Clinical trials: COPD - Chronic Obstructive Pulmonary Disease, open to volunteers
COPD (Chronic Obstructive Pulmonary Disease), Asthma (Diagnosis)
Validation of 1 Minute Sit-to Stand Test for Assessment of Breathlessness at Exertion in Individuals With Chronic Lung Disease
Breathlessness is a common symptom in people with chronic lung and heart diseases. It can affect daily activities, quality of life, and overall health.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Asthma (Diagnosis), Interstitial Lung Disease (ILD)
- Trial name
- V1BE (NCT07836764)
- Testing
- 1MSTS
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Jacob Sandberg
Chronic Obstructive Pulmonary Disease (COPD), Virtual Reality
SPARK: Supporting Physical Activity Through Reality-Augmented Knowledge in COPD
Chronic obstructive pulmonary disease (COPD) is associated with dyspnea, reduced physical activity, muscle deconditioning, and impaired quality of life.
- Trial name
- SPARK (NCT07837375)
- Testing
- Augmented Reality Virtual Coach
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Groupe Hospitalier du Havre
COPD, ILD
Validation and Clinical Utility of the Lung Sliding Index (LSI) for Differentiating Pulmonary Diseases
This upcoming case-control study aims to confirm the Lung Sliding Index (LSI), a new ultrasound score that measures how well the pleura moves, in various lung diseases.
- Conditions
- COPD, ILD, Bronchiectasis, Pneumothorax
- Trial name
- NCT06983366
- Testing
- Lung Ultrasound
- Where
- Egypt
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Assiut University
Chronic Obstructive Pulmonary Disease COPD
Long-term Real-world Study of Dupilumab in COPD : Patient Characteristics, Safety and Patient-reported Outcomes
The OBS19236 is a retrospective and prospective, non-interventional observational study in COPD patients treated with dupilumab as part of routine clinical care.
- Trial name
- AURORA (NCT07380711)
- Where
- 28 sites in France
- Volunteers
- 500 people
- Sponsor
- Sanofi
Chronic Obstructive Pulmonary Disease (COPD), Multimorbidities
IMPACT COPD Cohort (China)
Chronic obstructive pulmonary disease (COPD) is a major chronic respiratory condition with high prevalence of multimorbidity. COPD and comorbidities interact dynamically, contributing to symptom fluctuation, acute exacerbations…
- Trial name
- IMPACT (NCT07382986)
- Testing
- Not applicable- observational study
- Where
- 4 sites in China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Chao Yang Hospital
Interstitial Lung Disease, COPD
Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs
The objective of this registry is to collect and evaluate various clinical effectiveness parameters in patients with transplanted donor lung that were preserved and transported within the LUNGguard system, as well as…
- Conditions
- Interstitial Lung Disease, COPD, Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- GUARDIANLUNG (NCT04930289)
- Testing
- LungGuard, BAROGuard
- Where
- 15 sites in United States, Belgium
- Volunteers
- 3,500 people
- Sponsor
- Paragonix Technologies
Emphysema, Pulmonary, Emphysema or COPD
An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema
This is a prospective, open-label, multi-center, single-arm study planned to enroll 200 subjects with heterogeneous emphysema and collateral ventilation (CV) in the target lobe.
- Trial name
- CONVERT_II (NCT06035120)
- Testing
- AeriSeal System
- Where
- 38 sites in United States, Australia and 8 more
- Volunteers
- 200 people
- Sponsor
- Pulmonx Corporation
Emphysema, COPD
Zephyr Valve Japan Post-Marketing Surveillance
This is a multicenter, prospective, observational surveillance enrolling 140 consecutive patients with severe emphysema who are candidates for bronchoscopic lung volume reduction using Zephyr Endobronchial Valve at up to 20…
- Conditions
- Emphysema, COPD, Severe Emphysema
- Trial name
- NCT06332885
- Testing
- Zephyr Endobronchial Valve
- Where
- 17 sites in Japan
- Volunteers
- 140 people
- Sponsor
- Pulmonx Corporation
Chronic Obstructive Pulmonary Disease (COPD), Cardiovascular Diseases (CVD)
The HELlenic Thoracic Society Initiative for CΟPD and CVD
COPD is one of the most common respiratory diseases in Greece, and maybe more than half a million Greek citizens suffer both from COPD and CVD, however their characteristics and management remain unknown.
- Trial name
- HELICOPD (NCT06595784)
- Where
- 2 sites in Greece
- Volunteers
- 900 people
- Sponsor
- Hellenic Thoracic Society
Asthma, COPD (Chronic Obstructive Pulmonary Disease)
T2AIR: Real-World Efficacy and Safety of Biologics Targeting Type 2 Inflammation in Asthma and COPD
This prospective, real-world observational study (T2AIR Study) evaluates the long-term efficacy and safety of six biologics targeting Type 2 inflammation - omalizumab, mepolizumab, benralizumab, dupilumab, tezepelumab, and…
- Trial name
- T2AIR (NCT07823842)
- Testing
- Biologics targeting Type 2 inflammation, Patients with asthma and copd who received standard of care
- Where
- China
- Volunteers
- 538 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Chronic Obstructive Pulmonary Disease (COPD)
The Effect of Pranayama Practiced With Rain Sounds on Self-Efficacy, Dyspnea, and Respiratory Functions in Patients With COPD
Chronic obstructive pulmonary disease (COPD) ranks third among the leading causes of death worldwide. It causes a variety of symptoms resulting from irreversible obstruction of the airways.
