Clinical trials: COVID19 ARDS
Acute Respiratory Distress Syndrome, Coronavirus Infection
Vadadustat for the Prevention and Treatment of Acute Respiratory Distress Syndrome (ARDS) in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19)
The purpose of this study is to evaluate the efficacy of vadadustat for the prevention and treatment of acute respiratory distress syndrome (ARDS) in hospitalized patients with Coronavirus Disease 2019 (COVID-19).
- Trial name
- NCT04478071
- Testing
- vadadustat
- Where
- United States
- Volunteers
- 448 people
- Sponsor
- The University of Texas Health Science Center, Houston
Covid19, Post Traumatic Stress Disorder
Quality of Life After COVID-19 Related Acute respIratory Distress Syndrome Among ICU Survivors Patients in Italy: the ODISSEA Study.
Acute respiratory insufficiency is one of the principal causes of intensive care admission for COVID 19 positive patients. This may determine a variable mortality rate ranging from 25-30%.
- Conditions
- Covid19, Post Traumatic Stress Disorder, Quality of Life
- Trial name
- ODISSEA (NCT04860687)
- Where
- 8 sites in Italy
- Volunteers
- 309 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Covid19, ARDS
Closed Loop Ventilation in Patients With COVID-19
Transpulmonary pressure may be higher in ARDS patients due to decreased respiratory system compliance. The hypothesis is that tidal volumes which are generated by Intellivent- Adaptive support ventilation (ASV) are safe range by…
- Trial name
- NCT04873336
- Testing
- Intellivent ASV
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
COVID-19 Drug Treatment
Telmisartan for Treatment of COVID-19 Patients
In late 2019, a new coronavirus emerged in Wuhan Province, China, causing lung complications similar to those produced by the SARS coronavirus in the 2002-2003 epidemic.
- Trial name
- NCT04355936
- Testing
- Telmisartan arm will receive 80 mg Telmisartan twice daily plus standard care.
- Where
- 2 sites in Argentina
- Volunteers
- 400 people
- Sponsor
- Laboratorio Elea Phoenix S.A.
Covid19, COVID-19 Pneumonia
A Retrospective Study of COVID-19 Treatments
Surveys administered to subjects who have recovered from COVID-19 to assess how effective their treatment was.
- Conditions
- Covid19, COVID-19 Pneumonia, COVID-19 Respiratory Infection, COVID-19 Acute Bronchitis
- Trial name
- NCT04949230
- Testing
- No Intervention Used
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- ProgenaBiome
Acute Respiratory Distress Syndrome (ARDS), COVID-19
Impact of Intravenous Lidocaine on Clinical Outcomes of Patients With ARDS During COVID-19 Pandemia
The purpose of our prospective monocentric, randomized, controlled trial is to evaluate the effects of intravenous lidocaine on gas exchange and inflammation in acute respiratory distress syndrome (ARDS) due or not to Covid-19…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), COVID-19, Corona Virus Infection
- Trial name
- LidoCovid (NCT04609865)
- Testing
- Lidocaine 2%, Control
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Strasbourg, France
SARS-CoV 2 Pneumonia
Calcifediol in the Treatment of SARS-CoV-2 Disease (COVID-19).
Descriptive, retrospective, observational, anonymous, study to evaluate the potential effect of incorporating calcifediol into the therapeutic protocol of patients hospitalized for COVID-19 on mortality and other outcome…
- Trial name
- COVIDIOL (NCT06279910)
- Testing
- Calcifediol
- Where
- Spain
- Volunteers
- 230 people
- Sponsor
- Complejo Hospitalario Universitario de Albacete
COVID-19 Pneumonia, COVID-19
Safety of Nebulized Combination Therapy BromAc® in COVID-19 Respiratory Disease
COVID-19 has multiple facets including cytokine storm, thromboembolism and gelatinous secretions. It is known that oxygen exchange is the main problem in patients with COVID-19 and hypoxia is one of the most serious, in which…
- Conditions
- COVID-19 Pneumonia, COVID-19, Ventilator Associated Pneumonia, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05258682
- Testing
- Bromelains, Acetylcysteine
- Volunteers
- 30 people
- Sponsor
- Mucpharm Pty Ltd
Covid19, Acute Respiratory Distress Syndrome
Blood Volume Assessment in COVID-19 and Bacterial Sepsis
In patients with SARS-CoV-2 or bacterial infection admitted to the intensive care unit (ICU), the state of the intravascular volume, the characteristics of the blood volume components, and the development of a vascular leak is…
- Conditions
- Covid19, Acute Respiratory Distress Syndrome, Bacterial Sepsis, Bacterial Infections
- Trial name
- BVAC19 (NCT04517695)
- Testing
- BVA-100, Transpulmonary Thermodilution (TPTD), Sublingual Microcirculation
- Where
- 3 sites in United States
- Volunteers
- 39 people
- Sponsor
- NYU Langone Health
AKI, ARDS
Safety and Efficacy of SCD in AKI or ARDS Patients Associated With COVID-19 Infections
Selective Cytopheretic Device (SCD) treatments will improve survival in patients testing positive for COVID-19 infection diagnosed with Acute Kidney Injury (AKI) or ARDS.
