Clinical trials: COPD (Chronic Obstructive Pulmonary Disease)
COPD
A Chronic Obstructive Pulmonary Disease (COPD) Trial Investigating Roflumilast on Safety and Effectiveness in China, Hong Kong and Singapore:
The aim of this trial is to determine the efficacy, safety and tolerability of 500 µg Roflumilast tablets once daily in patients with COPD in China, Hong Kong, and Singapore.
- Trial name
- ACROSS (NCT01313494)
- Testing
- Roflumilast, Salbutamol
- Where
- 15 sites in China, Hong Kong and 1 more
- Volunteers
- 626 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease (COPD)
To Determine the Relationship Between Baseline Reversibility and the Efficacy of Indacaterol
In this 5-months study, the response of patients to salbutamol at baseline will be compared with their response to treatment with indacaterol.
- Trial name
- REVERBREZ (NCT01272362)
- Testing
- Indacaterol
- Where
- 137 sites in France
- Volunteers
- 625 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations
The purpose of this Phase III study is to evaluate the efficacy and safety of tozorakimab administered subcutaneously (SC) in adult participants with symptomatic COPD with a history of ≥ 2 moderate or ≥ 1 severe exacerbations of…
- Trial name
- MIRANDA (NCT06040086)
- Testing
- Tozorakimab
- Where
- 368 sites in United States, Argentina and 27 more
- Volunteers
- 1,454 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Correlation of Airflow Limitation and Other Respiratory Characteristics With Radiologic Changes of Lung Structure
The aim of the study is to assess the correlation between airflow limitation, perception of dyspnea and functional capacity with anatomic changes in pulmonary structure as seen on High Resolution CT in COPD patients.
- Trial name
- NCT00799305
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Hillel Yaffe Medical Center
COPD Exacerbation, COPD
The COPD CARE Study: Evaluating the Impact of a Virtual-First COPD Service on Major Cardiac and Respiratory Events
A 12 month interventional study of up to 1,050 people with COPD to determine if the NuvoAir virtual-first clinical service leads to fewer moderate and severe COPD exacerbations and cardiac events, reduces healthcare utilization…
- Conditions
- COPD Exacerbation, COPD, Cardio/Pulm: Heart Failure
- Trial name
- NCT06379529
- Testing
- NuvoAir clinical service
- Volunteers
- 1,050 people
- Sponsor
- NuvoAir Medical PC
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Open-Label Assessment of the Albuterol Spiromax® Dry Powder Inhaler (DPI)
This is a prospective, open-label, multicenter Phase 3 study evaluating the performance of the Albuterol Spiromax dose counter in patients with a diagnosis of asthma and/or COPD.
- Trial name
- NCT01857323
- Testing
- Albuterol Spiromax®
- Where
- 30 sites in United States
- Volunteers
- 317 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Pulmonary Disease, Chronic Obstructive
Effect of Traditional Chinese Medicine on Outcomes in Patients With Severe / Very Severe COPD
The aim of this study is to compare the effectiveness of two treatments for severe / very severe COPD patients: one, conventional medicine based on 2013 Global Initiative for Chronic Obstructive Lung Disease (GOLD) and Chinese…
- Trial name
- NCT02270424
- Testing
- Salmeterol / fluticasone (Seretide®), Bufeijianpi granule, Bufeiyishen granule
- Volunteers
- 564 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Chronic Obstructive Pulmonary Disease, Asthma
Video vs. TTG Respiratory Inhaler Technique Assessment and InstructioN (V-TRaIN)
The purpose of this study is to evaluate the effectiveness of two different ways to teach subjects while hospitalized how to use respiratory inhalers and to follow-up after discharge home from the hospital to determine durability…
- Trial name
- NCT02611531
- Testing
- Video Module Education (VME), Teach-To-Goal (TTG)
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- University of Chicago
Pulmonary Disease, Chronic Obstructive, Emphysema
Evaluating the Effects of Surgical and Non-Surgical Treatment Options in People With Emphysema
Emphysema is a lung disease that involves damage to the air sacs in the lungs and can lead to breathing difficulties. Treatment options for people with emphysema include pulmonary rehabilitation, lung volume reduction surgery…
- Trial name
- NCT00675454
- Where
- United States
- Volunteers
- 802 people
- Sponsor
- Washington University School of Medicine
Chronic Obstructive Pulmonary Disease
Educational Intervention for Managing Inhalers in Chronic Obstructive Pulmonary Disease (COPD) Patients
Given the importance of the correct use of inhalers by patients with Chronic Obstructive Pulmonary Disease (COPD) for the appropriate treatment of the disease, the self-care programme which will be assessed will consist of an…
- Trial name
- NCT01380405
- Testing
- education intervention
- Where
- Spain
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Chronic Obstructive Pulmonary Disease, Emphysema
Cost-Effectiveness of Lung Volume Reduction Surgery
Lung volume reduction surgery (LVRS) has been advanced as a therapy to significantly improve quality of life in patients with COPD, but to date no controlled studies have evaluated the impact of LVRS.
