Clinical trials: COPD Bronchitis
Cystic Fibrosis, Primary Ciliary Dyskinesia
Multiple Breath Washout, a Clinimetric Dataset
Monitoring patients with chronic, inflammatory airways disease particularly in the early stages is hampered by the relative insensitivity of current outcome measures to detect subtle changes.
- Conditions
- Cystic Fibrosis, Primary Ciliary Dyskinesia, Bronchiectasis, Asthma
- Trial name
- NCT03320382
- Testing
- Multiple breath washout testing
- Where
- United Kingdom
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Obstructive Chronic Pulmonary Disease, Emphysema
Effects of Exercise Training on Systemic Inflammation an Muscle Repair According to the Obstructive Chronic Pulmonary Disease (COPD) Phenotype
AIM: To identify those mechanisms involved in the systemic and muscular response to exercise treatment, in two different Obstructive Chronic Pulmonary Disease (COPD) phenotypes (emphysema and non-emphysema).
- Conditions
- Obstructive Chronic Pulmonary Disease, Emphysema, Chronic Bronchitis
- Trial name
- NCT01431625
- Testing
- Combined Training (endurance and strength exercises)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Respiratory Tract Diseases, Abnormal Mucus Secretions
A Clinical Trial to Compare the Efficacy and Safety of 1-week Treatment of Intravenous N-acetylcysteine (NAC) 600 mg Twice Daily, Ambroxol Hydrochloride 30 mg Twice Daily and Placebo as Expectorant Therapies in Adult Chinese Patients With Respiratory Tract Diseases and Abnormal Mucus Secretions
This is a phase 3, multicenter, randomized, rater- and patient-blind, placebo- and active-controlled, 3-arm parallel group clinical trial.
- Trial name
- NCT03843541
- Testing
- N-acetylcysteine (NAC) 600 mg, Ambroxol hydrochloride 30 mg
- Where
- 32 sites in China
- Volunteers
- 333 people
- Sponsor
- Zambon SpA
Chronic Bronchitis, COPD
RheOx Registry Study in Europe
Post-market clinical study (registry study) to collect post-market safety and clinical utility data in European patients with chronic bronchitis treated with RheOx.
- Trial name
- NCT04182841
- Testing
- RheOx
- Where
- 2 sites in Austria, Germany
- Volunteers
- 100 people
- Sponsor
- Gala Therapeutics, Inc.
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
Comparison of Two Programs to Encourage Physical Activity in Individuals With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease. Symptoms include shortness of breath, wheezing, and difficulty exercising.
- Trial name
- NCT00328484
- Testing
- Lifestyle Activity Program, Exercise Program
- Where
- United States
- Volunteers
- 318 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pulmonary Disease, Chronic Obstructive
Airway Limitation Study: Study In Primary Care Centers Of Chronic Bronchitis In Long-Term Cigarette Smokers Of At Least 40 Years Of Age With Symptoms Of Cough And Shortness Of Breath
The study does not involve testing of a drug (no treatment intervention). The study will will use spirometry (breathing tests) in subjects of 40 years of age and older with a history of cigarette smoking with chronic bronchitis…
- Trial name
- NCT00442468
- Testing
- Non-interventional study.
- Where
- 47 sites in United States
- Volunteers
- 1,283 people
- Sponsor
- GlaxoSmithKline
Lung Cancer, Lung Infection
Identification of Multiple Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Breath
The goal of this observational study is to develop an advanced expiratory algorithm model utilizing exhaled breath volatile organic compound (VOC) marker molecules.
- Conditions
- Lung Cancer, Lung Infection, COPD, Bronchitis
- Trial name
- NCT06528418
- Testing
- Gas chromatography-mass spectrometry(GC-MS) and micro Gas Chromatography-photoionisation detector (μGC-PID) system
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- ChromX Health
Lung Diseases, Bronchitis, Chronic
Intermittent Moxifloxacin Therapy For The Prevention Of Acute Exacerbations In Patients With Chronic Bronchitis
Moxifloxacin, is being tested at approximately 60 study centres in 15 countries to determine if this drug, when taken periodically in addition to the patients normal treatment, is effective at reducing the number of flare-ups of…
- Trial name
- NCT00473460
- Testing
- Avelox (Moxifloxacin, BAY12-8039)
- Where
- 78 sites in United States, Andorra and 13 more
- Volunteers
- 1,404 people
- Sponsor
- Bayer
Chronic Obstructive Pulmonary Disease
Efficacy of Simvastatin for the Treatment of COPD
To evaluate in patients with stable Chronic Obstructive Pulmonary Disease (COPD) the efficacy of statins (simvastatin) on: (1) endothelial function; (2) systemic inflammation; (3)BODE (B: body mass , O: bronchial obstruction, D…
- Trial name
- NCT02070133
- Testing
- Simvastatin
- Where
- 2 sites in Spain
- Volunteers
- 18 people
- Sponsor
- Hospital Universitari Son Dureta
COPD, Chronic Obstructive Pulmonary Disease
Melodica Orchestra for Dyspnea: Safety and Feasibility Pilot
This project seeks to pilot-test the feasibility of using a melodica training program to teach pursed lip breathing for Veterans with chronic obstructive pulmonary disease (COPD) with moderate to severe dyspnea (shortness of…
- Conditions
- COPD, Chronic Obstructive Pulmonary Disease, Dyspnea, Breathlessness
- Trial name
- MELODY (NCT03653104)
- Testing
- Melodica Intervention, Pulmonary Health Education
- Where
- United States
- Sponsor
- VA Quality Enhancement Research Intiative
Chronic Obstructive Pulmonary Disease (COPD), Chronic Obstructive Lung Disease
Mindfulness-based Cognitive Therapy for Chronic Obstructive Pulmonary Disease
The purpose of the study is to determine the efficacy of mindfulness-based cognitive therapy (MBCT) as an add-on to pulmonary rehabilitation (treatment as usual, TAU) in chronic obstructive pulmonary disease (COPD).
