Clinical trials: COPD (Chronic Obstructive Pulmonary Disease)
Pulmonary Disease, Chronic Obstructive
Spiriva (Tiotropium Bromide) Assessment of FEV1 - (SAFE-Portugal).
Evaluate whether the effect of inhaled tiotropium bromide on the change in trough forced expiratory volume (FEV1), compared to placebo in patients with chronic obstructive pulmonary disease (COPD), is affected by smoking status.
- Trial name
- NCT00239408
- Testing
- Pulmonary function Testing, tiotropium bromide
- Where
- 33 sites in Portugal
- Volunteers
- 311 people
- Sponsor
- Boehringer Ingelheim
Lung Diseases, Obstructive, Bronchitis
Medication Adherence in COPD--A Self-Regulation Study
To test the effectiveness of a self-management program for chronic obstructive disease (COPD) patients. The program to improve adherence could be conducted by nurses or other clinic staff in settings where comprehensive…
- Conditions
- Lung Diseases, Obstructive, Bronchitis, Emphysema, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT00005717
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pulmonary Disease, Chronic Obstructive
Evaluation of the Effect of Roflumilast in Hyperinflated COPD Patients Using Functional Respiratory Imaging
In this study the efficacy of Roflumilast in addition to LAMA/LABA therapy will be assessed using Functional Respiratory Imaging.
- Trial name
- NCT02451540
- Testing
- HRCT scan, Roflumilast
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- FLUIDDA nv
COPD
A Safety, Tolerability and Efficacy Study in Chronic Obstructive Pulmonary Disease (COPD) Patients With QBM076.
This was a 2 Part study. Part 1 was a safety and tolerability study in GOLD I-III COPD patients. Part 2 was an efficacy study in GOLD I-III COPD patients.
- Trial name
- NCT01972776
- Testing
- QBM076
- Where
- 7 sites in United States, Germany and 2 more
- Volunteers
- 48 people
- Sponsor
- Novartis Pharmaceuticals
Respiratory Disease, Lung Cancer
Evaluate Efficacy of Respiratory Rehabilitation Personalized Mobile Services for Respiratory Diseases
This trial is multicenter prospective study to evaluate clinical efficacy of respiratory rehabilitation personalized mobile services for respiratory disease.
- Conditions
- Respiratory Disease, Lung Cancer, COPD
- Trial name
- NCT03432117
- Testing
- Fixed respiratory rehabilitation, Responsive respiratory rehabilitation
- Where
- 5 sites in South Korea
- Volunteers
- 179 people
- Sponsor
- Asan Medical Center
Chronic Obstructive Pulmonary Disease
Treatment of Chronic Obstructive Pulmonary Disease (COPD) With Diffusion Capacity Defect by REGEND001 Cell Therapy
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide with the characterization of obstructed airflow.
- Trial name
- NCT05638776
- Testing
- REGEND001 cell therapy
- Where
- 8 sites in China
- Volunteers
- 58 people
- Sponsor
- Regend Therapeutics
Pulmonary Disease, Chronic Obstructive, COPD
Effect of Ensifentrine (MK-5884/RPL554) on Sputum Markers of Inflammation in Chronic Obstructive Pulmonary Disease (COPD) (MK-5884-023/RPL554-CO-207)
Researchers are looking for new ways to treat chronic obstructive pulmonary disease (COPD). COPD is a long-lasting swelling of the airways that makes it hard to breathe.
- Trial name
- NCT05270525
- Testing
- Ensifentrine, LABA/LAMA
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA
Chronic Obstructive Pulmonary Disease, Asthma
Novel Endpoints in Cough Challenge Testing
The sensitivity of a person's cough reflex can be measured by getting them to breathe in (inhale) irritant chemicals. There are different methods by which subjects are asked to inhale these chemicals, either by taking one deep…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Healthy, Chronic Cough
- Trial name
- NEAT (NCT01566968)
- Testing
- Cough challenge test, 24 hour ambulatory cough recording, Cough quality of life questionnaire
- Where
- United Kingdom
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations
The purpose of this Phase III study is to evaluate the efficacy and safety of tozorakimab Dose 1 and Dose 2 administered subcutaneously (SC) in adult participants with symptomatic COPD and history of ≥ 2 moderate or ≥ 1 severe…
- Trial name
- OBERON (NCT05166889)
- Testing
- Tozorakimab
- Where
- 212 sites in United States, Argentina and 19 more
- Volunteers
- 1,132 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive
Study Assessing Utility of a Clinical Questionnaire to Identify Subjects With Features of Both Asthma and Chronic Obstructive Pulmonary Disease (COPD)
The primary objective of the study is to identify demographic and non-spirometric clinical features predictive of the asthma-COPD overlap population.