- Trial name
- NCT00013156
- Testing
- Effectiveness of Lung Reduction Therapy
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- US Department of Veterans Affairs
Chronic Obstructive Pulmonary Disease
Safety and Efficacy of Adipose Derived Stem Cells for Chronic Obstructive Pulmonary Disease
The intent of this clinical study is to answer the questions: 1) Is the proposed treatment safe and 2) Is treatment effective in improving the health of patients with human Chronic Obstructive Pulmonary Disease.
- Trial name
- NCT01559051
- Testing
- Lipoaspiration with Local anesthesia
- Where
- United States
- Sponsor
- Ageless Regenerative Institute
Chronic Obstructive Pulmonary Disease (COPD)
Acute Effects of Acu-Transcutaneous Electrical Nerve Stimulation (Acu-TENS) on Forced Expiratory Flow Volume in One Second (FEV1) and Blood β-Endorphin Level in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
The objective of this study is to investigate the effectiveness of Acu-TENS (transcutaneous electrical nerve stimulation applied on acupoints) on lung functions, dyspnoeic symptoms and its association with beta endorphin level in…
- Trial name
- NCT00922051
- Testing
- Transcutaneous electrical nerve stimulation (TENS)
- Where
- China
- Volunteers
- 44 people
- Sponsor
- The Hong Kong Polytechnic University
Pulmonary Disease, Chronic Obstructive
Drug Use Survey of RESPIMAT in Patients With COPD
To investigate safety and effectiveness information on the use of Tiotropium Respimat for long time of period in daily practical clinical circumstances, and to obtain proper drug use information.
- Trial name
- NCT01145053
- Volunteers
- 361 people
- Sponsor
- Boehringer Ingelheim
Advanced Upper Lobe Predominant Emphysema
Phase 3 Study of the Biologic Lung Volume Reduction (BLVR) System in Advanced Upper Lobe Predominant (ULP) Emphysema
The purpose of the study is to evaluate the efficacy and safety of the 20 mL BLVR System in treating patients with advanced upper lobe predominant emphysema.
- Trial name
- NCT00716053
- Testing
- BLVR
- Volunteers
- 225 people
- Sponsor
- Aeris Therapeutics
Pulmonary Disease, Chronic Obstructive
Evaluation of Lung Function and Symptoms in Patients Diagnosed With Chronic Obstructive Pulmonary Disease (COPD) on Long-Acting Bronchodilator Monotherapy
A multicenter study to evaluate lung function and symptoms in subjects with COPD who have been on regular use of only one long-acting bronchodilator.
- Trial name
- LABD (NCT00791518)
- Testing
- No intervention
- Where
- 57 sites in United States
- Volunteers
- 1,084 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease, Lung Cancer
COPD Care Pathway Among Patients With Cancer
This study gathers information for the development of a COPD care pathway for patients with cancer that reduces the treatment burden of patients, implements critical components of COPD care, and overcomes common barriers to COPD…
- Conditions
- Chronic Obstructive Pulmonary Disease, Lung Cancer, Head and Neck Cancer
- Trial name
- NCT05984680
- Testing
- Observational Phase 1, Observational Phase 2, Group I, Observational Phase 2, Group II
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
COPD, Coronary Artery Calcification
Quebec Lung Cancer Screening PLUS Trial
Does an educational intervention for untreated COPD and cardiovascular disease which is integrated in an existing lung cancer screening program improve guideline concordant medication adherence at 12 months
- Trial name
- QLC+ (NCT05444062)
- Testing
- Educational material and treatment recommendations for patients, general practitioners and pharmacists
- Where
- Canada
- Volunteers
- 330 people
- Sponsor
- Nicole Ezer, MD, FRCPC, MPH
Chronic Obstructive Pulmonary Disease
Effects of an Air Purifying Device (PureNight) on Sleep Quality in Obstructive Lung Disease
Many individuals with chronic lung disease have night time symptoms that disrupt their sleep. The purpose of this study is to determine the effects of an air purifying device (PureNight, Halo Innovations, Minneapolis, MN) on…
- Trial name
- NCT01772342
- Testing
- HEPA filtration
- Volunteers
- 50 people
- Sponsor
- VA New York Harbor Healthcare System
Heart Failure, Chronic Obstructive Pulmonary Disease
Effects of HIIT in Tolerance to Exercise of Individuals With HF and Coexisting COPD
INTRODUCTION: The complexity of the pathophysiology of heterogeneous diseases such as heart failure and obstructive pulmonary disease causes a different approach to these diseases or with a view as much as a better understanding…
- Trial name
- NCT04350541
- Testing
- High-intensity interval training, Continuous aerobic training
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal de Pernambuco
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