Clinical trials: COPD (Chronic Obstructive Pulmonary Disease)
Chronic Obstructive Pulmonary Disease (COPD)
Impact of Systemic Manifestations/Comorbidities on Clinical State, Prognosis, Utilisation of Health Care Resources in Patients With COPD
The purpose of this study is to determine the prevalence and severity of extrapulmonary disorders and to quantify the impact of extrapulmonary organ manifestations on morbidity and mortality of COPD patients.
- Trial name
- COSYCONET (NCT01245933)
- Where
- 22 sites in Germany
- Volunteers
- 2,741 people
- Sponsor
- Philipps University Marburg
Asthma, Chronic Obstructive Pulmonary Disease
Study of ARO-MUC5AC in Healthy Subjects and Patients With Muco-Obstructive Lung Disease
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of ARO-MUC5AC in normal healthy volunteers (NHVs), patients with moderate-to-severe asthma and patients with moderate-to-severe chronic…
- Trial name
- NCT05292950
- Testing
- ARO-MUC5AC
- Where
- 13 sites in Australia, New Zealand and 5 more
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Arrowhead Pharmaceuticals
Pulmonary Disease, Chronic Obstructive, Asthma
Handling Inhalers - Technique Error Comparison (HI-TEC)
Randomised, cross sectional, observational study evaluating inhaler device critical errors (errors that could affect dose delivery to the lungs) for the Pulmojet inhaler compared to Diskus or Turbuhaler in asthma and COPD…
- Trial name
- HI-TEC (NCT01794390)
- Where
- United Kingdom
- Volunteers
- 431 people
- Sponsor
- Research in Real-Life Ltd
Chronic Respiratory Failure With Hypercapnia, Chronic Obstructive Pulmonary Disease (COPD)
Study Evaluating Telemonitoring and Experimentation in Telemedicine for the Improvement of Healthcare Pathways (ETAPES Program) Compared to Standard of Care in Patients With Chronic Respiratory Failure Receiving Non-invasive Home Ventilation
The ETAPES Program, a French national Experimentation in Telemedicine for the Improvement of Healthcare Pathways, was launched in 2018 for 4 years.
- Conditions
- Chronic Respiratory Failure With Hypercapnia, Chronic Obstructive Pulmonary Disease (COPD), Obesity Hypoventilation Syndrome (OHS)
- Trial name
- e-VENT (NCT04615078)
- Testing
- ETAPES Program
- Where
- 11 sites in France
- Volunteers
- 56 people
- Sponsor
- Air Liquide Santé International
COPD (Chronic Obstructive Pulmonary Disease)
The Study of Chronic Obstructive Pulmonary Disease (COPD) Participants Treated With Dupilumab (STRIDE) Registry
The STRIDE Registry will evaluate the real-world effectiveness and safety of dupilumab in participants with COPD. The primary objective is to describe characteristics of participants newly initiated with dupilumab for COPD.
- Trial name
- STRIDE (NCT07612878)
- Testing
- Cohort 1: Dupilumab, Cohort 2: usual care only
- Where
- 7 sites in United States
- Volunteers
- 350 people
- Sponsor
- Sanofi
COPD
COPD at a Street Level
The trial investigates and describes the prevalence of COPD among socially vulnerable individuals who come in contact with a mobile clinic and investigates the effect of opportunistic screening for COPD in these vulnerable…
- Trial name
- NCT05660460
- Testing
- Spirometry
- Where
- Denmark
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
COPD, Sedation
Sedation and Physiological Effects of Intranasal Dexmedetomidine in Severe COPD
A variety of medications have been used to treat the anxiety, discomfort, and fear associated with continuous and sudden episodic breathlessness in patients with advanced respiratory disease.
- Conditions
- COPD, Sedation, Dexmedetomidine
- Trial name
- NCT02211118
- Testing
- Intranasal dexemdetomidine (IN-DEX)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dayton VA Medical Center
Chronic Obstructive Pulmonary Disease
Iron and Chronic Obstructive Pulmonary Disease (COPD) Exercise Trial
This phase II single centre, double blind, placebo-controlled, randomised trial aims to test the hypothesis that intravenous iron improves exercise performance in Chronic Obstructive Pulmonary Disease (COPD) as measured by…
- Trial name
- ICE-T (NCT03050424)
- Testing
- Ferric Carboxymaltose, Sodium Chloride 0.9%
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Chronic Obstructive Pulmonary Disease
Pennsylvania Study Of Chronic Obstructive Pulmonary Exacerbations
The overall purpose of PA-SCOPE is to determine why black and rural residents of Pennsylvania might be at higher risk for deadly, debilitating, and costly hospitalizations for chronic obstructive pulmonary disease (COPD)- and…
- Trial name
- PA-SCOPE (NCT00774176)
- Where
- 3 sites in United States
- Volunteers
- 1,066 people, healthy volunteers welcome
- Sponsor
- Temple University
Asthma, COPD
An Open Study to Assess the Robustness of the CRC749 Inhaler
To confirm the robustness of the CRC749 inhaler.
