Clinical trials: COVID19 ARDS
COVID-19 Acute Respiratory Distress Syndrome, Acute Kidney Injury Due to COVID-19
Acute Kidney Dysfunction in COVID-19 and Non-COVID-19 Related ARDS
In addition to respiratory involvement, SARS-CoV 2, the virus responsible for coronavirus 2019 or Covid-19, appears to be responsible for renal involvement such as acute renal failure or proteinuria, so the mechanisms are not…
- Trial name
- URICOV (NCT05699889)
- Testing
- Data collection
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Severe Acute Respiratory Syndrome Coronavirus 2, Severe Acute Respiratory Distress Syndrome
Cell Therapy Using Umbilical Cord-derived Mesenchymal Stromal Cells in SARS-CoV-2-related ARDS
Whereas the pandemic due do Covid-19 continues to spread, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Severe Acute Respiratory Distress Syndrome in 30% of patients with a 30%-60% mortality rate for…
- Trial name
- STROMA-CoV2 (NCT04333368)
- Testing
- Umbilical cord Wharton's jelly-derived human, NaCl 0.9%
- Where
- 2 sites in France
- Volunteers
- 47 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ARDS, Human, COVID-19
Early Versus Late ECMO Therapy in COVID-19 Induced ARDS (ECMO-VID)
Experimental intervention: Insertion of Extracorporal Membrane Oxygenation (ECMO) within 24 hours of referral to an Intensive Care Unit.
- Trial name
- ECMO-VID (NCT04341285)
- Testing
- ECMO Implantation
- Where
- Germany
- Sponsor
- University Hospital Tuebingen
COVID-19 Acute Respiratory Distress Syndrome
Is Fetal Hemoglobin a Key for Improvement of Hypoxia and Saving Last Breath in COVID-19 Patient?. A Pilot Study.
In December 2019, a sudden public health incident (the corona virus disease [COVID-19] epidemic) occurred in Wuhan, China. Clinical features of those with pneumonia include fever and cough, and in many cases a sudden and…
- Trial name
- NCT05092724
- Testing
- fetal blood transfusion
- Volunteers
- 20 people
- Sponsor
- Zagazig University
Viral Lung Infection and Acute Respiratory Failure
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
The purpose of this study is to evaluate the effect of tozorakimab, as an add-on to SoC in patients with viral lung infection requiring supplemental oxygen, on the prevention of death or progression to IMV/ECMO.
- Trial name
- TILIA (NCT05624450)
- Testing
- Tozorakimab
- Where
- 473 sites in United States, Argentina and 37 more
- Volunteers
- 3,527 people
- Sponsor
- AstraZeneca
Pulmonary Fibrosis, COVID-19
Pulmonary Fibrosis After Severe COVID-19 Pneumonia
Patients discharged after hospitalization for COVID-19 pneumonia were retrospectively selected by radiologically established criteria that at admission presented at chest computed tomography (CT) (i) normal lung parenchyma <50%…
- Trial name
- SPIFFERO (NCT06423560)
- Testing
- Computed tomography
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- IRCCS San Raffaele
SARS CoV 2 Infection, Pneumonia
SP16 as a Therapeutic for COVID-19 Induced ARDS
This randomized, double-blind, placebo-controlled, Phase 1b study evaluates the safety and tolerability, and effects on cytokine and acute phase reactants of SP16, an anti-inflammatory drug, in patients with pneumonia due to…
- Trial name
- NCT05135624
- Testing
- SP16 (6mg), SP16 (12 mg)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Serpin Pharma, LLC
Respiratory Distress Syndrome, Adult, Covid-19
Dexamethasone for COVID-19 Related ARDS: a Multicenter, Randomized Clinical Trial
There is compelling data indicating that there is an excessive inflammatory response in some patients with COVID-19 leading them to develop ARDS that can be severe with a very poor prognosis.
- Trial name
- NCT04395105
- Testing
- High-Dose Dexamethasone
- Where
- 4 sites in Argentina
- Volunteers
- 100 people
- Sponsor
- Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno
COVID-19, Respiratory Failure
Effects of Cardiovascular and Pulmonary Optimization on Cerebral Oxygenation in COVID-19 Patients With Severe ARDS
The aim of the present study is to examine whether cerebral oxygenation could be a more useful parameter than peripheral oxygen saturation to guide clinical titration of permissive hypoxemia in COVID-19 ARDS patients
- Trial name
- NIRS-COV (NCT04392089)
- Testing
- Masimo, LidCO
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Hvidovre University Hospital
Covid19, SARS-CoV Infection
Direct Topical Lung T3 Treatment to Improve Outcome & Sequelae of COVID-19 Acute Respiratory Distress Syndrome
Acute treatment of COVID-ARDS with direct topical lung instilled T3 therapy for patients on mechanical ventilation.
