Clinical trials: CRC
Liver Cancer, Lung Cancer
Engineered TILs/CAR-TILs to Treat Advanced Solid Tumors
Tumor infiltration lymphocytes (TILs) have been harvested from advanced cancer patients and constructed to knockout PD1 gene and express scFvs against both PD1 and CTALA4 and CARs against various antigens, followed by transfusion…
- Conditions
- Liver Cancer, Lung Cancer, Breast Cancer, Colo-rectal Cancer
- Trial name
- NCT04842812
- Testing
- TILs and CAR-TILs targeting HER2, Mesothelin, PSCA, MUC1, Lewis-Y, GPC3, AXL, EGFR, Claudin18.2/6, ROR1, GD1, or B7-H3
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Colorectal Cancer
Probiotics In Colorectal Cancer Patients
Design: double blind controlled randomized trial with a parallel design and 3 treatment groups Description of subjects: Patients admitted in study centers for colorectal surgery under laporoscopy and/or laparotomy.
- Trial name
- NCT00936572
- Testing
- Probiotics (La1, BB536)
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University of Milano Bicocca
Colorectal Cancer
Study of Xeloxiri Regimen for Patients With Refractory Metastatic Colorectal Cancer
This is an open-label, single centre, single-arm phase II study which aims to assess the efficacy and tolerability of triplet combination of capecitabine, oxaliplatin and irinotecan (Xeloxiri regimen) in treating patients with…
- Trial name
- NCT03146377
- Testing
- Capecitabine, Oxaliplatin, Irinotecan
- Where
- Hong Kong
- Volunteers
- 32 people
- Sponsor
- The University of Hong Kong
Colon Cancer
Oral Green Tea Extract and Milk Thistle Extract to Colorectal Cancer Patients Undergoing Resection
Colorectal cancer is the third most common form of cancer found in the United States. To date surgical resection provides the best chance for cure.
- Trial name
- NCT01239095
- Testing
- Green Tea and Milk Thistle Supplements
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Richard Whelan
Colorectal Carcinoma, Cancer
Primary Colorectal Signet Ring Cell Carcinoma and the Risk of Multiple Primary Gastrointestinal Malignancies
This original research investigates the critical issue of gastrointestinal (GI) second primary malignancies (SPMs) in patients with signet ring cell carcinoma (SRCC), a rare and aggressive subtype of colorectal cancer.
- Conditions
- Colorectal Carcinoma, Cancer, Signet Ring Adenocarcinoma of the Colon
- Trial name
- NCT06978595
- Where
- Egypt
- Volunteers
- 8,171 people
- Sponsor
- asmaa salama ibrahim
Colorectal Cancer, Stage III Colon Cancer
Prognostic Value of the Immunoscore® Colon Test for Disease Free Survival Stratification in Stage III Patients Under Oxaliplatin Treatment
The primary objective is to validate that the Immunoscore® test (IS0 to IS4) is able to identify patients with high risk (IS 0-1) of relapse or death whichever occurs first among Stage III patients under oxaliplatin-based…
- Trial name
- NCT03422601
- Testing
- Immunoscore test
- Where
- France
- Volunteers
- 1,122 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Carcinoma, Colorectal Cancer
Tumor Antigen-sensitized DC Vaccine for Colorectal Cancer Liver Metastases
The aim of this study is to explore the safety and efficacy of tumor antigen-sensitized DC vaccine in postoperative adjuvant treatment of R0 excision Colorectal Cancer Liver Metastases.
- Trial name
- NCT06545630
- Testing
- Tumor antigen-sensitized DC vaccine
- Where
- China
- Volunteers
- 10 people
- Sponsor
- West China Hospital
Colorectal Cancer
Comparison of KRAS/BRAF Mutational Status With Conventional Techniques and Plasma Samples Analysis
The goal of this multicenter prospective study is to validate, and ultimately translate in routine clinical practice, the use of plasma analysis of ccfDNA for the determination of KRAS mutation status in mCRC patients.
- Trial name
- KPLEX2 (NCT02784639)
- Testing
- Plasma Analysis of circulating cell free DNA, Tumor tissue analysis of circulating cell free DNA
- Volunteers
- 115 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
DMMR Colorectal Cancer, Anti PD-1
Neoadjuvant Tisleizumab(BGB-A317) for dMMR/MSI-H Non-late Stage CRC Patients Before Surgery
According to the cancer statistics in 2020, colorectal cancer (CRC) remains a major public health issue worldwide, representing the third common cancer (10%) and second leading cause of death (9.4%) with 5-year survival rate…
- Conditions
- DMMR Colorectal Cancer, Anti PD-1, Immunotherapy
- Trial name
- NCT06262581
- Testing
- Tisleizumab(BGB-A317)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sun Yat-sen University
Gastrointestinal Cancer, Lung Cancer
A Study to Test Different Doses of BI 765049 Alone and in Combination With Ezabenlimab in Asian People With Advanced Cancer (Solid Tumours) Positive for B7-H6
This is a study in adults from Asia with different types of advanced cancer (solid tumours). People can join the study if they have cancer of the stomach, large bowel and rectum, pancreas, liver, head and neck or non-small cell…
- Conditions
- Gastrointestinal Cancer, Lung Cancer, Pancreatic Cancer, Colorectal Cancer
- Trial name
- NCT06091930
- Testing
- BI 765049, Ezabenlimab
- Where
- 3 sites in Japan
- Volunteers
- 21 people
- Sponsor
- Boehringer Ingelheim
Colonic Diseases
Low-fiber Diet for Colorectal Cancer Screening Colonoscopy
This trial will compare the efficacy of 2 different sets of dietary recommendations to be followed before colon cleansing for colorectal cancer screening colonoscopy.
