Clinical trials: CRS
Chronic Rhinosinusitis With Nasal Polyps, Allergic Fungal Sinusitis
Comparing Budesonide Via MAD or INSI Prospective Cohort Study
Chronic Rhinosinusitis (CRS) is a common disorder in North America, affecting more than 31 million people annually. Common therapy for CRS includes intranasal corticosteroids (INCS) such as budesonide.
- Trial name
- NCT04267042
- Testing
- Budesonide, Mucosal Atomization Device, NeilMed squeeze bottle for Impregnated Nasal Saline Irrigation
- Volunteers
- 60 people
- Sponsor
- St. Paul's Hospital, Canada
Plagiocephaly, Craniosynostosis
Hanger Helmet Study
The purpose of this study is to examine a group of patients requiring helmet therapy (either patients with plagiocephaly or post-surgical patients) to compare outcomes of infants treated with the Hanger helmet (Hanger, Inc.) to…
- Trial name
- NCT02561728
- Testing
- Hangar Helmet, P-Pod Helmet
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Disorders of Consciousness, Vegetative State
Effectiveness of tTIs for Improving Consciousness in Patients With DoC
The goal of this clinical trial is to learn if a new type of brain stimulation called theta-burst patterned temporal interference stimulation (tTIs) works to improve awareness in people with disorders of consciousness (DoC).
- Conditions
- Disorders of Consciousness, Vegetative State, Minimally Conscious State
- Trial name
- NCT07539740
- Testing
- Theta-burst Patterned Temporal Interference Stimulation (tTIs)
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Zhujiang Hospital
Endodontically Treated Teeth
Clini Asses of Retentn,Pt Satisfactn and Recurrent Caries of Endocrs Versus Post Crs Using Reinforced Lithium Silicate
Coronal retention of the restoration of RCT teeth is usually compromised, thus intraradicular posts combined or not with core material may be required.
- Trial name
- NCT03713918
- Testing
- Reinforced lithium silicate endocrowns, Post retained reinforced lith silicate crn
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Cairo University
Consciousness Disorders
Validation of the Russian Version of Coma Recovery Scale-Revised (CRS-R)
The purpose of this study is to validate Russian version of Coma Recovery Scale - Revised and to assess its psychometric properties.
- Trial name
- NCT03060317
- Testing
- Examination with neurological scales.
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Research Center of Neurology, Russia
Cardiorenal Syndrome (CRS)
CR Aim #2 - AT1 Receptor Blockade & ACE Inhibition Effect on Humoral Function
To advance our understanding of the mechanisms of human cardiorenal syndrome with emphasis upon the interaction of diuretic therapy and the renal-angiotensin-aldosterone -system and cGMP pathway.
- Trial name
- NCT01678794
- Testing
- Candesartan
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Mayo Clinic
Cancer, Appendiceal, ColoRectal Cancer
Comparing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) Using Mitomycin-C Versus Melphalan for Colorectal Peritoneal Carcinomatosis
The purpose of this trial is to compare the morbidity and mortality of CRS-HIPEC using mitomycin-C versus melphalan for colorectal peritoneal carcinomatosis.
- Trial name
- NCT03073694
- Testing
- Mitomycin c, Melphalan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Kansas Medical Center
Craniosynostosis
Qualitative and Quantitative Study Which Aims to Determine the Specifics of the Announcement for the Diagnosis of Patients With Craniosynostosis and Their Parents to Better Support Them in Their Care
The purposes of this study are: to better understand the experience of the announcement for the diagnostic of craniosynostosis to patients and their families to improve the understanding of it and it modes of appropriation to…
- Trial name
- AmAc (NCT02287805)
- Testing
- qualitative survey, quantitative survey
- Where
- France
- Volunteers
- 574 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
CRS
Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis (EDSPD Protocol)
The purpose of this study is to establish the novel endoscopically-directed sinus potential difference (EDSPD) assay as an endpoint for therapy of sinus disease.
- Trial name
- NCT02997020
- Testing
- EDSPD
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
CRS
Subjective and Objective Outcome of ESS in CRSwNP
(A): Beidseitige Fronto-Spheno-Ethmoidektomie mit Erweiterung des natürlichen Zuganges zur Stirnhöhle (Draf Typ II): Unter einem Draf Typ II Zugang versteht man die Erweiterung des natürlichen Zuganges zur Stirnhöhle mit…
- Trial name
- NCT04868695
- Testing
- 1) Fronto-Sphenoethmoidektomie 2) Draf 2b 3) Draf 3
- Where
- Switzerland
- Volunteers
- 99 people
- Sponsor
- University of Zurich
Craniosynostosis, Bleeding
Tranexamic Acid for Craniofacial Surgery
This is a randomized, blinded, prospective study that will investigate the potential benefit of tranexamic acid to reduce the intraoperative bleeding and blood transfusions in pediatric patients undergoing craniofacial surgeries.
