Clinical trials: COPD Patients
Chronic Obstructive Pulmonary Disease (COPD)
FITME Study: Formulating Individualised Exercise Prescription in Chronic Obstructive Pulmonary Disease
This randomised controlled trial aims to: i) compare the power output at the first metabolic threshold (WMT1) between the MT1 and the six-minute walking test (6MWT)-based cardiorespiratory exercise prescriptions in chronic…
- Trial name
- FITME (NCT07792642)
- Testing
- Pulmonary rehabilitation programme
- Where
- Portugal
- Volunteers
- 46 people
- Sponsor
- Aveiro University
COPD, Smoking
Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS
The purpose of this randomized study is to demonstrate direct clinical benefit, i.e., observed benefits in how humans with COPD feel in terms of symptoms (e.g., cough frequency, shortness of breath, and other respiratory…
- Conditions
- COPD, Smoking, Tobacco Use
- Trial name
- NCT07108166
- Testing
- Cigarette, THS
- Where
- 112 sites in United States, Bulgaria and 7 more
- Volunteers
- 290 people
- Sponsor
- Philip Morris Products S.A.
Emphysema or COPD
Inter-lobar Fissure Completion in Patients With Failed Bronchoscopic Lung Volume Reduction
The purpose of this protocol is to perform a pilot prospective controlled clinical trial to evaluate the potential role of lung fissure completion with pleural adhesiolysis strategy (experimental intervention) in severe…
- Trial name
- SAVED-1 (NCT05257681)
- Testing
- Interlobar fissure completion and pleural adhesiolysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Beth Israel Deaconess Medical Center
COPD (Chronic Obstructive Pulmonary Disease)
Validation of Chronic Obstructive Pulmonary Disease (COPD) Algorithm
Under-diagnosis of Chronic Obstructive Pulmonary Disease (COPD) is prevalent, with an estimated 75% of adults suffering from COPD in the US, without clinical recognition.
- Trial name
- COPD (NCT07223749)
- Where
- United States
- Volunteers
- 425 people
- Sponsor
- Wake Forest University Health Sciences
Hypoxemia, Gastric Cancer (Diagnosis)
High-Flow Nasal Cannula Oxygenation During Sedated Gastrointestinal Endoscopy in Patients With Chronic Obstructive Pulmonary Disease
Hypoxemia is the most common adverse event during propofol sedation for gastrointestinal endoscopy in patients with chronic obstructive pulmonary disease (COPD) due to diminished pulmonary reserve.
- Conditions
- Hypoxemia, Gastric Cancer (Diagnosis), Chronic Obstructive Pulmonary Disease (COPD), Esophageal Cancer
- Trial name
- NCT07791979
- Testing
- High-flow nasal cannula
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Zhejiang University
Hypercapnia, Asthma Exacerbation
Combination of High-flow Nasal Oxygen (Optiflow) and Vibrating Membrane Nebuliser (Aerogen) in the Pre-hospital Setting - Before/After Study
The aim of this observational before/after study is to determine how to optimally administer oxygen to patients experiencing an asthma or COPD exacerbation in emergency medical services.
- Conditions
- Hypercapnia, Asthma Exacerbation, COPD Exacerbation
- Trial name
- O2NAB (NCT07791992)
- Testing
- Vibrating membrane nebulizer and high-intensity nasal oxygen, nebulizer mask and oxygen therapy of 6 to 9 liters per minute
- Where
- France
- Sponsor
- Centre Hospitalier Sud Francilien
COPD (Chronic Obstructive Pulmonary Disease), Hypoxemia
Inhaled Treprostinil (Tyvaso Nebulizer) For COPD Patients With Hypoxemia
The goal of this clinical trial is to evaluate whether inhaled Treprostinil (Tyvaso) can improve oxygen delivery and blood flow in the lungs in adults (age ≥40) with chronic obstructive pulmonary disease (COPD) and hypoxemia who…
- Trial name
- Tyvaso (NCT07037836)
- Testing
- Inhaled Treprostinil (Tyvaso Nebulizer)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Bastiaan Driehuys
Chronic Obstructive Pulmonary Disease (COPD)
Functional Social Support in COPD Self-Management
This observational study aims to examine how different types of functional social support (emotional/informational, tangible, affectionate, and positive social interaction) predict self-management capacity among individuals with…
- Trial name
- NCT07353034
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Medical University of South Carolina
Chronic Obstructive Pulmonary Disease (COPD)
cfMSC Stem Cell Therapy Targeting COPD
The primary objectives are to evaluate the safety and efficacy of infusion of fully characterized clonally derived fetal mesenchymal stem cells (cfMSCs) for the control of severe symptoms associated with moderate to severe…
- Trial name
- NCT07477600
- Testing
- clonal fetal MSCs
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
COPD Patients, Depression in Chronic Obstructive Pulmonary Disease
Effect of Utilizing Virtual Reality With Pulmonary Rehabilitation on Depression in COPD Patients
The goal of this study is to find the effect of utilizing virtual reality with pulmonary rehabilitation on depression in COPD patients.
