Clinical trials: CORE
AML, Childhood, Relapse/Recurrence
Safety and Efficacy of Avapritinib in Relapsed or Refractory Pediatric CBF-AML With KIT Mutation
The purpose of this study is to evaluate the efficacy and safety of avapritinib in relapsed or refractory pediatric core binding factor acute myeloid leukemia with KIT mutation.
- Conditions
- AML, Childhood, Relapse/Recurrence, Refractory AML, Core Binding Factor Acute Myeloid Leukemia
- Trial name
- NCT06316960
- Testing
- Avapritinib, Azacitidine Injection, Decitabine Injection
- Where
- 12 sites in China
- Volunteers
- 50 people
- Sponsor
- Children's Hospital of Soochow University
Low Back Pain
Quebec Low Back Pain Study: Core Dataset
Persistent back pain is the leading cause of years lived with disability worldwide. Current therapeutic interventions are often either not effective or are associated with undesired consequences.
- Trial name
- QLBPS (NCT04791891)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- Laval University
Hepatitis B Reactivation
HBV Vaccine in Anti-core Positive Donors After LT
Anti-HBc positive liver donors frequently have occult HBV infection, and several studies in HBsAg-negative subjects have shown that there is often the detection in the liver of covalently closed circular DNA (cccDNA).
- Trial name
- NCT04442841
- Testing
- Hepatitis B vaccine
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Hospital Clinic of Barcelona
Down Syndrome
Weight Bearing Exercises With and Without Jaffrey's Core Stability Exercise Training in Children With Down Syndrome.
Down syndrome also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21.
- Trial name
- NCT05719662
- Testing
- Weight bearing exercises, Jaffrey's core stability exercises
- Where
- Pakistan
- Volunteers
- 18 people
- Sponsor
- Riphah International University
Postural Low Back Pain
Comparison of Core Stabilization and Neuromuscular Facilitation Exercises for Lowback Pain Prevention
Low back pain (LBP) is a leading cause of disability worldwide, particularly affecting individuals in occupations that demand prolonged sitting or standing, such as healthcare professionals.
- Trial name
- NCT06846203
- Testing
- Core stabilization Exercise Group, Neuromuscular Fascilitation Exercise Group
- Where
- Pakistan
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Respiratory Muscle Strength, Parity
Parity and Respiratory Muscle Strength in Women
The aim of this study is to investigate the relationship between parity and respiratory muscle strength in women.
- Conditions
- Respiratory Muscle Strength, Parity, Core Stability, Woman
- Trial name
- NCT06677346
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medipol University
Post COVID-19 Syndrome, Functional Inspiratory Muscle Training
Effectiveness of Functional Respiratory Muscle Training in Post-COVID-19 Syndrome
This study aims to investigate the effects of core stabilization exercises and functional inspiratory muscle training (IMT) on various physiological and psychological parameters in individuals with post-COVID-19 syndrome.
- Conditions
- Post COVID-19 Syndrome, Functional Inspiratory Muscle Training, Core Stabilization
- Trial name
- NCT07051954
- Testing
- Core Stabilization, Functional Inspiratory Muscle Training (IMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Hacettepe University
Temporomandibular Joint Disorders
Evaluation of the Efficacy of Cervical Core Exercises in Persons With Temporomandibular Joint Dysfunction
The aim is to reveal to what extent cervical core exercises affect the results of treatment in patients with Temporomandibular Joint Dysfunction caused by Myofascial pain syndrome.
- Trial name
- NCT06222736
- Testing
- Rocabado Exercises, Servical Core Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Gelisim University
Basilar Artery Occlusion, Ischemic Stroke
Basilar Artery Occlusion Chinese Endovascular Trial in Patients With Large Core Infarct
This study evaluates the safety and efficacy of endovascular therapy for acute basilar artery occlusion with large core infarcts in a multicenter randomized trial.
- Conditions
- Basilar Artery Occlusion, Ischemic Stroke, Large Core Infarct
- Trial name
- BAOCHE3 (NCT07046299)
- Testing
- Endovascular Therapy Plus Best Medical Treatment, Best Medical Treatment Alone
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Capital Medical University
Sports Physical Therapy
Investigation of the Relationship Between Core Endurance and Awareness of Injury Prevention in Adolescent Basketball Players
Injuries occurring during adolescence can lead to serious long-term problems. Such injuries can cause athletes to take breaks from their sports and physically strain themselves.