- Trial name
- NCT02474017
- Testing
- MGR001, CRC749 inhaler
- Where
- 2 sites in United Kingdom
- Volunteers
- 111 people
- Sponsor
- Mylan Pharma UK Ltd.
Pulmonary Disease, Chronic Obstructive
Randomized Study Evaluating the Effect of Danirixin on Neutrophil Extracellular Traps (NETs) in Chronic Obstructive Pulmonary Disease (COPD)
The inflammation associated with COPD is characterized by a prominent infiltration of neutrophils in lung tissue and airways. The CXC chemokine receptor type 2 (CXCR2) plays a pivotal role in neutrophil recruitment to the lungs…
- Trial name
- NCT03250689
- Testing
- Danirixin, Rescue medication, Inhaled COPD maintenance medication
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- GlaxoSmithKline
COPD (Chronic Obstructive Pulmonary Disease)
A Phase 2 Trial of JKN24011 in COPD
A Randomized, Double-Blind, Placebo-Controlled Phase II Study to Evaluate the Efficacy and Safety of Subcutaneous JKN24011 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT07440524
- Testing
- JKN24011
- Where
- China
- Volunteers
- 215 people
- Sponsor
- Joincare Pharmaceutical Group Industry Co., Ltd
COPD
Home-based Pulmonary Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease
This project aims to assess the short-term effectiveness and responsiveness of a home-based pulmonary rehabilitation (PR) program (reabilitAR) in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT04722224
- Testing
- Home-based pulmonary rehabilitation
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Polytechnic Institute of Porto
Pulmonary Disease, Chronic Obstructive
Evaluation With CT Scan of Possible Changes in Airways After Treatment With Daxas® in Severe Chronic Obstructive Pulmonary Disease Patients
In this study the possible changes in airway geometry and function induced by 6 month oral treatment with Daxas® (roflumilast) will be evaluated.
- Trial name
- NCT01480661
- Testing
- Roflumilast, Functional Respiratory Imaging
- Where
- 2 sites in Belgium
- Volunteers
- 41 people
- Sponsor
- FLUIDDA nv
Asthma, Pulmonary Disease
Examining the Role of Vitamin D in Asthma and Chronic Obstructive Pulmonary Disease (COPD)
Asthma and chronic obstructive pulmonary disease (COPD) are diseases that affect a person's ability to breathe normally. People who do not receive enough vitamin D may have a higher risk of developing asthma or COPD.
- Conditions
- Asthma, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT00851695
- Volunteers
- 2,266 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
COPD (Chronic Obstructive Pulmonary Disease)
High Intensity Interval Training and Inspiratory Muscle Training
The goal of this clinical trial is to investigate the effect of combined high intensity interval training (HIIT) and inspiratory muscle training (IMT) on pulmonary function and exercise capacity in patients COPD.
- Trial name
- training (NCT06836895)
- Testing
- HIIT and IMT, walking
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- Prince Sattam Bin Abdulaziz University
COPD
Effects of Breathing Exercises With and Without Inspiratory Muscle Training in COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is a major health issue that affects a large proportion of the population, especially those over 50 years old. It is characterized by breathlessness and reduced lung function.
- Trial name
- NCT06555445
- Testing
- BREATHING EXERCISE, BREATHING EXERCISE REGIMEN COUPLED WITH BREATHER DEVICE
- Where
- Pakistan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Pulmonary Disease, Chronic Obstructive
Safety and Efficacy Study of Losmapimod (GW856553) in Frequently Exacerbating Participants With Chronic Obstructive Pulmonary Disease (COPD)
This is a randomised, double-blind, parallel-group, multi-centre study evaluating 15 milligram (mg) twice daily/ Bi-daily (BID) of losmapimod versus placebo, in addition to standard of care (SoC).
- Trial name
- NCT02299375
- Testing
- Losmapimod tablets, Salbutamol MDI
- Where
- 36 sites in Argentina, Brazil and 6 more
- Volunteers
- 184 people
- Sponsor
- GlaxoSmithKline
COPD
Cardiac Effects of Spiolto®/Respimat® in Patients With Congestive Heart Failure and COPD
The aim of this study is to evaluate the pulmonary and cardiac effects of the LABA / LAMA combination Tiotropium / Olodaterol therapy in patients suffering from both congestive heart failure and chronic obstructive pulmonary…
- Trial name
- CREATES (NCT02812862)
- Testing
- Spiolto® Respimat® (Tiotropium / Olodaterol)
- Where
- Germany
- Sponsor
- RWTH Aachen University
Chronic Obstructive Pulmonary Disease, COPD
A Safety, Tolerability and Efficacy Study With QBW251 in COPD Patients With QBW251
To evaluate the efficacy, safety and tolerability of multiple doses of QBW251 vs placebo administered orally, on airway function, lung volume, and quality of life in patients with chronic obstructive pulmonary disease (COPD)
- Trial name
- NCT02449018
- Testing
- QBW251
- Where
- 16 sites in United States, Poland
- Volunteers
- 92 people
- Sponsor
- Novartis Pharmaceuticals
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