Clinical trials: COVID19 ARDS
COVID-19, COVID-19 Acute Respiratory Distress Syndrome
Study of Cysteamine-pantetheine Disulfide (TTI-0102) in Mild to Moderate COVID-19
This is multi-center, randomized, double-blind, placebo-controlled study to assess the safety, tolerability, pharmacodynamics (PD) and efficacy of TTI-0102 for the treatment of patients with mild to moderate COVID-19.
- Trial name
- NCT05212662
- Testing
- TTI-0102
- Sponsor
- Thiogenesis Therapeutics, Inc.
Corona Virus Infection, Acute Respiratory Distress Syndrome
Losartan for Patients With COVID-19 Not Requiring Hospitalization
This is a multi-center, double-blinded study of COVID-19 infected patients randomized 1:1 to daily losartan or placebo for 10 days or treatment failure (hospital admission).
- Conditions
- Corona Virus Infection, Acute Respiratory Distress Syndrome, SARS-CoV Infection
- Trial name
- NCT04311177
- Testing
- Losartan
- Where
- 4 sites in United States
- Volunteers
- 117 people
- Sponsor
- University of Minnesota
Respiratory Failure, Sars-CoV-2
The Effectiveness of Respiratory Tele-rehabilitation After COVID-19 Pneumonia Related: a Randomized Controlled Trial
In recent months, more and more studies suggest tele-rehabilitation as a means to be exploited to reduce the risk of contagion. The intent of our study is to verify the effectiveness of a tele-rehabilitation intervention through…
- Conditions
- Respiratory Failure, Sars-CoV-2, Covid19, ARDS
- Trial name
- NCT05007457
- Testing
- Telerehabilitation
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Respiratory Distress Syndrome, Adult, Covid19
High-Dose Vitamin C Treatment in Critically Ill COVID-19 Patients
Acute respiratory failure due to COVİD-19 pneumonia has poor prognosis and high mortality . Both the lack of an effective antiviral treatment and the low level evidence of the recommendations presented in the guidelines on other…
- Trial name
- NCT04710329
- Testing
- Ascorbic acid
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Coronavirus, SARS-CoV-2
Hemodynamic Characteristics of Patients With SARS-CoV-2
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a public health emergency of international concern.
- Conditions
- Coronavirus, SARS-CoV-2, COVID-19, Acute Respiratory Distress Syndrome
- Trial name
- PiCCOVID (NCT04337983)
- Testing
- Transpulmonary thermodilution, Echocardiography
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Bicetre Hospital
Covid19, Acute Respiratory Distress Syndrome
The MEseNchymal coviD-19 Trial: MSCs in Adults With Respiratory Failure Due to COVID-19 or Another Underlying Cause
This is a pilot, multi-centre, open-label randomised controlled study to assess the early efficacy of intravenous (IV) administration of CYP-001 in adults admitted to an intensive care unit (ICU) with respiratory failure
- Trial name
- MEND (NCT04537351)
- Testing
- CYP-001
- Where
- 5 sites in Australia
- Volunteers
- 14 people
- Sponsor
- Cynata Therapeutics Limited
Covid-19
Hydrogen Therapy in Patients With Moderate Covid-19
SARS-CoV-2 is the agent responsible for a new infectious respiratory disease called Covid-19 (for CoronaVirus Disease 2019) which is mainly characterized by potentially severe and fatal lung damage.
- Trial name
- H2Covid (NCT04633980)
- Testing
- Mixture 3,6% H2 in N2 (96.4%)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Grenoble
Lung Injury, ARDS
Point-of-care Lung Ultrasound (POCUS)-Integrated Study of Admitted Patients With COVID-19
This study seeks to define the ultrasound profile of patients with COVID-19, and document the progression of these ultrasound findings to develop prognostication and clinical decision instruments that can help guide management of…
- Conditions
- Lung Injury, ARDS, Acute Cardiac Event, Covid19
- Trial name
- PIOS-COVID (NCT05228717)
- Testing
- Point of Care Ultrasound
- Where
- 4 sites in United States
- Volunteers
- 240 people
- Sponsor
- Olive View-UCLA Education & Research Institute
ARDS Due to Disease Caused by SARS Co-V-2
Prediction of Conversion From Vv-ECMO to Va-ECMO in COVID-19 Patients
In December 2019, cases of a novel lung disease, later referred to as COVID-19, were first reported in China. The virus SARS-CoV-2 was identified as the causative agent.
- Trial name
- ECMOPred-vvva (NCT05910996)
- Testing
- Conversion from vv-ECMO to va-ECMO
- Where
- Austria
- Volunteers
- 99 people
- Sponsor
- Kepler University Hospital
ARDS, COVID-19
Monitoring Anticoagulation in Patients on ECMO for Severe Lung Failure
A monocentric observational study evaluates the accuracy of anticoagulation monitoring in critically ill patients on ECLS (extracorporeal life support) using new markers of the effect of direct thrombin inhibitors and also the…
- Trial name
- NCT06038682
- Testing
- Argatroban Injection, Heparin
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Ostrava
Covid-19, ARDS, Human
Nebulized Heparin for the Treatment of COVID-19 Induced Lung Injury
Randomized, placebo controlled study to determine if nebulized heparin may reduce the severity of lung injury caused by the novel coronavirus, also known as COVID-19
- Conditions
- Covid-19, ARDS, Human, Acute Lung Injury
- Trial name
- NCT04397510
- Testing
- Heparin, 0.9% Sodium-chloride
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Frederick Health
COVID-19
Decitabine for Coronavirus (COVID-19) Pneumonia- Acute Respiratory Distress Syndrome (ARDS) Treatment: DART Trial
This is a a randomized double blind placebo controlled Phase 2 trial with a 12 patient lead-in to evaluate safety, prior to full enrollment to an additional 28 patients (for a total of 40 patients) to assess efficacy of…
- Trial name
- DART (NCT04482621)
- Testing
- Decitabine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Johns Hopkins University
SARS-CoV 2, Respiratory Distress Syndrome, Adult
Characteristics and Outcomes of Patients With COVID-19 Admitted to the ICU
This is a case series of patients with COVID-19 admitted to the largest university hospital in Sao Paulo, Brazil, during the 2020 COVID-19 pandemic. Data will be collected prospectively and retrospectively.