- Trial name
- NCT06475833
- Testing
- Prone plank test, Side plank test, The Awareness of Sports Injuries Scales
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Mood Disorders, Major Depressive Diorder
Validation of Wearable Core Body Temperature-Based Circadian Rhythm Digital Biomarkers
This single-site prospective observational study aims to validate wearable-derived circadian and behavioral rhythm biomarkers using continuous core body temperature and raw accelerometry measurements and to explore longitudinal…
- Conditions
- Mood Disorders, Major Depressive Diorder, Bipolar Disorders, Mental Disorder
- Trial name
- Calera (NCT07905378)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Multiple Myeloma (MM), Multiple Myeloma Refractory
A Study of Elranatamab Outpatient Administration in Patients With Relapsed/Refractory Multiple Myeloma
This is a Phase II, open-label, nonrandomized, single-arm study of elranatamab that will be administered in the outpatient setting in 2 sequential cohorts of participants with relapsed or refractory multiple myeloma (RRMM).
- Conditions
- Multiple Myeloma (MM), Multiple Myeloma Refractory, Multiple Myeloma in Relapse, Multiple Myeloma
- Trial name
- CORE-MM (NCT07637578)
- Testing
- Elranatamab, Tocilizumab
- Where
- 6 sites in United States
- Volunteers
- 46 people
- Sponsor
- SCRI Development Innovations, LLC
Endometriosis
Effects of Aerobic Exercise and Core Muscle Strengthening on Pain, Menstrual Pattern and QOL in Endometriosis
Endometriosis is a complex and debilitating gynecological condition affecting millions of women worldwide. It is characterized by the abnormal growth of endometrial-like tissue outside the uterus, leading to chronic pelvic pain…
- Trial name
- NCT06241040
- Testing
- Aerobic Exercises with core Muscle strengthening, Aerobic Exercise without Core Muscle Strengthening
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Neck Pain
Investigation of the Efficacy of Thoracic Mobilization Exercises Performed in Addition to Core Stabilization Exercises in Individuals With Chronic Non-Specific Neck Pain
Neck pain is one of the most common musculoskeletal complaints worldwide and is an important health problem that restricts the daily life activities of individuals.
- Trial name
- NCT06991140
- Testing
- Thorocal Mobilization Exercises, Core Stabilization Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Core Muscle Endurance
Efficacy Testing of Les Mills Pilates
Objectives: Determine the effect of an 8-week intervention of the new group fitness program Les Mills Pilates on balance, core stability, abdominal, back, and hip muscle endurance, flexibility, and mood.
- Trial name
- NCT06409858
- Testing
- Pilates
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of the Fraser Valley
Dementia
Establishment of Core Competence and Training Model for Dementia Case Management
The purpose of this study is to develop the core competence and training model for case management of dementia. This study is the second phase of the project.
- Trial name
- NCT05151185
- Testing
- Case Management Service Program
- Where
- Taiwan
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Body Temperature Changes
Comparison Between Non-invasive Heat-flux and Invasive Core Temperature Monitoring
The body core temperature drops during general anesthesia. To maintain homeostasis, patients require warming measures. Different methods to measure body core temperature exist, which are either highly accurate but invasive, or…
- Trial name
- NCT03368040
- Testing
- Tcore
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- University Hospital, Bonn
Cystic Fibrosis
Muscle Endurance in Children With Cystic Fibrosis
Cystic fibrosis (CF) is a genetic disorder affecting exocrine glands, leading to thick, viscous secretions that damage organs such as the lungs, pancreas, and reproductive system.
- Trial name
- NCT06812793
- Testing
- Measurement of Core Muscle Endurance, Respiratory Muscle Strength, Respiratory Muscle Endurance
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Multiple Sclerosis
Impact of Core Performance on Functional Parameters in Multiple Sclerosis
Optimal trunk control relies on somatosensory, motor and musculoskeletal integrity, which is often damaged in multiple sclerosis (MS).
- Trial name
- NCT04750733
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Acute Basilar Artery Occlusion, Endovascular Therapy
The Efficacy and Safety of Endovascular Therapy for Acute Ischemic Stroke Due to Large Core Infarction
This study assesses the efficacy and safety of endovascular therapy in patients with acute basilar artery occlusion with large core infarction within a multicenter, prospective, open-label, blinded endpoint, randomized controlled…
- Conditions
- Acute Basilar Artery Occlusion, Endovascular Therapy, Large Core Infarction
- Trial name
- NCT07333950
- Testing
- Endovascular Recanalization Strategy, Best Medical Management
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Beijing Tiantan Hospital
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