic Liver Injury
A Randomized,Double-blind, Placebo Controlled, Multicenter Study to Evaluate the Safety and Efficacy of MT2004 Capsule in DILI Subjects
The goal of this randomized, double-blind, placebo controlled, Multicenter Phase II clinical trial is to initially evaluate the Safety and Efficacy of MT2004 Capsule in Cholestatic and Mixed drug induced liver injury (DILI)…
- Conditions
- Drug-Induced Liver Injury, Cholestatic Liver Injury, Mixed Liver Injury
- Trial name
- NCT06019936
- Testing
- MT2004 Capsule
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xi'An Aolitai Pharmaceutical Technology Co Ltd
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