Clinical trials: COVID-19
Haemoglobinopathies
Observational Study for Patients With Hemoglobinopathies and Rare Inherited Anemia and Covid 19
The COVID-19 pandemic is causing many deaths around the world, putting a strain on health services. Patients with pre-existing chronic conditions are most affected by the SARS-COV2 infection.
- Trial name
- NCT04746066
- Where
- 2 sites in Italy
- Volunteers
- 10,000 people
- Sponsor
- Società Italiana Talassemie ed Emoglobinopatie
Coronavirus Disease 2019
Expanded Access Remdesivir (RDV; GS-5734™)
Disease caused by 2019 Novel Coronavirus also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Trial name
- NCT04302766
- Testing
- Remdesivir
- Where
- 22 sites in United States, Afghanistan and 6 more
- Sponsor
- U.S. Army Medical Research and Development Command
Social Isolation, Physical Inactivity
Video-Based Exercises and Well-Being During Social Isolation
Both influenza and coronaviruses cause respiratory infections, which can lead to morbidity and mortality, especially in those who are immunocompromised or not immune to viruses (Zhu).
- Conditions
- Social Isolation, Physical Inactivity, Well-Being
- Trial name
- NCT04335851
- Testing
- Video based aerobic exercise
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Biruni University
Covid19, Aspergillosis
COVID-19 Associated Pulmonary Aspergillosis (CAPA) and Other Invasive Fungal Infections (IFI)
The purpose of this study is to identify the number of individuals with severe CoVID who require ventilator support and who develop serious fungal infections.
- Conditions
- Covid19, Aspergillosis, Fungal Infection
- Trial name
- CAPA IFI (NCT04818853)
- Testing
- Observation to monitor patients for these infections
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- University of Alabama at Birmingham
COVID-19
Crowdsourcing an Open COVID-19 Imaging Repository for AI Research
The objectives of this project are to (1) assemble a crowdsourced, de-identified radiographic repository; and (2) train and validate existing COVID-NET deep learning diagnostic models.
- Trial name
- NCT05384912
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
COVID-19
Efficacy of Breathox Device Inhalation Therapy in the Treatment of Acute Symptoms Associated With COVID-19 and in the Prevention of the Use of Health Resources
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), the new coronavirus, causes a disease called COVID-19 that can trigger aggressive inflammatory responses.
- Trial name
- BREATH (NCT05196581)
- Testing
- Dispersible NaCl powder 10 sessions, Dispersible NaCl powder 5 sessions
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Suzana Erico Tanni Minamoto
Acute Hypoxemic Respiratory Failure, COVID-19
Dexamethasone and Oxygen Support Strategies in ICU Patients With Covid-19 Pneumonia
The main manifestation of COVID-19 is acute hypoxemic respiratory failure (AHRF). In patients with AHRF, the need for invasive mechanical ventilation is associated with high mortality. Two hypotheses will be tested in this study.
- Trial name
- COVIDICUS (NCT04344730)
- Testing
- Dexamethasone injection, conventional oxygen, CPAP
- Where
- France
- Volunteers
- 550 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19 Pandemic
Fourth BNT162b2 COVID-19 Vaccine Dose
The Omicron variant of concern (VOC) is currently rapidly spreading worldwide, with extremely high transmission rates, with an estimated R of >3.
- Trial name
- NCT05231005
- Testing
- BNT162b2 vaccine
- Where
- Israel
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Hematologic Malignancy
Outcomes of Critically Ill Patients With Hematologic Malignancies
The investigators sought to report the outcomes of patients with haematological malignancies admitted to the intensive care units and to define pre-intensive care units prognostic factors for in-hospital all-cause mortality.
- Trial name
- NCT06410066
- Testing
- no intervention
- Volunteers
- 144 people
- Sponsor
- Soroka University Medical Center
Vaccine Hesitancy
Motivational Interviewing for Vaccine Uptake in Latinx Adults
The goal of this clinical trial is to test whether modified behavioral health services, integrating motivational interviewing, will reduce vaccine hesitancy and increase uptake for the COVID-19 and influenza vaccines among Latinx…
- Trial name
- MIVacuna (NCT06062056)
- Testing
- EHR alert, Motivational Interviewing, Warm hand off to nurse
- Where
- 2 sites in United States
- Volunteers
- 3,698 people, healthy volunteers welcome
- Sponsor
- Boston College
Covid19
COVID-19 Supplemental Vaccine Boost to Enhance T Cell Protection in Those Who Have Already Received EUA S-Based Vaccines
This is a phase 1/2 study in adult healthy subjects that have previously been vaccinated with an FDA-authorized vaccine against COVID-19.
