Clinical trials: COVID-19 Infection
COVID-19, Coronavirus Infection
Hydroxychloroquine and Lopinavir/ Ritonavir to Improve the Health of People With COVID-19: "The Hope Coalition - 1"
The COVID-19 pandemic has been characterized by high morbidity and mortality, especially in certain subgroups of patients. To date, no treatment has been shown to be effective in controlling this disease in hospitalized patients…
- Conditions
- COVID-19, Coronavirus Infection, Virus Disease, Acute Respiratory Infection
- Trial name
- NCT04403100
- Testing
- Hydroxychloroquine Sulfate Tablets, Lopinavir/ Ritonavir Oral Tablet, Hydroxychloroquine Sulfate Tablets plus Lopinavir/ Ritonavir Oral Tablets
- Where
- 4 sites in Brazil
- Volunteers
- 1,968 people
- Sponsor
- Cardresearch
Preventive Immunization COVID-19
An Open Study of the Safety, Tolerability and Immunogenicity of the Drug "Gam-COVID-Vac" Vaccine Against COVID-19
The purpose of the study is to assess safety, tolerability and immunogenicity of the drug "Gam-COVID-Vac ", a solution for intramuscular administration, with the participation of healthy volunteers Study objectives A safety and…
- Trial name
- NCT04436471
- Testing
- Gam-COVID-Vac
- Where
- Russia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
COVID-19 Pneumonia, COVID-19
Cardiac Magnetic Resonance Tissue Characterization in COVID-19 Survivors
The purpose of this study is to test if visualizing the heart with cardiac MRI/echo will be important in the understanding cardiac function and prediction of cardiopulmonary symptoms, physical effort tolerance, and outcomes in…
- Conditions
- COVID-19 Pneumonia, COVID-19, COVID-19 Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05164744
- Testing
- Cardiac MRI, Echocardiogram, 6-minute walk test
- Where
- 3 sites in United States
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Infertility, Male, COVID-19
Effect of COVID-19 on Platelet Mitochondrial Bioenergetic, Antioxidants and Oxidative Stress in Infertile Men.
To verify the hypothesis that infertility and the effect of SARS-CoV-2 on infertility may damage platelet mitochondrial bioenergetics and endogenous coenzyme Q10 levels in infertile men.
- Trial name
- COVInfertility (NCT05421234)
- Testing
- diagnostic test and sperm analysis
- Where
- Slovakia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Comenius University
Cough
Characteristics of Postinfectious Cough
Collect the age, sex and other demographic data of 1600 patients with chronic cough after COVID-19 infection and clinical parameters such as cough characteristics, establish a cohort of patients with chronic cough after COVID-19…
- Trial name
- NCT06951321
- Where
- China
- Volunteers
- 1,650 people, healthy volunteers welcome
- Sponsor
- Kefang Lai
COVID-19 Convalescent Plasma Treatment
Application of Convalescent Plasma in the Treatment of SARS CoV-2 Disease (COVID-19) With Evaluation of Therapy Effectiveness
A Multi-centre, 18-months, Single-group Study of Application of Convalescent Plasma in the Treatment of SARS CoV-2 Disease (COVID-19) With Metabolomic and Laboratory Evaluation of Plasma Therapy Effectiveness.
- Trial name
- EPIC-19 (NCT04642014)
- Testing
- COVID-19 convalescent plasma treatment
- Where
- Poland
- Volunteers
- 396 people
- Sponsor
- Wroclaw Medical University
Chronic Pain, Covid19
Effects of COVID-19 in Chronic Pain
The aim of this study is to evaluate the effects of the COVID-19 pandemic on pain, stress, sleep and quality of life in patients with chronic musculoskeletal pain and the relationships between them.
- Trial name
- NCT04878900
- Testing
- Survey
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ufuk University
Covid19
Total-Body Parametric 18F-FDG PET of COVID-19
The primary objective is to measure the change between COVID-19 patients and normal subjects; the secondary objective is to measure the change in COVID-19 patients between baseline and 4-month follow up.
