Clinical trials: COPD - Chronic Obstructive Pulmonary Disease, open to volunteers
Cough, Asthma
Validation of the C-mo System - Cough Monitoring
The goal of this clinical study is to validate C-mo System's ability to automatically detect and characterise cough, in patients over 2 years old with cough as a key or refractory symptom.
- Conditions
- Cough, Asthma, Chronic Obstructive Pulmonary Disease, Gastro Esophageal Reflux
- Trial name
- C-mo_01 (NCT05989698)
- Testing
- C-mo System
- Where
- 8 sites in Portugal
- Volunteers
- 300 people
- Sponsor
- Cough Monitoring Medical Solutions
COPD (Chronic Obstructive Pulmonary Disease)
Rehabilitation in Safety-net Environments (RISE) to Improve Outcomes in Vulnerable Patients With COPD
Chronic obstructive pulmonary disease (COPD), one of the leading causes of death in the US, disproportionately affects low socioeconomic communities.
- Trial name
- RISE (NCT05572632)
- Testing
- COPD Wellness, COPD Wellness Plus+, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 387 people
- Sponsor
- University of California, San Francisco
COPD Exacerbation Acute
The Use of Medical Devices to Monitor Chronic Obstructive Pulmonary Disease Patients Study BREATH-TRACHER 1
The proposed study will explore whether remote monitoring of a COPD patient can be undertaken using a wearable medical device.
- Trial name
- BREATH-TRACHER (NCT06419036)
- Testing
- Pneumowave DC
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Strathclyde
Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Nutritional Risk and Diaphragmatic Thickness in Mechanically Ventilated COPD Patients
Malnutrition and muscle wasting are frequent complications in patients with chronic obstructive pulmonary disease (COPD) experiencing acute exacerbations.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Malnutrition, Respiratory Failure
- Trial name
- NCT07788170
- Volunteers
- 120 people
- Sponsor
- Assiut University
Pulmonary Disease, Chronic Obstructive
Investigation of Walking Training With Different Slope Types in COPD Patients
Chronic obstructive pulmonary disease (COPD) is a disease that continues to generate a great deal of research and this research must continue, both because it is not completely curable and because of the large patient population.
- Trial name
- NCT06283004
- Testing
- Downhill walking training, Level walking training, Uphill walking training
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Acibadem University
COPD (Chronic Obstructive Pulmonary Disease), Caregiver
Validation of the French Version of the QASCI in Caregivers of Patients With COPD
This study aims to validate the French version of the QASCI questionnaire, initially written and validated in Portuguese language by Hipolito et al., to assess caregiving burden in chronic obstructive pulmonary disease (COPD).
- Trial name
- VALQASCI (NCT06652204)
- Testing
- questionnaire
- Where
- 2 sites in France
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
COPD (Chronic Obstructive Pulmonary Disease), Healthy Subjects
Pulmonary and Total Blood Volume in COPD
Background Patients with chronic obstructive lung disease (COPD) suffer from a progressive loss of lung function that leads to poor quality of life, and often invalidity and early death.
- Trial name
- COPD-TBV (NCT07428785)
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
COPD
Comparative Effects of Breather Device and Incentive Spirometer in Patients With COPD
Chronic obstructive pulmonary disease (COPD) is characterized and defined by limitation of expiratory airflow. This can result from several types of anatomical lesions, including loss of lung elastic recoil and fibrosis and…
- Trial name
- NCT07435532
- Testing
- breather device, incentive spirometer
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Phase II Study of RC1416 Injection in COPD
This is a multicenter, randomized, double-blind, placebo-controlled phase II clinical study to evaluate the efficacy and safety of RC1416 injection in patients with moderate to severe chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT07402551
- Testing
- RC1416
- Where
- 46 sites in China
- Volunteers
- 180 people
- Sponsor
- Nanjing RegeneCore Biotech Co., Ltd.
Chronic Obstructive Pulmonary Disease (COPD)
A Study on COPD Phenotypes, Endotypes and Treatable Traits
Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous and multisystemic disease with progressive increasing morbidity and mortality.
- Trial name
- NCT06952881
- Where
- Hong Kong
- Volunteers
- 460 people
- Sponsor
- Chinese University of Hong Kong
COPD (Chronic Obstructive Pulmonary Disease)
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease
This study will evaluate the effect of triple ICS/LAMA/LABA therapy with BGF MDI 320/14.4/9.6 μg on cardiopulmonary outcomes relative to LAMA/LABA therapy with GFF MDI 14.4/9.6 μg in a population with COPD and elevated…
- Trial name
- THARROS (NCT06283966)
- Testing
- BGF MDI 320/14.4/9.6 μg, GFF MDI 14.4/9.6 μg
- Where
- 922 sites in United States, Argentina and 35 more
- Volunteers
- 5,250 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease, Lung Diseases, Obstructive
Impact of Multidisciplinary Care, Structured and Targeted on the COPD Patient's Clinical Pathway.