- Trial name
- NCT02302417
- Testing
- Spirometry, ACOS clinical questionnaire
- Where
- 42 sites in United States, Argentina and 3 more
- Volunteers
- 1,215 people
- Sponsor
- GlaxoSmithKline
Asthma, COPD
An Open Study to Assess the Robustness of the CRC749 Inhaler
To confirm the robustness of the CRC749 inhaler.
- Trial name
- NCT02474017
- Testing
- MGR001, CRC749 inhaler
- Where
- 2 sites in United Kingdom
- Volunteers
- 111 people
- Sponsor
- Mylan Pharma UK Ltd.
Chronic Obstructive Pulmonary Disease
Effect of Short-term Oxygen During CPET in COPD
In a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with chronic…
- Trial name
- NCT03196089
- Testing
- Oxygen application
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Pulmonary Disease, Chronic Obstructive
Efficacy and Safety Comparison of Steroid or Placebo in Combination With Salmeterol and Tiotropium in COPD
This efficacy and safety study compares four different combinations of blinded inhaled steroid treatments on top of open-label tiotropium and salmeterol in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00535366
- Testing
- Tiotropium, Salmeterol, Fluticasone
- Where
- 12 sites in Belgium, Denmark and 2 more
- Volunteers
- 103 people
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease
Action Plan to Enhance Self-management and Early Detection of Exacerbations in Chronic Obstructive Pulmonary Disease (COPD) Patients
The purpose of this randomized controlled trial is to evaluate the hypothesis that the 'written' action plan, a self-management tool developed by the project group, enhances early detection and prompt action measures and…
- Trial name
- ACZiE (NCT00879281)
- Testing
- Action plan
- Where
- Netherlands
- Volunteers
- 233 people
- Sponsor
- UMC Utrecht
Chronic Obstructive Pulmonary Disease
Digital Therapeutics on Inhalation Medication Adherence in COPD
Digital Therapeutics (DTx) is an evidence-based，clinically evaluated software to treat，manage，and prevent a broad spectrum of diseases and disorders according to Digital Therapeutics Alliance，which may improve the adherence of…
- Trial name
- NCT05667363
- Testing
- Digital Intervention
- Where
- China
- Volunteers
- 582 people
- Sponsor
- China-Japan Friendship Hospital
COPD (Chronic Obstructive Pulmonary Disease)
Evaluation in Elderly Individuals with Chronic Obstructive Pulmonary Disease(COPD)
This study is conducted on the evaluation of balance, physical activity, functional capacity and activities of daily living in frail elderly individuals with COPD.
- Trial name
- NCT05811832
- Testing
- Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Kırıkkale University
Chronic Obstructive Pulmonary Disease (COPD)
Urban Training for COPD Patients
This project plans on a training intervention by using public spaces and urban walkable trails, adapted to each patient needs and capabilities.
- Trial name
- NCT01897298
- Testing
- Urban training
- Where
- 5 sites in Spain
- Volunteers
- 412 people
- Sponsor
- Judith Garcia-Aymerich
Chronic Obstructive Pulmonary Disease, COPD Exacerbation
Efficacy of Varenicline on Smoking Cessation at the Acute Phase of an Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the bronchi with an increasing prevalence. By 2020, the mortality related to COPD is expected to become the 3rd leading death worldwide.
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD Exacerbation, Smoking
- Trial name
- SAVE (NCT01694732)
- Testing
- Varenicline
- Where
- 13 sites in France
- Volunteers
- 83 people
- Sponsor
- University Hospital, Brest
Pulmonary Disease, Chronic Obstructive
Efficacy of Arm Training in COPD Patients
Recent guidelines on pulmonary rehabilitation (PR) recommend upper extremity exercise training (UEET) in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- UEET-COPD (NCT00825032)
- Testing
- comprehensive PR, UEET
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Villa Pineta Hospital
Chronic Obstructive Pulmonary Disease With (Acute) Exacerbation
Effectiveness and Feasibility of Delivering an Education Program to Patients With an Acute Exacerbation of COPD
The purpose of this study is to determine if it is effective and feasible to provide a chronic obstructive pulmonary disease (COPD) education program to patients admitted with an acute exacerbation of COPD.
- Trial name
- NCT02321215
- Testing
- Introductory Disease Education
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- West Park Healthcare Centre
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