- Trial name
- NCT07820059
- Testing
- pranayama breathing exercises, A group will perform pranayama breathing exercises accompanied by the sound of rain.
- Volunteers
- 114 people
- Sponsor
- Inonu University
Acute Respiratory Distress Syndrome (ARDS), Pneumonia
Medical Device Clinical Trial Without CE Marking to Evidence Safety and Performance of the INBENTUS VERSATILE Ventilator in Patients Requiring Assisted/Controlled Mechanical Ventilation and Weaning.
Pre-market clinical trial on 81 aldults participants to evidence safety and performance of the non-CE-marked medical device INBENTUS VERSATILE ventilator.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Pneumonia, COPD (Chronic Obstructive Pulmonary Disease), Postoperative Respiratory Distress
- Trial name
- NCT07432191
- Testing
- INBENTUS VERSATILE
- Where
- Spain
- Volunteers
- 81 people
- Sponsor
- Iconic Solutions By Murcia SL
Pulmonary Disease (COPD), Chronic Obstructive, Lung Resection Surgery
Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsic PEEP During One-lung Ventilation
This study investigates the effects of three extrinsic PEEP settings-5 cmH2O, 0 cmH2O, and an individualized PEEP (70% of the measured intrinsic PEEP)-on intrinsic PEEP and hemodynamic stability in patients with intrinsic PEEP…
- Trial name
- NCT07638176
- Testing
- PEEP0, PEEP5, PEEPi
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Samsung Medical Center
COPD (Chronic Obstructive Pulmonary Disease), Chronic Obstructive Pulmonary Disease (COPD)
Nebulizer Versus Handheld Maintenance Therapy for Patients With COPD
Multi-site, randomized controlled trial to determine whether patients who report NO symptomatic benefit with their maintenance hand-held inhaler(s), benefit upon switching to nebulized therapy using comparable classes of…
- Trial name
- DELIVERY (NCT07816835)
- Testing
- Nebulized therapy of similar medication solutions, Continue handheld therapy
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- COPD Foundation
COPD (Chronic Obstructive Pulmonary Disease)
Effectiveness of Active Cycle of Breathing Techniques in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial
This study aims to examine the effects of Active Cycle of Breathing Technique (ACBT) on pulmonary function, sleep quality, depressive symptoms, and dyspnea in patients with Chronic Obstructive Pulmonary Disease.
- Trial name
- NCT07818187
- Testing
- ACBT+OPEP, Usual Care (Standard Medical Care)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Yang Ming Chiao Tung University Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Hyperoxia During Outpatient Pulmonary Rehabilitation in Chronic Lung Disease - Does it Matter?
Chronic obstructive pulmonary disease (COPD) is a global burden. Treatment options have improved in recent years, pulmonary rehabilitation plays a key role.
- Trial name
- NCT06776731
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- Eastern Switzerland University of Applied Sciences
COPD
Continuous Versus High Intensity Interval Exercise in Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is characterized by exercise intolerance, which is a prognostic factor of disease severity and mortality and is usually attributed to ventilatory limitations.
- Trial name
- NCT07707271
- Testing
- Moderate intensity continuous aerobic exercise (MICE), High-intensity interval aerobic exercise (HIIE)
- Where
- Greece
- Volunteers
- 12 people
- Sponsor
- George Papanicolaou Hospital
COPD, Non Invasive Ventilation (NIV)
The Feasibility of Electrical Impedance Tomography to Guide Non-invasive Respiratory Interventions in Chronic Respiratory Disease
This study aims to use Electrical Impedance Tomography (EIT) to optimise breathing machines for people with problems with their breathing. This might improve their ability to use their breathing machine.
- Conditions
- COPD, Non Invasive Ventilation (NIV), Obesity, Neuromuscular Disability
- Trial name
- EIT-Guide (NCT07810283)
- Testing
- electrical impedance tomography
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Phase II Study of RC1416 Injection in COPD
This is a multicenter, randomized, double-blind, placebo-controlled phase II clinical study to evaluate the efficacy and safety of RC1416 injection in patients with moderate to severe chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT07402551
- Testing
- RC1416
- Where
- 46 sites in China
- Volunteers
- 180 people
- Sponsor
- Nanjing RegeneCore Biotech Co., Ltd.
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Exercise Order During Pulmonary Rehabilitation on Muscle Strength in Patients With COPD
Chronic Obstructive Pulmonary Disease (COPD) is a chronic multisystem disease frequently associated with peripheral muscle dysfunction, which is strongly linked to prognosis and survival.
- Trial name
- ISTOR-COPD (NCT07655011)
- Testing
- Pulmonary Rehabilitation - Strength First, Pulmonary Rehabilitation - Endurance First
- Where
- France
- Volunteers
- 138 people
- Sponsor
- CHU de Reims