- Trial name
- NCT04841707
- Testing
- uEXPLORER/mCT
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of California, Davis
COVID-19
Improving COVID-19 Vaccine Uptake Among Black and Latino Youth
Black and Latino youth may be less likely to get the COVID-19 vaccine than White youth. In this study we will work with community members to come up with ways to help Black and Latino families learn more about the COVID-19…
- Trial name
- NCT05293392
- Testing
- Culturally-Tailored COVID-19 Vaccine Uptake Intervention, Standard Care
- Where
- United States
- Volunteers
- 5,792 people
- Sponsor
- Nemours Children's Health System
COVID
Angiotensin Converting Enzyme Inhibitors in Treatment of Covid 19
ACEIs as treatment for COVID19
- Trial name
- NCT04345406
- Testing
- ACEIs, Conventional treatment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
COVID19, Thromboembolism
Impact of an Intensified Thromboprofylaxis Protocol in COVID-19
The aim of this study is to investigate and compare the mortality, the incidence of DVT and the incidence of kidney and liver failure in patients admitted to the ICU before and after the implementation of an intensified…
- Trial name
- NCT04394000
- Testing
- thromboprofylaxis protocol, standard protocol
- Where
- Belgium
- Volunteers
- 72 people
- Sponsor
- Jessa Hospital
Covid19
Characteristics and Outcomes of Hospitalized Patients With COVID-19 in Spain
COVID-19@Spain is a retrospective cohort study that aims to determine the clinical characteristics of hospitalized patients with COVID-19 in Spain and to identify prognostic factors of mortality and the need for mechanical…
- Trial name
- COVID19@Spain (NCT04355871)
- Where
- 128 sites in Spain
- Volunteers
- 4,035 people
- Sponsor
- Fundacion SEIMC-GESIDA
Smoking Cessation
The Impact of COVID-19 Pandemic on the Smoking Behaviour of Young Smokers and the Youth Quitline Service in Hong Kong
The aims of the present study are: 1. To explore the impact of COVID-19 pandemic on the smoking behavior of youth smokers 2. To explore the impact of COVID-19 pandemic on the Youth Quitline service in Hong Kong
- Trial name
- NCT04360863
- Testing
- Telephone survey
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- The University of Hong Kong
Covid19, Echocardiography
Evaluate Long Term Cardiovascular and Pulmonary Complications After COVID-19 With Point of Care Ultrasound
We hypothesize that recovered COVID-19 patients suffer long term cardiovascular and pulmonary complications, which can be detected by point of care ultrasound.
- Conditions
- Covid19, Echocardiography, Ultrasound
- Trial name
- NCT04756193
- Testing
- Point of care ultrasound including echocardiography, lung ultrasound, vascular ultrasound
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Louisville
COVID-19
Immunogenicity of Heterologous Versus Homologous Prime Boost Schedule With mRNA and Inactivated COVID-19 Vaccines
This study is a randomized, simple-blinded comparative phase III clinical trial comparing the immunogenicity of two doses Coronovac to that of a first dose of Coronovac (Sinovac, Beijing, China) followed by a booster shot with…
- Trial name
- NCT05668065
- Testing
- CoronaVac/CoronaVac, CoronaVac/BNT162b2
- Where
- 5 sites in Tunisia
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Tunis
Respiration, Artificial, COVID-19
Characteristics of Weaning From Mechanical Ventilation in COVID-19
This report is a multicenter, observational, analytical and prospective study. The objective was to describe the weaning of mechanical ventilation in patients with SARS-CoV-2 and the clinical results according to the different…
- Trial name
- CovWean (NCT05049200)
- Where
- 2 sites in Argentina
- Volunteers
- 326 people
- Sponsor
- Sanatorio Anchorena San Martin
Health Behavior
Partners For Life: Off-line Health Promotion Program for Ultra-orthodox Jewish Women During the COVID-19 Pandemic
The purpose of this study is to evaluate a unique culturally-tailored intervention aimed at increasing healthy eating and physical activity in Ultra-Orthodox Jewish women during the COVID-19 pandemic.
- Trial name
- NCT05135598
- Testing
- Partners for Life health behavior change program
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Donna R Zwas
Covid19, SARS-CoV Infection
COVID-19 Prophylaxis South Africa (COVER HCW)
This is a randomised, multi-center, open label, adaptive, exploratory trial to assess the efficacy of two different drug regimens in terms of preventing symptomatic COVID-19 disease in healthcare workers at high risk of exposure…
- Trial name
- COVER (NCT04561063)
- Testing
- Nitazoxanide, Sofosbuvir/Daclatasvir
- Where
- 2 sites in South Africa
- Volunteers
- 1,950 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
Long COVID, Post-acute COVID-19 Syndrome
Home-based Exercise Program in Patients With the Post-COVID-19 Condition
The management of the sequelae of COVID-19 is described as the next great challenge of global public health. Multiple symptoms may compose the clinical picture of these patients (eg, fatigue, dyspnea, cognitive dysfunction…
- Trial name
- NCT05360563
- Testing
- Home-based physical training
- Where
- Brazil
- Volunteers
- 94 people
- Sponsor
- University of Sao Paulo
Covid19
Study of the EpiVacCorona Vaccine With the Involvement of Volunteers Aged 60 Years and Above
The aim of the clinical study is to study the safety, reactogenicity and immunogenicity indicators of the EpiVacCorona vaccine, with the involvement of volunteers aged 60 years and above.
- Trial name
- NCT05021016
- Testing
- EpiVacCorona (EpiVacCorona vaccine based on peptide antigens for the prevention of COVID-19)
- Where
- Russia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Federal Budgetary Research Institution State Research Center of Virology and Biotechnology "Vector"