- Conditions
- Covid19, SARS-CoV Infection, ARDS, ARDS, Human
- Trial name
- NCT04725110
- Testing
- Instilled T3
- Where
- United States
- Sponsor
- University of Minnesota
COVID-19, Respiratory Failure
Tenecteplase in Patients With COVID-19
This is a placebo-controlled, double blind, randomized, Phase II dose escalation study intended to evaluate the potential safety and efficacy of tenecteplase for the treatment of COVID-19 associated respiratory failure.
- Conditions
- COVID-19, Respiratory Failure, ARDS
- Trial name
- NCT04505592
- Testing
- Tenecteplase
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Hooman Poor
Sars-CoV2
Endotracheal Tube Obstruction in Covid-19 Patients Requiring Mechanical Ventilation
The COVID-19 pandemic is very present in our region, the Grand-Est region is considered as one of the first COVID-19 epicentres in France.
- Trial name
- TubeObs-Covid (NCT04394429)
- Where
- France
- Volunteers
- 184 people
- Sponsor
- University Hospital, Strasbourg, France
Covid19, ARDS
Assessment of Lung Mechanics in COVID-19 Acute Respiratory Distress Syndrome
This study is meant to assess the lung mechanics in SARS-CoV-2 induced acute respiratory failure. A precise characterisation of lung mechanics and heart-lung-interactions might allow a better understanding of SARS-CoV-2 induced…
- Trial name
- LungMechCoV-19 (NCT04597853)
- Testing
- Assessment of lung mechanics and heart-lung interactions
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- University of Zurich
Pulmonary Embolism, Covid-19
Prevalence and Characteristics of Pulmonary Embolism on COVID-19 Patients Presenting Respiratory Symptoms
Multicentric case-control study that is aims at: evaluating the prevalence of pulmonary embolism among a large population of consecutive patients admitted for COVID-19 pneumonia into two large university hospitals in Paris…
- Trial name
- COVID-EP (NCT04420312)
- Where
- France
- Volunteers
- 1,024 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe)
Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19)
This is a multi-center, randomized, placebo controlled, interventional phase 2A trial to evaluate the safety profile and potential efficacy of multi-dosing of mesenchymal stromal cells (MSC) for patients with SARS-CoV-2…
- Conditions
- Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe), COVID-19 Pneumonia
- Trial name
- NCT04466098
- Testing
- Mesenchymal stromal cells
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Covid19
Remdesivir for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial)
This study looks at the safety and effectiveness of Remdesivir in treating COVID-19 in people who have been hospitalized with the infection and who have acute respiratory failure.
- Trial name
- NCT06729593
- Testing
- Remdesivir, Corticosteroid
- Where
- 40 sites in United States
- Volunteers
- 87 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19, Mechanical Ventilation Complication
Clinical Trial of Efficacy and Safety of Oral Drug in Adult Patients With COVID-19
This is a Phase 1, multi-center, dose escalation study that is followed by a Phase 2 randomized, double-blind, placebo-controlled study of the safety and efficacy of WP1122 administered q12h ±1 hr PO in adult patients with…
- Conditions
- COVID-19, Mechanical Ventilation Complication, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- WP1122 (NCT05365321)
- Testing
- WP1122
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- Andrei Carvalho Sposito
COVID-19, COVID-19 Acute Respiratory Distress Syndrome
The Effect of Listening to Music During CPAP on the Agitation Levels and Compliance.
Aim: This study was conducted to determine the effect of listening to music during CPAP on the agitation levels of intensive care patients who underwent CPAP due to COVID-19 and their compliance with the treatment.
- Trial name
- NCT05102084
- Testing
- Listening to music with a bluetooth headset to patients receiving CPAP support
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- SÜMEYYE BİLGİLİ
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Tocilizumab for Patients With Cancer and COVID-19 Disease
This phase II expanded access trial will study how well tocilizumab works in reducing the serious symptoms including pneumonitis (severe acute respiratory distress) in patients with cancer and COVID-19.
- Conditions
- Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Pneumonia, Pneumonitis
- Trial name
- NCT04370834
- Testing
- Tocilizumab
- Where
- 5 sites in United States
- Volunteers
- 1 people
- Sponsor
- National Cancer Institute (NCI)
Covid19
Tableted COVID-19 Therapeutic Vaccine
Safety and immunogenicity one-month study in healthy individuals administered once-daily pill of therapeutic vaccine made from heat-inactivated plasma from donors with COVID-19.
- Trial name
- COVID-19 (NCT04380532)
- Testing
- V-SARS
- Where
- 2 sites in Canada, Mongolia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Immunitor LLC