Clinical trials: COPD Exacerbation Acute
Pulmonary Disease, Chronic Obstructive
Nutritional Status in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
A cross sectional observation study of body composition in COPD patients consecutively hospitalized with acute exacerbation.
- Trial name
- NCT03709498
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Evangelismos Hospital
Chronic Obstructive Pulmonary Disease With (Acute) Exacerbation
Effect of Roflumilast at Acute Exacerbations of Chronic Obstructive Pulmonary Disease
The purpose of this trial is to investigate if roflumilast can reduce the neutrophilic inflammation at acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- TREAT (NCT01473758)
- Testing
- Roflumilast
- Where
- 2 sites in United Kingdom
- Volunteers
- 81 people
- Sponsor
- AstraZeneca
COPD Exacerbation, Chronic Obstructive Pulmonary Disease Exacerbation
Comparing Mortality for Low vs High Peripheral Oxygen Saturation in COPD-patients With Acute Exacerbation
Chronic obstructive pulmonary disease (COPD) is a common disorder that affects approximately 400,000 Danish citizens. About 3,000-3,500 Danes die yearly because of the disorder, and the costs associated with hospital admissions…
- Trial name
- O2flow-COPD (NCT04223050)
- Testing
- Oxygen gas
- Where
- 4 sites in Denmark
- Volunteers
- 23 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Chronic Obstructive Lung Disease (COLD)
ANTEAB: a Study of Early Antibiotherapy in the ICU Management of Acute Exacerbations of COPD
Intensive Care Unit (ICU) admission for acute exacerbation of chronic obstructive lung disease (COLD) is a major cause of morbidity and mortality in such patients. Although bacterial of mortality in such patients.
- Trial name
- NCT00190437
- Testing
- Amoxicillin-clavulanic
- Where
- 2 sites in France
- Volunteers
- 520 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Respiratory Conditions, COPD
The AcCREDiT 2 Study
The ACCREDIT study - Acute respiratory infections and chronic respiratory disease exacerbations characterisation and personalised treatment platform study 2 (AcCREDiT 2).
- Conditions
- Chronic Respiratory Conditions, COPD, Pneumonia, Bacterial Infections
- Trial name
- ACCREDIT2 (NCT07029672)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Manchester University NHS Foundation Trust
Acute Exacerbation of COPD
Use of MULTIplex PCR, Procalcitonin, and Sputum Appearance to Reduce Duration of Antibiotic Therapy During Severe COPD EXAcerbation: A Controlled, Randomized, Open-label, Parallel-Group, Multicenter Trial
COPD is a common chronic disease. Its natural course is characterized by Acute exacerbations (AE). This may require hospitalization or even ICU/RESUSCITATION admission.
- Trial name
- MULTI-EXA (NCT05280132)
- Testing
- Personalized antibiotic treatment, Usual antibiotic treatment
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Obstructive Pulmonary Disease With Acute Exacerbation, Unspecified
Comparison of Two Oxygen Setting During Non-invasive Mechanical Ventilation of Chronic Obstructive Pulmonary Disease
Hypoxaemic patients with exacerbations of chronic obstructive pulmonary disease (COPD) are at some risk of carbon dioxide (CO2) retention during oxygen therapy.
- Trial name
- OXYSET (NCT02563314)
- Testing
- Non-invasive mechanical ventilation - Normoxia, Non-invasive mechanical ventilation - Controlled hypoxemia
- Where
- 4 sites in France
- Volunteers
- 1 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Dyspnea, Decompensated Heart Failure ; COPD Exacerbation
Diagnosis of Heart Failure in Chronic Obstructive Pulmonary Disease Using the Lung Ultrasound
Acute Heart failure (AHF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis.