In 2020, chronic obstructive pulmonary disease (COPD) was the 4th leading cause of death worldwide. In France, its annual cost was estimated at 4366 euros per patient, including 25% related to management of exacerbations and 33%…
- Conditions
- Chronic Obstructive Pulmonary Disease, Lung Diseases, Obstructive, Lung Disease Chronic
- Trial name
- OPTI-BPCO (NCT07907601)
- Testing
- COPD targeted pharmaceutical interview and consultation, Respiratory Insufficiency Day Hospitalization, Pulmonary Function Test
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Blood Flow Restriction Rehabilitation on Functional Mobility and Balance Among Chronic Obstructive Pulmonary Disease Patients.
Background: Chronic obstructive pulmonary disease (COPD) is a common lung disease causing restricted airflow and breathing problems. It is sometimes called emphysema or chronic bronchitis.
- Trial name
- NCT07805330
- Testing
- Resistance Exercise without tourniquet, Blood flow restriction resistance exercise
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Rashid Latif Medical College
Alpha 1-Antitrypsin Deficiency
Alpha-1 Research Registry
The Alpha-1 Research Registry is a confidential database made up of individuals diagnosed with Alpha-1 Antitrypsin Deficiency (Alpha-1) and individuals identified as Alpha-1 carriers.
- Trial name
- NCT04157049
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Alpha-1 Foundation
Pulmonary Disease, Chronic Obstructive
Ensifentrine (MK-5884) Study for the Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbations in Adults With a History of Moderate or Severe Exacerbations While Receiving Standard of Care (SOC) (MK-5884-031/RPL554/ENHANCE-3)
The purpose of this study is to evaluate the efficacy and safety of ensifentrine (MK-5884) compared with placebo for the prevention of moderate and severe COPD exacerbation in adults with COPD and a history of exacerbations while…
- Trial name
- ENHANCE-3 (NCT07874815)
- Testing
- Ensifentrine, Standard of Care (SOC)
- Where
- 7 sites in United States
- Volunteers
- 2,136 people
- Sponsor
- Merck Sharp & Dohme LLC
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Decision-making and Optimization of Ventilatory Support for AECOPD Patients
The goal of this retrospective observational study is to learn about how respiratory support is selected and adjusted in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
- Trial name
- OPTIVENT-COPD (NCT07508943)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Sir Run Run Shaw Hospital
Lung Cancer, COPD
DEPRECAP: Lung Cancer Screening Programme by LDCT for Patients With COPD or Emphysema.
The DEPRECAP (Early detection of lung cancer) study is an ongoing, prospective, longitudinal, multicenter lung cancer screening program that recruited individuals with COPD or emphysema from the pulmonary clinics of Fundación…
- Conditions
- Lung Cancer, COPD, Emphysema
- Trial name
- DEPRECAP (NCT06690385)
- Where
- 2 sites in Spain
- Volunteers
- 1,998 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Chronic Obstructive Pulmonary Disease
Eosinopenia in Severe COPD Exacerbation
The goals of this observational study are to identify factors independently associated with admission eosinopenia in patients with a severe exacerbation of chronic obstructive pulmonary disease (COPD) and to determine when blood…
- Trial name
- A-TREC (NCT06188065)
- Testing
- Blood eosinophil count
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Northumbria Healthcare NHS Foundation Trust
Chronic Obstructive Pulmonary Disease
Effects of Elastic Tape on Pulmonary Rehabilitation of Patients with Chronic Obstructive Pulmonary Disease
Evaluate the effect of the use of elastic tape in chest wall and abdomen in the physical capacity, psychosocial distress levels, quality of life and anxiety, and depression symptoms of individuals with moderate to very severe…
- Trial name
- ETReaCOPD (NCT05939999)
- Testing
- Experimental: Elastic tape (ET)
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- University of Sao Paulo General Hospital
COPD
Digital Tool for Improved Self-management of COPD
Primary aim: To evaluate the feasibility, usability and safety of the investigational device in clinical practice over 6 months in 50 patients.
- Trial name
- FOCUS (NCT07573098)
- Testing
- COPD treatment check
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Björn Nordlund