Clinical trials: COPD (Chronic Obstructive Pulmonary Disease)
Subject Presenting Wheeze, COPD
Wheeze Detection Using Aevice Medical Device
The primary objective of this study is to determine if Aevice Medical Device can detect wheeze as accurately as a physician through auscultation.
- Conditions
- Subject Presenting Wheeze, COPD, Asthma
- Trial name
- NCT05194436
- Testing
- AeviceMD
- Where
- Singapore
- Volunteers
- 35 people
- Sponsor
- Aevice Health Pte. Ltd.
Seriously Ill Patients, Cancer
Goals of Care Conversations Study
The long term goal is to improve quality of care in Veterans with serious illnesses by aligning medical care with Veterans' goals and values.
- Conditions
- Seriously Ill Patients, Cancer, Heart Failure, Interstitial Lung Disease
- Trial name
- LSTDI (NCT05001009)
- Testing
- Clinician Implementation Strategy Stage 1: low intensity clinician training, Clinician Implementation Strategy Stage 2: high intensity clinician training, Low patient engagement
- Where
- 3 sites in United States
- Volunteers
- 2,859 people
- Sponsor
- VA Office of Research and Development
Chronic Obstructive Pulmonary Disease
Trial of Vitamin D Supplementation in Chronic Obstructive Pulmonary Disease
The study null hypothesis is that vitamin D supplementation will not influence time to upper respiratory tract infection or time to moderate/severe exacerbation of chronic obstructive pulmonary disease.
- Trial name
- ViDiCO (NCT00977873)
- Testing
- Cholecalciferol, Miglyol oil
- Where
- 4 sites in United Kingdom
- Volunteers
- 240 people
- Sponsor
- Barts & The London NHS Trust
COPD
Novel Predictors of Premature Aging in COPD Patients
•Examine whether COPD is associated with accelerated aging using a biological marker of aging and dermatological score
- Trial name
- NCT06019286
- Testing
- SCINEXA score
- Volunteers
- 100 people
- Sponsor
- Assiut University
COPD
THE FACTORS AFFECTING THE ADHERENCE TO THE PULMONARY REHABILITATION PROGRAM IN COPD
Investigators will compare the factors affecting the adherence to the outpatient pulmonary rehabilitation program in COPD patients
- Trial name
- NCT03252873
- Volunteers
- 359 people
- Sponsor
- Izmir Katip Celebi University
Chronic Obstructive Pulmonary Disease
Phenotypes and Vascular Damage in Chronic Obstructive Pulmonary Disease (COPD)
TOPDOCS is a prospective cohort study including COPD patients from currently six study centers in Switzerland. Patients with COPD GOLD stages I-IV will be enrolled and followed-up annually for at least 3 years.
- Trial name
- TOPDOCS (NCT01527773)
- Where
- Switzerland
- Volunteers
- 313 people
- Sponsor
- University of Zurich
COPD, Acute Exacerbation of COPD
Evaluating Customized Antibiotic Duration (CDA) Strategy in Acute Exacerbations of COPD
The goal of this clinical trial is to learn whether a shorter course of antibiotics (7 days) works as well as the usual longer course (14 days) for adults admitted to hospital with a flare-up of chronic obstructive pulmonary…
- Trial name
- CDA (NCT07708337)
- Testing
- 7-day antibiotic course, 14-day antibiotic course
- Where
- Pakistan
- Volunteers
- 560 people
- Sponsor
- Capital Development Authority (CDA)
Chronic Obstructive Pulmonary Disease
Chronic Beta-blockade and Cardiopulmonary Exercise in COPD
What are the differential effects of beta-blockers on lung and heart function during exercise in chronic obstructive pulmonary disease (COPD)? COPD is a major cause of illness and death.
- Trial name
- CPET1 (NCT02380053)
- Testing
- Bisoprolol, Celiprolol
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Dundee
COPD
Efficacy and Safety Study of Acetylcysteine/Doxofylline 1200/400 mg Effervescent Tablet in the Treatment of Moderate-Severe COPD.
