Clinical trials: COPD (Chronic Obstructive Pulmonary Disease)
Chronic Disease, Lung Diseases, Obstructive
Home-based Exercise Training for COPD Patients
The aim of this study is to assess the effectiveness of a home-based exercise training program in COPD patients who have completed a pulmonary rehabilitation.
- Conditions
- Chronic Disease, Lung Diseases, Obstructive, Respiratory Disease
- Trial name
- HOMEX-1 (NCT03461887)
- Testing
- Exercise
- Where
- 5 sites in Switzerland
- Volunteers
- 123 people
- Sponsor
- University of Zurich
COPD (Chronic Obstructive Pulmonary Disease), COPD
Balance Training Following Pulmonary Rehabilitation on Balance in People With Chronic Obstructive Pulmonary Disease (COPD)
This study aims to see if a co-designed balance training programme called Sport4Steadiness (S4S), is acceptable to people with COPD and if the study procedures, including recruitment and the collection of outcomes, is feasible.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), COPD, Balance Exercise, Falls, Intervention
- Trial name
- B-PuRe (NCT07750821)
- Testing
- Sport4Steadiness
- Where
- 3 sites in United Kingdom
- Volunteers
- 77 people
- Sponsor
- Samantha Harrison
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
A Study to Assess the Bioavailability and to Compare the Pharmacokinetics of AZD7594 Inhaled Via Monodose Inhaler and Multiple-dose Dry Powder Inhalers (DPI) or Pressurized Metered-dose Inhaler (pMDI) in Healthy Male Subjects
This is an open-label,partially randomized, four-period study in healthy male subjects to assess the bioavailability and pharmacokinetics of a single dose of AZD7594 when administered intravenously, orally and inhaled via two…
- Trial name
- NCT02648438
- Testing
- AZD7594 Solution for infusion (150 μg intravenous formulation), AZD7594 Oral suspension (1200 μg oral formulation), AZD7594 Inhalation powder (400 μg) by DPI Device 1 (monodose inhaler)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
COPD, Healthy
The Effectiveness of Dual-task Exercises in Individuals With COPD
The goal of this clinical trial is to evaluate the effect of dual-task performance on motor and cognitive functions and to determine the effect of dual-task exercises given together with the pulmonary rehabilitation program on…
- Trial name
- NCT05930158
- Testing
- Dual Task Exercises, Pulmonary Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Marmara University
Pulmonary Disease, Chronic Obstructive
An Observational Study of Beta-Blocker Use in Patients With COPD and Acute MI
The study is a prospective, observational study of patients admitted to the BLOCK COPD network hospitals with acute AMI and Chronic Obstructive Pulmonary Disease (COPD) to determine the prevalence of COPD in patients admitted to…
- Trial name
- BLOCK2 (NCT04717492)
- Testing
- Observational
- Where
- 24 sites in United States
- Volunteers
- 584 people
- Sponsor
- University of Minnesota
COPD
Evaluation by Electrical Impedancemetry of the Variation in Lung Volumes Under Non-invasive Ventilation (NIV) in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The aim of this physiologic research is to assess lung volumes variations under NIV in stable COPD patients to understand the impact of "high-intensity" ventilation following the current recommendations.
- Trial name
- Eval 3V-BPCO (NCT05953298)
- Testing
- Electrical impedance tomography (EIT)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bordeaux
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Comparative Effectiveness of Telemedicine in Primary Care
Leveraging a natural experiment approach, the investigators will examine rapidly changing telemedicine and in-person models of care during and after the COVID-19 crisis to determine whether certain patients could safely choose to…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease (COPD), Congestive Heart Failure, Diabetes
- Trial name
- NCT04684836
- Testing
- Exposure to telemedicine, after the onset of the pandemic
- Where
- 4 sites in United States
- Volunteers
- 33,100 people
- Sponsor
- Weill Medical College of Cornell University
Chronic Bronchitis, COPD
Gala Treatment for Chronic Bronchitis in Canada
Feasibility trial (FIH) to assess the safety and clinical utility in patients with chronic bronchitis in Canada.
- Trial name
- NCT03385616
- Testing
- Gala Airway Treatment System
- Where
- 3 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Gala Therapeutics, Inc.
Respiratory Failure, Congestive Heart Failure
Effect of High-flow Nasal Oxygen on Extubation Outcome
The purpose of this study is to determine whether high flow nasal cannula is effective in lowering the reintubation rate after extubation for high risk patients in medical intensive care unit
- Conditions
- Respiratory Failure, Congestive Heart Failure, COPD
- Trial name
- NCT02290548
- Testing
- high flow nasal cannula
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Mackay Memorial Hospital
Pulmonary Disease, Chronic Obstructive
Muscle Metabolism and Oxygenation During Localized Fatigue-exercise in COPD
The purpose of this study is to investigate whether a localized exercise, in which cardiorespiratory demand is reduced, will result in greater limb muscle fatigue in patients with COPD as a consequence of muscle oxygenation and…
- Trial name
- NCT01909544
- Testing
- Fatiguing exercise
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laval University
Chronic Obstructive Pulmonary Disease, COPD
Activity Monitor Use in COPD Patients Undergoing Rehabilitation
In patients with Chronic Obstructive Pulmonary Disease (COPD) lifestyles with lower physical activity levels have been shown to increase the risk of hospital admissions and shorten survival rates.