- Trial name
- NCT00722436
- Testing
- Tranexamic acid, saline
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
CRS - Cytokine Release Syndrome, Myeloma
A Phase II Study of Siltuximab for CRS/ICANs After CAR-T in Multiple Myeloma
This is a prospective Phase II study evaluating Siltuximab for CRS and ICANS after CAR-T infusion in multiple myeloma patients.
- Trial name
- NCT07106671
- Testing
- Siltuximab
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Craniosynostosis
Endoscopic Treatment for Isolated, Single Suture Craniosynostosis
This is a prospective study to evaluate outcomes in patients undergoing endoscopic craniectomy for isolated, single-suture craniosynostosis.
- Trial name
- NCT00769847
- Testing
- Endoscopic strip craniectomy
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Utah
Myeloma Multiple, Plasma Cell Leukemia
The Norwegian Immunotherapy in Multiple Myeloma Study
The goal of this observational study is to study the effectiveness and complications of novel immunotherapies used in the treatment of multiple myeloma in routine care in Norway.
- Conditions
- Myeloma Multiple, Plasma Cell Leukemia, AL Amyloidosis
- Trial name
- NIMMS (NCT06855121)
- Testing
- Teclistamab, Elranatamab, Ciltacabtagene Autoleucel
- Where
- 23 sites in Norway
- Volunteers
- 400 people
- Sponsor
- St. Olavs Hospital
Cytokine Release Syndrome, ICANS
Adjunctive Methylene Blue for Immunotherapy-related CRS and ICANS: Phase I Study
This Phase I, prospective, single-arm clinical study aims to evaluate the efficacy and safety of adjunctive methylene blue (MB) in patients experiencing cytokine release syndrome (CRS) or immune effector cell-associated…
- Trial name
- NCT07169487
- Testing
- Methylene Blue
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Cardiorenal Syndrome (CRS)
Screening of Predictive Biomarkers for Cardiorenal Syndrome
This study aims to explore the predictive value of specific biomarkers for cardiorenal syndrome (CRS) in patients with chronic heart failure (CHF).
- Trial name
- NCT07139626
- Testing
- This is an observational Study.
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Haiyan Pan
NSAID-Induced Asthma, NSAIDs Hypersensitivity
Long-term Effect of Dupilumab in N-ERD
This prospective observational study investigates the long-term effects of Dupilumab in patients with NSAID-exacerbated respiratory disease (N-ERD).
- Conditions
- NSAID-Induced Asthma, NSAIDs Hypersensitivity, Chronic Rhinosinusitis (CRS), Asthma Bronchiale
- Trial name
- NCT07049978
- Testing
- Observational follow-up of standard Dupilumab treatment
- Where
- Austria
- Volunteers
- 15 people
- Sponsor
- Medical University of Vienna
Craniosynostoses
Clinical Feasibility Study of Preoperative Surgical Planning
Most children diagnosed with craniosynostosis undergo a relatively extensive cranial vault remodeling procedure. The decision of performing surgical cranial shape correction for patients with craniosynostosis typically rests on a…
- Trial name
- NCT03812159
- Testing
- iCSPlan
- Where
- United States
- Sponsor
- Gary F. Rogers, MD
Cholangiocarcinoma
Efficacy and Safety of Pemigatinib in Subjects With Advanced/Metastatic or Surgically Unresectable Cholangiocarcinoma Who Failed Previous Therapy - (FIGHT-202)
The purpose of this study is evaluate the efficacy of pemigatinib in subjects with advanced/metastatic or surgically unresectable cholangiocarcinoma with FGFR2 translocation who have failed at least 1 previous treatment.
- Trial name
- NCT02924376
- Testing
- Pemigatinib
- Where
- 120 sites in United States, Belgium and 10 more
- Volunteers
- 147 people
- Sponsor
- Incyte Corporation
Heart Failure
Calcium, Phosphate, Renal Impairment and Coronary Artery Disease in the Cardio-renal Syndrome, The CAPRICORN-CRS Study
Heart failure (HF) is a major public health problem, which affects about 5 million Americans.HF is when the heart muscle does not pump as much blood as the body needs.
- Trial name
- CAPRICORN (NCT00853541)
- Where
- United States
- Sponsor
- Massachusetts General Hospital