Clinical trials: CORE
Obesity
Metformin and Core Temperature in Obese and Lean Males
Metformin is known to increase 18F-FDG uptake in subjects using metformin in retrospective trials. In this study the researchers aim to investigate the influence of metformin (500 mg 1/day) on temperature in the colon, glucose…
- Trial name
- McTOM (NCT02783053)
- Testing
- Metformin
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Stroke
Postural Assessment of Stroke Patients by Pose Estimation and Effects of Dynamic Core Postural Chain Stabilization
This study focuses on a two-pronged strategy to enhance the rehabilitation of stroke patients. It first investigates the application of pose estimating technologies to objectively measure posture.
- Trial name
- NCT06478069
- Testing
- Group A, Group B
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Superior University
Coronary Artery Disease
Ultra-high-resolution CT vs. Conventional Angiography for Detecting Coronary Heart Disease
Cardiac catheterization with invasive coronary angiography is the gold standard for determining the presence or absence of significant coronary heart disease (CHD).
- Trial name
- NCT04272060
- Testing
- CT angiography, Invasive coronary angiography
- Where
- 3 sites in United States, Brazil and 1 more
- Volunteers
- 175 people
- Sponsor
- Johns Hopkins University
DDX3X, Mental Retardation, X-linked 102
DDX3X Syndrome -The Seaver Autism Center for Research and Treatment is Characterizing DDX3X-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures.
DDX3X syndrome is a genetic cause of intellectual disability and other neurologic features including, in some cases, autism. Variants in the DDX3X gene are thought to account for 1-3% of unexplained intellectual disability in…
- Conditions
- DDX3X, Mental Retardation, X-linked 102, Autism Spectrum Disorder
- Trial name
- NCT03718910
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Atopic Dermatitis
Follow-Up Study of Patients Previously Treated With Pimecrolimus Tablets for Atopic Dermatitis
This extension study is being conducted to collect post-treatment safety information on patients who previously participated in the core clinical trial.
- Trial name
- NCT00098150
- Volunteers
- 66 people
- Sponsor
- Novartis
Athletic Injuries, Sports Physical Therapy
The Relationship Between Scapular Endurance, Core Endurance, and Functional Performance in Adolescent Tennis Players
This study aims to examine the relationship between scapular endurance, core endurance, and upper extremity performance in adolescent tennis players.
- Trial name
- NCT06291701
- Testing
- Assessment of scapular endurance, Prone Bridge Test, Side Bridge Test
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ordu University
Quality Improvement, Medical Education
Workshops in Sustainable Healthcare to Assess How Teaching Can Aid Core Principle Implementation
With more frequent extreme weather events, climbing atmospheric Carbon dioxide and unabated use of fossil fuels, planetary health and sustainability will become crucial to future medical practice.
- Trial name
- WISH (NCT05980819)
- Testing
- Sustainability lecture and opportunity to create a project
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Breast Cancer
Feasibility in Identification of Breast Cancer Candidates for Elimination of Axillary Surgery
Preoperative identification of patients with pathologic complete response or residual disease in axilla can aid in tailoring subsequent axillary surgery including omission of axillary surgery based on tumor biology and response…
- Trial name
- NCT05663021
- Testing
- Ultrasound-guided core needle biopsy in breast
- Where
- China
- Volunteers
- 191 people
- Sponsor
- Fudan University
Cooling Fabrics, Exercise Performance
Cooling Fabrics and Exercise Performance in Endurance Athletes
In humans, the primary means of cooling the body during exercise is through the evaporation of sweat from the skin surface. Clothing represents a layer of insulation that hinders the evaporation of sweat from the surface of the…
- Conditions
- Cooling Fabrics, Exercise Performance, Thermoregulation
- Trial name
- NCT02016521
- Testing
- Cooling Fabric
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McGill University
Body Temperature Changes, Body Composition
The Association Between Core Temperature and Health
The goal of this clinical trial is to learn if cold water drinking could promote body composition and further extend healthy lifespan in Chinese older adults. The main questions it aims to answer are: 1.
- Conditions
- Body Temperature Changes, Body Composition, Aging
- Trial name
- NCT06432491
- Testing
- Drinking cold water
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Schizophrenia, Major Depression
Procedures for Sample Acquisition and Distribution for The Human Brain Collection Core
Background: The Human Brain Collection Core (HBCC) collects brain and other tissues. They get these from deceased people who may or may not have had psychiatric disorders.