- Trial name
- NCT04843722
- Testing
- hAd5-S-Fusion+N-ETSD vaccine
- Volunteers
- healthy volunteers welcome
- Sponsor
- ImmunityBio, Inc.
Rheumatic Diseases
Coronaphobia in Rheumatic Diseases
COVID-19 is a contagious respiratory disease that is caused Severe Acute Respiratory Syndrome causing Coronavirus-2 (SARS-CoV-2). The most common symptoms are fever, cough and dyspnoea.
- Trial name
- NCT05554029
- Testing
- Coronaphobia
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
COVID19 Infection
Clinical Trial to Assess Efficacy of cYclosporine Plus Standard of Care in Hospitalized Patients With COVID19
The study hypothesis is that cyclosporine, added to standard treatment of hospitalized patients with COVID19 infection may improve their prognosis.
- Trial name
- NCT04392531
- Testing
- Cyclosporine, Standard treatment
- Where
- 7 sites in Spain
- Volunteers
- 111 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Sperm Preservation in Oncological Patients, Fertility
Presence of SARS-CoV-2 (COVID-19) in Semen: Impact on Fertility Preservation in Male Oncological Patients ?
During the COVID-19 pandemic, the French Agency of Biomedicine has recommended maintaining fertility preservation for patients requiring immediate oncological treatments exhibiting gonadotoxic effects.
- Conditions
- Sperm Preservation in Oncological Patients, Fertility, Cryopreservation
- Trial name
- FERTICOVID (NCT04487639)
- Testing
- SARS-CoV-2 research in nasopharyngeal swab, sperm and serologics
- Where
- 16 sites in France
- Volunteers
- 129 people
- Sponsor
- University Hospital, Clermont-Ferrand
Long Covid19, Pulmonary Rehabilitation
Combined Pulmonary Rehabilitation and PMR for Long-Term COVID-19 Symptoms: A RCT
Our study aimed to evaluate the effectiveness of a 21-day program combining pulmonary rehabilitation (PR) with progressive muscle relaxation (PMR) in patients experiencing long-term symptoms of COVID-19.
- Conditions
- Long Covid19, Pulmonary Rehabilitation, Progressive Muscle Relaxation
- Trial name
- NCT06492577
- Testing
- Pulmonary rehabilitation protocol, Progressive muscle relaxation protocol
- Where
- Romania
- Volunteers
- 61 people
- Sponsor
- Spitalul Clinic de Boli Infecțioase și Pneumoftiziologie Dr. Victor Babeș Timișoara
COVID-19
Sirolimus Treatment in Hospitalized Patients With COVID-19 Pneumonia
The main objective of our study is to determine if treatment with sirolimus can improve clinical outcomes in hospitalized patients with COVID-19.
- Trial name
- SCOPE (NCT04341675)
- Testing
- Sirolimus
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Cincinnati
COVID-19 Pneumonia, Virus Diseases
Investigation of Efficacy and Safety of Electrical Signal Therapy Provided by Dr Biolyse® Device in COVID-19 Disease
Dr. Biolyse® is a device with artificial intelligence that works in sync with the immune system and can be integrated like an element of this system. It is designed to develop chemical immunity within the body against infections.
- Conditions
- COVID-19 Pneumonia, Virus Diseases, COVID-19
- Trial name
- DoBiC-19 (NCT06113757)
- Testing
- Signal Therapy provided by Dr.Biolyse device, Liquid Support Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- AVB Biotechnology
Rheumatic Diseases, COVID-19 Vaccine
Vaccine Hesitancy in Black/African Americans With Rheumatic Diseases
To establish the efficacy of a community-based POL (Popular Opinion Leader) intervention with two different trainings designed to increase COVID-19 vaccine and booster uptake and reduce hesitancy among social networks of Black…
- Conditions
- Rheumatic Diseases, COVID-19 Vaccine, COVID-19, SLE
- Trial name
- NCT05822219
- Testing
- COVID-19 vaccine and booster training, and importance
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Disordered Eating, Stress
Biofeedback for CHAMPS
As a result of the COVID-19 pandemic, the degree of burnout and consequential negative psychological effects experienced by healthcare providers has been substantially exacerbated.
- Trial name
- NCT04921228
- Testing
- Heart rate variability biofeedback
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Villanova University
COVID-19
The Evaluation of Hemostasis in Hospitalized COVID-19 Patients
Coronavirus disease 2019 (COVID-19), a viral respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been shown to predispose patients to thrombotic diseases (venous and arterial) with…
- Trial name
- TARGET-COVID (NCT04493307)
- Testing
- Phlebotomy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- LifeBridge Health