Clinical trials: COVID-19 Pneumonia
Covid19
Hyperbaric Oxygen for COVID-19 Patients With Moderate to Severe Hypoxemia
Of the many treatments proposed for COVID-19, few directly address the severe hypoxia among COVID-19 patients. Interim results from our single-center, non-randomized clinical trial (NCT04332081) suggest that hyperbaric oxygen…
- Trial name
- NCT04619719
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Legacy Health System
SARS-CoV-2 Infection
Evusheld Japan PMS_Japan Post-Marketing Surveillance (PMS)
To investigate intends to evaluate the incidence of adverse drug reactions (ADRs) in individuals who receive Evusheld in clinical practice to determine its post-marketing safety profile in Japanese.
- Trial name
- NCT05687877
- Where
- 18 sites in Japan
- Volunteers
- 366 people
- Sponsor
- AstraZeneca
COVID-19 Infection
Changes in Seroprevalence and Wellness Over Time in Healthcare Workers (CONSERVE-HCW)
The Investigators propose a multi-center, observational, longitudinal, cohort study of the serology and wellness of HCWs over a year of the COVID-19 pandemic.
- Trial name
- CONSERVE-HCW (NCT04595175)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Brian Tiffany, MD
Covid19, Kidney Transplant Infection
Anti-Viral Effects of Voclosporin in COVID-19 Positive Kidney Transplant Recipients
An open-label, 56 day, single-center, exploratory, proof-of-concept study of the anti-viral effect of voclosporin (VCS) with an extended safety follow-up, up to 1 year.
- Trial name
- VOCOVID (NCT04701528)
- Testing
- Voclosporin, Tacrolimus
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Leiden University Medical Center
COVID-19
A Study to Evaluate the Safety and Immunogenicity of Omicron COVID-19 Vaccine (Vero Cell), Inactivated in Population 18 Years Old of Age and Above
This is a non-randomized, open-label, externally controlled study to evaluate the safety and immnunogenicity of the Omicron COVID-19 Vaccine (Vero Cell), Inactivated in population aged 18 years old and above with no vaccination…
- Trial name
- COVID-19 (NCT05365724)
- Testing
- Omicron COVID-19 Vaccine (Vero Cell), Inactivated
- Where
- China
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- China National Biotec Group Company Limited
SARS (Severe Acute Respiratory Syndrome), COVID-19
Sero-epidemiological Study of the SARS-CoV-2 Virus Responsible for COVID-19 in France
On January 2020, the discovery of a new coronavirus (SARS-CoV-2) was officially announced by the Chinese health authorities and the World Health Organization (WHO).
- Trial name
- CORSER (NCT04325646)
- Testing
- Human Biological samples
- Where
- 21 sites in France
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Coronavirus Disease 2019 (Covid19), Hematopoietic Neoplasms
Impact of the Immune System on Response to Anti-Coronavirus Disease 19 (COVID-19) Vaccine in Allogeneic Stem Cell Recipients (Covid Vaccin Allo)
The present study is a prospective phase IV study. All participants will receive the anti-Coronavirus Disease 2019 (COVID-19) Vaccine (messenger Ribonucleic acid-based vaccine, BNT162b2 or Comirnaty®, commercialized by…
- Trial name
- NCT04951323
- Testing
- anti-COVID19 mRNA-based vaccine (BNT162b2, Comirnaty®, commercialized by Pfizer)
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Liege
Sars-CoV2, Covid-19
Interferon Lambda for Immediate Antiviral Therapy at Diagnosis in COVID-19
Interferon lambda is one of the main arms of the innate antiviral immune response and is critical for controlling respiratory viral infections in mice.
- Trial name
- ILIAD (NCT04354259)
- Testing
- Peginterferon Lambda-1A
- Where
- 7 sites in Brazil, Canada
- Volunteers
- 157 people
- Sponsor
- University Health Network, Toronto
Covid19, SARS-CoV Infection
COVID-19 in Polish Ice Swimmers.
Ice swimming is an increasingly common phenomenon in Poland. It has been confirmed that it has a beneficial effect on health by increasing the natural non-specific immunity to infections.
- Conditions
- Covid19, SARS-CoV Infection, Resistance, Disease, Hypothermia
- Trial name
- ICE (NCT04817280)
- Testing
- Ice Swimming
- Where
- 3 sites in Poland
- Volunteers
- 2,534 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Infections, Critical Illness
Ventilator-Associated Pneumonia in Critically Ill COVID-19 vs. Non-COVID-19 Patients
The COVID-19 pandemic has led to an increased incidence of ventilator-associated pneumonia (VAP) among critically ill patients. However, in a context of high prevalence of multidrug-resistant organisms (MDROs) there is a lack of…
- Conditions
- Infections, Critical Illness, Superinfection, Organ Failure, Multiple
- Trial name
- NCT05972980
- Testing
- COVID-19
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Covid-19
Efficacy of Nano-Ivermectin Impregnated Masks in Prevention of Covid-19 Among Healthy Contacts and Medical Staff
Antiviral efficacy of Ivermectin against Covid-19 in vitro was stated by many stusies all over the world with decreased effecacy in vivo so ,usage of masks impregnated into nano Ivermectin solution will theoretically increase the…
- Trial name
- NCT04723459
- Testing
- ivermectin impregnated mask
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- South Valley University
Trauma, COVID-19 Pandemic
The Impact of the Covid-19 Pandemic on Orthopedic Trauma Management
The aim of the study is to compare emergency orthopedic trauma admissions between the pre-pandemic period and the pandemic period and to detect changes in orthopedic trauma epidemiology.