- Conditions
- SARS-CoV 2, Respiratory Distress Syndrome, Adult, Corona Virus Infection, Critical Illness
- Trial name
- EpiCoV-Brazil (NCT04378582)
- Testing
- risk factors
- Where
- Brazil
- Volunteers
- 1,589 people
- Sponsor
- University of Sao Paulo General Hospital
Mechanical Ventilation Complication, Hypoxemia
Trial of Venovenous ECMO to De-Sedate, Extubate and Mobilise in Hypoxic Respiratory Failure
To determine whether a strategy of adding venovenous ECMO to mechanical ventilation, as compared to mechanical ventilation alone, increases the number of intensive care free days at day 60, in patients with moderate to severe…
- Conditions
- Mechanical Ventilation Complication, Hypoxemia, Acute Respiratory Distress Syndrome Due to COVID-19, COVID-19 Respiratory Infection
- Trial name
- REDEEM (NCT05562505)
- Testing
- Venovenous ECMO
- Where
- 7 sites in Australia, Germany
- Volunteers
- 140 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Covid19, ARDS
A Prospective Clinical Study to Explore Response to Prone Positioning in ARDS Patients
The proposed study will be conducted to investigate the mechanism of patients' responses to prone positioning with coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) and non-COVID-19 ARDS utilizing…
- Trial name
- NCT04692779
- Testing
- Lung Ultrasound (LUS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rush University Medical Center
COVID-19, SARS-CoV 2
Clinical Scores for Outcome Prediction in Patients With Severe COVID-19 Pneumonia Requiring ECMO
The prognosis of patients with severe COVID-19 disease, whose lungs are so severely diseased that they need to be supported by veno-venous ECMO (extracorporeal membrane oxygenation), is difficult to assess so far.
- Conditions
- COVID-19, SARS-CoV 2, Extracorporeal Membrane Oxygenation, ARDS
- Trial name
- NCT04405973
- Testing
- vv-ECMO
- Where
- Germany
- Volunteers
- 133 people
- Sponsor
- Dr. Alexander Supady
Acute Respiratory Distress Syndrome, SARS-CoV-2
Valsartan for Prevention of Acute Respiratory Distress Syndrome in Hospitalized Patients With SARS-COV-2 (COVID-19) Infection Disease
Rationale: The current SARS-CoV-2 pandemic has a high burden of morbidity and mortality due to development of the so-called acute respiratory distress syndrome (ARDS).
- Conditions
- Acute Respiratory Distress Syndrome, SARS-CoV-2, COVID, COVID-19
- Trial name
- NCT04335786
- Testing
- Valsartan (Diovan)
- Where
- 7 sites in Netherlands
- Volunteers
- 23 people
- Sponsor
- Radboud University Medical Center
ARDS, COVID19
Evaluation of Airway Pressure Release Ventilation in COVID-19 ARDS
The 2020 pandemic of the coronavirus (SARS-CoV2) has lead to an increase in ARDS cases requiring invasive mechanical ventilation in the ICU (Intensive Care Unit).
- Trial name
- APRV-COVID19 (NCT04386369)
- Testing
- Airway pressure release ventilation
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Central Hospital, Nancy, France
COVID-19 Acute Respiratory Distress Syndrome
Efficacy of Nebulized Lidocaine, Salbutamol, and Beclomethasone Plus Salbutamol in the Covid-19 Patients With ARDS on Non-invasive Ventilation; Randomized Control Trial
The COVID-19, a pandemic as declare by WHO1, has a devastating impact on health and economic worldwide2. Literature suggests that acute respiratory distress syndrome (ARDS) develops over 20% of the infected individuals with…
- Trial name
- NCT04979923
- Testing
- Lidocaine
- Where
- Pakistan
- Volunteers
- 81 people
- Sponsor
- Sheikh Zayed Medical College
COVID19, Oxygen Therapy
Impact of Prone Position in Patients Under Spontaneous Breathing on Intubation or Non-invasive Ventilation or Death Incidence During COVID-19 Acute Respiratory Distress
The SARS-Cov2 viral pandemic is responsible for a new infectious disease called COVID-19 (CoronaVIrus Disease), is a major health problem.
- Conditions
- COVID19, Oxygen Therapy, Prone Position, Spontaneous Ventilation
- Trial name
- PROVID-19 (NCT04363463)
- Testing
- prone position
- Where
- 19 sites in France, Monaco
- Volunteers
- 268 people
- Sponsor
- Centre Hospitalier Régional d'Orléans