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Chronic Obstructive Lung Disease, Chronic Obstructive Airway Disease, Chronic Bronchitis
- Trial name
- NCT02042976
- Testing
- Mindfulness-based cognitive therapy, Pulmonary rehabilitation
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- University of Aarhus
Chronic Obstructive Pulmonary Disease (COPD)
Examine the Impact of Early Education on COPD Management
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease primarily caused by smoking. COPD creates a tremendous burden to the healthcare system, as disease exacerbations result in frequent, prolonged…
- Trial name
- NCT02398643
- Testing
- Pulmonary Education (PE), Usual Care
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Alberta
Chronic Obstructive Pulmonary Disease (COPD)
The CaNadian Standardized Pulmonary Rehabilitation Efficacy Trial
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease primarily caused by smoking. Pulmonary rehabilitation (PR) is an evidence-based, interdisciplinary, and comprehensive intervention for COPD patients that…
- Trial name
- CoNSPiRE (NCT02917915)
- Testing
- Canadian Standardized PR, Traditional PR
- Where
- Canada
- Volunteers
- 207 people
- Sponsor
- University of Alberta
COPD
Study of the Effects of Education on Patients With Chronic Obstructive Pulmonary Disease
The investigators hypothesize that education will improve exercise capacity, symptoms and quality of life in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT01633697
- Testing
- Pranayama, Education alone
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of Vermont
Lung Diseases, Obstructive, Bronchitis
Medication Adherence in COPD--A Self-Regulation Study
To test the effectiveness of a self-management program for chronic obstructive disease (COPD) patients. The program to improve adherence could be conducted by nurses or other clinic staff in settings where comprehensive…
- Conditions
- Lung Diseases, Obstructive, Bronchitis, Emphysema, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT00005717
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pulmonary Disease, Chronic Obstructive, Bronchitis, Chronic
A Blinded Study Comparing the Safety and Efficacy of a Fully Human Anti-IL8 Monoclonal Antibody (ABX-IL8) to Placebo in Patients With Chronic Bronchitis and COPD
To determine if ABX-IL8 will improve shortness of breath.
- Trial name
- NCT00035828
- Testing
- ABX-IL8
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Abgenix
Chronic Obstructive Pulmonary Diseases, Chronic Airways Limitation
Mepolizumab in Chronic Obstructive Pulmonary Diseases (COPD) With Eosinophilic Bronchitis
Some patients with chronic obstructive pulmonary diseases (COPD) have large number of specific white blood cells called eosinophils in their airways.
- Conditions
- Chronic Obstructive Pulmonary Diseases, Chronic Airways Limitation, Bronchitis
- Trial name
- NCT01463644
- Testing
- Mepolizumab
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- McMaster University
Chronic Obstructive Pulmonary Disease (COPD), Emphysema
The Relationship Between GOLD Risk Group and Clinical Outcomes in a Community-based COPD Cohort
This is an observational study examining outcomes and treatment patterns in a community-based cohort of subjects with Chronic obstructive pulmonary disease (COPD) who are based in the Kannapolis, NC area.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Emphysema, Chronic Bronchitis
- Trial name
- NCT02838108
- Where
- United States
- Volunteers
- 452 people
- Sponsor
- Duke University
COPD
A Study to Assess the Safety and Efficacy of Different AD 237 Doses in Adults With COPD
The purpose of this study is to investigate the efficacy, safety and tolerability of AD 237 in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00242333
- Testing
- AD 237
- Where
- 33 sites in Bulgaria, Hungary and 2 more
- Volunteers
- 300 people
- Sponsor
- Sosei
Pulmonary Disease, Chronic Obstructive
Clinical Evaluation Of GW815SF For Chronic Obstructive Pulmonary Disease (Chronic Bronchitis, Emphysema)
This study compares the effect of two medicines on COPD (Chronic Obstructive Pulmonary Disease). This study will last up to 18 weeks, and subjects will visit the clinic 5 times.
- Trial name
- NCT00269126
- Testing
- fluticasone propionate/salmeterol combination DISKUS, salmeterol xinafoate
- Where
- 2 sites in Japan
- Volunteers
- 150 people
- Sponsor
- GlaxoSmithKline