Clinical trials: COVID-19 Induced Pneumonia
Covid19
Characterization and Durability of COVID-19 Vaccine Induced Immune Responses in Healthcare/Frontline Workers
Rationale: Early in the covid-19 pandemic, it was unclear whether and how individuals and populations would develop protective and enduring immunity against SARS-CoV-2, either after infection or vaccination.
- Trial name
- NCT05049187
- Where
- India
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Tuberculosis Research Centre, India
Stress Disorder
Stress Induced by the COVID-19 Pandemic and Nonconfinement: Study of Anxiety Factors and Potential Effects on Immunity.
The aim of this project is to evaluate the impact of pandemic and nonconfinement related to anxiety and eventual immune diseases with several standardized questionnaires : Implant Stability Quotient (ISQ) , Generalized Anxiety…
- Trial name
- SCEI (NCT04491071)
- Testing
- Generalized Anxiety Disorder-7 (GAD 7), Background questionnaire, Impact of COVID-19 questionnaire
- Where
- 2 sites in France, United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Stress, Covid19
The Effect of Aromatherapy on COVID-19-induced Anxiety
The purpose of this study is to assess the potential for a non-invasive sensory based intervention to reduce the stress associated with a COVID-19 diagnosis.
- Conditions
- Stress, Covid19, Anxiety
- Trial name
- NCT04495842
- Testing
- Essential Oil Blend, Control Blend
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nutraceuticals Research Institute
CoronaVirus Induced Disease-2019 (COVID-19)
Study of Oral Ibrutinib Capsules to Assess Respiratory Failure in Adult Participants With Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Pulmonary Injury
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Lung failure is the main cause of death related to COVID-19 infection.
- Trial name
- iNSPIRE (NCT04375397)
- Testing
- Ibrutinib
- Where
- 9 sites in United States
- Volunteers
- 46 people
- Sponsor
- AbbVie
COVID-19, SARS-CoV-2 Infection
A Phase 1/2A, Randomized Study of a T Follicular Helper (TFH)-Targeting Genetic Vaccine Strategy Designed to Induce Broad, Durable Immune Responses
The goal of this clinical trial is to test two investigational COVID-19 booster vaccines, called CoTend-s3BXBB and CoTend-BXBB, in healthy volunteers ages 40-64.
- Trial name
- CONTENDER (NCT06810934)
- Testing
- CoTend-BXBB (SARS2-30404), CoTend-s3BXBB (SARS2-17032)
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kara Chew
Covid19
Study of Intravenous COVI-MSC for Treatment of COVID-19-Induced Acute Respiratory Distress
This is a Phase 2 randomized controlled study to assess the safety and efficacy of COVI-MSC in the setting of current standard of care treatments for COVID-19 infection in hospitalized subjects with acute respiratory distress…
- Trial name
- NCT04903327
- Testing
- COVI-MSC
- Where
- 6 sites in Brazil
- Volunteers
- 43 people
- Sponsor
- Sorrento Therapeutics, Inc.
Covid-19, ARDS, Human
Nebulized Heparin for the Treatment of COVID-19 Induced Lung Injury
Randomized, placebo controlled study to determine if nebulized heparin may reduce the severity of lung injury caused by the novel coronavirus, also known as COVID-19
- Conditions
- Covid-19, ARDS, Human, Acute Lung Injury
- Trial name
- NCT04397510
- Testing
- Heparin, 0.9% Sodium-chloride
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Frederick Health
COVID-19 Induced Pneumonia, Covid19
Asunercept in Patients With Severe COVID-19
This is an open-label, randomized, phase II study with the main objective to investigate the effectiveness and safety of an investigational drug (APG101; International Nonproprietary Name: asunercept) in patients with severe…
- Trial name
- ASUNCTIS (NCT04535674)
- Testing
- Asunercept
- Where
- 13 sites in Russia, Spain
- Volunteers
- 438 people
- Sponsor
- Apogenix AG
Covid19, ARDS
Study of Intravenous Administration of Allogeneic Adipose-Derived Mesenchymal Stem Cells for COVID-19-Induced Acute Respiratory Distress
This is a Phase 2, randomized controlled, multicenter study to assess the safety and efficacy of COVI-MSC in the setting of current standard of care (SOC) treatments for COVID-19 infection in hospitalized subjects with ARD/ARDS.