The objective is to assess efficacy and safety of Acetylcysteine/Doxofylline 1200/400 mg Effervescent Tablet once daily treatment besides standard/usual treatment, as compared with placebo once daily in patients with stable…
- Trial name
- NCT03388853
- Testing
- Acetylcysteine/Doxofylline
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Neutec Ar-Ge San ve Tic A.Ş
Copd, Fatigue
L-carnitine for Fatigue in COPD
supplementation with L-carnitine that is available both as an FDA-approved therapy for primary carnitine deficiency, as well as widely available as an over-the-counter ergogenic aid will improve wellbeing and function measured by…
- Trial name
- LC4COPD (NCT03008356)
- Testing
- L-carnitine 1000 mg twice daily, Weekly health coaching calls
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Mayo Clinic
COPD, Asthma
AirSonea Wheeze Detection Study
The purpose of this study is to determine if the AirSonea device provides an objective assessment of breath sounds for the presence of wheeze in both medical and home environments.
- Trial name
- NCT01927172
- Testing
- AirSonea
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- iSonea
Asthma Acute, COPD Exacerbation Acute
Rademikibart IV for Acute Asthma and COPD Exacerbation
A Phase 2, open-label, single-arm trial to evaluate IV rademikibart as an add-on treatment for acute exacerbation in participants with asthma or COPD with type 2 inflammation
- Trial name
- NCT07705737
- Testing
- Rademikibart
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Connect Biopharm LLC
Chronic Obstructive Pulmonary Disease (COPD)
Examining Pulmonary Rehabilitation on Discharged COPD Patients
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease primarily caused by smoking. COPD creates a tremendous burden to the healthcare system, as disease exacerbations result in frequent, prolonged…
- Trial name
- NCT02426437
- Testing
- Pulmonary Rehabilitation (PR), Usual Care
- Where
- Canada
- Volunteers
- 87 people
- Sponsor
- University of Alberta
COPD
Portable Oxygen Concentrator Improvements to Physical Activity, Oxygen Usage, and Quality of Life in Chronic Obstructive Pulmonary Disease Patients Using Long-term Oxygen Therapy (POC-STEP)
To evaluate changes in activity based on the use of portable oxygen concentrators combined with standard of care (SOC) long- term oxygen therapy versus SOC long-term oxygen therapy alone at 12 weeks in patients with COPD who…
- Trial name
- POC-STEP (NCT03513068)
- Testing
- Portable Oxygen Concentrator (POC)
- Where
- 11 sites in United States
- Volunteers
- 108 people
- Sponsor
- ResMed
Pulmonary Disease, Chronic Obstructive, E-cigarettes
Ventilation and Pulmonary Endothelium Toxicities of E-cigarettes: A Randomized Crossover Pilot Study
Determination of the acute pulmonary toxicities of e-cigarettes in young adults is of major public health importance, as e-cigarette vapor contains established toxicants that as hypothesized cause acute damage to the airways and…
- Trial name
- VaPE-Tox (NCT02783768)
- Testing
- E-cigarette, Hyperpolarized 3-Helium, Gadolinium
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Columbia University
COPD
Bronchodilators and Lung Mechanics During Exercise in COPD
Bronchodilators are medications that open the bronchi to help patients with COPD to breathe better. It is still not known exactly how this effect improves shortness of breath in people with COPD.
- Trial name
- SOUND (NCT06825013)
- Testing
- Bronchodilators inhalation
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Dr. J. Alberto Neder
Chronic Obstructive Pulmonary Disease
Expression of SLC25A48 in Chronic Obstructive Pulmonary Disease
This study aims to investigate the expression level of SLC25A48, a mitochondrial choline transporter, in peripheral blood mononuclear cells of patients with chronic obstructive pulmonary disease, and to analyze its correlation…
- Trial name
- NCT07474220
- Where
- 2 sites in Taiwan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fu Jen Catholic University
Chronic Obstructive Pulmonary Disease Exacerbation, Magnesium Sulfate
Acute Exacerbation of COPD and Nebulized Magnesium Sulphate
This study is designed to determine the effect of Nebulized Magnesium Sulphate as an add-on therapy with conventional treatment on In-hospital outcome in patients having acute exacerbation of COPD.
- Trial name
- NCT05699720
- Testing
- Nebulized Magnesium Sulphate
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- King Edward Medical University
Pulmonary Disease, Chronic Obstructive
The Nasal Airway in Chronic Obstructive Pulmonary Disease
The study is based on the theory of a "unified airway" that considers the nose and paranasal sinuses together with lower airways as one integrated unit.
- Trial name
- COPD (NCT02826954)
- Testing
- Upper airway assessment, including nasal biopsy
- Where
- Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Chronic Obstructive Pulmonary Disease, Emphysema
Lung Volume Reduction Coil Microbiome Study
Studying the microbiome of the lung in patients treated with endobronchial lung volume reduction coils for emphysema
- Trial name
- LVRC-Micro (NCT03010566)
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
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