- Conditions
- AKI, ARDS, COVID
- Trial name
- NCT04395911
- Testing
- SCD
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- SeaStar Medical
ARDS, COVID-19 Acute Respiratory Distress Syndrome
Comparison of ARDS COVID-19 (WHO) vs ARDS Influenza in the ICU
Since the beginning of the SARS CoV 2 pandemia, the SARS CoV 2 was frequently compared with the seasonal influenza virus. However, few studies compared patients presenting acute respiratory distress syndrome (ARDS) induced by…
- Conditions
- ARDS, COVID-19 Acute Respiratory Distress Syndrome, Influenza
- Trial name
- NCT04941092
- Testing
- no intervention
- Where
- France
- Volunteers
- 157 people
- Sponsor
- Central Hospital, Nancy, France
Sedation Complication, Acute Respiratory Distress Syndrome Due to COVID-19
Assessment of Sedation Depth Using Processed EEG in ICU Patients With ARDS Receiving Neuromuscular Blockade: A Prospective Observational Study"
"In intensive care units, therapeutic paralysis has been a routine treatment method for many years in a select group of patients.
- Conditions
- Sedation Complication, Acute Respiratory Distress Syndrome Due to COVID-19, Anesthesia Awareness
- Trial name
- NCT06337877
- Testing
- Depth of sedation monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Tepecik Training and Research Hospital
Severe Pneumonia, Acute Respiratory Distress Syndrome
Treatment of COVID-19 Positive/Negative Bangladeshi Adults With Severe Respiratory Complaints by a Locally Made bCPAP: Feasibility Study
Low and middle-income countries (LMICs) urgently need cost-effective adaptive technologies to provide CPAP. The lead investigator has designed a device that has already been approved by the Directorate General of Drug…
- Conditions
- Severe Pneumonia, Acute Respiratory Distress Syndrome, Covid19
- Trial name
- Adult-bCPAP (NCT05158842)
- Testing
- Adult bubble CPAP oxygen therapy device
- Where
- 2 sites in Bangladesh
- Volunteers
- 20 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
ARDS Due to Disease Caused by SARS Co-V-2
Prediction of Conversion From Vv-ECMO to Va-ECMO in COVID-19 Patients
In December 2019, cases of a novel lung disease, later referred to as COVID-19, were first reported in China. The virus SARS-CoV-2 was identified as the causative agent.
- Trial name
- ECMOPred-vvva (NCT05910996)
- Testing
- Conversion from vv-ECMO to va-ECMO
- Where
- Austria
- Volunteers
- 99 people
- Sponsor
- Kepler University Hospital
COVID19 ARDS
Mild Hypothermia for COVID-19 ARDS
Some patients with COVID have abnormally high carbon dioxide and low oxygen levels despite being on the ventilator. The hypothesis of the study is that the application of mild hypothermia to patients with COVID will decrease…
- Trial name
- NCT04570462
- Testing
- Hypothermia Via Cooling Machine- Arctic Sun 5000
- Where
- United States
- Sponsor
- Northwell Health
Covid19, ARDS
Risk Factors and Computed Tomography Findings in COVID-19.
In the SARS-CoV2 pandemic, imaging studies proved its diagnostic utility to determine the severity of lung involvement. Computed tomography (CT) is a state-of-the-art study proven to be a highly sensitive diagnostic test…
- Conditions
- Covid19, ARDS, Pneumonia, Viral, Computed Tomography
- Trial name
- NCT04577105
- Testing
- Simple chest tomography
- Where
- Mexico
- Volunteers
- 233 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Covid19, ARDS, Human
Exhaled Breath Particles as a Clinical Indicator for Lung Injury and Acute Respiratory Distress Syndrome (ARDS)
Acute Respiratory Distress Syndrome (ARDS) reflects the hallmark of the critical course of coronavirus (COVID19). The investigators have recently shown that Exhaled Breath Particles (EBP) measured as particle flow rate (PFR) from…
- Conditions
- Covid19, ARDS, Human, ALI
- Trial name
- NCT04503057
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Lund University Hospital
COVID-19 Acute Respiratory Distress Syndrome
Perceptions and Representations of Vaccination Against COVID-19
SARS COV2, the virus that causes COVID-19, was first described in Wuhan, China. For this pathology, which causes severe respiratory infections, preventing the transmission of the virus has become fundamental, that is why vaccines…
- Trial name
- PERCECOVAC (NCT04896957)
- Testing
- Interview
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Acute Respiratory Failure, Covid19
Proportional Open Ventilation (POV) Device and Its Efficacy in Managing Acute Respiratory Failure in COVID-19 Patients
To evaluate the use of Life2000® Ventilator, a novel proportional open ventilation system in critical care use of acute onset of respiratory failure (ARF) and mild to moderate forms of acute respiratory distress syndrome (ARDS)…
- Trial name
- NCT04581161
- Testing
- Life2000® Ventilator
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Hill-Rom
COVID-19 Acute Respiratory Distress Syndrome
Chest and Abdominal Compression Versus PROne Position
Acute respiratory distress syndrome (ARDS) is a severe pulmonary insult responsible for major, life-threatening hypoxemia. The alteration of hematosis is secondary to alveolar edema, following damage to the alveolocapillary…
- Trial name
- CA_C_PRO (NCT05327205)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Fondation Hôpital Saint-Joseph