- Trial name
- NCT04728698
- Testing
- COVI-MSC
- Where
- United States
- Sponsor
- Sorrento Therapeutics, Inc.
COVID-19
The Safety & Efficacy of Imatinib for the Treatment of SARS-COV-2 Induced Pneumonia
A randomized controlled pilot study on the safety \& efficacy of imatinib for the treatment of patient with moderate to severe SARS-COV-2 induced pneumonia.
- Trial name
- NCT04422678
- Testing
- Imatinib Mesylate, Standard of Care
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Stress Reaction, Stress, Emotional
COVID-19 Pandemic Induced Stress and Symptoms
The previous survey of oncology patients at University of California, San Francisco in 2020-2021 found an alarmingly high symptom burden and high levels of stress and loneliness among respondents.
- Conditions
- Stress Reaction, Stress, Emotional, Stress, COVID-19 Pandemic
- Trial name
- NCT06036251
- Testing
- Questionnaires
- Where
- United States
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
COVID-19
Aerosol Combination Therapy of All-trans Retinoic Acid and Isotretinoin as A Novel Treatment for Inducing Neutralizing Antibodies in COVID -19 Infected Patients Better Than Vaccine : An Innovative Treatment
Aerosol Combination therapy of All-trans retinoic acid and Isotretinoin as A novel Treatment for Inducing Neutralizing Antibodies in COVID -19 Infected Patients better than vaccine : An innovative Treatment Mahmoud…
- Trial name
- Antibodies (NCT04396067)
- Testing
- Aerosolized 13 cis retinoic acid, Aerosolized All trans retinoic acid
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Stress, Psychological, Stress, Emotional
Investigation of Stress Levels and Lifestyle of a Sample of Greek General Surgeons in Covid-19
A new pandemic appeared in early 2020, also known as the coronavirus (Covid-19), affecting all health systems worldwide. Medical and nursing staff make every effort to treat patients resulting in physical and psychological…
- Conditions
- Stress, Psychological, Stress, Emotional, Life Style Induced Illness, Anxiety Depression
- Trial name
- NCT04791085
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
ARDS, COVID-19
Paradoxical Response to Chest Wall Loading in Mechanically Ventilated Patients
The purposes of our study are to: 1) determine the incidence of paradoxical response to chest wall loading in mechanically ventilated patients; 2) identify sub-populations in which it is most likely to occur (e.g., severe ARDS)…
- Conditions
- ARDS, COVID-19, Mechanical Ventilation Pressure High, Ventilator-Induced Lung Injury
- Trial name
- NCT06093958
- Testing
- Manual loading of the chest wall
- Where
- United States
- Sponsor
- HealthPartners Institute
Covid19
COVID-19 Vaccine Induced Immunity
This study aims to address the following three objectives: 1. Longitudinal evaluation of the development of CMI responses in response to SARS-CoV-2 Vaccine: T cells isolated from the blood of COVID-19 vaccine recipients will be…
- Trial name
- NCT04713163
- Testing
- covid19 vaccine
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Hearing, COVID - 19
Investigation of the Impact of Medications Used in COVID-19 Treatment and COVID-19 Vaccine on Hearing
Investigation of the Impact of Medications Used in COVID-19 Treatment and COVID-19 Vaccine on Hearing
- Conditions
- Hearing, COVID - 19, Ototoxicity
- Trial name
- NCT07254442
- Testing
- Hearing tests
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
COVID-19, Respiratory Failure
Infusion of Prostacyclin (Iloprost) vs Placebo for 72-hours in COVID-19 Patients With Respiratory Failure
The purpose of this trial is to investigate the efficacy and safety of continuous intravenous administration of low dose iloprost versus placebo for 72-hours, in 80 patients with COVID-19 suffering from respiratory failure.
- Trial name
- COMBAT-COVID (NCT04420741)
- Testing
- Iloprost, Isotonic saline
- Where
- 5 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- Pär Johansson