Clinical trials: COVID-19; Immunity
Sars-CoV-2 Infection
Immune Response to Third Dose of SARS-CoV-2 Vaccine in a Cohort of Cancer Patients on Active Treatment
The Coronavirus Disease 2019 (COVID-19) pandemic has claimed over 5 million lives globally. Fortunately, a substantial and growing number of SARS-CoV-2 vaccines with very high efficacy have been developed, manufactured, and…
- Trial name
- NCT05119738
- Testing
- Three doses of BNT162b2 (observational), Two doses of Coronavac and one dose BNT162b2 (observational)
- Where
- Chile
- Volunteers
- 122 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Zinc Deficiency, Sars-CoV-2 Infection
Zinc Supplementation Impact in Acute COVID-19 Clinical Outcomes
Infections with SARS-CoV-2 result in a systemic disease with a variety of outcomes, from no symptoms to severe and diverse pathologies.
- Trial name
- MARZINC (NCT05778383)
- Testing
- Zinc Acetate
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Parc de Salut Mar
Multiple Sclerosis, Healthy
COVID-19 Vaccine Response in Treated MS Patients
The primary goal of this study is to assess the impact of the two major disease modifying therapy (DMT) classes (B cell therapies and S1P modulators) on humoral and cell-mediated immunity to SARS- CoV-2 vaccination compared to…
- Trial name
- NCT05060354
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
COVID, Sars-CoV2
Whole Blood Collection From Individuals in the Convalescent Phase of SARS-CoV-2 Infection
The study was not opened.
- Trial name
- NCT04409184
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Covid19, NAFLD
COVID-19 and Nonalcoholic Fatty Liver Disease
COVID-19 is currently the leading public health problem, associated with a high risk of complications and death in risk groups of patients.
- Trial name
- CovidFAT (NCT04982328)
- Testing
- Th17 cytokine profile, Screening for the components of metabolic syndrome, Evaluation of the degree of steatosis
- Where
- Croatia
- Volunteers
- 120 people
- Sponsor
- University Hospital for Infectious Diseases, Croatia
COVID-19
A Safety and Immune Response Study to Evaluate Varying Doses of an mRNA Vaccine Against Coronavirus Disease 2019 (COVID-19) in Healthy Adults
The purpose of this study is to evaluate the safety, reactogenicity and immune responses of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA-CR-04 vaccine construct when administered in healthy adults…
- Trial name
- NCT05972993
- Testing
- mRNA-CR-04 vaccine 10μg, mRNA-CR-04 vaccine 30μg, mRNA-CR-04 vaccine 100μg
- Where
- 4 sites in United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COVID-19
Assessment of Incidence of SARS-CoV-2 Infection and COVID-19 in Brazil (AVISA)
This is an observational study, meaning that no interventions is tested, to determine incidence of SARS-CoV-2 infection and COVID-19 in different clinical sites in Brazil in several age groups.
- Trial name
- AVISA (NCT04355338)
- Where
- 11 sites in Brazil
- Volunteers
- 3,520 people, healthy volunteers welcome
- Sponsor
- Butantan Institute
Covid19
Sustained Immunity to COVID-19 as Measured by SARS-CoV-2 Serology Assays
The primary objective is to assess the ability of COVID-19 IgG and IgM assays to detect an immune response in COVID-19 patients in the Henry Ford Health System (HFHS), both during hospitalization and over the following 12 months.
- Trial name
- NCT04562285
- Testing
- Serologic immunoassays to SARS-CoV-2 antibodies
- Where
- United States
- Volunteers
- 829 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Vaccination; Infection, COVID-19
Intradermal Administration of a COVID-19 mRNA Vaccine in Elderly
Respiratory tract infections, e.g. caused by SARS-CoV-2, disproportionately affect elderly. Vaccination has shown to be the most cost-effective approach to prevent infections.
- Trial name
- HVaNa (NCT05977127)
- Testing
- Comirnaty
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
COVID-19, Sars-CoV2
BCG Vaccination for Healthcare Workers in COVID-19 Pandemic
A novel betacoronavirus, SARS-CoV-2, is spreading rapidly throughout the world. A large epidemic in South Africa may overwhelm available hospital capacity and healthcare resources which would be worsened by absenteeism of…
- Trial name
- NCT04379336
- Testing
- Bacille Calmette-Guérin (BCG)
- Where
- South Africa
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- TASK Applied Science
Post-Acute COVID-19 Syndrome
Second Prospective Cohort of Patients Entering the Multidisciplinary Care Pathway for Post-Covid Syndromes - SyPoCo2 Cohort
The study aims to identify clinical profiles of long-COVID patients and correlate them with immunological and molecular data in order to identify prognostic biomarkers and potential therapeutic targets.