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD, Emphysema, Chronic Bronchitis
- Trial name
- NCT02895152
- Testing
- Feedback
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Northern Care Alliance NHS Foundation Trust
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Helmet Ventilation in Acute Hypercapnic Respiratory Failure
Lack of tolerance to the treatment, makes the interface choice for non-invasive ventilation (NIV) one of the key factor. To date the helmet is rarely used in Acute Hypercapnic Respiratory Failure (AHRF), because of its large dead…
- Trial name
- NCT01645358
- Testing
- Helmet (Starmed), Total Face mask (Respironics)
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Chronic Obstructive Pulmonary Disease
Safety, Preliminary Pharmacokinetics and Bronchodilator Properties of V0162
Pulmonary administered anticholinergic agents have shown their importance in the chronic obstructive pulmonary disease (COPD) management to reduce morbidity, disability and mortality.
- Trial name
- NCT01348555
- Testing
- Bronchodilatator
- Where
- 2 sites in Belgium, France
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Medicament
COPD
Pharmacokinetic Interaction Study of Glycopyrrolate and Formoterol in Healthy Volunteers
This study will be carried out in healthy volunteers with the primary objective to evaluate the pharmacokinetic interaction between Glyco and Formoterol administered using a pressurised metered dose inhaler (pMDI).
- Trial name
- TRIPLE 1 (NCT01398111)
- Testing
- Glycopyrrolate + Formoterol, Glycopyrrolate, Formoterol
- Where
- Belgium
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Chronic Obstructive Pulmonary Diseases, Chronic Airways Limitation
Mepolizumab in Chronic Obstructive Pulmonary Diseases (COPD) With Eosinophilic Bronchitis
Some patients with chronic obstructive pulmonary diseases (COPD) have large number of specific white blood cells called eosinophils in their airways.
- Conditions
- Chronic Obstructive Pulmonary Diseases, Chronic Airways Limitation, Bronchitis
- Trial name
- NCT01463644
- Testing
- Mepolizumab
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- McMaster University
COPD, Exercise
Evaluation of Automatic Oxygen Flow Titration During Walking in Patients With COPD
The aim of the current study was to evaluate a new system (FreeO2) that automatically titrates oxygen flow to maintain stable SpO2, in patients with moderate or severe chronic obstructive pulmonary disease during exercise.
- Conditions
- COPD, Exercise, Endurance Shuttle Walking Test (Exercise at 85% of Maximal Shuttle Walking Test)
- Trial name
- FreeO2rehab (NCT02150434)
- Testing
- Automated oxygen titration, Compressed air, Oxygen constant flow
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Laval University
Pulmonary Disease, Chronic Obstructive
Safety, Tolerability and Pharmacokinetics and Effect on Inflammation of Oral BI 1026706 in Patients With COPD
The main objective of the current trial is to investigate safety, tolerability, pharmacokinetics and effect on inflammation of oral BI 1026706 administered twice daily for 4 weeks in patients with COPD.
- Trial name
- NCT02642614
- Testing
- BI 1026706
- Where
- 10 sites in Denmark, Germany and 2 more
- Volunteers
- 120 people
- Sponsor
- Boehringer Ingelheim
Asthma, COPD
Inhaler Technique in Elderly Patients: Impact on Disease Exacerbations
Introduction COPD and Asthma affect more than 10% of the population. Most patients use their inhaler incorrectly, mainly the elderly, thereby becoming more susceptible to poor clinical control and exacerbations.
- Trial name
- NCT03449316
- Testing
- Inhaler technique education
- Volunteers
- 146 people
- Sponsor
- Aveiro-Aradas Family Health Unit
Chronic Obstructive Pulmonary Disease
This Study Will Investigate How Food and Age Effect the Way the Body Handles the AZD5069 Drug Given as a Oral Dose
AZD5069 is a new drug being tested for the possible treatment of people with chronic obstructive pulmonary disease (COPD). This is not the first time that AZD5069 will be administered to humans in clinical trials.
- Trial name
- NCT01083238
- Testing
- AZD5069
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
COPD
NIV-Training in Hypercapnic COPD Patients
The aim of the study is to investigate the additional effects of the use of NIV during exercise within a 3-week PR program on exercise capacity in COPD patients with chronic hypercapnic respiratory failure.
- Trial name
- NCT03803358
- Testing
- exercise training with non-invasive ventilation, standard exercise training without NIV
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Schön Klinik Berchtesgadener Land
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