Clinical trials: COVID-19; Immunity
Tunis Military Hospital Staff Vaccinated Against Covid 19
Immunity After COVID-19 Vaccination
The purpose of the research is to evaluate kinetic after vaccination to the COVID-19 coronavirus by measurements of specific and neutralizant antibodies for spike antigenic sequences .
- Trial name
- IACOVV (NCT04924855)
- Testing
- Blood sampling (4 per year)
- Where
- Tunisia
- Volunteers
- 300 people
- Sponsor
- General Administration of Military Health, Tunisia
SARS CoV 2 Infection, SARS CoV 2 Vaccination
COVID-19 Transmission and Morbidity in Malawi
SARS-CoV-2 transmission was expected to have a devastating impact in sub-Saharan African countries. Instead, morbidity and mortality rates in nearly the whole region are an order of magnitude lower than in Europe and the…
- Trial name
- COVID-TMM (NCT05973084)
- Where
- 2 sites in United States, Malawi
- Volunteers
- 1,500 people
- Sponsor
- Boston University
Covid19
Characterization and Durability of COVID-19 Vaccine Induced Immune Responses in Healthcare/Frontline Workers
Rationale: Early in the covid-19 pandemic, it was unclear whether and how individuals and populations would develop protective and enduring immunity against SARS-CoV-2, either after infection or vaccination.
- Trial name
- NCT05049187
- Where
- India
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Tuberculosis Research Centre, India
COVID-19, SARS-CoV-2 Infection
Novel Experimental COVID-19 Therapies Affecting Host Response
The overarching goal of the Master Protocol is to find effective strategies for inpatient management of patients with COVID-19. Therapeutic goals for patients hospitalized for COVID-19 include hastening recovery and preventing…
- Conditions
- COVID-19, SARS-CoV-2 Infection, Coronavirus Infection
- Trial name
- NECTAR (NCT04924660)
- Testing
- TXA127, TRV027, Fostamatinib
- Where
- 51 sites in United States
- Volunteers
- 1,060 people
- Sponsor
- Sean Collins
Covid19
COVADIAL - Immunogenicity of COVID-19 Vaccine in Hemodialysis Patients
COVID-19 is a severe disease with poor prognosis in patients receiving in-center haemodialysis (HD). A population-based registry of >4,000 patients with a diagnosis of COVID-19 receiving kidney replacement therapy (either…
- Trial name
- COVADIAL (NCT04728828)
- Testing
- Serological COVID-19 vaccine immunogenicity
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier de Cornouaille
Coronavirus, Coronavirus Infection
BCG Vaccine for Health Care Workers as Defense Against COVID 19
SARS-CoV-2 spreads rapidly throughout the world. A large epidemic would seriously challenge the available hospital capacity, and this would be augmented by infection of healthcare workers (HCW).
- Conditions
- Coronavirus, Coronavirus Infection, Coronavirus as the Cause of Diseases Classified Elsewhere
- Trial name
- BADAS (NCT04348370)
- Testing
- BCG Vaccine
- Where
- 6 sites in United States
- Volunteers
- 659 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
COVID-19, Non-specific Effects of Vaccines
Using BCG Vaccine to Protect Health Care Workers in the COVID-19 Pandemic
Background: The COVID-19 pandemic challenges the available hospital capacity, and this will be augmented by absenteeism of healthcare workers (HCW).
- Conditions
- COVID-19, Non-specific Effects of Vaccines, Morbidity, Absenteeism
- Trial name
- NCT04373291
- Testing
- BCG-Denmark, Saline
- Where
- Denmark
- Volunteers
- 1,293 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Cardiovascular Disease Acute, Cardiomyopathies
The Role of Adaptive Immunity in COVID-19 Associated Myocardial Injury
COVID-19 is associated with complications including ARDS and myocardial injury, which informs prognosis and patient outcome. The laboratory plans to perform immunophenotyping of peripheral T-cells in patients with COVID-19 and…
- Conditions
- Cardiovascular Disease Acute, Cardiomyopathies, COVID
- Trial name
- NCT04340921
- Testing
- COVID-19 exposure
- Where
- United Kingdom
- Sponsor
- Barts & The London NHS Trust
Covid19, SARS-CoV2 Infection
Clinical and Immunological Responses After SARS-CoV-2 Infection Causing COVID-19
There are very few long-term studies that analyze the immune responses in patients recovered from COVID-19 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Conditions
- Covid19, SARS-CoV2 Infection, Olfactory Disorder, COVID-19
- Trial name
- NCT05038475
- Testing
- COVID-19 antibody test
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Association "Naso Sano" Onlus
SARS-CoV 2, COVID-19
COVID-19: Longitudinal Study of Seroprevalence of SARS-CoV-2 Antibodies and Development of Immunity in School Children
There is a lack of knowledge about how many children are infected with SARS-CoV-2, how often they are asymptomatic, and how long the immunity persists.