- Trial name
- NCT06237023
- Testing
- epidemyolojical
- Where
- Turkey (Türkiye)
- Volunteers
- 57,635 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
TB, COVID-19
Evaluation of the Truenat™MTB Plus/COVID-19 Test for TB (Tuberculosis) and COVID-19 (SARS-CoV2)
This is a prospective, multicentre study in which the accuracy of the Molbio Diagnostics Truenat™ MTB (Mycobacterium tuberculosis) Plus/COVID-19multiplex will be assessed for TB and COVID-19 case detection using prospectively…
- Trial name
- Truenat COMBO (NCT05405296)
- Testing
- Truenat™ MTB Plus/COVID-19
- Where
- Uganda
- Volunteers
- 1,984 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Covid19, Corona Virus Infection
Study Designed to Evaluate the Effect of CimetrA in Patients Diagnosed With COVID-19
Multi-center multinational-controlled study in Israel, Brazil, Spain, and South-Africa. 240 adult patients who suffer from moderate COVID-19 infection.
- Trial name
- CimetrA (NCT05037162)
- Testing
- Biochemistry blood test, Hematology blood test, D-Dimer test (coagulation)
- Where
- Israel
- Volunteers
- 240 people
- Sponsor
- MGC Pharmaceuticals d.o.o
COVID
Study of the Safety of Therapeutic Tx With Immunomodulatory MSC in Adults With COVID-19 Infection Requiring Mechanical Ventilation
This is a phase 1b randomized, double-blind, placebo-controlled study in adult subjects with Coronavirus Disease 2019 (COVID-19).
- Trial name
- NCT04397796
- Testing
- BM-Allo.MSC
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- ImmunityBio, Inc.
Covid19, SARS-CoV Infection
Tenofovir-DF Versus Hydroxychloroquine in the Treatment of Hospitalized Patients With COVID-19 (TEDHICOV)
Although several therapeutic agents have been suggested for the treatment of the disease caused by the Coronavirus of the year 2019 (COVID-19), no antiviral has yet demonstrated consistent efficacy.
- Conditions
- Covid19, SARS-CoV Infection, Tenofovir
- Trial name
- TEDHICOV (NCT04812496)
- Where
- Peru
- Volunteers
- 100 people
- Sponsor
- Hospital Nacional Carlos Alberto Seguin Escobedo - EsSalud
Covid19, SARS-CoV2 Infection
Canine COVID-19 Detection Phase 2 and 3
The purpose of this study is to determine whether trained medical detection dogs can accurately detect the presence of COVID-19 in people infected with the virus, or using samples of their clothing or body odour.
- Trial name
- LSH1394 (NCT04948190)
- Testing
- Testing with medical detection dogs
- Where
- United Kingdom
- Volunteers
- 11,015 people, healthy volunteers welcome
- Sponsor
- ARCTEC
COVID-19 (Coronavirus Disease 2019), COVID-19 Pandemic
University Hospital of Ioannina COVID-19 (Coronavirus Disease 2019) Registry
COVID-19 (Coronavirus Disease 2019) Registry of University Hospital of Ioannina. Retrospective datasource registry with quantitative and qualitative patient data from the hospital medical records.
- Conditions
- COVID-19 (Coronavirus Disease 2019), COVID-19 Pandemic, COVID-19 Pneumonia, COVID-19 Respiratory Infection
- Trial name
- NCT05534074
- Where
- Greece
- Volunteers
- 2,500 people
- Sponsor
- University Hospital, Ioannina
Apnea, Obstructive Sleep, SARS CoV 2 Infection
Impact of Sleep Disorders on Innate Immunity in COVID-19 Patients
Sleep is an important modulator of the immune response, whereby sleep disturbances (ie, poor sleep quality, insufficient sleep and/or primary sleep disorder, obstructive sleep apnea (OSA)) contribute to inflammatory disease risk…
- Trial name
- NCT06341374
- Testing
- Influvac Tetra
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Parc Taulí Hospital Universitari
Covid19
Use of Monoclonal Antibodies for the Treatment of Mild to Moderate COVID-19 in Non-Hospitalized Setting
No therapeutic agent is currently approved for the treatment of SARSCoV-2 infection. More importantly, no intervention is currently available to mitigate the progression of disease from mid/moderate to serve particularly in high…
- Trial name
- NCT04840459
- Testing
- BAMLANIVIMAB, CASIRIVIMAB, IMDEVIMAB
- Where
- 3 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Sohail Rao
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