- Trial name
- DIETCOL (NCT02401802)
- Testing
- Low-residue diet, Usual care
- Where
- Spain
- Volunteers
- 276 people
- Sponsor
- Parc de Salut Mar
Colorectal Neoplasms, Intestinal Neoplasms
Usefulness of GI-GENIUS in FIT-based Colorectal Cancer Screening Program.
Deep learning technology has an increasing role in medical image applications and, recently, an artificial intelligence device has been developed and commercialized by Medtronic for identification of polyps during colonoscopy…
- Conditions
- Colorectal Neoplasms, Intestinal Neoplasms, Gastrointestinal Neoplasms, Colonic Polyp
- Trial name
- CADILLAC (NCT04673136)
- Testing
- GI-GENIUS Medtronic, Colonoscopy
- Where
- 6 sites in Spain
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- Asociación Española de Gastroenterología
Colorectal Cancer, Surgery
CPET in Colorectal Surgery
The present study is a retrospective analysis of prospectively collected clinical data. Anonymized data from patients collected during routine clinical care from 7 major colorectal units in the UK who perform pre-operative…
- Trial name
- NCT02298907
- Where
- United Kingdom
- Volunteers
- 170 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Hepatic Arterial Infusion Plus Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Liver
Phase II trial to study the effectiveness of hepatic arterial infusion plus chemotherapy in treating patients who have colorectal cancer metastatic to the liver.
- Conditions
- Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Liver Metastases, Recurrent Colon Cancer
- Trial name
- NCT00026234
- Testing
- floxuridine, dexamethasone, oxaliplatin
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Cancer Institute (NCI)
Liver Metastases
CAR-T Hepatic Artery Infusions or Pancreatic Venous Infusions for CEA-Expressing Liver Metastases or Pancreas Cancer
This is an open label, fixed dose, phase Ib trial of anti-CEA CAR-T cell infusions delivered via the hepatic artery or splenic vein using the Surefire Infusion System (SIS) for patients with CEA-expressing liver metastases or…
- Trial name
- HITM-SURE (NCT02850536)
- Testing
- anti-CEA CAR-T cells
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Roger Williams Medical Center
Pancreatic Cancer, Gastrointestinal Neoplasms
Permission to Collect Blood Over Time for Research
To determine whether biomarkers assessed in blood samples can be used to detect individuals at risk for developing blood clots or worsening of their underlying disease.
- Conditions
- Pancreatic Cancer, Gastrointestinal Neoplasms, Colon Rectal Cancer Adenocarcinoma, Esophageal Cancer
- Trial name
- NCT00767234
- Testing
- Observation
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Stanford University
For Patients With Colorectal Cancer Liver Metastases Who Were Not Able to Curative Surgical Resection.Focused on the Treatment Effect With the Quintuple Method
Quintuple Method for Treatment of Multiple Refractory Colorectal Liver Metastases
The aim of this study is to explore the therapeutic effect of Quintuple method in the treatment of patients with multiple and refractory liver metastases from colorectal cancer.
- Trial name
- NCT05774964
- Testing
- Oxaliplatin, S1, Cetuximab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Liaoning Cancer Hospital & Institute
Oligometastatic Disease, Liver Metastases
Comparison of Contrast Agents in Liver Magnetic Resonance (MR) for the Detection of Hepatic Metastases
If an abbreviated hepatobiliary phase (HBP) protocol liver MR with gadobenate dimeglumine is shown clinically comparable to standard of care liver MR with gadoxetate disodium for detecting hepatic metastasis from colorectal…
- Conditions
- Oligometastatic Disease, Liver Metastases, Colorectal Cancer
- Trial name
- NCT04973007
- Testing
- Gadoxetate disodium, Gadobenate dimeglumine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Cystic Fibrosis, Colorectal Cancer
Colorectal Cancer Screening in Cystic Fibrosis
This multi-center study will compare multi-target DNA and quantitative FIT stool-based testing to colonoscopy in individuals with Cystic Fibrosis (CF) undergoing colon cancer screening with colonoscopy.
- Conditions
- Cystic Fibrosis, Colorectal Cancer, Adenoma
- Trial name
- NICE-CF (NCT05362344)
- Testing
- Stool tests
- Where
- 26 sites in United States
- Volunteers
- 350 people
- Sponsor
- University of Washington, the Collaborative Health Studies Coordinating Center
Metastatic Colorectal Cancer
Erbitux Study of CPT11, Oxaliplatin, UFToral Targeted Therapy
A Phase II trial to demonstrate the response rate, using the Response evaluation criteria in solid tumours (RECIST) criteria, of patients with locally advanced / metastatic colorectal cancer treated with combination of…
- Trial name
- eSCOUT (NCT01225744)
- Testing
- Cetuximab, Irinotecan, Oxaliplatin
- Where
- 3 sites in United Kingdom
- Volunteers
- 47 people
- Sponsor
- The Christie NHS Foundation Trust