- Trial name
- CiaoCorona (NCT04448717)
- Testing
- COVID-19 Antibody testing
- Where
- Switzerland
- Volunteers
- 4,250 people, healthy volunteers welcome
- Sponsor
- University of Zurich
SARS-CoV-2
Analysis of the Inflammatory Response and the Development of Humoral and Cellular Immunity in Patients With COVID-19
The SARS-CoV-2 infection in the airway epithelium induces cytopathic effects and the cessation of ciliary movement. Increased cytokines and chemokines have been reported to be associated with the severity of the disease.
- Trial name
- NCT04423640
- Testing
- Active COVID-19 disease
- Where
- Mexico
- Volunteers
- 200 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
SAR-CoV-2, Cellular Immune Response
Study of Immune Response in Subjects Vaccinated Against SARS-CoV-2 Infection
Twelve months after the first SARS-CoV-2 cases in Wuhan, the FDA approved the first COVID-19 vaccine (Pfizer-BioNTech). Early studies on healthcare workers showed that antibody levels, especially against the Spike protein…
- Conditions
- SAR-CoV-2, Cellular Immune Response, Antibody Response
- Trial name
- BioVAC-immunit (NCT07049497)
- Testing
- Evaluation of the T cell response in terms of IFN-γ measured by ELISpot
- Where
- Italy
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Liver Transplant
Immune Response to COVID-19 Vaccine in Recipients of Living Donor Liver Transplantation
A prospective cohort study to evaluate the response to COVID-19 vaccine in liver transplantation patients.
- Trial name
- NCT05051605
- Testing
- COVID-19 Vaccine
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Hypohidrotic Ectodermal Dysplasia
Pediatric SARS-CoV-2 Infections: Course of COVID-19, Immune Responses, Complications and Long-term Consequences
Longitudinal study of 56 households with at least one member who had COVID-19 to compare the course of illness, immune responses, and long-term consequences of SARS-CoV-2 infection in HED patients with those of control subjects…
- Trial name
- PEDCOVID-19 (NCT04741412)
- Where
- Germany
- Volunteers
- 231 people
- Sponsor
- University Hospital Erlangen
SARS-CoV Infection, Covid-19
Characterizing the Immune Response and Neuronal Damage in COVID-19
The Investigators plan to study the innate and adaptive immune response, the inflammatory response, and associated complications such as complement activation and neurological damage in SARS-Cov-2 infected individuals.
- Trial name
- NCT04510012
- Testing
- Analysis of cytokine response, innate and adaptive immune response, complement activation, and serum neurofilaments as a marker of neurological damage.
- Where
- Switzerland
- Volunteers
- 88 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
COVID-19
Effect of Bronchipret on Antiviral Immune Response in Patients With Mild COVID-19
There is currently an urgent need for effective and safe treatments of Coronavirus Disease (COVID) - 19 and the cytokine storm that is responsible for the development of patient's Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- BroVID (NCT05276375)
- Testing
- Bronchipret
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- Dr. Frank Behrens
COVID-19
Establishment of a Biological Collection During COVID-19 Serological Screening in APHP Professionals (COVID-HOP)
The objective of the COVID-HOP study is to identify biological and non-biological markers associated to: a positive or negative serology anti SRAS-Cov-2; a positive serology and having presented symptoms or, on the contrary, not…
- Trial name
- COVID-HOP (NCT04418375)
- Where
- France
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Inflammatory Bowel Diseases
Determining the Relationship Between Gut Microbiota and Immune Response to Influenza or COVID-19 Vaccine
This study will evaluate the effect of the microorganisms in the gut on how well the flu or COVID-19 vaccine works in people who have a weakened immune system due to inflammatory bowel disease.
- Trial name
- NCT05584735
- Testing
- Influenza vaccine, COVID-19 vaccine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Wisconsin, Madison
Accelerated Phase CML, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia
SARS-CoV-2 Donor-Recipient Immunity Transfer
This study investigates whether donors with previous exposure to COVID-19 can pass their immunity by hematopoietic (blood) stem cell transplant (HCT) donation to patients that have not been exposed.
- Conditions
- Accelerated Phase CML, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Chronic Lymphocytic Leukemia
- Trial name
- NCT04666025
- Testing
- Biospecimen Collection, Diagnostic Laboratory Biomarker Analysis, Electronic Health Record Review
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- City of Hope Medical Center
COVID-19, Solid Tumor
National Project on Vaccines, COVID-19 and Frail Patients
This is a multicentre observational study with the aim of evaluating the antibody and cellular response after vaccination for SARS-CoV-2 with Pfizer-BioNTech or Moderna vaccines in frail subjects with impaired immuno-competence…
- Conditions
- COVID-19, Solid Tumor, Hematologic Diseases, Neurologic Disorder
- Trial name
- VAX4FRAIL (NCT04848493)
- Testing
- COVID-19 vaccines
- Where
- 12 sites in Italy
- Volunteers
- 747 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS