Clinical trials: COPD (Chronic Obstructive Pulmonary Disease)
COPD Exacerbation
Exacerbantes Study
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is understood as a complex and heterogeneous syndrome, which requires an increasingly personalized approach.
- Trial name
- NCT06147206
- Volunteers
- 400 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
COPD (Chronic Obstructive Pulmonary Disease), Caregiver
Validation of the French Version of the QASCI in Caregivers of Patients With COPD
This study aims to validate the French version of the QASCI questionnaire, initially written and validated in Portuguese language by Hipolito et al., to assess caregiving burden in chronic obstructive pulmonary disease (COPD).
- Trial name
- VALQASCI (NCT06652204)
- Testing
- questionnaire
- Where
- 2 sites in France
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Chronic Obstructive Pulmonary Disease
Effect of Extremity Exercise in COPD
Objective: is to find out the effect of unsupported upper extremity exercise versus lower extremity exercise on dyspnea and lung function Methodology: Sample and design: 60 patients with Randomized study design will be included…
- Trial name
- NCT04076085
- Testing
- exercise
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- King Khalid University
COPD, ILD
Recognition of Early Pulmonary Structural Changes by Using Real-time High Fidelity Expiratory CO2 Analysis
In this study the investigators aim to detect and characterize structural airway and lung vessel changes due to COPD or ILD as assessed by real-time high fidelity expiratory CO2 analysis.
- Trial name
- NCT05092035
- Testing
- single high-fidelity expiratory CO2 analysis
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Emphysema
Assessment of Emphysema Using 1.5T MRI With UTE Pulse Sequences
Emphysema is a major pathological feature of Chronic Obstructive Pulmonary Disease (COPD). Non-invasive assessment of emphysema is a crucial issue for the phenotype and follow-up of COPD patients.
- Trial name
- EMPHYREM (NCT02100800)
- Testing
- MR and CT measurements of emphysema quantification
- Where
- France
- Volunteers
- 33 people
- Sponsor
- University Hospital, Bordeaux
Pulmonary Disease, Chronic Obstructive, Hypercapnia
Sleep and Daytime Use of Humidified Nasal High-flow Oxygen in COPD Outpatients
Humidified Nasal High-flow with Oxygen (HNHF-O2) therapy has been reported to have acute beneficial effects in patients with hypoxemic respiratory failure who have been hospitalized.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Hypercapnia, Hypoxia
- Trial name
- NCT03221387
- Testing
- Humidified nasal high flow with oxygen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Temple University
COPD, EBV
Epstein-Barr Virus Suppression in Chronic Obstructive Pulmonary Disease (EViSCO): a Phase 2 Randomised Control Trial
COPD is a major public health problem and will shortly become the third most common cause of global mortality. There are currently no treatments that can meaningfully alter the progression of COPD or the time to death.
- Trial name
- EViSCO (NCT03699904)
- Testing
- Valaciclovir
- Where
- United Kingdom
- Volunteers
- 85 people
- Sponsor
- Belfast Health and Social Care Trust
Chronic Obstructive Pulmonary Disease, Adherence, Treatment
Role of Inhaler Adherence and Blood Eosinophil Count in Exacerbations of COPD
This is an observational study examining inhaler adherence and subsequent changes in blood eosinophil count in exacerbations of Chronic obstructive pulmonary disease (COPD) population.
- Trial name
- INCLINE (NCT05814484)
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- University of Leicester
COPD
Sustainability of Pulmonary Rehab Gains
People with moderate to severe COPD trap air in their lungs. This lessens their ability to exercise. The investigators developed a computerized breathing retraining program to help patients empty their lungs during exercise.
- Trial name
- NCT02241733
- Testing
- Breathing retraining plus exercise, Exercise only
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Emphysema
Evaluation of the Spiration® Valve System for Emphysema to Improve Lung Function
EMPROVE is a multicenter, prospective, randomized, controlled study designed to evaluate the safety and long-term effectiveness of the Spiration Valve System in patients with emphysema.
- Trial name
- EMPROVE (NCT01812447)
- Testing
- Spiration Valve System, Medical Management
- Where
- 34 sites in United States, Canada
- Volunteers
- 172 people
- Sponsor
- Olympus Corporation of the Americas
Chronic Obstructive Pulmonary Disease
Study on Single and Multiple Atomization Inhalation of HRS-9821 Suspension for Inhalation in Healthy Subjects and COPD Patients
The increased safety and tolerance of single and multiple atomized inhalation of HRS-9821 suspension for inhalation doses in healthy subjects and COPD patients.
