Clinical trials: COVID, Coronavirus
SARS Coronavirus 2 RT-PCR Testing
Nasal Swab Objective and Statistical Evaluation (NOSE Study)
Supply chain disruptions have led to shortages in test swabs which are used to collect respiratory samples. Lack of these test swabs can reduce a hospital or state's ability to test patients for COVID-19.
- Trial name
- Nasal Swab (NCT07469670)
- Where
- United States
- Volunteers
- 1,179 people
- Sponsor
- VA Office of Research and Development
COVID-19
Human COVID-19 Immunoglobulin (COVID-HIG) Therapy for COVID-19 Patients
A randomized, double-blind, placebo-controlled phase II exploratory clinical trial to evaluate the efficacy and safety of Human COVID-19 immunoglobulin (pH4) for intravenous injection (COVID-HIG) in the treatment of patients with…
- Trial name
- NCT05173441
- Testing
- Human COVID-19 immunoglobulin (pH4) for intravenous injection
- Where
- United Arab Emirates
- Volunteers
- 180 people
- Sponsor
- Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd.
COVID
Primary Prevention of Infection by COVID-19 in Workers
Introduction: The SARS Co-2 contagious rate is high (Ro: 2.0-3.0). The infection is aggressive with high pathogenicity. Global confinement impacts all social and economic fields of human activity.
- Trial name
- PI-Covid-19 (NCT04420260)
- Testing
- Group A: oropharygeal spray and immunostimulant emulsion
- Where
- Colombia
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Unidad de Investigación Genética Molecular
Post-Acute COVID-19 Syndrome
Care for Veterans Post-COVID-19
The evidence-based Concordant Care approach involves engaging in processes that: 1) validate the patient's experience, 2) develop a shared understanding of the condition, and 3) create a patient-centered, whole health-oriented…
- Trial name
- NCT05787379
- Testing
- Concordant Care Training, Education Packet Training
- Where
- United States
- Volunteers
- 348 people
- Sponsor
- VA Office of Research and Development
Covid19, SARS-CoV-2 PNEUMONIA
Safety and Efficiency of Method of Exosome Inhalation in COVID-19 Associated Pneumonia
Coronavirus is an acute viral disease with prevailing upper respiratory tract infections caused by the RNA-containing virus of the genus Betacoronavirus of the Coronaviridae family.
- Conditions
- Covid19, SARS-CoV-2 PNEUMONIA, COVID-19
- Trial name
- COVID-19EXO2 (NCT04602442)
- Testing
- EXO 1 inhalation, EXO 2 inhalation
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- Olga Tyumina
Sars-CoV2
Endotracheal Tube Obstruction in Covid-19 Patients Requiring Mechanical Ventilation
The COVID-19 pandemic is very present in our region, the Grand-Est region is considered as one of the first COVID-19 epicentres in France.
- Trial name
- TubeObs-Covid (NCT04394429)
- Where
- France
- Volunteers
- 184 people
- Sponsor
- University Hospital, Strasbourg, France
COVID-19, Chronic Lung Diseases
Chronic Lung Disease and COVID-19: Understanding Severity, Recovery and Rehabilitation Needs
This is study is comprised of three approaches. First, the investigators will conduct a retrospective cohort study to determine factors associated with COVID-19 severity and complications and understand COVID-19 outcomes…
- Trial name
- LAUREL (NCT04628039)
- Where
- 2 sites in United States
- Volunteers
- 622 people
- Sponsor
- VA Office of Research and Development
Surgical Procedures, Operative, COVID-19
The Impact of the COVID-19 Pandemic on the Patient in Need of an Intervention
Mixed-method observational study: the impact of pandemic related changes in healthcare on quality of life and experiences with healthcare in Dutch patients undergoing surgery or another intervention during the covid pandemic…
- Conditions
- Surgical Procedures, Operative, COVID-19, SARS-CoV-2
- Trial name
- COVID Surg III (NCT05736822)
- Where
- Netherlands
- Volunteers
- 5,277 people
- Sponsor
- University Medical Center Groningen
Pulmonary Complications in Surgical Patients, COVID
Preventing Pulmonary Complications in Surgical Patients at Risk of COVID-19
The aim of this study is to reduce pulmonary complications in adult patients undergoing abdominal or thoracic surgery in COVID-19 exposed hospital environments. A Trial in Low and Middle Income Countries (LMICs)
- Conditions
- Pulmonary Complications in Surgical Patients, COVID, Severe Acute Respiratory Syndrome
- Trial name
- PROTECT-Surg (NCT04386070)
- Testing
- RESP301
- Where
- 9 sites in Nigeria, Rwanda
- Volunteers
- 6,400 people
- Sponsor
- University of Birmingham
COVID-19 Pandemic, COVID-19 Vaccines
UNAIR Inactivated COVID-19 Vaccine as Heterologue Booster (Immunobridging Study)
This is an observer blind randomized controlled trial study to evaluate the humoral immunogenicity profile - neutralizing antibody - after 28 days following vaccination with Vaksin Merah Putih - UA SARS-CoV-2 (Vero Cell…
- Trial name
- NCT05918939
- Testing
- Vaksin Merah Putih - UA SARS-CoV-2 (Vero Cell Inactivated) 5 µg, CoronaVac Biofarma COVID-1 9 Vaccine 3 µg
- Where
- Indonesia
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Dr. Soetomo General Hospital
COVID-19
Phase I Trial of a Recombinant SARS-CoV-2 Vaccine (Sf9 Cell)
This is a phase I, single-center, randomized, placebo-controlled, double-blind study, to evaluate safety, tolerability and immunogenicity of a recombinant SARS-CoV-2 vaccine (Sf9 cell) in Chinese healthy population aged 18 years…
- Trial name
- NCT04530656
- Testing
- Two doses of middle-dose recombinant SARS-CoV-2 vaccine (Sf9 Cell) at the schedule of day 0, 28, Two doses of high-dose recombinant SARS-CoV-2 vaccine (Sf9 Cell) at the schedule of day 0, 28, Three doses of high-dose recombinant SARS-CoV-2 vaccine (Sf9 Cell) at the schedule of day 0, 14, 28
- Where
- China
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Covid-19
Clinical Features and Risk Factors Associated With Worse Outcome in Patients Hospitalized for Covid-19 Pneumonia
The aim of the research is to improve patient management by rapidly identifying, based on the terrain and clinical and biological characteristics, those patients likely to present a severe form of ARDS at risk of leading to…
- Trial name
- NCT04362345
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Posttraumatic Stress Disorder, Covid19
Efficacy of TBCT, MBHP and PPT for PTSD During the Covid-19 Pandemics
The psychotherapies to be assessed in the present study, delivered on-line, are: trial-based cognitive therapy (TBCT), mindfulness-based health promotion (MBHP), and positive psychotherapy (PPT).