- Trial name
- NCT05352490
- Testing
- calculate LUS score
- Where
- Tunisia
- Volunteers
- 350 people
- Sponsor
- University of Monastir
Asthma Acute, COPD Exacerbation Acute
Rademikibart IV for Acute Asthma and COPD Exacerbation
A Phase 2, open-label, single-arm trial to evaluate IV rademikibart as an add-on treatment for acute exacerbation in participants with asthma or COPD with type 2 inflammation
- Trial name
- NCT07705737
- Testing
- Rademikibart
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Connect Biopharm LLC
Lung Diseases, Obstructive
Prospective Randomized Study of Nasal High Flow in Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The main oxygen therapy to the patients with acute exacerbation of Chronic obstructive pulmonary disease, who are mild to moderate respiratory insufficiency (arterial blood gas analysis showed pH = 7.35, PO2 <…
- Trial name
- NCT02439333
- Testing
- Nasal high flow cannula (Fisher & Paykel Healthcare, Auckland, New Zealand), nasal catheter or Venturi mask
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Li Xuyan
Chronic Obstructive Pulmonary Disease (COPD)
Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)
The goal of this cluster randomized controlled trial is to determine the optimal treatment for Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
- Trial name
- NCT06892210
- Testing
- Methylprednisolone (drug), Hydrocortisone
- Where
- 14 sites in Denmark
- Volunteers
- 2,000 people
- Sponsor
- Copenhagen Respiratory Research
COPD
The Clinical Characteristics, Treatment and Prognosis of Tuberculosis-associated COPD
Chronic obstructive pulmonary disease (COPD) still imposes a substantial health and economic burden worldwide. Pulmonary tuberculosis has been confirmed as an important risk factor for COPD and this specific phenotype is thereby…
- Trial name
- NCT06074042
- Testing
- previous pulmonary tuberculosis
- Where
- China
- Volunteers
- 540 people
- Sponsor
- Peking University Third Hospital
Copd, COPD Exacerbation
Change in Breathing Pattern on Non-invasive Ventilation of COPD Patients Under Home Mechanical Ventilation
Acute exacerbation of COPD (AECOPD) worsen prognosis and quality of life of COPD patients. Telemonitoring could be a useful tool for early identification of AECOPD. Parameters that have to be monitored are not well defined.
- Trial name
- NCT03018470
- Testing
- Analysis of data from NIV built-in software
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Rouen
Chronic Obstructive Pulmonary Disease, COPD Exacerbation
Effects of High Flow Nasal Cannula on Sputum Clearance in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Acute exacerbation of COPD usually presents with more sputum production leading to worsening airflow obstruction. Often patients complain of sensation of sputum (phlegm) stuck in throat, which leads to worsening cough and…
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD Exacerbation, Airflow Obstruction
- Trial name
- NCT04217746
- Testing
- High Flow Nasal Cannula
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Tufts Medical Center
COPD, COPD Exacerbation
Using Mobile Health to Respond Early to Acute Exacerbations of COPD in HIV
Investigators propose to develop methods to improve early identification of acute exacerbations of COPD (AECOPD) among HIV-infected individuals.
- Trial name
- mReach (NCT01892566)
- Testing
- mHealth Intervention
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
Changes in Cytokine Levels During an Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine whether there is a statistical association between changes in sputum serial levels of two cytokines, interleukin (IL)-17 and IL-6, during the treatment course of a severe acute…
- Trial name
- NCT00281242
- Testing
- blood draw
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Michigan
Pulmonary Disease, Chronic Obstructive
Magnesium Sulfate to Prevent Hospitalisation of Acute Exacerbations of Chronic Obstructive Pulmonary Disease
The purpose of this study is to assess whether administration of a bolus dose of MgSO4 (magnesium sulfate) plus standard therapy is superior to standard therapy alone for the management of Acute Exacerbations of Chronic Pulmonary…
- Trial name
- NCT02498496
- Testing
- Magnesium Sulfate
- Sponsor
- Hôpital de Verdun
Pulmonary Disease, Chronic Obstructive
Effects of Tai Chi for Early Pulmonary Rehabilitation in Elderly Patients With AECOPD
The goal of this clinical trial is to learn about the therapeutic effect of Chinese traditional exercise Tai Chi in elderly acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with malnutrition.
- Trial name
- NCT05986448
- Testing
- Tai-chi exercise
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Houmei SHEN
Chronic Obstructive Pulmonary Disease
Comparison Between Symbicort® and Prednisolone in COPD
To assess if Symbicort forte Turbuhaler (during two weeks) is as effective as an oral course of prednisolone + Oxis Turbuhaler (during two weeks) for the treatment of an acute exacerbation of Chronic Obstructive Pulmonary Disease…
- Trial name
- SPACE (NCT00259779)
- Testing
- budesonide/formoterol, Prednisolone
- Where
- 37 sites in Denmark, Finland and 3 more
- Volunteers
- 120 people
- Sponsor
- AstraZeneca
Pneumonia, Acute Exacerbation of Chronic Obstructive Airways Disease
Procalcitonin as a Marker of Antibiotic Therapy in Patients With Lower Respiratory Tract Infections
The purpose of this study is to investigate weather or not the use of a procalcitonin(PCT)-based treatment in the daily clinical work could lower the consumption of antibiotics in patients with lower respiratory tract infections.
- Trial name
- NCT02171338
- Testing
- PCT-level, Antibiotic treatment based on PCT-level
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- Holbaek Sygehus