- Trial name
- SYPOCO 2 (NCT07356570)
- Testing
- Blood sample collection
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
COVID-19, Pregnancy Related
Evaluation of Humoral Immunity Following COVID-19 in Pregnancy
The proposed study is designed to investigate if and how pregnant women infected with Coronavirus Disease-19 (COVID-19) infection go on to develop long-term immunity.
- Conditions
- COVID-19, Pregnancy Related, Influenza, Human
- Trial name
- ImmunoCOVID (NCT04568044)
- Testing
- Blood sample
- Where
- 2 sites in United Kingdom
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Imperial College London
SARS-CoV-2, COVID-19
Rapid Diagnostic Profiling of SARS-CoV-2 (COVID-19)
The investigators will evaluate the profile of the immune response of Ethiopian population and examine its relationship with the noted low CD4+ T-cell count and underlying immune activation status among participants with COVID-19…
- Trial name
- Profile-Cov (NCT04473365)
- Testing
- Intestinal parasite
- Where
- Ethiopia
- Volunteers
- 838 people, healthy volunteers welcome
- Sponsor
- Mekelle University
Vitamin D Deficiency, Covid19
Nutrition, Immunity, and Covid-19 in Obese People
The increased risk of transmission of COVID-19 infection causes the incidence of death in health workers to escalate. It requires further research on risk factors and intervention in health worker professionals, especially on…
- Conditions
- Vitamin D Deficiency, Covid19, Overweight and Obesity, Immune Deficiency
- Trial name
- NICO (NCT04979065)
- Testing
- Probiotics, Vitamin D
- Where
- 4 sites in Indonesia
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Comorbidities and Coexisting Conditions, Healthy
Immune Response of an Interchangeable Booster Vaccine Against COVID-19 Among Individuals With Risk Factors for Severity
Experimental, single-arm study in participants with comorbidities, previously immunized with 2 doses of CoronaVac, who will receive a booster vaccine with 1 dose of the Oxford/AstraZeneca vaccine.
- Trial name
- COVACManaus2 (NCT05289206)
- Testing
- Vaccine - ChAdOx1-S/nCoV-19 [recombinant]
- Where
- Brazil
- Volunteers
- 4,446 people, healthy volunteers welcome
- Sponsor
- Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
Infection, Viral, Agent as Cause of Disease Classified Elsewhere
Efficacy of BCG Vaccination in the Prevention of COVID19 Via the Strengthening of Innate Immunity in Health Care Workers
Healthcare Workers (HCW) are at high risk for COVID-19. In addition to the risk of serious forms among HCW, significant absenteeism due to illness would have dramatic consequences in our ability to fight COVID-19.
- Trial name
- COVID-BCG (NCT04384549)
- Testing
- BCG GROUP
- Where
- France
- Volunteers
- 1,120 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Influenza A Infection, Influenza B Virus Infection
Age Related Differences in Respiratory Immune Responses in Influenza Virus Infection
The goal of this observational study is to understand immune responses to viral airway infection in adults, including the elderly.
- Conditions
- Influenza A Infection, Influenza B Virus Infection, SARS CoV 2 Infection, RSV Infection
- Trial name
- NPA-DC (NCT06401720)
- Where
- 5 sites in Sweden
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Covid19
The Corona and COVID-19 Study in Telemark and Agder
Through SARS-CoV-2 IgG testing of PCR positive and negative cases the study will follow the COVID-19 immune response by monitoring the SARS-CoV-2 IgG antibody levels over a period of two years.
- Trial name
- COVITA (NCT04514003)
- Where
- Norway
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Sykehuset Telemark
Coronavirus Infections
In-depth Immunological Investigation of COVID-19.
The COntAGIouS trial (COvid-19 Advanced Genetic and Immunologic Sampling; an in-depth characterization of the dynamic host immune response to coronavirus SARS-CoV-2) proposes a transdisciplinary approach to identify host factors…
- Trial name
- COntAGIouS (NCT04327570)
- Testing
- Patient sampling
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Covid19
Safety, Tolerability, and Immunogenicity of the COVID-19 Vaccine Candidates VBI-2902a and VBI-2905a
VBI-2902a and VBI-2905a are investigational vaccine candidates that use enveloped virus-like particle (eVLP) expression of a modified version of the SARS-CoV-2 spike (S) glycoprotein and are designed to induce neutralizing…
- Trial name
- NCT04773665
- Testing
- VBI-2902a, VBI-2905a
- Where
- 4 sites in Canada
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- VBI Vaccines Inc.