- Trial name
- NCT07790627
- Testing
- virtual reality with pulmonary rehabilitation, controlled group received pulmonary rehabilitation without utilizing virtual reality
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Chronic Obstructive Pulmonary Disease (COPD), Interstitial Lung Disease (ILD)
Cross-Regional Unmanned Aircraft Transport of Donor Lungs
This prospective, single-arm study will evaluate the feasibility, timeliness, operational reliability, and preliminary safety of transporting donor lungs by a long-range unmanned aircraft system from Nanning to Guangzhou, China.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Interstitial Lung Disease (ILD), End-stage Lung Disease
- Trial name
- UAV-LUNG (NCT07790822)
- Testing
- Cross-Regional Unmanned Aircraft Transport of Donor Lungs
- Where
- China
- Volunteers
- 25 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
COPD Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease
Assessing Functional Capacity in Directly and Remotely Monitored Home-based Settings: A Protocol for a Multinational Validation Study in Individuals With Chronic Respiratory Diseases
The goal of this validation study is to provide further evidence of the metrological properties of the 6-minute stepper test in individuals with chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD).
- Trial name
- 6MST (NCT06447831)
- Where
- 3 sites in Canada, France
- Volunteers
- 89 people
- Sponsor
- Laval University
COPD (Chronic Obstructive Pulmonary Disease)
Photon-counting CT in Chest Imaging
Purpose and objective: This project aims to evaluate photon-counting computed tomography (PCCT) quantitative accuracy using COPDGene subjects.
- Trial name
- NCT07031336
- Testing
- Photon-counting CT, Energy-integrating CT
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Chronic Obstructive Pulmonary Disease (COPD)
Improving Medication Management in COPD
A pilot trial to examine feasibility of a pharmacist-led intervention for patients with COPD (Chronic Obstructive Pulmonary Disease) and multimorbidity to improve medication safety and reduce dyspnea.
- Trial name
- NCT07453719
- Testing
- Pharmacist-led Medication Management Intervention
- Volunteers
- 92 people
- Sponsor
- Duke University
COPD
Cognitive Load and Inhaler Technique in COPD
This study evaluates whether cognitive load affects inhaler technique in adults with chronic obstructive pulmonary disease (COPD).
- Trial name
- DUAL-INH (NCT07786220)
- Testing
- Working-Memory Cognitive Load During Inhaler Use, Single-Task Inhaler Use
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Spitalul Clinic de Boli Infecțioase și Pneumoftiziologie Dr. Victor Babeș Timișoara
COPD (Chronic Obstructive Pulmonary Disease), COPD
Dupilumab in Type 2-Inflamed COPD Across the Full Spectrum of Airflow Limitation: An Italian Multicentre Retrospective Cohort Study
This multicentre retrospective cohort study describes lung function and patient-reported outcomes in adults with chronic obstructive pulmonary disease (COPD) and type 2 inflammation who received add-on dupilumab in routine…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), COPD, Eosinophilia
- Trial name
- DUPICENTRO (NCT07788092)
- Testing
- Dupilumab
- Where
- 6 sites in Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliera di Perugia
Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Nutritional Risk and Diaphragmatic Thickness in Mechanically Ventilated COPD Patients
Malnutrition and muscle wasting are frequent complications in patients with chronic obstructive pulmonary disease (COPD) experiencing acute exacerbations.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Malnutrition, Respiratory Failure
- Trial name
- NCT07788170
- Volunteers
- 120 people
- Sponsor
- Assiut University
COPD (Chronic Obstructive Pulmonary Disease), Cardiovascular Diseases
Cardiovascular Assessment and Treatment During COPD Exacerbation to Improve Diagnosis and Outcomes
This is a research study involving patients hospitalized for COPD flare-ups. Patients will be assigned using a non-randomized, sequential allocation strategy (a control cohort followed by an intervention cohort) to two groups…
- Trial name
- CATCH (NCT06723795)
- Testing
- Cardiologist evaluation, Pulmonologist evaluation
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
COPD (Chronic Obstructive Pulmonary Disease)
Internet-Based Cognitive Behavioral Therapy and Educational Program for People Living With Chronic Obstructive Pulmonary Disease (COPD)
The goal of this clinical trial is to learn if an internet-based cognitive behavioral therapy (CBT) and education program can help improve mental health, disease knowledge, and quality of life in adults with chronic obstructive…
- Trial name
- COPD BALANCE (NCT06891677)
- Testing
- Internet-Based Cognitive Behavioral Therapy (CBT) with ACT and COPD Education
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- Jonas Agholme
COPD (Chronic Obstructive Pulmonary Disease), Asthma (Diagnosis)
Creation of a Biological Collection of BRonchiaI and Pulmonary Tissues From Surgical wastE
The biological samples and associated data will facilitate the successful implementation of the research collaboration between Bordeaux University Hospital and the University of Bordeaux on the pathophysiology of bronchopulmonary…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Asthma (Diagnosis), Safe Volunteers
- Trial name
- BRISE (NCT07780630)
- Testing
- Fiberscopic samples, Sputum, Nasal brushing
- Where
- France
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux