Clinical trials: CORE
Myopathy, Myositis
Ultrasound in Muscle Biopsy
The objective of the proposed study is to evaluate the clinical utility of muscle ultrasonography for improving the diagnostic yield and safety of core muscle biopsy.
- Conditions
- Myopathy, Myositis, Muscular Dystrophy
- Trial name
- NCT01790178
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Bone Marrow Aspiration and Biopsy Specimen Collection
A Study Comparing Use of Manual and Power Bone Marrow Aspiration and Biopsy Devices in Children
The purpose of this study is to compare use of a powered bone marrow aspiration and biopsy device (OnControl) to use of a standard manual bone marrow aspiration and biopsy device to obtain bone marrow biopsy specimens in…
- Trial name
- NCT02159118
- Testing
- Manual bone marrow aspiration and biopsy device, Powered bone marrow aspiration and biopsy device
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Vidacare Corporation
Esophageal Subepithelial Lesions
EUS-CNB Versus EUS-SINK for Diagnosis of Upper Gastrointestinal (UGI) Subepithelial Tumors
This is a single-blinded randomized control trial trying to compare the effectiveness of diagnosis between two techniques employed in tissue sampling for subepithelial tumors (SETs) of the gastrointestinal tract.
- Trial name
- NCT02282111
- Testing
- 22-gauge Procore needle (ProCore, Cook Medical Inc., Winston-Salem, NC), conventional needle-knife sphincterotome (Microknife XL; Boston Scientific Inc, Natick, Mass)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Johns Hopkins University
Perioperative Optimization
Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data
This REMAP Periop ERP domain study falls under the Periop Core Protocol, which compares the different recommended strategies for enhancing recovery through the use of various standard of care treatments before, during and after…
- Trial name
- NCT04606264
- Testing
- Neuraxial Analgesia, Regional Block 1: Paravertebral, Perphenazine
- Where
- 3 sites in United States
- Volunteers
- 3,395 people
- Sponsor
- Jennifer Holder-Murray
Breast Cancer, Anxiety
Self Hypnotic Relaxation As An Adjunct To Local Anesthesia During Large Core Breast Biopsy
Percutaneous large core image-guided breast biopsy is a well established tool in diagnosing breast cancer, but the associated anxiety and pain can tax the coping mechanism of even well functioning individuals.
- Conditions
- Breast Cancer, Anxiety, Pain
- Trial name
- NCT00122369
- Testing
- Self-hypnotic Relaxation, Empathic Attention
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Beth Israel Deaconess Medical Center
Surgery
Efficacy of Warming Device During Surgery
This study will test the hypothesis that an electric heating device, the Hot Dog warming system is as effective as the Bair Hugger forced air heating system.
- Trial name
- NCT00715728
- Testing
- Intraoperative warming with Bair Hugger forced air system, Intraoperative warming with Hotdog resistive heating system
- Where
- Austria
- Volunteers
- 28 people
- Sponsor
- The Cleveland Clinic
Thermometry Device Comparisons
Comparison Study of Core Temperature Thermometry Systems
The purpose of this trial is the generation of clinical data required for a 510(k) submission to the FDA.
- Trial name
- NCT01255865
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- 3M
Hypothermia
Effects of Warmed, Humidified CO2 Insufflation on Body Core Temperature and Cytokine Response
The aim of this study is to assess if the conditioning of the insufflation carbon dioxide (CO2) allows for an additional benefit in terms of prevention of the heat loss, when compared with the usual prevention with a forced warm…
- Trial name
- NCT02586974
- Testing
- Humigard
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Diabetic Macular Edema
A 12 Month Core Study to Assess the Efficacy and Safety of Ranibizumab (Intravitreal Injections) in Patients With Visual Impairment Due to Diabetic Macular Edema and a 24 Month Open-label Extension Study
CRFB002D2301: The core study was designed to confirm the efficacy and safety of ranibizumab (0.5 mg) as adjunctive therapy when added to laser photocoagulation and/or mono-therapy in patients with visual impairment due to…
- Trial name
- RESTORE (NCT00687804)
- Testing
- Ranibizumab, Laser
- Where
- 13 sites in Australia, Belgium and 11 more
- Volunteers
- 345 people
- Sponsor
- Novartis
Spinal Cord Injury
Body Temperature in Persons With Tetraplegia When Exposed to Heat
The deleterious effects of hyperthermia are well appreciated in able-bodied persons. However, the consequences of impaired regulation of normal body temperature on cognitive performance of persons with tetraplegia is not known.
- Trial name
- NCT01890915
- Testing
- Heat Exposure
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Sporadic Inclusion Body Myositis
An Extension Study of the Efficacy, Safety and Tolerability of BYM338 (Bimagrumab) in Patients With Sporadic Inclusion Body Myositis Who Previously Participated in the Core Study CBYM338B2203
This extension study will provide data to further evaluate the efficacy, safety, and tolerability of three doses of BYM338 and to assess the long-term effects of BYM338 in patients with sporadic inclusion body myositis.
- Trial name
- NCT02573467
- Testing
- Bimagrumab
- Where
- 38 sites in United States, Australia and 8 more
- Volunteers
- 211 people
- Sponsor
- Novartis Pharmaceuticals
Hepatitis B, Liver Transplantation
Adefovir Plus Vaccination in Transplant Patients Without Hepatitis B That Receive a Core Antibody Positive Liver
The primary purpose of this study is to evaluate the efficacy of adefovir (ADV) in preventing de novo Hepatitis B in patients who receive Hepatitis B core antibody (HBcAb) positive grafts but who are not Hepatitis B Surface…
- Trial name
- NCT01146808
- Testing
- Adefovir dipivoxil and hepatitis B vaccination
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Columbia University
Breast Augmentation, Breast Reconstruction
Sientra Sponsored Silimed Gel-Filled Breast Implant Core Clinical Study
Safety and effectiveness of the Silimed Gel-Filled Mammary Implant as indicated for primary augmentation, primary reconstruction, and/or revision of the female breast.
- Conditions
- Breast Augmentation, Breast Reconstruction, Breast Revision
- Trial name
- NCT00905645
- Testing
- Silimed Gel-Filled Mammary Implant
- Where
- United States
- Volunteers
- 1,788 people
- Sponsor
- Tiger Biosciences, LLC.
Breast Cancer
Gene Expression in Tumor Tissue From Women Undergoing Surgery for Breast Cancer or Core Biopsy of the Breast
RATIONALE: Studying samples of breast tissue in the laboratory may help doctors learn more about the genes and proteins found in breast tissue.
- Trial name
- NCT00898937
- Testing
- microarray analysis, breast biopsy
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Georgetown University
Inadvertent Perioperative Hypothermia, Preoperative Anxiety Experienced by the Patient
Evaluation of Core Body Temperature When Using Forced Air Warming or an Active Blanket to Prevent Perioperative Hypothermia
This investigation is undertaken to investigate if patient warming with BARRIER® EasyWarm active self-warming blanket differs compared to active warming with forced air warming in terms of core body temperature perioperatively.
- Trial name
- NCT02079311
- Testing
- Active self warming blanket, Forced air warming device
- Where
- 3 sites in Germany, Norway and 1 more
- Volunteers
- 55 people
- Sponsor
- Molnlycke Health Care AB
Pancreatic Cancer
Endoscopic Ultrasound Guided Fine Needle Biopsy (EUS-FNB-SC) Using a Novel Fork Needle
This is a clinical trial to compare two needles used in biopsy techniques to acquire tissue from pancreatic cancer. The hypothesis is that the tissue yield, as measured by tumor DNA and cellular material is superior for Flexible…
- Trial name
- NCT02678442
- Testing
- Fine Needle Biopsy (FNB), Fine Needle Aspiration (FNA)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Hypothermia; Anesthesia
Accuracy of the Drager Dual-sensor Temperature Measurement System
Our primary hypothesis is that the Draeger dual-sensor temperature monitoring system, used at the forehead, is sufficiently accurate compared to tympanic, bladder or esophageal temperature and oral temperature for routine…
- Trial name
- NCT00980642
- Testing
- Draeger double-sensor, Esophageal stethoscope temperature sensor, Foley catheter temperature sensor
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- The Cleveland Clinic
Prostate Cancer, Vitamin D Deficiency
Vitamin D Supplementation in RNA-seq Profiles of Single-core Prostate Samples, Among Veterans
Veterans between the ages of 50-75, who are having a prostate biopsy, will be recruited for their permission to collect an extra biopsy core for RNA-sequencing.
- Conditions
- Prostate Cancer, Vitamin D Deficiency, Stress Reaction
- Trial name
- VitD/RNA-seq (NCT04621500)
- Testing
- cholecalciferol, Standard of Care Prostate Biopsy - collection of 13th core for RNA-seq, Standard of Care Prostate Biopsies at baseline and after one year vitamin D3 supplementation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Psoriasis, Plaque-type Psoriasis
Efficacy and Safety Study of Apremilast (CC-10004) in Subjects With Moderate-to-Severe Plaque-Type Psoriasis (Core Study)
The purpose of this study was to test if the drug apremilast was safe, if it helped improve psoriasis, and how well the participants tolerated it.
- Trial name
- NCT00773734
- Testing
- Apremilast 10mg, Apremilast 20mg, Apremilast 30 mg
- Where
- 35 sites in United States, Canada
- Volunteers
- 352 people
- Sponsor
- Amgen
Multiple Sclerosis
Safety and Efficacy of Fingolimod in Pediatric Patients With Multiple Sclerosis
To evaluate the safety and efficacy of fingolimod vs. interferon beta-1a i.m. in pediatric patients with multiple sclerosis (MS)
- Trial name
- NCT01892722
- Testing
- Interferon beta-1a, Fingolimod
- Where
- 73 sites in United States, Australia and 23 more
- Volunteers
- 240 people
- Sponsor
- Novartis Pharmaceuticals