- Trial name
- NCT05622864
- Testing
- HRS-9821
- Where
- China
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
Severe Chronic Obstructive Pulmonary Disease
Breathing Control Exercises in Patients With Chronic Obstructive Pulmonary Disease.
The purpose of this study is to test whether breathing control exercises embedded in occupational therapy sessions have an impact on quality of life and dyspnea in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT05199987
- Testing
- Standard Occupational Therapy, Occupational Therapy with Breathing Control Exercises
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
COPD
Diagnostic and Therapeutic Approaches to Hyperinflation and Small Airway Disease in COPD
Current guideline-based criteria defining COPD do not meet the challenges set by the complex pathophysiology of the disease. Hyperinflation and affection of the small airways are two components that are not represented in current…
- Trial name
- NCT03287921
- Testing
- mono bronchodilatation, dual bronchodilatation
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Universitätsmedizin Mannheim
Pulmonary Disease, Chronic Obstructive
Study Evaluating the 24-Hour Pulmonary Function Profile of Fluticasone Furoate (FF) /GW642444 (Vilanterol) (VI) Inhalation Powder 100/25mcg Once Daily Compared With Fluticasone Propionate/Salmeterol Inhalation Powder 250/50mcg Twice Daily in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to evaluate the 24-hour spirometry effect (FEV1) of FF/VI 100/25mcg once daily compared with Fluticasone Propionate/Salmeterol 250/50mcg twice daily over a 12-week treatment period in subjects with…
- Trial name
- NCT01323621
- Testing
- Fluticasone Furoate 100mcg/ GW642444 (vilanterol) 25mcg, Fluticasone Propionate 250mcg / salmeterol 50mcg, Salbutamol as needed
- Where
- 51 sites in United States, Germany and 4 more
- Volunteers
- 512 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease With Acute Exacerbation, Unspecified
Comparison of Two Oxygen Setting During Non-invasive Mechanical Ventilation of Chronic Obstructive Pulmonary Disease
Hypoxaemic patients with exacerbations of chronic obstructive pulmonary disease (COPD) are at some risk of carbon dioxide (CO2) retention during oxygen therapy.
- Trial name
- OXYSET (NCT02563314)
- Testing
- Non-invasive mechanical ventilation - Normoxia, Non-invasive mechanical ventilation - Controlled hypoxemia
- Where
- 4 sites in France
- Volunteers
- 1 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Chronic Obstructive Lung Disease (n=10), Interstitial Lung Disease (n=10)
Cardiorespiratory Response During Whole Body Vibration Training in Patients With Chronic Lung Disease
Whole body vibration training seems to be a useful adjunct in exercise training in patients with severe COPD. The basic principle relies on reflectory muscle contractions caused by a vibration stimulus.
- Trial name
- NCT01898143
- Testing
- Whole body vibration
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Schön Klinik Berchtesgadener Land
COPD
Pursed Lip Breathing With Arm Ergometry After Chin Supported Position in COPD Patients.
Randomized control Trial, Purposive sampling was used to obtain the sample for the study and then randomly allocated into groups by coin toss method.
- Trial name
- NCT04357743
- Testing
- Chin supported Arm ergometry with pursed lip breathing, Arm ergometry with pursed lip breathing
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- Riphah International University
High-Flow Nasal Cannula, COPD
Effect of Postextubation High-Flow Nasal Cannula vs Noninvasive Ventilation in Patients With Hypercapnic COPD
To test if high-flow conditioned oxygen therapy is noninferior to NIV for preventing postextubation respiratory failure and reintubation in patients with hypercapnic COPD, investigators plan to conduct the participants level, 1:1…
- Trial name
- COPD (NCT03928535)
- Testing
- High-FlowNasal Cannula, Noninvasive Ventilation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xiangya Hospital of Central South University
Chronic Obstructive Pulmonary Disease
Residential Cleaning of Indoor Air to Protect COPD Patients
This study looks at whether air cleaning devices put in the bedroom and living room of your home could reduce the irritation of your lungs and body that is caused by indoor air pollution.
- Trial name
- CARE (NCT03750292)
- Testing
- HEPAirX air filter, control air filter
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Rochester
Chronic Obstructive Pulmonary Disease (COPD), Asthma (Diagnosis)
Construction and Validation of an Impulse Oscillometry (IOS)-Based Platform for Screening, Diagnosis, and Management of Chronic Airway Diseases
This is a multicenter, observational study aiming to construct and validate an Impulse Oscillometry (IOS)-based platform for the screening, diagnosis, and management of chronic airway diseases (COPD and asthma).
- Trial name
- NCT07910409
- Where
- China
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
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