- Conditions
- Schizophrenia, Major Depression, Bipolar Disorder, PTSD
- Trial name
- NCT03092687
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- National Institute of Mental Health (NIMH)
Non-specific Low Back Pain
The Effects of Blood Flow Restriction-based Abdominal draw-in Maneuver on Activation of Abdominal Core Muscles in Patients With Non-specific Low Back Pain
The transverse abdominis (TrA) is the deepest muscle layer of lateral and anterior abdominal wall and also known as a significant component of core stability.
- Trial name
- NCT05996341
- Testing
- blood flow restriction
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Upper Extremity Injury
Effects of Abdominal Bracing Maneuver on the Upper Extremity Performance in Volleyball Athletes
The goal of this cross-sectional study is to investigate the effects of abdominal bracing, a trunk co-activation maneuver that activates core muscles, on upper extremity performance tests in adolescent female volleyball athletes.
- Trial name
- NCT07124286
- Testing
- Abdominal Bracing Training
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Ankara Yildirim Beyazıt University
Amphetamine Use Disorders
Closed-loop tACS Modulation for the Core Clinical Features of Drug Addiction
Using specific EEG biomarkers in methamphetamine-dependent individuals, this study systematically probes the effect of closed-loop tACS based on brain states
- Trial name
- NCT06454474
- Testing
- Closed-loop tACS stimulation based on addiction-induced states
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Shanghai Mental Health Center
Low Back Pain and Core Muscle
Low Back Pain Intensity and Core Muscle Strength After Different Delivery Modes
Cesarean delivery (CD) may trigger an increase in low back pain (LBP) intensity and induce core muscle weakness. This study will assess the correlation between low back pain intensity and core muscle strength of transverse…
- Trial name
- NCT05493891
- Testing
- Visual analogue scale (VAS), Pressure Biofeedback Unit (PBU)
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- South Valley University
Cognitive Training, Functional Core Stability Training
Effect of Functional Core Stability Training or Cognitive Training on Balance and Postural Control in Chronic Ankle Instability
The purpose of the study is to investigate dynamic core stability training versus cognitive training on balance, functional performance, postural control, ankle instability scores, ankle dorsiflexion range of motion, and mental…
- Conditions
- Cognitive Training, Functional Core Stability Training, Balance; Distorted, Postural Control
- Trial name
- NCT07283276
- Testing
- strengthening exercises, Balance training, Functional core training
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University
Diagnosis of a Pancreaticobiliary Disorder, Biopsy
Comparison of FNB to EUS-CNB for Pancreatic Lesions
The primary aim of this study is to compare the tissue specimen quality and diagnostic accuracy of biopsies obtained with one puncture of a regular 22 FNB G needle and the motorized EUS CNB device of pancreatic lesions.
- Conditions
- Diagnosis of a Pancreaticobiliary Disorder, Biopsy, EUS Guided Biopsy
- Trial name
- NCT07240818
- Testing
- endoscopic ultrasound guided biopsy with core needle biopsy device, EUS-FNB
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Davis
Substance Use Disorders, Substance Abuse
Effects of Core Stabilization Exercises on Pulmonary Functions, Respiratory Muscle Strength and Functional Capacity
In recent years adolescent substance abuse is a serious and growing problem. Substance use among adolescents means the use of alcohol, opiates, amphetamines, inhalants, cocaine, marijuana, benzodiazepines, hallucinogens, and…
- Conditions
- Substance Use Disorders, Substance Abuse, Substance Use
- Trial name
- NCT03461614
- Testing
- Exercise group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people
- Sponsor
- Istanbul University
Lumbar Hyperlordosis, Athletic Injuries
Effectiveness of Abdominal Muscle Strengthening and Pelvic Control in the Prevention of Dance Injuries
Introduction. After observing the lack of lumbo-pelvic control and the difficulty in identifying the musculature used when performing the different dance positions, it was decided to carry out an exercise intervention to…
- Trial name
- NCT05771233
- Testing
- Prevention
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Cerebral Palsy
Effects of Core Stability Program on Abdominal Endurance in Wheelchair Bound Cerebral Palsy
This study aims to evaluate the effects of a Core Stability Program on abdominal endurance and constipation severity in wheelchair-bound children with cerebral palsy.
- Trial name
- NCT07764952
- Testing
- Core Stability Program, traditional Physiotherapy
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
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