- Trial name
- NCT04852770
- Testing
- Trial-Based Cognitive Therapy, Mindfulness-Based Health Promotion, Positive psychotherapy
- Where
- 3 sites in Brazil
- Volunteers
- 135 people
- Sponsor
- Fundação Bahiana de Infectologia
Severe Acute Respiratory Syndrome (SARS), Acute Respiratory Distress Syndrome (ARDS)
Extracellular Vesicles From Mesenchymal Cells in the Treatment of Acute Respiratory Failure
This is a phase I/II, randomized, double-blind, placebo-controlled clinical trial that will evaluate the safety and potential efficacy of therapy with extracellular vesicles (EVs) obtained from mesenchymal stromal cells (MSCs)…
- Conditions
- Severe Acute Respiratory Syndrome (SARS), Acute Respiratory Distress Syndrome (ARDS), Pneumonia
- Trial name
- NCT06002841
- Testing
- intravenous treatment with EVs
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- D'Or Institute for Research and Education
COVID-19
A Dose Finding, Efficacy and Safety Study of Ensovibep (MP0420) in Ambulatory Adult Patients With Symptomatic COVID-19
The purpose of this study is to establish the antiviral efficacy of ensovibep against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans, identify the optimal dose, and demonstrate its clinical value for…
- Trial name
- EMPATHY (NCT04828161)
- Testing
- ensovibep
- Where
- 48 sites in United States, Hungary and 3 more
- Volunteers
- 407 people
- Sponsor
- Novartis Pharmaceuticals
2019-nCoV
Clinical Study of Arbidol Hydrochloride Tablets in the Treatment of Pneumonia Caused by Novel Coronavirus
In the absence of 2019-ncov specific therapeutic drugs, arbidol is effective against a variety of coronaviruses in vitro pharmacodynamics.
- Trial name
- NCT04260594
- Testing
- Arbidol, basic treatment
- Where
- China
- Volunteers
- 236 people
- Sponsor
- Jieming QU
Post-COVID-19 Syndrome
Methylprednisolone in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS)
This clinical trial aims to learn about the therapeutic value of Methylprednisolone, a well-known immunosuppressant, on cognitive deficits in patients with post-COVID-19 syndrome (PCS).
- Trial name
- NCT05986422
- Testing
- Methylprednisolone
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- Charite University, Berlin, Germany
COVID-19
A Clinical Trial of Immunobridging and Lot-to-lot Consistency of COVID-19 Vaccine (Ad5-nCoV) in Different Age Groups.
The study is a single-center, randomized and double-blinded trial to evaluate the immunobridging between different manufacture scales, lot-to-lot consistency of the Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5…
- Trial name
- NCT04916886
- Testing
- Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) 0.5ml, Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) 0.3ml
- Where
- China
- Volunteers
- 2,021 people, healthy volunteers welcome
- Sponsor
- CanSino Biologics Inc.
Oncology
COVID-19 Detection Test in Oncology
EVIDENCE is a non interventional, French, multicenter study. Patients will be screened by local severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoassay in their oncology department (rapid diagnostic test (RDT) or…
- Trial name
- EVIDENCE (NCT04367870)
- Where
- 7 sites in France
- Volunteers
- 441 people
- Sponsor
- UNICANCER
COVID-19, SARS-CoV-2
Study of Self-Amplifying Messenger Ribonucleic Acid (samRNA) Vaccines Against COVID-19 in Healthy Adults and People Living With Human Immunodeficiency Virus (HIV)
The primary objective is to assess the safety and tolerability of samRNA vaccines GRT-R912, GRT-R914, and GRT-R918 when administered as prime and/or boost in healthy adult participants naïve to severe acute respiratory syndrome…
- Trial name
- NCT05435027
- Testing
- GRT-R912, samRNA-Spikebeta-TCE11, GRT-R914, samRNA-Spikebeta-TCE9, GRT-R918, samRNA-SpikeOmicron-N-TCE11
- Where
- 4 sites in South Africa
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- Gritstone bio, Inc.
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